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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fj0HHF17beta-hydroxysteroid dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fj0HHF17beta-hydroxysteroid dehydrogenase/1.000
3qwhKMP17beta-hydroxysteroid dehydrogenase/0.665
4fj1GEN17beta-hydroxysteroid dehydrogenase/0.653
3qwiCUE17beta-hydroxysteroid dehydrogenase/0.645
4fj2QSO17beta-hydroxysteroid dehydrogenase/0.603
4fizCUE17beta-hydroxysteroid dehydrogenase/0.585
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.503
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.503
1synF89Thymidylate synthase/0.500
1kquBR4Phospholipase A2, membrane associated/0.498
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.497
1cqp803Integrin alpha-L/0.496
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.495
3h3r14HCollagen type IV alpha-3-binding protein/0.494
1dgfNDPCatalase1.11.1.60.493
4dyn0MRNucleoprotein/0.492
1zg32HIIsoflavone 4'-O-methyltransferase/0.490
3tdaPN0Cytochrome P450 2D6/0.489
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.488
1db56INPhospholipase A2, membrane associated/0.487
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.487
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.486
1r8qAFBCytohesin-2/0.485
1r8qAFBADP-ribosylation factor 1/0.485
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.485
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.485
4lb2DM5Serum albumin/0.485
3nxvD2FDihydrofolate reductase1.5.1.30.482
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.482
4qtuSAM18S rRNA (guanine(1575)-N(7))-methyltransferase/0.482
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.481
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.481
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.481
7catNDPCatalase1.11.1.60.481
1fvpFMANon-fluorescent flavoprotein/0.480
1xddAAYIntegrin alpha-L/0.480
1zdwFLVPrenyltransferase/0.480
3lfeZ84Mitogen-activated protein kinase 14/0.480
4uy6SAHHistidine N-alpha-methyltransferase/0.480
1qiqACCIsopenicillin N synthase1.21.3.10.479
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.478
2rqfJH3Hemolymph juvenile hormone binding protein/0.478
2y6fM9FIsopenicillin N synthase1.21.3.10.478
3aosJH2Hemolymph juvenile hormone binding protein/0.478
3qm4PN0Cytochrome P450 2D6/0.478
1uhhCZPAequorin-2/0.477
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.476
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.476
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.476
4j6cSTRCytochrome P450 monooxygenase/0.476
5p2pDHGPhospholipase A2, major isoenzyme3.1.1.40.476
5g53NECAdenosine receptor A2a/0.476
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.475
1hb1OCVIsopenicillin N synthase1.21.3.10.474
1pwuGM6Lethal factor3.4.24.830.474
3h3sH15Collagen type IV alpha-3-binding protein/0.474
3nxyD2HDihydrofolate reductase1.5.1.30.474
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.473
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.473
3gwnFADProbable FAD-linked sulfhydryl oxidase R5961.8.3.20.473
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.473
4eiyZMAAdenosine receptor A2a/0.473
1ja0FMNNADPH--cytochrome P450 reductase/0.472
1osvCHCBile acid receptor/0.472
2xviFADPutative flavin-containing monooxygenase/0.472
3da24MDCarbonic anhydrase 134.2.1.10.472
1db48INPhospholipase A2, membrane associated/0.471
1u1d181Uridine phosphorylase2.4.2.30.471
2z3uCRRCytochrome P450/0.471
3hl0NADMaleylacetate reductase/0.471
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.471
1p8dCO1Oxysterols receptor LXR-beta/0.470
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.470
3d2dRENReticuline oxidase1.21.3.30.470
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
5a4vQUEGlutathione S-transferase F22.5.1.180.470
1fmjRTLRetinol dehydratase/0.469
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.469
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.469
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.469
4bfxZVXPantothenate kinase2.7.1.330.469
