Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4x5hFOLDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4x5hFOLDihydrofolate reductase1.5.1.31.000
1ra8FOLDihydrofolate reductase1.5.1.30.759
4x5jFOLDihydrofolate reductase1.5.1.30.748
4x5iFOLDihydrofolate reductase1.5.1.30.723
1ra3MTXDihydrofolate reductase1.5.1.30.704
1dyhDZFDihydrofolate reductase1.5.1.30.656
1dyiFOLDihydrofolate reductase1.5.1.30.656
3och2MXDihydrofolate reductase1.5.1.30.653
1ddrMTXDihydrofolate reductase1.5.1.30.650
1re7FOLDihydrofolate reductase1.5.1.30.650
1jolFFODihydrofolate reductase1.5.1.30.635
4dfrMTXDihydrofolate reductase1.5.1.30.630
1draMTXDihydrofolate reductase1.5.1.30.628
1ddsMTXDihydrofolate reductase1.5.1.30.622
1dyjDDFDihydrofolate reductase1.5.1.30.614
5hi6MTXDihydrofolate reductase/0.612
2drcMTXDihydrofolate reductase1.5.1.30.610
1rb2FOLDihydrofolate reductase1.5.1.30.606
1rd7FOLDihydrofolate reductase1.5.1.30.605
3drcMTXDihydrofolate reductase1.5.1.30.603
1dhjMTXDihydrofolate reductase1.5.1.30.602
1rb3MTXDihydrofolate reductase1.5.1.30.602
1rx7FOLDihydrofolate reductase1.5.1.30.600
2d0kFOLDihydrofolate reductase1.5.1.30.600
1tdrMTXDihydrofolate reductase1.5.1.30.591
4cd2FOLDihydrofolate reductase1.5.1.30.578
1dhiMTXDihydrofolate reductase1.5.1.30.573
2cig1DGDihydrofolate reductase1.5.1.30.572
1u71MXADihydrofolate reductase1.5.1.30.563
1rc4DDFDihydrofolate reductase1.5.1.30.555
1dr2TAPDihydrofolate reductase1.5.1.30.552
1rx5DDFDihydrofolate reductase1.5.1.30.550
1s3vTQDDihydrofolate reductase1.5.1.30.550
1dr3HBIDihydrofolate reductase1.5.1.30.547
4ej1FOLDihydrofolate reductase1.5.1.30.547
5cccDDFDihydrofolate reductase1.5.1.30.547
1drbMTXDihydrofolate reductase1.5.1.30.546
1rx6DDFDihydrofolate reductase1.5.1.30.546
3oafOAGDihydrofolate reductase1.5.1.30.545
1s3uTQDDihydrofolate reductase1.5.1.30.541
4qi9MTXDihydrofolate reductase/0.541
1rx8FOLDihydrofolate reductase1.5.1.30.540
4i13FOLDihydrofolate reductase1.5.1.30.540
1dr3TAPDihydrofolate reductase1.5.1.30.538
1ia3TQ5Dihydrofolate reductase1.5.1.30.538
1rf7DHFDihydrofolate reductase1.5.1.30.537
3d84NDPDihydrofolate reductase1.5.1.30.537
3nxxNDPDihydrofolate reductase1.5.1.30.532
3eigMTXDihydrofolate reductase1.5.1.30.530
2dhfDZFDihydrofolate reductase1.5.1.30.529
4kne1CYDihydrofolate reductase1.5.1.30.529
5cc9DDFDihydrofolate reductase1.5.1.30.529
1dhfFOLDihydrofolate reductase1.5.1.30.526
4g95OAGDihydrofolate reductase1.5.1.30.525
5eccNAPDehydrofolate reductase type I/0.525
1ia4TQ6Dihydrofolate reductase1.5.1.30.522
2w9hTOPDihydrofolate reductase1.5.1.30.522
3n0hTOPDihydrofolate reductase1.5.1.30.519
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.515
3r7kFDAProbable acyl CoA dehydrogenase/0.513
1ao8MTXDihydrofolate reductase1.5.1.30.512
1rx1NAPDihydrofolate reductase1.5.1.30.512
3s7a684Dihydrofolate reductase1.5.1.30.507
1dr5NAPDihydrofolate reductase1.5.1.30.506
1mvsDTMDihydrofolate reductase1.5.1.30.505
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.504
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.504
3s3vTOPDihydrofolate reductase1.5.1.30.503
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.502
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.502
3qlrNDPDihydrofolate reductase1.5.1.30.502
3hl0NADMaleylacetate reductase/0.501
1ai9NDPDihydrofolate reductase1.5.1.30.500
1diuBDMDihydrofolate reductase1.5.1.30.500
1ia1NDPDihydrofolate reductase1.5.1.30.500
1rx4DDFDihydrofolate reductase1.5.1.30.499
1dg5TOPDihydrofolate reductase1.5.1.30.497
1drfFOLDihydrofolate reductase1.5.1.30.497
1lkdBP6Biphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.496
4cdmFO1Deoxyribodipyrimidine photolyase/0.496
4m83ERYOleandomycin glycosyltransferase2.4.10.496
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.495
1h51FMNPentaerythritol tetranitrate reductase/0.494
2fs4PZ1Renin3.4.23.150.492
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.492
2g263LGRenin3.4.23.150.491
