sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1mdr | APG | Mandelate racemase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1mdr | APG | Mandelate racemase | / | 1.000 | |
| 1mra | APG | Mandelate racemase | / | 0.581 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.493 | |
| 2j0s | ANP | Eukaryotic initiation factor 4A-III | 3.6.4.13 | 0.491 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.490 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.485 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.484 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.484 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.482 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.481 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.480 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.480 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.480 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.480 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.478 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.477 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.476 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.476 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.476 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.476 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.474 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.474 | |
| 4l1x | STR | Aldo-keto reductase family 1 member C2 | / | 0.474 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.474 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.473 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.473 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.472 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.472 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.471 | |
| 4yao | 2AM | NADPH--cytochrome P450 reductase | / | 0.471 | |
| 1gs3 | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.470 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.470 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.470 | |
| 3zlm | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.470 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.469 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.469 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.469 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.469 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.468 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.468 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.468 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.468 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.467 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.467 | |
| 2aqb | TL6 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.467 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.467 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.467 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.467 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.467 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.466 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.465 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.465 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.465 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.465 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.464 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.464 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.464 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.463 | |
| 1q3h | ANP | Cystic fibrosis transmembrane conductance regulator | / | 0.463 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.463 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.463 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.462 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.462 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.462 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.462 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.462 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.461 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.461 | |
| 2bra | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.461 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.461 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3p9t | TCL | Repressor | / | 0.461 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.461 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.460 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.460 | |
| 1swt | BTN | Streptavidin | / | 0.460 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.460 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.460 | |
| 2oyf | IAC | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.460 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.460 | |
| 1m8j | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.459 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.459 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.459 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.459 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.459 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.459 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.459 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.458 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.458 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.458 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.457 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.457 | |
| 2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.457 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.457 | |
| 2izf | BTN | Streptavidin | / | 0.457 | |
| 2ji7 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.457 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.457 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.457 | |
| 3i0a | DBH | Neutrophil gelatinase-associated lipocalin | / | 0.457 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.457 | |
| 4l8u | 9AZ | Serum albumin | / | 0.457 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.456 | |
| 1n3r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.456 | |
| 1pwu | GM6 | Lethal factor | 3.4.24.83 | 0.456 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.456 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.456 | |
| 3nmn | PYV | Abscisic acid receptor PYL1 | / | 0.456 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.456 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.456 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.456 | |
| 4yau | 2AM | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.455 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.455 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.455 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.455 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.455 | |
| 4awt | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.455 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 5kf8 | ACO | Predicted acetyltransferase | / | 0.455 | |
| 1ez0 | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.454 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.454 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.454 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.454 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.454 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.454 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.454 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.454 | |
| 4rsl | FAD | Fructosyl peptide oxidase | / | 0.454 | |
| 4yaf | 2AM | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.453 | |
| 1sri | DMB | Streptavidin | / | 0.453 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.453 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 4eix | NIM | Phospholipase A2 VRV-PL-VIIIa | / | 0.453 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.453 | |
| 4pkw | GM6 | Lethal factor | 3.4.24.83 | 0.453 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.452 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.452 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.452 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.452 | |
| 1y5x | E89 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.452 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.452 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.452 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.452 | |
| 3v2u | ATP | Protein GAL3 | / | 0.452 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.451 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.451 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.451 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2rti | GLL | Streptavidin | / | 0.451 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.451 | |
| 3evb | SAH | Genome polyprotein | 2.1.1.56 | 0.451 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.451 | |
| 4jv3 | N32 | Beta-ketoacyl synthase | / | 0.451 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.451 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.450 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.450 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.450 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.450 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.450 | |