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.469
4y7cFADNADPH--cytochrome P450 reductase/0.469
1yhjR6CPyridoxal kinase2.7.1.350.468
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
2rjp886A disintegrin and metalloproteinase with thrombospondin motifs 43.4.24.820.468
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.468
3nwlNDPCatalase1.11.1.60.468
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.468
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.468
1ej3CZHAequorin-2/0.467
1gt5BZQOdorant-binding protein/0.467
1hfqMOTDihydrofolate reductase1.5.1.30.467
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.467
2zb8IMNProstaglandin reductase 21.3.1.480.467
3b3mH4BNitric oxide synthase, brain1.14.13.390.467
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.467
3oiaA31Camphor 5-monooxygenase1.14.15.10.467
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.467
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.467
5k2aZMAAdenosine receptor A2a/0.467
5jtbZMAAdenosine receptor A2a/0.467
1fm4DXCMajor pollen allergen Bet v 1-L/0.466
1y6oMJIPhospholipase A2, major isoenzyme3.1.1.40.466
2a9z26AAdenosine kinase2.7.1.200.466
2vcmM11Isopenicillin N synthase1.21.3.10.466
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.466
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.466
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
3fcjFADNitroalkane oxidase1.7.3.10.466
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
4dm6TTBRetinoic acid receptor beta/0.466
1fmlRTLRetinol dehydratase/0.465
1itzTPPTransketolase, chloroplastic2.2.1.10.465
1sqvUHDCytochrome b/0.465
2gvdFKPAdenylate cyclase type 2/0.465
2gvdFKPAdenylate cyclase type 5/0.465
2w6pOA4Biotin carboxylase6.3.4.140.465
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.465
4cdmFO1Deoxyribodipyrimidine photolyase/0.465
4ead0NPThymidine phosphorylase2.4.2.40.465
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.465
4qzuRTLRetinol-binding protein 2/0.465
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.465
1vkgCRIHistone deacetylase 83.5.1.980.464
2po7CHDFerrochelatase, mitochondrial4.99.1.10.464
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.464
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.464
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.464
3emlZMAAdenosine receptor A2a/0.464
1opbRETRetinol-binding protein 2/0.463
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.463
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.463
1zgaHMKIsoflavone 4'-O-methyltransferase/0.463
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
2uzfCAA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.463
3c35KAIGlutamate receptor ionotropic, kainate 1/0.463
3pg3DG7Mitogen-activated protein kinase 14/0.463
3qpg3QPAspartate aminotransferase2.6.1.10.463
4ddrMMVDihydrofolate reductase1.5.1.30.463
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4m9aFDAAcyl-CoA dehydrogenase/0.463
5agpH4BNitric oxide synthase, brain1.14.13.390.463
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.463
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.462
1hb3SCVIsopenicillin N synthase1.21.3.10.462
1pkfEPDEpothilone C/D epoxidase1.140.462
1rpwDIDHTH-type transcriptional regulator QacR/0.462
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.462
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
3gwfNAPCyclohexanone monooxygenase/0.462
3zpqXF5Beta-1 adrenergic receptor/0.462
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.462
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.462
4bfuZVUPantothenate kinase2.7.1.330.462
4xoqF42Coenzyme F420:L-glutamate ligase/0.462
1bk0ACVIsopenicillin N synthase1.21.3.10.461
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.461
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.461
1re0AFBADP-ribosylation factor 1/0.461
1re0AFBARF guanine-nucleotide exchange factor 1/0.461
1uzwCDHIsopenicillin N synthase1.21.3.10.461
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