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.490
3l63CAMCamphor 5-monooxygenase1.14.15.10.490
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.490
4x5fFOLDihydrofolate reductase1.5.1.30.490
1jomFFODihydrofolate reductase1.5.1.30.489
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.488
4m6jNDPDihydrofolate reductase1.5.1.30.488
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.488
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.487
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.487
4esoNAPPutative oxidoreductase/0.487
1h50FMNPentaerythritol tetranitrate reductase/0.486
4xr9NADCalS8/0.485
1m78NDPDihydrofolate reductase1.5.1.30.484
1pd9CO4Dihydrofolate reductase1.5.1.30.484
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.484
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.484
4itmATPTetraacyldisaccharide 4'-kinase/0.484
2jb4A14Isopenicillin N synthase1.21.3.10.483
2y37A54Nitric oxide synthase, inducible1.14.13.390.483
3lqfNADGalactitol dehydrogenase/0.483
2a1oCAMCamphor 5-monooxygenase1.14.15.10.481
2jfgUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.481
2rh9IGPTryptophan synthase alpha chain/0.481
3sh25DRDihydrofolate reductase1.5.1.30.481
1klkPMDDihydrofolate reductase1.5.1.30.480
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.480
2yozOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.480
3atzFMNProstaglandin F2a synthase/0.480
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.480
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.479
2g1r3IGRenin3.4.23.150.479
3gwfNAPCyclohexanone monooxygenase/0.479
3t3r9PLCytochrome P450 2A61.14.130.479
4i1nFOLDihydrofolate reductase1.5.1.30.479
2iviACWIsopenicillin N synthase1.21.3.10.478
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.478
4p9dTMPDeoxycytidylate deaminase/0.478
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.477
3oagLPQRenin3.4.23.150.477
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.477
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.476
1vzdCB3Thymidylate synthase/0.476
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.476
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.476
2g1n1IGRenin3.4.23.150.476
2g1y5IGRenin3.4.23.150.476
4x5gFOLDihydrofolate reductase1.5.1.30.476
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.476
3fwfCAMCamphor 5-monooxygenase1.14.15.10.475
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.475
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.474
1ra2FOLDihydrofolate reductase1.5.1.30.474
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.474
3t3q9PLCytochrome P450 2A61.14.130.474
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.474
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.474
1m9tINENitric oxide synthase, inducible1.14.13.390.473
1x8lOXRRetinol dehydratase/0.473
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.473
2zbaZBATrichothecene 3-O-acetyltransferase/0.473
4a81DXCMajor pollen allergen Bet v 1-A/0.473
4elb34SDihydrofolate reductase/0.473
5bp9SAHPutative methyltransferase protein/0.473
5hs1VORLanosterol 14-alpha demethylase/0.473
1eupASD6-deoxyerythronolide B hydroxylase/0.472
3k1wBFXRenin3.4.23.150.472
3zeiAWHO-acetylserine sulfhydrylase/0.472
1aoeGW3Dihydrofolate reductase1.5.1.30.471
4zj8SUVOrexin receptor type 1/0.471
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.470
2uxoTACHTH-type transcriptional regulator TtgR/0.470
3b9oFMNAlkane monoxygenase/0.470
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.470
3oadLPORenin3.4.23.150.470
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.470
4oqyNDP(S)-imine reductase/0.470
1bzfTMQDihydrofolate reductase1.5.1.30.469
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.469
1galFADGlucose oxidase1.1.3.40.469
2he5NDPAldo-keto reductase family 1 member C211.1.10.469
3wrhCAMCamphor 5-monooxygenase1.14.15.10.469
