sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
2.200 Å
X-ray
2009-09-09
| Name: | Fibroblast growth factor receptor 1 |
|---|---|
| ID: | FGFR1_HUMAN |
| AC: | P11362 |
| Organism: | Homo sapiens |
| Reign: | Eukaryota |
| TaxID: | 9606 |
| EC Number: | / |
| Chain Name: | Percentage of Residues within binding site |
|---|---|
| B | 100 % |
| B-Factor: | 41.989 |
|---|---|
| Number of residues: | 19 |
| Including | |
| Standard Amino Acids: | 19 |
| Non Standard Amino Acids: | 0 |
| Water Molecules: | 0 |
| Cofactors: | |
| Metals: | |
| Ligandability | Volume (Å3) |
|---|---|
| 1.131 | 1572.750 |
| % Hydrophobic | % Polar |
|---|---|
| 47.00 | 53.00 |
| According to VolSite | |
| HET Code: | VM1 |
|---|---|
| Formula: | C10H6NO2S |
| Molecular weight: | 204.225 g/mol |
| DrugBank ID: | - |
| Buried Surface Area: | 51.96 % |
| Polar Surface area: | 81.25 Å2 |
| Number of | |
|---|---|
| H-Bond Acceptors: | 3 |
| H-Bond Donors: | 0 |
| Rings: | 2 |
| Aromatic rings: | 2 |
| Anionic atoms: | 1 |
| Cationic atoms: | 0 |
| Rule of Five Violation: | 0 |
| Rotatable Bonds: | 2 |
| X | Y | Z |
|---|---|---|
| 18.5681 | -24.8555 | 54.4931 |
Image generated by PoseView
Represent the protein/ligand binding mode, centered on the ligand
Dashed lines represents hydrogen bonds and metal interactions
Green residue labels for amino acids with hydrophobic contacts (green lines) to the ligand
| Ligand | Protein | Interaction | |||
|---|---|---|---|---|---|
| Atom | Atom | Residue | Distance (Å) | Angle (°) | Type |
| C1G | CD1 | LEU- 484 | 4.08 | 0 | Hydrophobic |
| C1I | CB | ALA- 512 | 4.26 | 0 | Hydrophobic |
| S1D | CG2 | ILE- 545 | 4.2 | 0 | Hydrophobic |
| S1D | CG2 | VAL- 561 | 3.72 | 0 | Hydrophobic |
| N1M | N | ALA- 564 | 2.95 | 161.93 | H-Bond (Protein Donor) |
| S1D | CD1 | LEU- 630 | 4.12 | 0 | Hydrophobic |
| C1I | CD1 | LEU- 630 | 3.47 | 0 | Hydrophobic |