3dgeADPSensor histidine kinase/0.461
3pd3A3TThreonine--tRNA ligase6.1.1.30.461
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
4awo99BHeat shock protein HSP 90-alpha/0.461
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.461
4jt91NSNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.461
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.461
1kvoOAPPhospholipase A2, membrane associated/0.460
1upw444Oxysterols receptor LXR-beta/0.460
1ykdCMPAdenylate cyclase/0.460
2fhkMFNFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.460
3iktNADRedox-sensing transcriptional repressor Rex/0.460
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.459
1pqc444Oxysterols receptor LXR-beta/0.459
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.459
3c34KAIGlutamate receptor ionotropic, kainate 1/0.459
3gncQQQGlutaryl-CoA dehydrogenase/0.459
3mauEXTPutative sphingosine-1-phosphate lyase/0.459
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
4iarERM5-hydroxytryptamine receptor 1B/0.459
4ktl1CQCytochrome P450/0.459
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.459
4rrlA3SProbable threonine--tRNA ligase 26.1.1.30.459
5fm7ADPRuvB-like helicase/0.459
5k2cZMAAdenosine receptor A2a/0.459
1ay0TPPTransketolase 12.2.1.10.458
1i59ANPChemotaxis protein CheA2.7.13.30.458
1ry0PG2Aldo-keto reductase family 1 member C3/0.458
2pamTYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.458
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.458
3njoPYVAbscisic acid receptor PYR1/0.458
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
4ap1NAPSteroid monooxygenase/0.458
1blzACVIsopenicillin N synthase1.21.3.10.457
1dcyI3NPhospholipase A2, membrane associated/0.457
1oc1ASVIsopenicillin N synthase1.21.3.10.457
1zgbA1EAcetylcholinesterase3.1.1.70.457
2e0nSAHPrecorrin-2 C20-methyltransferase/0.457
2jb4A14Isopenicillin N synthase1.21.3.10.457
3bl7DD1m7GpppX diphosphatase3.6.1.590.457
3n0hTOPDihydrofolate reductase1.5.1.30.457
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.457
3qfrFADNADPH--cytochrome P450 reductase/0.457
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
4twnB96Ephrin type-A receptor 32.7.10.10.457
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
1c7oPPGHemolysin/0.456
1disBDMDihydrofolate reductase1.5.1.30.456
1diuBDMDihydrofolate reductase1.5.1.30.456
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
3n87N873-dehydroquinate dehydratase4.2.1.100.456
3nlyH4BNitric oxide synthase, brain1.14.13.390.456
3nxrD2DDihydrofolate reductase1.5.1.30.456
3up0D7SaceDAF-12/0.456
3sn6P0GBeta-2 adrenergic receptor/0.456
1dgbNDPCatalase1.11.1.60.455
1gky5GPGuanylate kinase2.7.4.80.455
1qjfACSIsopenicillin N synthase1.21.3.10.455
2p1t3TNRetinoic acid receptor RXR-alpha/0.455
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.455
2rds1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.455
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.455
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.455
4ixc1JDGlucokinase2.7.1.20.455
4j6dTESCytochrome P450 monooxygenase/0.455
4yauFADNADPH--cytochrome P450 reductase/0.455
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.455
1qxlFR8Adenosine deaminase3.5.4.40.454
1s1rNAPAldo-keto reductase family 1 member C3/0.454
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2ay95PVAromatic-amino-acid aminotransferase2.6.1.570.454
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.454
2xtbKRMAdenosine kinase, putative/0.454
3v94WYQPhosphodiesterase/0.454
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.454
4dyp0MSNucleoprotein/0.454
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.454
4kxjP34Nucleoprotein/0.454
2bjfDXCCholoylglycine hydrolase3.5.1.240.453
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.453
2gjlFMNNitronate monooxygenase1.13.12.160.453
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.453
3ba6AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.453
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.453
4a83DXCMajor pollen allergen Bet v 1-A/0.453
