sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xdr | NDP | NAD/NADP-dependent betaine aldehyde dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2xdr | NDP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 1.000 | |
| 3zqa | NDP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 0.632 | |
| 2wme | NAP | NAD/NADP-dependent betaine aldehyde dehydrogenase | / | 0.616 | |
| 4i1w | NAD | 2-aminomuconate 6-semialdehyde dehydrogenase | / | 0.505 | |
| 1bpw | NAD | Betaine aldehyde dehydrogenase | 1.2.1.8 | 0.504 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.499 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.496 | |
| 4nmk | NAP | Aldehyde dehydrogenase | / | 0.494 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.485 | |
| 1bi9 | NAD | Retinal dehydrogenase 2 | / | 0.481 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.481 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.480 | |
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 | 0.479 | |
| 4i8q | NAD | Putative betaine aldehyde dehyrogenase | / | 0.477 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.476 | |
| 3gb4 | D3M | DdmC | / | 0.474 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.473 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.473 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.473 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.473 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.472 | |
| 4ixg | IXG | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4h73 | NDP | Aldehyde dehydrogenase | / | 0.471 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.470 | |
| 3v0t | ATR | Perakine reductase | 1.1.1.317 | 0.470 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.469 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.468 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.468 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.467 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.467 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.467 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.467 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.466 | |
| 1ad3 | NAD | Aldehyde dehydrogenase, dimeric NADP-preferring | / | 0.465 | |
| 3rbq | GLY_ALA_GLY_DAO | Protein unc-119 homolog A | / | 0.465 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.465 | |
| 4k9n | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.465 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.464 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.464 | |
| 1oxo | IK2 | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.464 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.464 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.464 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.464 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.463 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.463 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.462 | |
| 2kce | D16 | Thymidylate synthase | / | 0.462 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.462 | |
| 1uxn | NAP | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.461 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.461 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.461 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.461 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.461 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.460 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.460 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.460 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 3ih0 | ANP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.460 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.460 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.460 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.459 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.459 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.459 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.459 | |
| 4phl | PIL | Phosphodiesterase | / | 0.459 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.459 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.458 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.458 | |
| 3stu | DK3 | Methylketone synthase I | / | 0.458 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.457 | |
| 4i3w | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.457 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.456 | |
| 4pzd | NAD | 3-Hydroxyacyl-CoA dehydrogenase | / | 0.456 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.456 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.455 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.455 | |
| 1vrw | NAI | Enoyl-ACP reductase | / | 0.455 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.455 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.455 | |
| 3gob | HXX | DdmC | / | 0.455 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.455 | |
| 4kxn | 6K6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.455 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.454 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.454 | |
| 2cts | COA | Citrate synthase, mitochondrial | 2.3.3.1 | 0.454 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.454 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.454 | |
| 3nta | COA | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.454 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.454 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.454 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 1kvt | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.453 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.453 | |
| 2vtb | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.453 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.453 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.453 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 5i2f | BS5 | Histidine triad nucleotide-binding protein 1 | 3 | 0.453 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.452 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.452 | |
| 1osv | CHC | Bile acid receptor | / | 0.452 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.452 | |
| 3cgc | FAD | Coenzyme A disulfide reductase | / | 0.452 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 3zux | TCH | Transporter | / | 0.452 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.452 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 5c3z | ACP | Ribokinase | / | 0.452 | |
| 5dp2 | NAP | CurF | / | 0.452 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.452 | |
| 1a7k | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.451 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.451 | |
| 1lny | IMO | Adenylosuccinate synthetase isozyme 1 | / | 0.451 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.451 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.451 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.451 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.451 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.451 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.451 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.451 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.451 | |
| 4c6u | TLG | 3-oxoacyl-ACP synthase | / | 0.451 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.450 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.450 | |
| 1iy8 | NAD | Levodione reductase | / | 0.450 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.450 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.450 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.450 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.450 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.450 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.450 | |
| 3qtu | X44 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.450 | |
| 3zzn | ADP | L-lactate dehydrogenase | / | 0.450 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.450 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
| 4nt0 | 3DU | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.450 | |
| 4zrn | UPG | UDP-glucose 4-epimerase, putative | / | 0.450 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.449 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.449 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.449 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.449 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 3dxm | N24 | Actin-related protein 3 | / | 0.449 | |
| 3moh | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.449 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.449 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.449 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.449 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.449 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 4oe2 | NAD | 2-aminomuconate 6-semialdehyde dehydrogenase | / | 0.449 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.449 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.448 | |
