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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2e0nSAHPrecorrin-2 C20-methyltransferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2e0nSAHPrecorrin-2 C20-methyltransferase/1.000
2gv8NDPThiol-specific monooxygenase1.14.130.512
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.506
2qbuSAHPrecorrin-2 methyltransferase/0.505
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.499
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.499
3h3t16HCollagen type IV alpha-3-binding protein/0.497
2uxoTACHTH-type transcriptional regulator TtgR/0.496
3p62FMNPentaerythritol tetranitrate reductase/0.491
1bk0ACVIsopenicillin N synthase1.21.3.10.488
1xddAAYIntegrin alpha-L/0.486
2iviACWIsopenicillin N synthase1.21.3.10.486
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.484
3k1wBFXRenin3.4.23.150.484
3rpeFADPutative modulator of drug activity/0.484
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.483
3h3sH15Collagen type IV alpha-3-binding protein/0.483
4df2FMNNADPH dehydrogenase/0.482
3qwbNDPProbable quinone oxidoreductase1.6.5.50.481
3rsv3RSBeta-secretase 13.4.23.460.481
1icpFMN12-oxophytodienoate reductase 11.3.1.420.480
1obnASVIsopenicillin N synthase1.21.3.10.480
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.479
3h3r14HCollagen type IV alpha-3-binding protein/0.479
3p74FMNPentaerythritol tetranitrate reductase/0.477
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
1bwlFMNNADPH dehydrogenase 11.6.99.10.476
4b4dFADFerredoxin-NADP reductase/0.476
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.476
4xnw2IDP2Y purinoceptor 1/0.476
1kkq471Peroxisome proliferator-activated receptor alpha/0.475
3f03FMNPentaerythritol tetranitrate reductase/0.475
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.475
5kwvANPPantothenate synthetase/0.475
4bb3KKAIsopenicillin N synthase1.21.3.10.474
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.474
4yaoFMNNADPH--cytochrome P450 reductase/0.474
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.473
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.473
2clfF6FTryptophan synthase alpha chain/0.473
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.473
3g6zA7TRenin3.4.23.150.473
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.473
3qe2FMNNADPH--cytochrome P450 reductase/0.473
4mlp2CXCryptochrome-2/0.473
1txtCAAHMG-CoA synthase/0.472
2ejzSAHDiphthine synthase/0.472
3vt9YI4Vitamin D3 receptor/0.472
4i1nFOLDihydrofolate reductase1.5.1.30.472
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.471
2fs4PZ1Renin3.4.23.150.471
3hub469Mitogen-activated protein kinase 14/0.471
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.471
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.471
1fmlRTLRetinol dehydratase/0.470
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
3f63GTXGlutathione transferase GST1-4/0.470
3vf60H6Glucokinase2.7.1.20.470
3zeiAWHO-acetylserine sulfhydrylase/0.470
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.470
4e2bFMNDehydrogenase/0.470
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.470
2cy0NAPShikimate dehydrogenase (NADP(+))/0.469
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.469
2g8yNADHydroxycarboxylate dehydrogenase B/0.469
2hpsCTZCa2+-triggered coelenterazine-binding protein 1/0.469
2jibADPOxalyl-CoA decarboxylase4.1.1.80.469
4uymVOR14-alpha sterol demethylase Cyp51B/0.469
3l0lHC3Nuclear receptor ROR-gamma/0.468
3uleC69Actin-related protein 3/0.468
4c49HCYCorticosteroid-binding globulin/0.468
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.468
4fk8FADFerredoxin--NADP reductase/0.468
1h50FMNPentaerythritol tetranitrate reductase/0.467
1qiqACCIsopenicillin N synthase1.21.3.10.467
2gciMRRProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.467
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.467
3p67FMNPentaerythritol tetranitrate reductase/0.467
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