4uymVOR14-alpha sterol demethylase Cyp51B/0.469
1drhNAPDihydrofolate reductase1.5.1.30.468
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.468
3f03FMNPentaerythritol tetranitrate reductase/0.468
3phiNDPShikimate dehydrogenase (NADP(+))/0.468
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
4xq9NADHomospermidine synthase2.5.1.440.468
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.467
3kxw1ZZSaframycin Mx1 synthetase B/0.467
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.467
3zoiM2WIsopenicillin N synthase1.21.3.10.467
4fhbFOLDihydrofolate reductase1.5.1.30.467
1fmlRTLRetinol dehydratase/0.466
1xe65FPPlasmepsin-23.4.23.390.466
2il2LIXRenin3.4.23.150.466
2iyfERYOleandomycin glycosyltransferase2.4.10.466
2vn0TDZCytochrome P450 2C8/0.466
3wrjCAMCamphor 5-monooxygenase1.14.15.10.466
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.466
2a5kAZPReplicase polyprotein 1ab3.4.220.465
3uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.465
4loi1YCStimulator of interferon genes protein/0.465
1cd2FOLDihydrofolate reductase1.5.1.30.464
1fmjRTLRetinol dehydratase/0.464
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.464
2bktRPFRenin3.4.23.150.464
2el0SAHDiphthine synthase/0.464
2qk8MTXDihydrofolate reductase/0.464
2w6oOA3Biotin carboxylase6.3.4.140.464
2zuiCAMCamphor 5-monooxygenase1.14.15.10.464
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.464
1bwsNDPGDP-L-fucose synthase/0.463
1m78CLZDihydrofolate reductase1.5.1.30.463
1xddAAYIntegrin alpha-L/0.463
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.463
2x7hPFNProstaglandin reductase 310.463
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.463
3aw9GDUNAD-dependent epimerase/dehydratase/0.463
3fwiCAMCamphor 5-monooxygenase1.14.15.10.463
3ibqATPPyridoxal kinase/0.463
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.463
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
4e2bFMNDehydrogenase/0.463
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.463
1kh3ANPArgininosuccinate synthase/0.462
1l7x700Glycogen phosphorylase, liver form2.4.1.10.462
1m8h6NINitric oxide synthase, inducible1.14.13.390.462
2a1nCAMCamphor 5-monooxygenase1.14.15.10.462
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.462
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.462
3fwjCAMCamphor 5-monooxygenase1.14.15.10.462
3ibdCPZCytochrome P450 2B61.14.130.462
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
4a83DXCMajor pollen allergen Bet v 1-A/0.462
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.461
1ep4S11Gag-Pol polyprotein2.7.7.490.461
1hb1OCVIsopenicillin N synthase1.21.3.10.461
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
1tj0FADBifunctional protein PutA1.5.5.20.461
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
2xweAMFGlucosylceramidase3.2.1.450.461
3nr4PYVAbscisic acid receptor PYL2/0.461
4h9753SDihydrofolate reductase1.5.1.30.461
4iqqUMPThymidylate synthase/0.461
4jx1CAHCamphor 5-monooxygenase1.14.15.10.461
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.461
2g226IGRenin3.4.23.150.460
2qblCAMCamphor 5-monooxygenase1.14.15.10.460
2rlcCHDCholoylglycine hydrolase3.5.1.240.460
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3fwgCAMCamphor 5-monooxygenase1.14.15.10.460
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3nmpPYVAbscisic acid receptor PYL2/0.460
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
3vyfVYFRenin3.4.23.150.460
4ipw1G7Mycocyclosin synthase1.14.21.90.460
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.460
4xqcNADHomospermidine synthase2.5.1.440.460
5irnADPNucleotide binding oligomerization domain containing 2/0.460
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
1t85CAMCamphor 5-monooxygenase1.14.15.10.459
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
2g274LGRenin3.4.23.150.459
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.459
2v34CTN4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.459