4b2gV1NUncharacterized protein/0.453
4bb3KKAIsopenicillin N synthase1.21.3.10.453
4gqiM49Ribosyldihydronicotinamide dehydrogenase [quinone]/0.453
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.453
4nbiD3YD-tyrosyl-tRNA(Tyr) deacylase/0.453
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.453
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.453
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.453
4uhrNGIAdenosine receptor A2a/0.453
1ek2CDUBifunctional epoxide hydrolase 2/0.452
1hfrMOTDihydrofolate reductase1.5.1.30.452
1qv0CZHObelin/0.452
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.452
1s36CEIObelin/0.452
1tl3H20Gag-Pol polyprotein2.7.7.490.452
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.452
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.452
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3ha3SAHHydroxymycolate synthase MmaA42.1.10.452
3jpuTY4Transcriptional activator protein LasR/0.452
3qlhT27Gag-Pol polyprotein2.7.7.490.452
3vf60H6Glucokinase2.7.1.20.452
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
3zkyWT4Isopenicillin N synthase1.21.3.10.452
4dlcUMPDeoxyuridine triphosphatase, putative/0.452
4iah1DXAlr2278 protein/0.452
4kak06UDihydrofolate reductase1.5.1.30.452
4uz6SCRPalmitoleoyl-protein carboxylesterase NOTUM/0.452
1g63FMNEpidermin decarboxylase4.1.10.451
2pdlTOLAldose reductase1.1.1.210.451
2tohHBITyrosine 3-monooxygenase1.14.16.20.451
2ydvNECAdenosine receptor A2a/0.451
3ghvGHCDihydrofolate reductase1.5.1.30.451
3rtnRTNBeta-secretase 13.4.23.460.451
3vg9ZMAAdenosine receptor A2a/0.451
3w0hW12Vitamin D3 receptor/0.451
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4h7c10HAldo-keto reductase family 1 member C3/0.451
4jlk1NODeoxycytidine kinase2.7.1.740.451
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.450
1c1c612Gag-Pol polyprotein2.7.7.490.450
1p33MTXPteridine reductase 11.5.1.330.450
1pd9CO4Dihydrofolate reductase1.5.1.30.450
1rkhVD2Vitamin D3 receptor/0.450
1towCRZFatty acid-binding protein, adipocyte/0.450
1tsdF89Thymidylate synthase/0.450
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
1yw8A75Methionine aminopeptidase 2/0.450
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2gv8NDPThiol-specific monooxygenase1.14.130.450
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.450
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.450
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3eon341Glutaryl-CoA dehydrogenase/0.450
3h4vDVPPteridine reductase 11.5.1.330.450
3nhfVVVRibosyldihydronicotinamide dehydrogenase [quinone]/0.450
3rviRVIBeta-secretase 13.4.23.460.450
3s41S41Glucokinase2.7.1.20.450
3wznBTNStreptavidin/0.450
4an4DUDPutative glycosyl transferase/0.450
4eh8IRGMitogen-activated protein kinase 14/0.450
4glx0XSDNA ligase6.5.1.20.450
4l5b1UXDeoxycytidine kinase2.7.1.740.450
4y6nUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.450
8catNDPCatalase1.11.1.60.450
5iu86DZAdenosine receptor A2a/0.450
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.449
1o6qR17Squalene--hopene cyclase4.2.1.1290.449
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1trgCB3Thymidylate synthase/0.449
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2g0gSP0Peroxisome proliferator-activated receptor gamma/0.449
2g6iHBINitric oxide synthase, brain1.14.13.390.449
2iluNDPLactaldehyde dehydrogenase1.2.1.220.449
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.449
2ykcYKCHeat shock protein HSP 90-alpha/0.449
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3k1wBFXRenin3.4.23.150.449
3r8gIZPAldo-keto reductase family 1 member C3/0.449
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.449
3w78CBDFMN-dependent NADH-azoreductase/0.449
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
4dhyS41Glucokinase2.7.1.20.449
5bn3ADPV-type ATP synthase alpha chain/0.449
5bn3ADPNEQ263/0.449
3reyXACAdenosine receptor A2a/0.449
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.448
1kt3RTLRetinol-binding protein 4/0.448