4iwv1J9Glucokinase2.7.1.20.467
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.467
4y0kNAPAntE/0.467
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.466
1jolFFODihydrofolate reductase1.5.1.30.466
2d29FADAcyl-CoA dehydrogenase/0.466
3slkNDPPolyketide synthase extender module 2/0.466
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1g63FMNEpidermin decarboxylase4.1.10.465
1jomFFODihydrofolate reductase1.5.1.30.465
1krrACOGalactoside O-acetyltransferase2.3.1.180.465
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.465
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.465
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.465
2g274LGRenin3.4.23.150.465
2pa7TYDTDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase5.3.2.30.465
3bac3B9DNA ligase/0.465
3fl4FL4Mitogen-activated protein kinase 14/0.465
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.465
4nieNBHNuclear receptor ROR-gamma/0.465
4phlPILPhosphodiesterase/0.465
5bn3ADPV-type ATP synthase alpha chain/0.465
5bn3ADPNEQ263/0.465
1cf3FADGlucose oxidase1.1.3.40.464
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
1e7qNAPGDP-L-fucose synthase/0.464
1nzdUPGDNA beta-glucosyltransferase/0.464
3h3qH13Collagen type IV alpha-3-binding protein/0.464
4az3S35Lysosomal protective protein3.4.16.50.464
4gdcNDPUDP-galactopyranose mutase/0.464
4qi5FADCellobiose dehydrogenase/0.464
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.464
4yaw2AMNADPH--cytochrome P450 reductase/0.464
1blzACVIsopenicillin N synthase1.21.3.10.463
1h73ANPHomoserine kinase2.7.1.390.463
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.463
1u1d181Uridine phosphorylase2.4.2.30.463
2a9y26AAdenosine kinase2.7.1.200.463
2ahrNAPPyrroline-5-carboxylate reductase/0.463
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.463
4ez8DHFThymidylate synthase2.1.1.450.463
3zoiM2WIsopenicillin N synthase1.21.3.10.462
3zsh469Mitogen-activated protein kinase 14/0.462
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.462
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.462
1hb1OCVIsopenicillin N synthase1.21.3.10.461
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
2ejvNADL-threonine 3-dehydrogenase/0.461
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.461
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.461
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.461
4ryvZEAProtein LlR18A/0.461
1f8fNADBenzyl alcohol dehydrogenase/0.460
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.460
1rf7DHFDihydrofolate reductase1.5.1.30.460
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.460
3q44D50M1 family aminopeptidase3.4.110.460
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.460
4g7gVFVLanosterol 14-alpha-demethylase/0.460
4nh82LCHeat shock protein HSP 90-alpha/0.460
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.460
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1ddrMTXDihydrofolate reductase1.5.1.30.459
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.459
2e9dB76Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.459
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.459
3qt62P0Mevalonate diphosphate decarboxylase/0.459
4fkzUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.459
4tuvCPZCytochrome P450 1191.140.459
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.459
1icqOPD12-oxophytodienoate reductase 11.3.1.420.458
1pkfEPDEpothilone C/D epoxidase1.140.458
2gd6ACOProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.458
2jb4A14Isopenicillin N synthase1.21.3.10.458
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3fkoFKOMitogen-activated protein kinase 14/0.458
3gwfNAPCyclohexanone monooxygenase/0.458
3ukoNADAlcohol dehydrogenase class-3/0.458
3zuyTCHTransporter/0.458
4b4w9L9Bifunctional protein FolD/0.458
4gddNAIUDP-galactopyranose mutase/0.458
1ia3TQ5Dihydrofolate reductase1.5.1.30.457
1qoqIGPTryptophan synthase alpha chain/0.457
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.457
2rcyNAPPyrroline-5-carboxylate reductase/0.457