3p84FMNPentaerythritol tetranitrate reductase/0.459
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
3qls55VDihydrofolate reductase1.5.1.30.459
4enhFVXCholesterol 24-hydroxylase/0.459
1b5dDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.458
1hb3SCVIsopenicillin N synthase1.21.3.10.458
1qiqACCIsopenicillin N synthase1.21.3.10.458
1vyrFMNPentaerythritol tetranitrate reductase/0.458
2y6fM9FIsopenicillin N synthase1.21.3.10.458
3ctyFADProbable thioredoxin reductase/0.458
3fl9TOPDihydrofolate reductase/0.458
3fr5I4AFatty acid-binding protein, adipocyte/0.458
3nsh957Beta-secretase 13.4.23.460.458
3zkyWT4Isopenicillin N synthase1.21.3.10.458
4bfvZVVPantothenate kinase2.7.1.330.458
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.458
4i0i957Beta-secretase 13.4.23.460.458
4lgaA2OAbscisic acid receptor PYL2/0.458
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.458
4x7vMIVMycinamicin III 3''-O-methyltransferase2.1.1.2370.458
4xe606UDihydrofolate reductase1.5.1.30.458
1t86CAMCamphor 5-monooxygenase1.14.15.10.457
1yrdCAMCamphor 5-monooxygenase1.14.15.10.457
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.457
2feuCAMCamphor 5-monooxygenase1.14.15.10.457
2v16C47Renin3.4.23.150.457
3apwDP0Alpha-1-acid glycoprotein 2/0.457
3p74FMNPentaerythritol tetranitrate reductase/0.457
3s1dZIRCytokinin dehydrogenase 11.5.99.120.457
3vsxR32Renin3.4.23.150.457
4du82P0Mevalonate diphosphate decarboxylase/0.457
4kkyCAMCamphor 5-monooxygenase1.14.15.10.457
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.457
4xymCOAAcyl-CoA synthetase (NDP forming)/0.457
1bk0ACVIsopenicillin N synthase1.21.3.10.456
1jioDEB6-deoxyerythronolide B hydroxylase/0.456
1obnASVIsopenicillin N synthase1.21.3.10.456
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
2gjlFMNNitronate monooxygenase1.13.12.160.456
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
2vbdV10Isopenicillin N synthase1.21.3.10.456
2yx6ADPUncharacterized protein/0.456
4c9oCAMCytochrome P450/0.456
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.456
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.456
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
1rz1NADPhenol 2-hydroxylase component B/0.455
2lfoGCHFatty acid-binding protein, liver/0.455
2po7CHDFerrochelatase, mitochondrial4.99.1.10.455
3jwcEKBDihydrofolate reductase/0.455
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.455
3w6hAZMCarbonic anhydrase 14.2.1.10.455
3zbsOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.455
4bfzZVZPantothenate kinase2.7.1.330.455
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4rbs0RVMetallo-beta-lactamase type 2/0.455
4zowCLMMultidrug transporter MdfA/0.455
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1d6w00RProthrombin3.4.21.50.454
1kijNOVDNA gyrase subunit B/0.454
1mvtDTMDihydrofolate reductase1.5.1.30.454
1nooCAHCamphor 5-monooxygenase1.14.15.10.454
1towCRZFatty acid-binding protein, adipocyte/0.454
2g1o2IGRenin3.4.23.150.454
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.454
2pklDHTAndrogen receptor/0.454
3b6pTMPThree-prime repair exonuclease 13.1.11.20.454
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3zkuHCVIsopenicillin N synthase1.21.3.10.454
4nmbFADBifunctional protein PutA/0.454
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
1bil0IURenin3.4.23.150.453
1dliUDXUDP-glucose 6-dehydrogenase/0.453
1dljUGAUDP-glucose 6-dehydrogenase/0.453
1jmfUMPThymidylate synthase/0.453
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
2qbmCAMCamphor 5-monooxygenase1.14.15.10.453
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.453
2y3rTIRTamL/0.453
2y4gTIRTamL/0.453
3cseN22Uncharacterized protein/0.453
3h3qH13Collagen type IV alpha-3-binding protein/0.453
3h3t16HCollagen type IV alpha-3-binding protein/0.453
3p8iFMNPentaerythritol tetranitrate reductase/0.453
3u8l09QAcetylcholine-binding protein/0.453
3w0tHPULactoylglutathione lyase4.4.1.50.453