1m00H4BNitric oxide synthase, brain1.14.13.390.448
1o5rFR9Adenosine deaminase3.5.4.40.448
1rt7UC4Gag-Pol polyprotein2.7.7.490.448
1xuoLA1Integrin alpha-L/0.448
2amaDHTAndrogen receptor/0.448
2nn7M29Carbonic anhydrase 14.2.1.10.448
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
2y60M8FIsopenicillin N synthase1.21.3.10.448
3i6rJ5ZDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.448
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.448
3pneH4BNitric oxide synthase, brain1.14.13.390.448
3u8dU8DPhospholipase A2, membrane associated/0.448
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.448
4amjCVDBeta-1 adrenergic receptor/0.448
4bftZVTPantothenate kinase2.7.1.330.448
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.448
4y9rFADNADPH--cytochrome P450 reductase/0.448
3pwhZMAAdenosine receptor A2a/0.448
1dggNDPCatalase1.11.1.60.447
1icqOPD12-oxophytodienoate reductase 11.3.1.420.447
1ihiIU5Aldo-keto reductase family 1 member C2/0.447
1kqwRTLCellular retinol-binding protein type II/0.447
1mrqSTRAldo-keto reductase family 1 member C1/0.447
1qv1CZHObelin/0.447
1ve3SAMUncharacterized protein/0.447
2a5kAZPReplicase polyprotein 1ab3.4.220.447
2a9y26AAdenosine kinase2.7.1.200.447
2dvlFADAcyl-CoA dehydrogenase/0.447
2fszOHTEstrogen receptor beta/0.447
2i62SAHNicotinamide N-methyltransferase2.1.1.10.447
2wu4HBPAcetylcholinesterase3.1.1.70.447
2xf3J01Uncharacterized protein/0.447
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.447
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3mlaJJZProbable nicotinate-nucleotide adenylyltransferase/0.447
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.447
3ojiPYVAbscisic acid receptor PYL3/0.447
3r8hZOMAldo-keto reductase family 1 member C3/0.447
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.447
3vvpBNUUncharacterized protein/0.447
4a86H35Major pollen allergen Bet v 1-A/0.447
4c13UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase/0.447
4dm8REARetinoic acid receptor beta/0.447
4do30LAFatty-acid amide hydrolase 13.5.1.990.447
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4fsa0V3Queuine tRNA-ribosyltransferase2.4.2.290.447
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
4hmn16JAldo-keto reductase family 1 member C3/0.447
4i1nFOLDihydrofolate reductase1.5.1.30.447
4jvnYUGEstrogen sulfotransferase2.8.2.40.447
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.447
4q71FADBifunctional protein PutA/0.447
4uymVOR14-alpha sterol demethylase Cyp51B/0.447
5iua6DXAdenosine receptor A2a/0.447
1f5fDHTSex hormone-binding globulin/0.446
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.446
1kqgMGDFormate dehydrogenase, nitrate-inducible, major subunit1.1.5.60.446
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.446
1rszDIHPurine nucleoside phosphorylase2.4.2.10.446
1tllFADNitric oxide synthase, brain1.14.13.390.446
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.446
2ed3SAHDiphthine synthase/0.446
2ga2A19Methionine aminopeptidase 2/0.446
2j83BATUlilysin3.4.240.446
2vd0D27Hematopoietic prostaglandin D synthase/0.446
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.446
2zsaADPPantothenate kinase2.7.1.330.446
3br3ETHTH-type transcriptional regulator QacR/0.446
3c14FOKAdenylate cyclase type 2/0.446
3c14FOKAdenylate cyclase type 5/0.446
3ezpB3NHistone deacetylase 83.5.1.980.446
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3h3t16HCollagen type IV alpha-3-binding protein/0.446
3jq8DX3Pteridine reductase, putative/0.446
3ojxFMNNADPH--cytochrome P450 reductase/0.446
3p9tTCLRepressor/0.446
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.446
4fnyI3KALK tyrosine kinase receptor2.7.10.10.446
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.446
4jx1CAMCamphor 5-monooxygenase1.14.15.10.446
4yp6NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.446
1dpmEBPParathion hydrolase3.1.8.10.445
1rywEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
1yw7A41Methionine aminopeptidase 2/0.445
2fk8SAMHydroxymycolate synthase MmaA42.1.10.445
2lbdREARetinoic acid receptor gamma/0.445
