Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ce7 | ADP | ATP-dependent zinc metalloprotease FtsH |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ce7 | ADP | ATP-dependent zinc metalloprotease FtsH | / | 1.000 | |
| 4ww0 | ADP | ATP-dependent zinc metalloprotease FtsH | / | 0.587 | |
| 2cea | ADP | ATP-dependent zinc metalloprotease FtsH | / | 0.569 | |
| 1e32 | ADP | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.532 | |
| 3hu1 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.519 | |
| 3hu3 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.518 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.504 | |
| 1ofh | ADP | ATP-dependent protease ATPase subunit HslU | / | 0.501 | |
| 1s3s | ADP | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.498 | |
| 4d81 | ADP | AAA ATPase, central domain protein | / | 0.495 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.492 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.488 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.486 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.485 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.483 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.482 | |
| 2ghm | LIC | Mitogen-activated protein kinase 14 | / | 0.480 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.480 | |
| 4fcw | ADP | Chaperone protein ClpB | / | 0.480 | |
| 4kod | ADP | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.480 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.479 | |
| 3qxp | X64 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.479 | |
| 2e2q | ADP | ATP-dependent hexokinase | / | 0.477 | |
| 3rak | 03Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.477 | |
| 1gii | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.476 | |
| 1im2 | ADP | ATP-dependent protease ATPase subunit HslU | / | 0.476 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.475 | |
| 1ovm | TPP | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.474 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 4i7f | NVE | Gag-Pol polyprotein | 2.7.7.49 | 0.474 | |
| 4izy | 1J2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.474 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 3r7u | X96 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.471 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.471 | |
| 4lj5 | ADP | Chaperone protein ClpB | / | 0.471 | |
| 4lj8 | ADP | Chaperone protein ClpB | / | 0.471 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.470 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.470 | |
| 5c3c | ADP | CbbQ/NirQ/NorQ domain protein | / | 0.470 | |
| 1b14 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.469 | |
| 2g9u | G27 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.469 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.469 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.468 | |
| 1e94 | ANP | ATP-dependent protease ATPase subunit HslU | / | 0.468 | |
| 2d4v | NAD | Isocitrate dehydrogenase [NADP] | / | 0.468 | |
| 2zoq | 5ID | Mitogen-activated protein kinase 3 | 2.7.11.24 | 0.468 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.468 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.467 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.466 | |
| 2a0c | CK9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 2eq7 | NAD | Dihydrolipoyl dehydrogenase | / | 0.466 | |
| 3hrc | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.466 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.465 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.465 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.465 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.465 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.464 | |
| 1w1r | ZEA | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.464 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 4fd2 | ADP | Chaperone protein ClpB | / | 0.464 | |
| 4hyu | 1BK | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.464 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.464 | |
| 4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.464 | |
| 4lrz | ADP | PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.464 | |
| 2j3k | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.463 | |
| 3u9e | COA | Lmo1369 protein | / | 0.463 | |
| 4c04 | SFG | Protein arginine N-methyltransferase 6 | / | 0.463 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.463 | |
| 1dq9 | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.462 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 1in5 | ADP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.462 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.462 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.462 | |
| 3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.462 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.462 | |
| 4h50 | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.462 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.462 | |
| 4rqv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.462 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.462 | |
| 1sxj | ADP | Replication factor C subunit 5 | / | 0.461 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.461 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.461 | |
| 2e94 | 364 | Geranylgeranyl pyrophosphate synthase | / | 0.461 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.461 | |
| 3oqu | A8S | Abscisic acid receptor PYL9 | / | 0.461 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 3ump | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.461 | |
| 4hxy | NDP | Plm1 | / | 0.461 | |
| 4jrn | ANP | Rhoptry kinase family protein | / | 0.461 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.461 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.460 | |
| 2pzi | AXX | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.460 | |
| 2vk4 | TPP | Pyruvate decarboxylase | 4.1.1.1 | 0.460 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.460 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.459 | |
| 1yol | S03 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.459 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.459 | |
| 3nxe | 2NC | Protease | / | 0.459 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.459 | |
| 4g1w | G1W | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.459 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.459 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.458 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.458 | |
| 3lxp | IZA | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.458 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 1iy8 | NAD | Levodione reductase | / | 0.457 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.457 | |
