sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3u04 | BB2 | Peptide deformylase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3u04 | BB2 | Peptide deformylase | / | 1.000 | |
| 3m6p | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.626 | |
| 3pn4 | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.615 | |
| 4e9a | QAP | Peptide deformylase | / | 0.599 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.579 | |
| 1g27 | BB1 | Peptide deformylase | 3.5.1.88 | 0.564 | |
| 2ew5 | Y12 | Peptide deformylase | / | 0.563 | |
| 2ew6 | Y13 | Peptide deformylase | / | 0.561 | |
| 3o3j | BB4 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.560 | |
| 1ws1 | BB2 | Peptide deformylase 1 | / | 0.554 | |
| 1lru | BB2 | Peptide deformylase | 3.5.1.88 | 0.547 | |
| 1g2a | BB2 | Peptide deformylase | 3.5.1.88 | 0.534 | |
| 3uwb | BB2 | RIIA-RIIB membrane-associated protein | / | 0.512 | |
| 3e3u | NVC | Peptide deformylase | 3.5.1.88 | 0.510 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.507 | |
| 3k6l | 2BB | Peptide deformylase | 3.5.1.88 | 0.500 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.499 | |
| 1lry | BB2 | Peptide deformylase | / | 0.496 | |
| 3e8x | NAP | BH1520 protein | / | 0.496 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.495 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.494 | |
| 4e9b | BB2 | Peptide deformylase | / | 0.492 | |
| 1s17 | GNR | Peptide deformylase | / | 0.490 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.490 | |
| 3g5k | BB2 | Peptide deformylase, mitochondrial | 3.5.1.88 | 0.490 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.486 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.485 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.485 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.485 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.480 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.480 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.479 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.478 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.478 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.477 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.477 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.476 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.475 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.475 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.475 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.473 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.473 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.473 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.472 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.471 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 4y35 | F90 | Endothiapepsin | 3.4.23.22 | 0.471 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.470 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.470 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.470 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.470 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.470 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.469 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.469 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.469 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.469 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.469 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.468 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.468 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.468 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.467 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.467 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.467 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.467 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.467 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.466 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.466 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.465 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.465 | |
| 1rkd | ADP | Ribokinase | / | 0.465 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.465 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.465 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.464 | |
| 2ejz | SAH | Diphthine synthase | / | 0.464 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.464 | |
| 3m6r | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.464 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.464 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.464 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.464 | |
| 4udq | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.464 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.463 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.463 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.463 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 2emu | SAH | Diphthine synthase | / | 0.462 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.462 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.462 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.462 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.462 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.461 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.461 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.461 | |
| 5djt | FMN | NPH1-2 | / | 0.461 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.460 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.460 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.460 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4eox | 0S5 | Peptide deformylase | / | 0.460 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.459 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.459 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2vmy | FFO | Serine hydroxymethyltransferase | / | 0.459 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.459 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.458 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.458 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.458 | |
| 2dsg | SAH | Diphthine synthase | / | 0.458 | |
| 2e8h | SAH | Diphthine synthase | / | 0.458 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.458 | |
| 2zr9 | DTP | Protein RecA | / | 0.458 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.457 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.457 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.457 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.457 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.457 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.457 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4m11 | MXM | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.457 | |
| 4yfy | 1YJ | VioF | / | 0.457 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.457 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.456 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.456 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.456 | |
| 2zrf | DTP | Protein RecA | / | 0.456 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.456 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.456 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.456 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.456 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.456 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.456 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.455 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.455 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.455 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.455 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.455 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.454 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1snf | UMP | Deoxyuridine 5'-triphosphate nucleotidohydrolase | 3.6.1.23 | 0.454 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.454 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.454 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.454 | |
| 3eld | SFG | Methyltransferase | / | 0.454 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.454 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.454 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.454 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.454 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.453 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.453 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.453 | |
| 2e16 | SAH | Diphthine synthase | / | 0.453 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.453 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2zre | AGS | Protein RecA | / | 0.453 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.453 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.453 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.453 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1qrr | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.452 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.452 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.452 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.452 | |
| 2tys | PLT | Tryptophan synthase beta chain | 4.2.1.20 | 0.452 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.452 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.452 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.452 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.452 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.451 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.451 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.451 | |
