sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1yum | NCN | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1yum | NCN | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 1.000 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.503 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.496 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.491 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.490 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.489 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.488 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.488 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.486 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.486 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.486 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.485 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.484 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.484 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.484 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.482 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.481 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.481 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.481 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.480 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.480 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.479 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.479 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.478 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.478 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.478 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.478 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.477 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.477 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.476 | |
| 1nj5 | P5A | Proline--tRNA ligase | / | 0.475 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.475 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.475 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.475 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 1zp3 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.474 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.474 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.474 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.473 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.473 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.473 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.472 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.472 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.472 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.472 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.470 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.470 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.470 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.469 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.469 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.469 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.468 | |
| 3s7d | LEU_SER_LYS_LYS_MLZ | N-lysine methyltransferase SMYD2 | / | 0.468 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.468 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.467 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.466 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.466 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.466 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.465 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.465 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.465 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.465 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.465 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.465 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.464 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.464 | |
| 3fst | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.464 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.464 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.464 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.464 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.463 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.463 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.463 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.463 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.463 | |
| 1q6i | FK5 | FKBP-type peptidyl-prolyl cis-trans isomerase FkpA | 5.2.1.8 | 0.462 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.462 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.462 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.462 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.462 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.462 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.462 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.462 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.461 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.461 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.461 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.461 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.461 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.461 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.461 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.461 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.461 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.461 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 3n71 | SFG | Histone-lysine N-methyltransferase Smyd1 | / | 0.460 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.460 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.460 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.460 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1zp4 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.459 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.459 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.459 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.459 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.459 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.459 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.459 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.459 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.459 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.458 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.458 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.458 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.458 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.458 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.457 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.457 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.457 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.457 | |
| 2yqs | UD1 | UDP-N-acetylglucosamine pyrophosphorylase | 2.7.7.23 | 0.457 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.457 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.457 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.457 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.456 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.456 | |
| 2c27 | MA8 | Mycothiol acetyltransferase | 2.3.1.189 | 0.456 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.456 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.456 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4ef4 | C2E | Stimulator of interferon genes protein | / | 0.456 | |
| 4ikz | AFS | Di-tripeptide ABC transporter (Permease) | / | 0.456 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.456 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.456 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.456 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.455 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.455 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.455 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.455 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.455 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.455 | |
| 4h12 | SAH | Histone-lysine N-methyltransferase SETD2 | 2.1.1.43 | 0.455 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.454 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.454 | |
| 1nj6 | A5A | Proline--tRNA ligase | / | 0.454 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.454 | |
| 1zrq | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.454 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.454 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.454 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.454 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.454 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 4yqf | GDP | Septin-9 | / | 0.454 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.454 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.454 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.453 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.453 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.453 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.453 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.453 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.452 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.452 | |
| 2ydd | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 3d2p | COA | Amino-acid acetyltransferase | / | 0.452 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.452 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 4jfi | 1KT | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.452 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.452 | |
| 6cts | CIC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.452 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.451 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.451 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.451 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.451 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.451 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.451 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.451 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.451 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 4dja | FAD | (6-4) photolyase | / | 0.451 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.451 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.450 | |
| 1dor | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.450 | |
| 1e1q | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.450 | |
| 1e1q | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.450 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1vf3 | GDN | Glutathione S-transferase 3 | 2.5.1.18 | 0.450 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.450 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.450 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.450 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.450 | |
| 2gqp | PA7 | Endoplasmin | / | 0.450 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.450 | |
| 3eku | CY9 | Actin-5C | / | 0.450 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.450 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.450 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3kp0 | Z98 | D-ornithine 4,5-aminomutase subunit beta | / | 0.450 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 3qwp | SAM | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.450 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.450 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.450 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.450 | |
| 4h1q | 0XX | Matrix metalloproteinase-9 | 3.4.24.35 | 0.450 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.450 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.450 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.449 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.449 | |
| 1qs2 | NAD | Vip2Ac | / | 0.449 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.449 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.449 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.449 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.449 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.449 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.449 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.448 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.448 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.448 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.448 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.448 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.448 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.448 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.448 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.448 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.448 | |
| 3o7b | SAH | Ribosomal RNA small subunit methyltransferase Nep1 | / | 0.448 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.448 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.448 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.448 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.448 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.447 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.447 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 2fmo | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.447 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.447 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.447 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 3e4a | QIX | Insulin-degrading enzyme | 3.4.24.56 | 0.447 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.447 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.447 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.447 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.447 | |
| 4qen | SAH | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 | 2.1.1.43 | 0.447 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.447 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.446 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.446 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.446 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.446 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.446 | |
| 2tmn | 0FA | Thermolysin | 3.4.24.27 | 0.446 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.446 | |
| 3bnk | FMN | Flavoredoxin | / | 0.446 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.446 | |
| 3fsu | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.446 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.446 | |
| 3koz | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.446 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.446 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.446 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.446 | |
| 4j7g | TRH | PCZA361.3 | / | 0.446 | |
| 1a9c | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.445 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.445 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.445 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.445 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.445 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.445 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.445 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3t6i | NC8 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.445 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.444 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.444 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.444 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.444 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.444 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.444 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.444 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.444 | |
| 4e2y | JHZ | Methyltransferase | / | 0.444 | |
| 4mo2 | FAD | UDP-galactopyranose mutase | / | 0.444 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 5hyn | SAH | Histone-lysine N-methyltransferase EZH2 | 2.1.1.43 | 0.444 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.444 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1h8h | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.443 | |
| 1h8h | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 1jil | 485 | Tyrosine--tRNA ligase | / | 0.443 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.443 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.443 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2vrb | NAP | Triphenylmethane reductase | / | 0.443 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.443 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.443 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.443 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3t0i | SAH | Putative methyltransferase | / | 0.443 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.443 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4drm | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.443 | |
| 4hr2 | ADP | Nucleoside diphosphate kinase | / | 0.443 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4lut | DCS | Alanine racemase | / | 0.443 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.443 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.443 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.443 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.443 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.442 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1zpt | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.442 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.442 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.442 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.442 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.442 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.442 | |
| 2po3 | T4K | 4-dehydrase | / | 0.442 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.442 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.442 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.442 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.442 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.442 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.442 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.442 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.442 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.442 | |
| 4qtu | SAM | 18S rRNA (guanine(1575)-N(7))-methyltransferase | / | 0.442 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.442 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.442 | |
| 5k5z | ANP | Uncharacterized protein | / | 0.442 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.441 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
| 1iki | REY | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.441 | |
| 1ja0 | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.441 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.441 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.441 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.441 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.441 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2qw0 | 34Z | 4-chlorobenzoyl CoA ligase | / | 0.441 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.441 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.441 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 3pdn | SFG | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.441 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.441 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.441 | |
| 3rq6 | APR | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.441 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.441 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.441 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.441 | |
| 4coj | CTP | Uncharacterized protein | / | 0.441 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.441 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.441 | |
| 5cku | FAD | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.440 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.440 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.440 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.440 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.440 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 3ckq | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.440 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.440 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.440 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.440 | |
| 4b64 | FAD | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.440 | |
| 4zgs | NAD | Putative D-lactate dehydrogenase | / | 0.440 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.440 |