2ydwWSHBromodomain-containing protein 2/0.457
3g72A6TRenin3.4.23.150.457
3p0fBAUUridine phosphorylase 22.4.2.30.457
3tneRITCandidapepsin-13.4.23.240.457
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.457
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.457
1h63FMNPentaerythritol tetranitrate reductase/0.456
1ygkRRCPyridoxal kinase2.7.1.350.456
2q28ADPOxalyl-CoA decarboxylase4.1.1.80.456
2vnjFADNADPH:ferredoxin reductase/0.456
2wjoQUDBeta-secretase 13.4.23.460.456
3fhxPLPPyridoxal kinase2.7.1.350.456
3gobHXXDdmC/0.456
3gwfFADCyclohexanone monooxygenase/0.456
3otwCOAPhosphopantetheine adenylyltransferase/0.456
3uk6ADPRuvB-like 23.6.4.120.456
4alhA9PBromodomain-containing protein 2/0.456
4jlj1NMDeoxycytidine kinase2.7.1.740.456
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.455
2abbFMNPentaerythritol tetranitrate reductase/0.455
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.455
3nw3MU2Peptidoglycan recognition protein 1/0.455
3nx4NAPPutative oxidoreductase/0.455
3pqbVGPPutative oxidoreductase/0.455
4a8v2ANMajor pollen allergen Bet v 1-J/0.455
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.455
1bwsNDPGDP-L-fucose synthase/0.454
1icsFMN12-oxophytodienoate reductase 11.3.1.420.454
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.454
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1ri1GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.454
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.454
2y6fM9FIsopenicillin N synthase1.21.3.10.454
3itzP66Mitogen-activated protein kinase 14/0.454
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.454
3qlrNDPDihydrofolate reductase1.5.1.30.454
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.454
4bfxZVXPantothenate kinase2.7.1.330.454
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.454
4m5pFMNNADPH dehydrogenase/0.454
5dbfNDPIridoid synthase1.3.1.990.454
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.454
1g6kNADGlucose 1-dehydrogenase1.1.1.470.453
1rb3MTXDihydrofolate reductase1.5.1.30.453
1vyrFMNPentaerythritol tetranitrate reductase/0.453
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
2a9z26AAdenosine kinase2.7.1.200.453
2ed3SAHDiphthine synthase/0.453
2po7CHDFerrochelatase, mitochondrial4.99.1.10.453
2w6zL21Biotin carboxylase6.3.4.140.453
2zsaADPPantothenate kinase2.7.1.330.453
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.453
3o9lLPNRenin3.4.23.150.453
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.453
4b65FADL-ornithine N(5)-monooxygenase/0.453
4dfrMTXDihydrofolate reductase1.5.1.30.453
4gevCB3Thymidylate synthase/0.453
1gpdNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.452
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.452
2h12CMXCitrate synthase/0.452
2ji9ADPOxalyl-CoA decarboxylase4.1.1.80.452
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.452
2rh9IGPTryptophan synthase alpha chain/0.452
2vbdV10Isopenicillin N synthase1.21.3.10.452
2wzySQXSoluble acetylcholine receptor/0.452
3bgxMEFThymidylate synthase/0.452
3gkaFMNN-ethylmaleimide reductase/0.452
3rtnRTNBeta-secretase 13.4.23.460.452
3wqmB29Diterpene synthase3.1.7.80.452
4q71FADBifunctional protein PutA/0.452
5ftfADPTPR domain protein/0.452
1gcoNADGlucose 1-dehydrogenase1.1.1.470.451
1icqFMN12-oxophytodienoate reductase 11.3.1.420.451
1k6tXN1Gag-Pol polyprotein3.4.23.160.451
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.451
1wn3HXCPhenylacetic acid degradation protein PaaI/0.451
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.451
2i7pACOPantothenate kinase 32.7.1.330.451
2vn1FK5Peptidylprolyl isomerase/0.451
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.451
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.451
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.451
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.451
4i6gFADCryptochrome-2/0.451
4j7gTRHPCZA361.3/0.451
1dirNADDihydropteridine reductase1.5.1.340.450
1e3eNAIAlcohol dehydrogenase 41.1.1.10.450