| 2hux | SAH | Diphthine synthase | / | 0.451 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 3eku | CY9 | Actin-5C | / | 0.451 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.451 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1pwu | GM6 | Lethal factor | 3.4.24.83 | 0.450 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.450 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.450 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.450 | |
| 3q5d | GDP | Atlastin-1 | 3.6.5 | 0.450 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.450 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.450 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.450 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.450 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.449 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.449 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.449 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.449 | |
| 2el3 | SAH | Diphthine synthase | / | 0.449 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.449 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.449 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.449 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.449 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.449 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.449 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.449 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.449 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.449 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.448 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 2zro | ADP | Protein RecA | / | 0.448 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.448 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.448 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.448 | |
| 3ozc | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 4cvl | ACP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.448 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.448 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.448 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.448 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.448 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.447 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1gc5 | ADP | ADP-dependent glucokinase | 2.7.1.147 | 0.447 | |
| 1lqu | NDP | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.447 | |
| 2web | PP4 | Penicillopepsin-1 | 3.4.23.20 | 0.447 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 2zrj | AGS | Protein RecA | / | 0.447 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.447 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.446 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.446 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.446 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.446 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.446 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.446 | |
| 2owk | SAH | Diphthine synthase | / | 0.446 | |
| 2pci | SAH | Diphthine synthase | / | 0.446 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.446 | |
| 2xb8 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.446 | |
| 3ae4 | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.446 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3sfd | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.446 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.446 | |
| 5fsi | 8DG | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.446 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1qf4 | RPD | Adenylosuccinate synthetase | / | 0.445 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.445 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.445 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3dzv | ADP | Hydroxyethylthiazole kinase | / | 0.445 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.445 | |
| 4afg | QMR | Achbp | / | 0.445 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.445 | |
| 4ees | FMN | Phototropin-2 | 2.7.11.1 | 0.445 | |
| 4jld | ADP | Adenylate kinase | / | 0.445 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.444 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.444 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.444 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.444 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2owf | SAH | Diphthine synthase | / | 0.444 | |
| 2pch | SAH | Diphthine synthase | / | 0.444 | |
| 3ftx | RE2 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.444 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 3k4y | IPE | Isopentenyl phosphate kinase | 2.7.4.26 | 0.444 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.444 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.444 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 1gqt | ACP | Ribokinase | / | 0.443 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.443 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.443 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.443 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.443 | |
| 2gz8 | F3F | Orf1a polyprotein | / | 0.443 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2y3s | TIR | TamL | / | 0.443 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.443 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.443 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.443 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.443 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.443 | |
| 4hxy | NDP | Plm1 | / | 0.443 | |
| 4ih7 | 1ER | Genome polyprotein | 2.7.7.48 | 0.443 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.443 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.442 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.442 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.442 | |
| 2xhx | T5M | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3a6q | FMN | FMN-binding protein | / | 0.442 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.442 | |
| 3ely | SAH | Methyltransferase | / | 0.442 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.442 | |
| 3gol | XND | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.442 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.442 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.442 | |
| 3td7 | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.442 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.442 | |
| 4e5p | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.442 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4jwj | SAH | tRNA (guanine(9)-N1)-methyltransferase | / | 0.442 | |
| 4lwa | Q13 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.442 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.442 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.442 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.441 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1vgr | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.441 | |
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.441 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.441 | |
| 2dxv | SAH | Diphthine synthase | / | 0.441 | |
| 2e15 | SAH | Diphthine synthase | / | 0.441 | |
| 2fr1 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.441 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.441 | |
| 2pcg | SAH | Diphthine synthase | / | 0.441 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.441 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.441 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.441 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.441 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.441 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.441 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.441 | |
| 4egn | TWO | Cytochrome P450 | / | 0.441 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.441 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.441 | |
| 4lb2 | DM5 | Serum albumin | / | 0.441 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.441 | |
| 4qec | NAP | ElxO | / | 0.441 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 5c3z | ACP | Ribokinase | / | 0.441 | |
| 5efw | FMN | NPH1-1 | / | 0.441 | |
| 1fml | RTL | Retinol dehydratase | / | 0.440 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.440 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.440 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.440 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.440 | |
| 2egb | SAH | Diphthine synthase | / | 0.440 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.440 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.440 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.440 | |
| 2owv | SAH | Diphthine synthase | / | 0.440 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.440 | |
| 3ihz | FK5 | Peptidylprolyl isomerase | / | 0.440 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.440 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.440 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.440 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.440 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.440 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.440 |