3c3xNAPEugenol synthase 11.1.1.3180.445
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.445
3ix8TX3Transcriptional activator protein LasR/0.445
3o3jBB4Peptide deformylase 1B, chloroplastic/mitochondrial3.5.1.880.445
3oagLPQRenin3.4.23.150.445
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3of1CMPcAMP-dependent protein kinase regulatory subunit/0.445
3qp8HL0Transcriptional activator, LuxR/UhpA family of regulators/0.445
3r7mSUZAldo-keto reductase family 1 member C3/0.445
3s5wFADL-ornithine N(5)-monooxygenase/0.445
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3ufuH4BNitric oxide synthase, brain1.14.13.390.445
3up3XCAaceDAF-12/0.445
3zdfNADGlyceraldehyde-3-phosphate dehydrogenase/0.445
4d04NAPPhenylacetone monooxygenase1.14.13.920.445
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.445
4pkl1GHUncharacterized protein/0.445
4qa2SHHHistone deacetylase 83.5.1.980.445
5a0112VO-glycosyltransferase/0.445
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4s0vSUVOrexin receptor type 2/0.445
2bzsCB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.444
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.444
2v59LZKBiotin carboxylase6.3.4.140.444
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
2zcePYLPyrrolysine--tRNA ligase/0.444
3fhxPLPPyridoxal kinase2.7.1.350.444
3fr5I4AFatty acid-binding protein, adipocyte/0.444
3jzfJZKBiotin carboxylase6.3.4.140.444
3p3c3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.444
3vtbTKAVitamin D3 receptor/0.444
3zoiM2WIsopenicillin N synthase1.21.3.10.444
4ea13RXDehydrosqualene synthase/0.444
4jlj1NMDeoxycytidine kinase2.7.1.740.444
4jlm1NNDeoxycytidine kinase2.7.1.740.444
4jsgH4BNitric oxide synthase, brain1.14.13.390.444
4rujVDXVitamin D3 receptor A/0.444
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.444
5bp9SAHPutative methyltransferase protein/0.444
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.443
1g3mPCQEstrogen sulfotransferase2.8.2.40.443
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1k7fIAVTryptophan synthase alpha chain/0.443
1qknRALEstrogen receptor beta/0.443
1rxhBNIStreptavidin/0.443
1swtBTNStreptavidin/0.443
1w06W05Isopenicillin N synthase1.21.3.10.443
2fxuBIDActin, alpha skeletal muscle/0.443
2h55DZ8Heat shock protein HSP 90-alpha/0.443
2r0pK2CPutative FAD-monooxygenase/0.443
2wzySQXSoluble acetylcholine receptor/0.443
2z2w770Wee1-like protein kinase2.7.10.20.443
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.443
3b9lAZZSerum albumin/0.443
3hziATPSerine/threonine-protein kinase toxin HipA/0.443
3l0lHC3Nuclear receptor ROR-gamma/0.443
3nmpPYVAbscisic acid receptor PYL2/0.443
3r6iJMSAldo-keto reductase family 1 member C3/0.443
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.443
3w5tLHPVitamin D3 receptor/0.443
4b4w9L9Bifunctional protein FolD/0.443
4l9kEHFSerum albumin/0.443
4rr8A3SProbable threonine--tRNA ligase 26.1.1.30.443
5k2bZMAAdenosine receptor A2a/0.443
1dibL34C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.442
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1ndzFR5Adenosine deaminase3.5.4.40.442
1o6rR19Squalene--hopene cyclase4.2.1.1290.442
1s7gNADNAD-dependent protein deacylase 2/0.442
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2ab8MTPAdenosine kinase2.7.1.200.442
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2oaxSNLMineralocorticoid receptor/0.442
2oliIOPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.442
2uywBTNAvd protein/0.442
2yk2YJXHeat shock protein HSP 90-alpha/0.442
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3ix4TX1Transcriptional activator protein LasR/0.442
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3nfrEWQRibosyldihydronicotinamide dehydrogenase [quinone]/0.442
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4iwv1J9Glucokinase2.7.1.20.442
4klaCHDFerrochelatase, mitochondrial4.99.1.10.442
4kwi1TJReductase homolog/0.442
4n1gCEIObelin/0.442
5ab7MLCNonspecific lipid-transfer protein, putative/0.442
5dozNDPJamJ/0.442