| 3nun | JMZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 3qcs | 3Q1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 3qd0 | 3Q4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.457 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.456 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.456 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 3le6 | 2BZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3r7y | Z04 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3tnw | F18 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 4aw1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.456 | |
| 4nxw | ADP | Mitochondrial dynamics protein MID51 | / | 0.456 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.455 | |
| 2gr0 | ADP | Ferredoxin reductase | / | 0.455 | |
| 3lfn | A27 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3vs4 | VSF | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.455 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.455 | |
| 4lgg | VGG | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.455 | |
| 1lik | ADN | Adenosine kinase | 2.7.1.20 | 0.454 | |
| 1zgy | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 2biy | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.454 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.454 | |
| 4hys | 1BJ | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.454 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.454 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.453 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2vtt | LZD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3ezr | EZR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3qx4 | X4B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.453 | |
| 3zsi | 52P | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 4c3s | NAD | Aldehyde Dehydrogenase | / | 0.453 | |
| 4dlj | 6RG | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.453 | |
| 4fr0 | SAM | Arsenic methyltransferase | / | 0.453 | |
| 4kb8 | 1QO | Casein kinase I isoform delta | 2.7.11.1 | 0.453 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.453 | |
| 1ckp | PVB | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.452 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1sn5 | T3 | Transthyretin | / | 0.452 | |
| 1um0 | FMN | Chorismate synthase | / | 0.452 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.452 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2vto | LZ8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.452 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.452 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.452 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.452 | |
| 4fks | 46K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.452 | |
| 4kb8 | 1QN | Casein kinase I isoform delta | 2.7.11.1 | 0.452 | |
| 4z07 | PCG | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.452 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.451 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.451 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.451 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.451 | |
| 1rby | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.450 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 2r3l | SCW | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 2r3p | 3SC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.450 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.450 | |
| 3ezv | EZV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3gxo | MQA | Mitomycin biosynthesis 6-O-methyltransferase | / | 0.450 | |
| 3ml8 | ML8 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 3sju | NDP | Keto reductase | / | 0.450 | |
| 3tx1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.450 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.449 | |
| 2ccu | 2D9 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2nxe | SAM | Ribosomal protein L11 methyltransferase | 2.1.1 | 0.449 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.449 | |
| 3bhy | 7CP | Death-associated protein kinase 3 | / | 0.449 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.449 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 4asy | N5Y | Glucose-1-phosphate thymidylyltransferase | / | 0.449 | |
| 4bgh | 3I6 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.449 | |
| 4ct1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.449 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 4mcb | 21W | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.449 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.449 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.448 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.448 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.448 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.448 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.448 | |
| 2xvq | 9DS | Serum albumin | / | 0.448 | |
| 2zv9 | PP2 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.448 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.448 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.448 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3s1h | 56Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.448 | |
| 4mcc | 21X | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.448 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.447 | |
| 1y8y | CT7 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.447 | |
| 2j3i | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.447 | |
| 2r3k | SCQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 3qai | XNN | Ketohexokinase | / | 0.447 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.447 | |
| 3zls | 92P | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.447 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.447 | |
| 4agu | D15 | Cyclin-dependent kinase-like 1 | / | 0.447 | |
| 4e73 | 0NR | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.447 | |
| 4h0n | SAH | Dnmt2 | / | 0.447 | |
| 4oau | ADP | 2-5A-dependent ribonuclease | 3.1.26 | 0.447 | |
| 5d12 | G97 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.447 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.446 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.446 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.446 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.446 | |
| 1zao | ATP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.446 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.446 | |
| 2vth | LZ2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.446 | |
| 3rni | 21Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.446 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.446 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.446 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.446 | |
| 4jk3 | NAD | Uncharacterized protein | / | 0.446 | |
| 4zse | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 1ouy | 094 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 1svm | ATP | Large T antigen | 3.6.4 | 0.445 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.445 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.445 | |
| 2q6c | HR1 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.445 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 2vtp | LZ9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.445 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.445 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.445 | |