4h3g10QBeta-secretase 13.4.23.460.453
4qedNAPElxO/0.453
4xoqF42Coenzyme F420:L-glutamate ligase/0.453
1cf3FADGlucose oxidase1.1.3.40.452
1dz4CAMCamphor 5-monooxygenase1.14.15.10.452
1g6kNADGlucose 1-dehydrogenase1.1.1.470.452
1m9jCLWNitric oxide synthase, endothelial1.14.13.390.452
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.452
2cppCAMCamphor 5-monooxygenase1.14.15.10.452
3eai328Nitric oxide synthase, inducible1.14.13.390.452
3g6zA7TRenin3.4.23.150.452
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.452
3p67FMNPentaerythritol tetranitrate reductase/0.452
3tm5SFGUncharacterized protein/0.452
3wrmCAMCamphor 5-monooxygenase1.14.15.10.452
4a6rTA8Probable aminotransferase/0.452
4o63NADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.452
1h63FMNPentaerythritol tetranitrate reductase/0.451
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.451
3kkzSAMUncharacterized protein/0.451
3kmyD8YBeta-secretase 13.4.23.460.451
3oqfS51Renin3.4.23.150.451
3qizQI2Botulinum neurotoxin type A3.4.24.690.451
3wrlCAMCamphor 5-monooxygenase1.14.15.10.451
4elg52JDihydrofolate reductase/0.451
4ixeIXEDihydrofolate reductase1.5.1.30.451
4ke11R6Beta-secretase 13.4.23.460.451
4qenSAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH42.1.1.430.451
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.451
1cjvFOKAdenylate cyclase type 2/0.450
1cjvFOKAdenylate cyclase type 5/0.450
1psa0ZLPepsin A3.4.23.10.450
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2bn4FMNNADPH--cytochrome P450 reductase/0.450
2e17SAHDiphthine synthase/0.450
2fonFADAcyl-coenzyme A oxidase/0.450
2i4qUA4Renin3.4.23.150.450
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2qw034Z4-chlorobenzoyl CoA ligase/0.450
2y60M8FIsopenicillin N synthase1.21.3.10.450
3a783EVVitamin D3 receptor/0.450
3e7iB2Nitric oxide synthase, inducible1.14.13.390.450
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.450
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.450
3ohh3HHBeta-secretase 13.4.23.460.450
3sai9DRDihydrofolate reductase/0.450
4bb3KKAIsopenicillin N synthase1.21.3.10.450
4ejh0QACytochrome P450 2A131.14.14.10.450
4ihl1F514-3-3 protein zeta/delta/0.450
4l4fCAMCamphor 5-monooxygenase1.14.15.10.450
4psbGA3Cytokinin-specific binding protein/0.450
5f8eSAHPossible transcriptional regulatory protein/0.450
1rneC60Renin3.4.23.150.449
1uyuCAMCamphor 5-monooxygenase1.14.15.10.449
2bxmIMNSerum albumin/0.449
2g247IGRenin3.4.23.150.449
2v58LZJBiotin carboxylase6.3.4.140.449
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3e68AT6Nitric oxide synthase, inducible1.14.13.390.449
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.449
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.449
4ek1CAMCamphor 5-monooxygenase1.14.15.10.449
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.449
4r1lADPPhenylacetate-coenzyme A ligase/0.449
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.449
4zm3PLPAminotransferase/0.449
1bim0QBRenin3.4.23.150.448
1dz6CAMCamphor 5-monooxygenase1.14.15.10.448
1ex75GPGuanylate kinase2.7.4.80.448
1jmhUMPThymidylate synthase/0.448
1mokFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.448
1mzs6693-oxoacyl-[acyl-carrier-protein] synthase 3/0.448
1o76CAMCamphor 5-monooxygenase1.14.15.10.448
1yqzCOACoenzyme A disulfide reductase/0.448
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.448
2gv8NDPThiol-specific monooxygenase1.14.130.448
2jn3JN3Fatty acid-binding protein, liver/0.448
2q9fC3SCholesterol 24-hydroxylase/0.448
2zcvNDPQuinone oxidoreductase 21.6.5.20.448
3ed1GA3Gibberellin receptor GID1/0.448
3eej53RUncharacterized protein/0.448
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.448
3ggcH26Hypoxanthine-guanine phosphoribosyltransferase2.4.2.80.448
3i53SAH2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.448
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.448
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.448
