sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ohv | NHL | Glutamate racemase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2ohv | NHL | Glutamate racemase | / | 1.000 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.513 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.504 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.504 | |
| 4jic | FMN | GTN Reductase | / | 0.501 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.500 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.498 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.496 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.493 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.492 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.490 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.489 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.486 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.485 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.485 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.484 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.483 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.483 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.483 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.482 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.482 | |
| 3rnm | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.482 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.482 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.481 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.481 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.481 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.480 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.478 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.477 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.477 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.477 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.476 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.476 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.475 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.475 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.475 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.473 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.473 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.473 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.473 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.473 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.472 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.472 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.472 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.472 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2f1k | NAP | Prephenate dehydrogenase | / | 0.471 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.471 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.471 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.471 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.471 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.470 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.470 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.469 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.469 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.469 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.469 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.469 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 2vou | FAD | 2,6-dihydroxypyridine 3-monooxygenase | 1.14.13.10 | 0.468 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.467 | |
| 2a8x | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.467 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.467 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.467 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.467 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.467 | |
| 4p8r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.467 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.467 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.466 | |
| 1p31 | EPU | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.466 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.466 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.466 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.466 | |
| 3of2 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.466 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.466 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.465 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.465 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.465 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.465 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.464 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.464 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.464 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.464 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.464 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.464 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.464 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.463 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.463 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.463 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.463 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.463 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.463 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.462 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.462 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.462 | |
| 2y05 | RAL | Prostaglandin reductase 1 | / | 0.462 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.462 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.461 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.461 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.461 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.461 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.461 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.461 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.461 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.461 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.460 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.460 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.460 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.460 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.460 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.460 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.459 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.459 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.459 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.459 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.459 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.459 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.459 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.458 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.458 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.458 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.458 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.458 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.457 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.457 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.457 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.457 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.457 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4ck2 | NVU | Integrase | / | 0.457 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.457 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.457 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1ee9 | NAD | Methylenetetrahydrofolate dehydrogenase [NAD(+)] | 1.5.1.15 | 0.456 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.456 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.456 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.456 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.456 | |
| 3cgc | FAD | Coenzyme A disulfide reductase | / | 0.456 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.456 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.456 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.456 | |
| 4g3s | UD1 | Bifunctional protein GlmU | / | 0.456 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.456 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.456 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.455 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.455 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.455 | |
| 5dt9 | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.455 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.454 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.454 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.454 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.454 | |
| 2f5z | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.454 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.453 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.453 | |
| 3eku | CY9 | Actin-5C | / | 0.453 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.453 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.453 | |
| 4e2b | FMN | Dehydrogenase | / | 0.453 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.453 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.453 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.452 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.452 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.452 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.452 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.452 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.452 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.452 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.452 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.452 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.452 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.452 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.452 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.452 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.451 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.451 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.451 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.451 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.451 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.451 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.451 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.451 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.451 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.451 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.451 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.451 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.451 | |
| 4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.451 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.451 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.451 | |
| 1ib6 | NAD | Malate dehydrogenase | / | 0.450 | |
| 1j1z | ATP | Argininosuccinate synthase | / | 0.450 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.450 | |
| 1u1i | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.450 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.450 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.450 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.450 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 2pxa | SAH | Genome polyprotein | 2.7.7.48 | 0.450 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.450 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.450 | |
| 4e2d | FMN | Dehydrogenase | / | 0.450 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.450 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.450 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 5eoy | ADP | Type 4 fimbrial biogenesis protein PilM | / | 0.450 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.449 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.449 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.449 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.449 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.449 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.449 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.449 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.449 | |
| 3zhb | NAP | Putative dehydrogenase | / | 0.449 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.449 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.449 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1r00 | SAH | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.448 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.448 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.448 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.448 | |
| 3spt | UD1 | Bifunctional protein GlmU | / | 0.448 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.448 | |
| 3v2u | ATP | Protein GAL3 | / | 0.448 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.448 | |
| 4ccq | FAD | Thioredoxin reductase | / | 0.448 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.448 | |
| 4uth | FMN | Xenobiotic reductase | / | 0.448 | |
| 5a3b | APR | SIR2 family protein | / | 0.448 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.447 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.447 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.447 | |
| 1qr6 | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.447 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.447 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.447 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.447 | |
| 3lm9 | ADP | Putative fructokinase | 2.7.1.4 | 0.447 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.447 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.447 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.447 | |
| 4j1r | I5R | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.447 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.447 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.447 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.446 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.446 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.446 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.446 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
| 2y4g | TIR | TamL | / | 0.446 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.446 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.446 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.446 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.446 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.446 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4h4q | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.446 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.446 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.446 | |
| 1hzz | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.445 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.445 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.445 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 2vxo | XMP | GMP synthase [glutamine-hydrolyzing] | 6.3.5.2 | 0.445 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.445 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.445 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.445 | |
| 3anx | MTA | Polyamine aminopropyltransferase | / | 0.445 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.445 | |
| 3u9e | COA | Lmo1369 protein | / | 0.445 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4dld | TZG | Glutamate receptor ionotropic, kainate 1 | / | 0.445 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.445 | |
| 4h6p | FMN | Chromate reductase | / | 0.445 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.445 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.445 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 1dj2 | GDP | Adenylosuccinate synthetase, chloroplastic | / | 0.444 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.444 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.444 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1zrq | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.444 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.444 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.444 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3b2e | ADP | ATPase GET3 | / | 0.444 | |
| 3b89 | 5GP | 16S rRNA methylase | / | 0.444 | |
| 3kpb | SAM | Uncharacterized protein MJ0100 | / | 0.444 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.444 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.444 | |
| 3w1t | WRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.444 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.444 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.444 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.444 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.444 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.444 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.443 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1sxj | AGS | Replication factor C subunit 1 | / | 0.443 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.443 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 1zdw | FLV | Prenyltransferase | / | 0.443 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.443 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2idz | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.443 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.443 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.443 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.443 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4jdr | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.443 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.443 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.443 | |
| 4m52 | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.443 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.443 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.443 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.442 | |
| 2qc8 | ADP | Glutamine synthetase | 6.3.1.2 | 0.442 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.442 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.442 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.442 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.442 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.441 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 1owo | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.441 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.441 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.441 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.441 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.441 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.441 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.441 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.441 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.441 | |
| 4nvk | 2NY | Peroxidase | / | 0.441 | |
| 4qxm | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.441 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1k8y | 13P | Tryptophan synthase alpha chain | / | 0.440 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.440 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.440 | |
| 1zpt | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.440 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.440 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2wcg | MT5 | Glucosylceramidase | 3.2.1.45 | 0.440 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.440 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.440 | |
| 3pym | NAD | Glyceraldehyde-3-phosphate dehydrogenase 3 | 1.2.1.12 | 0.440 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.440 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.440 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.440 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.440 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.440 |