sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 1.000 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.775 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.745 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.644 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.595 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.574 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.569 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.553 | |
| 1ysl | COA | Hydroxymethylglutaryl-CoA synthase | 2.3.3.10 | 0.526 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.501 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.493 | |
| 2vd7 | PD2 | Lysine-specific demethylase 4A | 1.14.11 | 0.492 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.492 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.491 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.489 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.488 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.488 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.487 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.487 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.486 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.485 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.485 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.484 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.483 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.482 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.482 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.482 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.482 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.481 | |
| 4l4x | NDP | AmphI | / | 0.481 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.480 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.480 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.479 | |
| 2ejz | SAH | Diphthine synthase | / | 0.479 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.477 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.476 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.476 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.476 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.476 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.475 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.475 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.475 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.474 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.473 | |
| 3ndj | JHZ | Methyltransferase | / | 0.473 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.473 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.472 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.472 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.472 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.471 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.471 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.471 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.471 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.471 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.471 | |
| 2e15 | SAH | Diphthine synthase | / | 0.470 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.470 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.470 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.470 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.469 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.469 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.469 | |
| 4e32 | DWN | Methyltransferase | / | 0.469 | |
| 4phl | PIL | Phosphodiesterase | / | 0.469 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.469 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.468 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.468 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.467 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.467 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.467 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.467 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.467 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.466 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.466 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.465 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.465 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.465 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.465 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.465 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.465 | |
| 2ibw | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.465 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.465 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.464 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.464 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.464 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.464 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.463 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.463 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4nv1 | TYD | Formyl transferase | / | 0.463 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.462 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.462 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.462 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.462 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.462 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.462 | |
| 5il2 | SAH | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.462 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.461 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.461 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.461 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 2eeq | SAH | Diphthine synthase | / | 0.460 | |
| 2f3f | AXF | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.460 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.460 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.460 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.460 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.460 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.460 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.459 | |
| 1zdw | FLV | Prenyltransferase | / | 0.459 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.459 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.459 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.459 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.459 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.459 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.459 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.459 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.458 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.458 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.458 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.458 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.458 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.458 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.458 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.458 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.457 | |
| 1qf4 | RPD | Adenylosuccinate synthetase | / | 0.457 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.457 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.457 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.457 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.457 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.457 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.457 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.457 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.457 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.457 | |
| 5cyo | GDP | Septin-9 | / | 0.457 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.456 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.456 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.456 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.456 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.456 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.456 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.456 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.456 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.456 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.455 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.455 | |
| 1zpt | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.455 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.455 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.455 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.455 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.455 | |
| 3zsx | N44 | Integrase | / | 0.455 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.455 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.455 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.455 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.455 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.454 | |
| 2c31 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.454 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.454 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.454 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.454 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.454 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.454 | |
| 3up0 | D7S | aceDAF-12 | / | 0.454 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.454 | |
| 4e2d | FMN | Dehydrogenase | / | 0.454 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.454 | |
| 4jxr | ACO | Acetyltransferase | / | 0.454 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.454 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1kia | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.453 | |
| 1n4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.453 | |
| 2dxv | SAH | Diphthine synthase | / | 0.453 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.453 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 3e6e | DCS | Alanine racemase | / | 0.453 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.453 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.453 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.453 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.453 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.452 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.452 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.452 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.452 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.452 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.452 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.452 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.452 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.452 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.452 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.452 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.452 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.452 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.452 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.452 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.452 | |
| 5c4f | UPG | Histo-blood group ABO system transferase | / | 0.452 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.451 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.451 | |
| 2emr | SAH | Diphthine synthase | / | 0.451 | |
| 2owu | SAH | Diphthine synthase | / | 0.451 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.451 | |
| 2ym2 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 2z6r | SAH | Diphthine synthase | / | 0.451 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.451 | |