4e2dFMNDehydrogenase/0.448
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4gqe6KJNitric oxide synthase, brain1.14.13.390.448
4kgkGTPUncharacterized protein/0.448
4yaoFMNNADPH--cytochrome P450 reductase/0.448
5cp4CAMCamphor 5-monooxygenase1.14.15.10.448
1enpNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.447
1oc1ASVIsopenicillin N synthase1.21.3.10.447
1q45FMN12-oxophytodienoate reductase 31.3.1.420.447
2a1mCAMCamphor 5-monooxygenase1.14.15.10.447
2bu9HFVIsopenicillin N synthase1.21.3.10.447
2cy0NAPShikimate dehydrogenase (NADP(+))/0.447
2f6rACOBifunctional coenzyme A synthase/0.447
2qimZEAClass 10 plant pathogenesis-related protein/0.447
2wo7ASVIsopenicillin N synthase1.21.3.10.447
2xpuTDCTetracycline repressor protein class D/0.447
3ebf332Nitric oxide synthase, inducible1.14.13.390.447
3g72A6TRenin3.4.23.150.447
3lfcZ86Mitogen-activated protein kinase 14/0.447
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.447
4ead0NPThymidine phosphorylase2.4.2.40.447
4ebfNADPhosphonate dehydrogenase1.20.1.10.447
4elh53IDihydrofolate reductase/0.447
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4glx0XSDNA ligase6.5.1.20.447
4h9506UDihydrofolate reductase1.5.1.30.447
4hnc0UTMandelate racemase/0.447
4hx519VCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.446
1fm4DXCMajor pollen allergen Bet v 1-L/0.446
1m13HYFNuclear receptor subfamily 1 group I member 2/0.446
1yw8A75Methionine aminopeptidase 2/0.446
2bjfDXCCholoylglycine hydrolase3.5.1.240.446
2xw7NDPDihydrofolate reductase/0.446
2y3rTRKTamL/0.446
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3p62FMNPentaerythritol tetranitrate reductase/0.446
3qlrQLRDihydrofolate reductase1.5.1.30.446
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.446
4da7AC2Purine nucleoside phosphorylase DeoD-type2.4.2.10.446
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.446
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.445
1m9rINENitric oxide synthase, endothelial1.14.13.390.445
1pagFMPAntiviral protein I3.2.2.220.445
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.445
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.445
1t79DHTAndrogen receptor/0.445
2j9lATPH(+)/Cl(-) exchange transporter 5/0.445
2w6pOA4Biotin carboxylase6.3.4.140.445
3k8q22APurine nucleoside phosphorylase2.4.2.10.445
3n63XFNNitric oxide synthase, brain1.14.13.390.445
3p8jFMNPentaerythritol tetranitrate reductase/0.445
3qt62P0Mevalonate diphosphate decarboxylase/0.445
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.445
4b2gV1NUncharacterized protein/0.445
4eqrCOACoenzyme A disulfide reductase/0.445
4fvz4KJNitric oxide synthase, brain1.14.13.390.445
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4isk1JYThymidylate synthase/0.445
4l4cCAMCamphor 5-monooxygenase1.14.15.10.445
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.445
1bpjUMPThymidylate synthase/0.444
1m9m6NINitric oxide synthase, endothelial1.14.13.390.444
1njaDCMThymidylate synthase/0.444
1njcDCMThymidylate synthase/0.444
2cdcNAPGlucose 1-dehydrogenase/0.444
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.444
2yeiXQIHeat shock protein HSP 90-alpha/0.444
3iodA6DPantothenate synthetase6.3.2.10.444
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.444
3p3zP3ZPutative cytochrome P450/0.444
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.444
3v2uATPProtein GAL3/0.444
3x21FMNOxygen-insensitive NAD(P)H nitroreductase/0.444
3zbnCOA3-ketoacyl-CoA thiolase-like protein/0.444
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.444
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.444
4dbs0HVAldo-keto reductase family 1 member C3/0.444
4ele31IDihydrofolate reductase/0.444
4ugaQ05Nitric oxide synthase oxygenase1.14.13.1650.444
1h74ADPHomoserine kinase2.7.1.390.443
1pqc444Oxysterols receptor LXR-beta/0.443
2a7r5GPGMP reductase 2/0.443