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.442
4zj8SUVOrexin receptor type 1/0.442
1bzfTMQDihydrofolate reductase1.5.1.30.441
1cjvFOKAdenylate cyclase type 2/0.441
1cjvFOKAdenylate cyclase type 5/0.441
1fxfMJIPhospholipase A2, major isoenzyme3.1.1.40.441
1lwlDSOCamphor 5-monooxygenase1.14.15.10.441
1mczRMNBenzoylformate decarboxylase4.1.1.70.441
1u1gBBBUridine phosphorylase2.4.2.30.441
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.441
1v35NAIEnoyl-ACP reductase/0.441
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.441
2hamC33Vitamin D3 receptor/0.441
2oymMNIEndoglycoceramidase II/0.441
2rehFADNitroalkane oxidase1.7.3.10.441
2v58LZJBiotin carboxylase6.3.4.140.441
2xvfFADPutative flavin-containing monooxygenase/0.441
2ykiYKIHeat shock protein HSP 90-alpha/0.441
3akn11DFatty acid-binding protein, intestinal/0.441
3clxX22E3 ubiquitin-protein ligase XIAP6.3.20.441
3h59H59Genome polyprotein2.7.7.480.441
3jrxS1AAcetyl-CoA carboxylase 2/0.441
3ntz3TZDihydrofolate reductase1.5.1.30.441
3nxtD2EDihydrofolate reductase1.5.1.30.441
3otqMZLBifunctional epoxide hydrolase 23.3.2.100.441
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.441
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.441
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.441
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.441
4a81DXCMajor pollen allergen Bet v 1-A/0.441
4a87NARMajor pollen allergen Bet v 1-A/0.441
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.441
4bfvZVVPantothenate kinase2.7.1.330.441
4eh4IRGMitogen-activated protein kinase 14/0.441
4gdpFADPolyamine oxidase FMS1/0.441
4hy6FJ1Heat shock protein HSP 90-alpha/0.441
4jauADPSensor histidine kinase/0.441
4knzCB3Thymidylate synthase/0.441
5c93ACPTwo-component system histidine protein kinase/0.441
5fd8A5APutative carboxypeptidase yocD/0.441
5hs1VORLanosterol 14-alpha demethylase/0.441
5uviZMAAdenosine receptor A2a/0.441
1dghNDPCatalase1.11.1.60.440
1hvyD16Thymidylate synthase2.1.1.450.440
1i5aACPChemotaxis protein CheA2.7.13.30.440
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.440
1jnzFADAdenylylsulfate reductase, subunit A (AprA)/0.440
1jomFFODihydrofolate reductase1.5.1.30.440
1n5qTNCActVA 6 protein/0.440
1puaCOAHAT A1/0.440
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.440
2gjnFMNNitronate monooxygenase1.13.12.160.440
2ohjFMNType A flavoprotein FprA10.440
2pauD5M5'-deoxynucleotidase YfbR/0.440
2qg2A91Heat shock protein HSP 90-alpha/0.440
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
3b3pH4BNitric oxide synthase, brain1.14.13.390.440
3bi6396Wee1-like protein kinase2.7.10.20.440
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.440
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.440
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.440
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3fl4FL4Mitogen-activated protein kinase 14/0.440
3irxUDRGag-Pol polyprotein2.7.7.490.440
3oadLPORenin3.4.23.150.440
3ogkOGKCoronatine-insensitive protein 1/0.440
3p2oNADBifunctional protein FolD/0.440
3pnfH4BNitric oxide synthase, brain1.14.13.390.440
3pqbVGPPutative oxidoreductase/0.440
3qe2FADNADPH--cytochrome P450 reductase/0.440
3qe2FMNNADPH--cytochrome P450 reductase/0.440
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.440
3slkNDPPolyketide synthase extender module 2/0.440
3ug8IMNAldo-keto reductase family 1 member C3/0.440
3vi7CBDHematopoietic prostaglandin D synthase/0.440
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4d03NAPPhenylacetone monooxygenase1.14.13.920.440
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
4eqsCOACoenzyme A disulfide reductase/0.440
4eqwCOACoenzyme A disulfide reductase/0.440
4h6pFMNChromate reductase/0.440
4ixd1HVIntegrin alpha-L/0.440
4jnc1LFBifunctional epoxide hydrolase 23.1.3.760.440
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.440
4oztP1AEcdysone receptor, putative/0.440
4phlPILPhosphodiesterase/0.440
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.440
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.440