| 3kbz | 2T4 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.445 | |
| 3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.445 | |
| 3q3c | NAD | NAD-dependent L-serine dehydrogenase | / | 0.445 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.445 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.445 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.445 | |
| 4fyo | 0VF | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 4kiq | 1RA | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 1c70 | L75 | Protease | / | 0.444 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.444 | |
| 1eyq | NAR | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.444 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.444 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 1pxl | CK4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1tqp | ATP | RIO-type serine/threonine-protein kinase Rio2 | 2.7.11.1 | 0.444 | |
| 2csn | CKI | Casein kinase I homolog 1 | 2.7.11.1 | 0.444 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.444 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 2yr5 | FAD | Phenylalanine 2-monooxygenase precursor | 1.13.12.9 | 0.444 | |
| 3js2 | VM1 | Fibroblast growth factor receptor 1 | / | 0.444 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.444 | |
| 3qcx | 3Q2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 3r7i | X9I | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.444 | |
| 3sw4 | 18K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.444 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.444 | |
| 4zoh | FAD | Putative oxidoreductase FAD-binding subunit | / | 0.444 | |
| 5fsx | ADP | Uncharacterized protein | / | 0.444 | |
| 5im3 | DTP | Ribonucleoside-diphosphate reductase | / | 0.444 | |
| 1dq8 | COA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.443 | |
| 1e8w | QUE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.443 | |
| 1ori | SAH | Protein arginine N-methyltransferase 1 | / | 0.443 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.443 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 1xjj | DGT | Vitamin B12-dependent ribonucleotide reductase | / | 0.443 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.443 | |
| 2i5b | ADP | Pyridoxine kinase | / | 0.443 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.443 | |
| 2xcl | ANP | Phosphoribosylamine--glycine ligase | / | 0.443 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3h8b | NSY | Cathepsin L1 | 3.4.22.15 | 0.443 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3qcy | 3Q3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3r71 | X86 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3zok | NAD | 3-dehydroquinate synthase, chloroplastic | 4.2.3.4 | 0.443 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.443 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.443 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.443 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4im0 | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.443 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.443 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.443 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 5eox | ADP | Type 4 fimbrial biogenesis protein PilM | / | 0.443 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.442 | |
| 1geg | NAD | Diacetyl reductase [(S)-acetoin forming] | 1.1.1.304 | 0.442 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1pvd | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.442 | |
| 1qpb | TPP | Pyruvate decarboxylase isozyme 1 | / | 0.442 | |
| 1v1k | 3FP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1yp4 | ADP | Glucose-1-phosphate adenylyltransferase small subunit, chloroplastic/amyloplastic | 2.7.7.27 | 0.442 | |
| 1z7e | UGA | Bifunctional polymyxin resistance protein ArnA | / | 0.442 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.442 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 2vtq | LZA | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3bqr | 4RB | Death-associated protein kinase 3 | / | 0.442 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.442 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3r73 | X87 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3uk6 | ADP | RuvB-like 2 | 3.6.4.12 | 0.442 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.442 | |
| 4g6o | E28 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4ksh | HTT | DNA gyrase subunit B | / | 0.442 | |
| 4nj3 | 2KD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.442 | |
| 4ros | APR | Malate dehydrogenase | / | 0.442 | |
| 5a3c | NAD | SIR2 family protein | / | 0.442 | |
| 5ap7 | SVE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.442 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.441 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.441 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.441 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.441 | |
| 2q6b | HR2 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.441 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.441 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.441 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.441 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.441 | |
| 3ih0 | ANP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.441 | |
| 3pxy | JWS | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.441 | |
| 3wbf | NAP | Meso-diaminopimelate D-dehydrogenase | / | 0.441 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.441 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.441 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.441 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.441 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.441 | |
| 5ce3 | ADP | Protein kinase YopO | / | 0.441 | |
| 5ifi | PRX | Acetyl-coenzyme A synthetase | / | 0.441 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.440 | |
| 1ht2 | ADP | ATP-dependent protease ATPase subunit HslU | / | 0.440 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.440 | |
| 1u28 | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.440 | |
| 1uuo | BRF | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.440 | |
| 1ykr | 628 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2a5u | QYT | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.440 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.440 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.440 | |
| 2vwy | 7X5 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.440 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3ac5 | KZM | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.440 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3nuy | JPZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3r8l | Z30 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.440 | |
| 4eon | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.440 |