| 1ojt | FAD | Dihydrolipoyl dehydrogenase | / | 0.448 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.448 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.448 | |
| 2p9e | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.448 | |
| 3cge | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.448 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.448 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.448 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.448 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.448 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.447 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.447 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.447 | |
| 2ay9 | 5PV | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.447 | |
| 2b4r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2gs7 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.447 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.447 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.447 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.447 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.447 | |
| 3lki | ATP | Fructokinase | / | 0.447 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.447 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.447 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.447 | |
| 4eqg | A5A | Histidine triad nucleotide-binding protein 1 | 3 | 0.447 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.447 | |
| 4l4x | NDP | AmphI | / | 0.447 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 1jed | ADP | Sulfate adenylyltransferase | / | 0.446 | |
| 1jut | LYD | Thymidylate synthase | / | 0.446 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.446 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.446 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.446 | |
| 2ejz | SAH | Diphthine synthase | / | 0.446 | |
| 2rgh | FAD | Alpha-Glycerophosphate Oxidase | / | 0.446 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.446 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.446 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 3u78 | E67 | Lysine-specific demethylase 7A | 1.14.11 | 0.446 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.446 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4e2d | FMN | Dehydrogenase | / | 0.446 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.446 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.445 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.445 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.445 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.445 | |
| 1ppj | ANY | Cytochrome b | / | 0.445 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.445 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.445 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.445 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2yyy | NAP | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.59 | 0.445 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.445 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.445 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.445 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.445 | |
| 3nbw | TR4 | Ketohexokinase | / | 0.445 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.445 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.445 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.445 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.445 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.444 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.444 | |
| 1ksz | PGS | Adenylosuccinate synthetase | / | 0.444 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.444 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1sdm | ADP | Kinesin heavy chain-like protein | / | 0.444 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1uxt | NAD | NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.444 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.444 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.444 | |
| 2pa7 | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.444 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 2y5s | 78H | Dihydropteroate synthase | / | 0.444 | |
| 2yww | ATP | Aspartate carbamoyltransferase regulatory chain | / | 0.444 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3if9 | FAD | Glycine oxidase | 1.4.3.19 | 0.444 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.444 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.444 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.444 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.444 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.444 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.444 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.444 | |
| 5kf1 | ACO | Predicted acetyltransferase | / | 0.444 | |
| 1csc | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.443 | |
| 1f12 | 3HC | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1i3m | UD1 | UDP-glucose 4-epimerase | / | 0.443 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.443 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.443 | |
| 2x4f | 16X | Myosin light chain kinase family member 4 | 2.7.11.1 | 0.443 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.443 | |
| 3i0a | DBH | Neutrophil gelatinase-associated lipocalin | / | 0.443 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.443 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.443 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.443 | |
| 4ix4 | ADP | Uncharacterized protein | / | 0.443 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.443 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.443 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.442 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.442 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1yba | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.442 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.442 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.442 | |
| 3csc | ACO | Citrate synthase, mitochondrial | 2.3.3.1 | 0.442 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3gts | D3M | DdmC | / | 0.442 | |
| 3hja | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.442 | |
| 3rqq | BA3 | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.442 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.442 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.442 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4juc | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.442 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 5ify | UMP | Glucose-1-phosphate thymidylyltransferase | / | 0.442 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.441 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.441 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2bja | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.441 | |
| 2ceo | T44 | Thyroxine-binding globulin | / | 0.441 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.441 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.441 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.441 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.441 | |
| 3nuu | JOZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3rq6 | APR | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.441 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.441 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.441 | |
| 4avl | TMP | Polymerase acidic protein | / | 0.441 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.441 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.441 | |
| 4xf7 | ACP | Carbohydrate/pyrimidine kinase, PfkB family | / | 0.441 | |
| 1bmd | NAD | Malate dehydrogenase | / | 0.440 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.440 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1gqt | ACP | Ribokinase | / | 0.440 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.440 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.440 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.440 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.440 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.440 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.440 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3zuy | TCH | Transporter | / | 0.440 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.440 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.440 | |
| 4z69 | DIF | Serum albumin | / | 0.440 |