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2gjnFMNNitronate monooxygenase1.13.12.160.443
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.443
3eah327Nitric oxide synthase, endothelial1.14.13.390.443
3fl8RARDihydrofolate reductase/0.443
3h3r14HCollagen type IV alpha-3-binding protein/0.443
3h3sH15Collagen type IV alpha-3-binding protein/0.443
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.443
4djy0KRBeta-secretase 13.4.23.460.443
4eb5PLPCysteine desulfurase IscS 2/0.443
4elf35IDihydrofolate reductase/0.443
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.443
4idpGNPAtlastin-13.6.50.443
4jbtASDCytochrome P450 monooxygenase/0.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
4r20AERCytochrome P450 family 17 polypeptide 2/0.443
4rrbA3TProbable threonine--tRNA ligase 26.1.1.30.443
1blzACVIsopenicillin N synthase1.21.3.10.442
1m9k7NINitric oxide synthase, endothelial1.14.13.390.442
1ml6GBXGlutathione S-transferase A22.5.1.180.442
1p0pBCHCholinesterase3.1.1.80.442
1vceSAHDiphthine synthase/0.442
1vi2NADQuinate/shikimate dehydrogenase/0.442
2ft9CHDFatty acid-binding protein 2, liver/0.442
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2rhrEMOPutative ketoacyl reductase1.3.10.442
2uxhQUEHTH-type transcriptional regulator TtgR/0.442
2xviFADPutative flavin-containing monooxygenase/0.442
3cppCAMCamphor 5-monooxygenase1.14.15.10.442
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3mjrAC2Deoxycytidine kinase2.7.1.740.442
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3vswR31Renin3.4.23.150.442
4boeCLRJapanin/0.442
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.442
4k6fNAPPutative Acetoacetyl-CoA reductase/0.442
4kbyC2EStimulator of interferon genes protein/0.442
4nm9FADBifunctional protein PutA/0.442
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.442
6cp4CAMCamphor 5-monooxygenase1.14.15.10.442
1bp0UMPThymidylate synthase/0.441
1qxlFR8Adenosine deaminase3.5.4.40.441
1y9dTPPPyruvate oxidase1.2.3.30.441
2a94AP0L-lactate dehydrogenase1.1.1.270.441
2an9GDPGuanylate kinase2.7.4.80.441
2vbpVB1Isopenicillin N synthase1.21.3.10.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.441
3cv9VDXVitamin D3 dihydroxylase/0.441
3fr4F8AFatty acid-binding protein, adipocyte/0.441
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3s79ASDAromatase1.14.14.140.441
4bmpFMNProtein NrdI/0.441
4m55NADUDP-glucuronic acid decarboxylase 14.1.1.350.441
4o1mNADEnoyl-acyl carrier reductase/0.441
4oeyDHTAndrogen receptor/0.441
4xj43ATCyclic GMP-AMP synthase/0.441
4y8wSTRSteroid 21-hydroxylase/0.441
1culFOKAdenylate cyclase type 2/0.440
1culFOKAdenylate cyclase type 5/0.440
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1qjfACSIsopenicillin N synthase1.21.3.10.440
1vjtNADAlpha-glucosidase, putative/0.440
2gtbAZPOrf1ab polyprotein/0.440
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.440
2nnqT4BFatty acid-binding protein, adipocyte/0.440
2ohjFMNType A flavoprotein FprA10.440
2qbnCAMCamphor 5-monooxygenase1.14.15.10.440
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.440
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.440
3akzGSUGlutamate--tRNA ligase 2/0.440
3c15FOKAdenylate cyclase type 2/0.440
3c15FOKAdenylate cyclase type 5/0.440
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3ex8AIFRiboflavin biosynthesis protein RibD1.1.1.1930.440
3fr28CAFatty acid-binding protein, adipocyte/0.440
3lxiCAMCytochrome P450/0.440
3pd4A3GThreonine--tRNA ligase6.1.1.30.440
3pvt3HC1,2-phenylacetyl-CoA epoxidase, subunit A1.14.13.1490.440
3qlxQLRUncharacterized protein/0.440
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.440
4fxfATPPyruvate kinase PKM2.7.1.400.440
4gk3L87Ephrin type-A receptor 32.7.10.10.440
4r21STRCytochrome P450 family 17 polypeptide 2/0.440
4v2gITCTetracycline repressor protein class D/0.440
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.440
4y1bNAPAntE/0.440
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.440