| 3klb | FMN | Uncharacterized protein | / | 0.451 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.451 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.451 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.451 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.451 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.451 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.451 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.450 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.450 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.450 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.450 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.450 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.450 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.450 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 2p6k | SAH | Diphthine synthase | / | 0.450 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3kmx | G00 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.450 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.450 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.450 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.450 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.449 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.449 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.449 | |
| 1nht | PGS | Adenylosuccinate synthetase | / | 0.449 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.449 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.449 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.449 | |
| 2dxw | SAH | Diphthine synthase | / | 0.449 | |
| 2eka | SAH | Diphthine synthase | / | 0.449 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.449 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.449 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.449 | |
| 3ih0 | ANP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.449 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.449 | |
| 3tfy | MET_LEU_GLY_PRO | N-alpha-acetyltransferase 50 | 2.3.1 | 0.449 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.449 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.449 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.448 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.448 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.448 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.448 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.448 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 1vsv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2pfg | DDD | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.448 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.448 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.448 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3eks | CY9 | Actin-5C | / | 0.448 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.448 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.448 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.448 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.448 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.448 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.448 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.447 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.447 | |
| 1d2h | SAH | Glycine N-methyltransferase | 2.1.1.20 | 0.447 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.447 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.447 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.447 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.447 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.447 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.447 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.447 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.447 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.447 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.447 | |
| 2wf2 | ZY2 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2zxu | DST | tRNA dimethylallyltransferase | 2.5.1.75 | 0.447 | |
| 3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.447 | |
| 4blr | UTP | NTPase P4 | / | 0.447 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.447 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.446 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.446 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.446 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.446 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2z9d | FMN | FMN-dependent NADH-azoreductase | / | 0.446 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.446 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.446 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.446 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.446 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.446 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.446 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.446 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.446 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.445 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.445 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.445 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.445 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 1wng | SAH | Diphthine synthase | / | 0.445 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.445 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.445 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.445 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.445 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.445 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.445 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.445 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.445 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.445 | |
| 4d04 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.445 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.445 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.445 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4lut | DCS | Alanine racemase | / | 0.445 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.444 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.444 | |
| 1nqm | BTN | Streptavidin | / | 0.444 | |
| 1osv | CHC | Bile acid receptor | / | 0.444 | |
| 1ppj | ANY | Cytochrome b | / | 0.444 | |
| 1wwz | ACO | Uncharacterized protein | / | 0.444 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.444 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.444 | |
| 2ohv | NHL | Glutamate racemase | / | 0.444 | |
| 2p6l | SAH | Diphthine synthase | / | 0.444 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.444 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.444 | |
| 2ylw | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.444 | |
| 3c1o | NAP | Eugenol synthase | / | 0.444 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.444 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.444 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.444 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.444 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.444 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.444 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.444 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.444 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.444 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.443 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.443 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.443 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.443 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.443 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.443 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.443 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.443 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.443 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.443 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.443 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.443 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4nau | AGS | Phosphopantetheine adenylyltransferase | / | 0.443 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.443 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.443 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.443 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.443 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.443 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.443 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.442 | |
| 1ksz | PGS | Adenylosuccinate synthetase | / | 0.442 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.442 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.442 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.442 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.442 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2g94 | ZPQ | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.442 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.442 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.442 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.442 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.442 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.442 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.442 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.442 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.442 | |
| 5e7o | MGD | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.442 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.441 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1dc6 | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.441 | |
| 1gnw | GTX | Glutathione S-transferase F2 | 2.5.1.18 | 0.441 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.441 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.441 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.441 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.441 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.441 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.441 | |
| 2dsg | SAH | Diphthine synthase | / | 0.441 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.441 | |
| 2e8s | SAH | Diphthine synthase | / | 0.441 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.441 | |
| 2owg | SAH | Diphthine synthase | / | 0.441 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2ylx | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.441 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.441 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.441 | |
| 3v1y | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.441 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.441 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.441 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.441 | |
| 4i8q | NAD | Putative betaine aldehyde dehyrogenase | / | 0.441 | |
| 4lj6 | ACP | Chaperone protein ClpB | / | 0.441 | |
| 4lrz | ADP | PEP-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL | 2.7 | 0.441 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 1aj2 | 2PH | Dihydropteroate synthase | / | 0.440 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.440 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.440 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.440 | |
| 2e8q | SAH | Diphthine synthase | / | 0.440 | |
| 2egl | SAH | Diphthine synthase | / | 0.440 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.440 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.440 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.440 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.440 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.440 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.440 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.440 | |
| 3v2u | ATP | Protein GAL3 | / | 0.440 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.440 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.440 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.440 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.440 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.440 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.440 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 | |
| 5itz | GTP | Tubulin alpha-1B chain | / | 0.440 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.440 |