| 4fwj | FAD | Lysine-specific histone demethylase 1B | 1 | 0.450 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.450 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.449 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.449 | |
| 1p5r | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.449 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.449 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.449 | |
| 2oth | NIM | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.449 | |
| 2v74 | SAH | Histone-arginine methyltransferase CARM1 | / | 0.449 | |
| 2zym | ACX | Periplasmic binding protein | / | 0.449 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.449 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.449 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.449 | |
| 4ai8 | DZA | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.449 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.449 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.448 | |
| 1lke | DOG | Bilin-binding protein | / | 0.448 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.448 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.448 | |
| 2c31 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.448 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.448 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 2wge | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.448 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3n87 | N87 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.448 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.448 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4bhw | 01K | Histone acetyltransferase p300 | / | 0.448 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.448 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.448 | |
| 4phl | PIL | Phosphodiesterase | / | 0.448 | |
| 1nbu | PH2 | Dihydroneopterin aldolase | / | 0.447 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.447 | |
| 2j4k | U5P | Uridylate kinase | 2.7.4.22 | 0.447 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.447 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.447 | |
| 3wo0 | ADP | Alanine--anticapsin ligase | / | 0.447 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.447 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.447 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.447 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1dtn | APG | Mandelate racemase | / | 0.446 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.446 | |
| 1n3s | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.446 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1r0e | DFN | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.446 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.446 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 2oli | IOP | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.446 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.446 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.446 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.446 | |
| 4dph | P65 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.446 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.446 | |
| 4h7z | GUN | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
| 5kf9 | COA | Predicted acetyltransferase | / | 0.446 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.445 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.445 | |
| 1m0w | ANP | Glutathione synthetase | 6.3.2.3 | 0.445 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.445 | |
| 2ejz | SAH | Diphthine synthase | / | 0.445 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.445 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.445 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.445 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.445 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.445 | |
| 1g9c | BAB | Botulinum neurotoxin type B | 3.4.24.69 | 0.444 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 1kt7 | RTL | Retinol-binding protein 4 | / | 0.444 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.444 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.444 | |
| 2pws | IBP | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.444 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.444 | |
| 2uza | HTL | Pyruvate synthase | / | 0.444 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.444 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.444 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.444 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.444 | |
| 3pre | 3RE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3up3 | XCA | aceDAF-12 | / | 0.444 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.444 | |
| 3zy6 | GFB | GDP-fucose protein O-fucosyltransferase 1 | 2.4.1.221 | 0.444 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 4lrr | CF9 | Thymidylate synthase | / | 0.444 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.444 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.444 | |
| 4y9u | NAP | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.443 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.443 | |
| 1syn | F89 | Thymidylate synthase | / | 0.443 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.443 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 2bn4 | NAP | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.443 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.443 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.443 | |
| 3rdq | DTB | Streptavidin | / | 0.443 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 4lb2 | DM5 | Serum albumin | / | 0.443 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.443 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.443 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.443 | |
| 1efa | NPF | Lactose operon repressor | / | 0.442 | |
| 1g0r | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 1i2l | DCS | Aminodeoxychorismate lyase | 4.1.3.38 | 0.442 | |
| 1oho | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.442 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 2imp | NAI | Lactaldehyde dehydrogenase | 1.2.1.22 | 0.442 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.442 | |
| 2rtk | GLL | Streptavidin | / | 0.442 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.442 | |
| 3upt | TPP | Transketolase | / | 0.442 | |
| 3zv6 | 4HB | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.442 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.442 | |
| 1cjv | DAD | Adenylate cyclase type 2 | / | 0.441 | |
| 1cjv | DAD | Adenylate cyclase type 5 | / | 0.441 | |
| 1cm8 | ANP | Mitogen-activated protein kinase 12 | / | 0.441 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.441 | |
| 1efz | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1pr0 | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.441 | |
| 1qjg | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.441 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.441 | |
| 1srj | NAB | Streptavidin | / | 0.441 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.441 | |
| 1xuz | MMN | Capsule biosynthesis protein | / | 0.441 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.441 | |
| 2mok | FMN | Flavodoxin 1 | / | 0.441 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.441 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.441 | |
| 3kqj | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 4b1u | LAB | Actin, alpha skeletal muscle | / | 0.441 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.441 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.441 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.440 | |
| 1e79 | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.440 | |
| 1e79 | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.440 | |
| 1j9z | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.440 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.440 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 1r00 | SAH | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.440 | |
| 1txz | APR | Probable ADP-ribose 1''-phosphate phosphatase YML087W | 3.1.3.84 | 0.440 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.440 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.440 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.440 | |
| 2qds | MCO | Metallo-beta-lactamase type 2 | / | 0.440 | |
| 2r8o | T5X | Transketolase 1 | / | 0.440 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.440 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2z1w | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.440 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 3cvu | FAD | RE11660p | / | 0.440 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.440 | |
| 3sl2 | ATP | Sensor histidine kinase WalK | / | 0.440 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4ask | K0I | Lysine-specific demethylase 6B | 1.14.11 | 0.440 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.440 | |
| 4mv4 | ACP | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 4qen | SAH | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 | 2.1.1.43 | 0.440 | |
| 5bt9 | NAP | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.440 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.440 |