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.450
1qorNDPQuinone oxidoreductase 1/0.450
1vceSAHDiphthine synthase/0.450
2g263LGRenin3.4.23.150.450
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.450
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.450
2vnhFADNADPH:ferredoxin reductase/0.450
2y37A54Nitric oxide synthase, inducible1.14.13.390.450
3gw9VNILanosterol 14-alpha-demethylase/0.450
3s5wFADL-ornithine N(5)-monooxygenase/0.450
3uwlFOZThymidylate synthase/0.450
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.450
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.450
4bftZVTPantothenate kinase2.7.1.330.450
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.450
4ipw1G7Mycocyclosin synthase1.14.21.90.450
4jjiNADAlcohol dehydrogenase class-3/0.450
4k36SAMAnaerobic sulfatase-maturating enzyme1.8.980.450
4ktl1CQCytochrome P450/0.450
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.450
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.449
1mewXMPInosine-5'-monophosphate dehydrogenase/0.449
1zeoC01Peroxisome proliferator-activated receptor gamma/0.449
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.449
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2wzwFMNNitroreductase NfnB/0.449
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.449
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.449
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.449
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
3i0pNADMalate dehydrogenase, putative/0.449
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.449
3oadLPORenin3.4.23.150.449
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.449
3wrhCAMCamphor 5-monooxygenase1.14.15.10.449
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.449
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.449
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
4l8u9AZSerum albumin/0.449
5ctsCMCCitrate synthase, mitochondrial2.3.3.10.449
5stdUNNScytalone dehydratase4.2.1.940.449
1fxsNAPGDP-L-fucose synthase/0.448
1mv8GDXGDP-mannose 6-dehydrogenase1.1.1.1320.448
1xs7MMIBeta-secretase 13.4.23.460.448
1y0s331Peroxisome proliferator-activated receptor delta/0.448
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.448
2vprTDCTetracycline repressor protein class H/0.448
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
2ykeYKEHeat shock protein HSP 90-alpha/0.448
3atzFMNProstaglandin F2a synthase/0.448
3eigMTXDihydrofolate reductase1.5.1.30.448
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.448
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.448
3icrFADCoenzyme A disulfide reductase/0.448
3maaFKPAdenylate cyclase type 2/0.448
3maaFKPAdenylate cyclase type 5/0.448
3q9bB3NAcetylpolyamine amidohydrolase/0.448
3vt8YI3Vitamin D3 receptor/0.448
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4wx2F6FTryptophan synthase alpha chain/0.448
4wx2F6FTryptophan synthase beta chain4.2.1.200.448
4xbjIN5Alanine racemase, biosynthetic/0.448
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
5a9sNAPPutative dehydrogenase/0.448
1diuBDMDihydrofolate reductase1.5.1.30.447
1mp0NADAlcohol dehydrogenase class-31.1.1.10.447
1synF89Thymidylate synthase/0.447
1uymPU3Heat shock protein HSP 90-beta/0.447
1uzwCDHIsopenicillin N synthase1.21.3.10.447
2a5kAZPReplicase polyprotein 1ab3.4.220.447
2vbpVB1Isopenicillin N synthase1.21.3.10.447
2xviFADPutative flavin-containing monooxygenase/0.447
3ekuCY9Actin-5C/0.447
3k47D09Dihydrofolate reductase1.5.1.30.447
3l77NJPShort-chain alcohol dehydrogenase/0.447
3uceNDPDehydrogenase/0.447
3vdqNAD3-hydroxybutyrate dehydrogenase/0.447
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.447
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.447
4v2gITCTetracycline repressor protein class D/0.447
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.447
6ctsCICCitrate synthase, mitochondrial2.3.3.10.447
1b2lNDCAlcohol dehydrogenase1.1.1.10.446
1di8DTQCyclin-dependent kinase 22.7.11.220.446
1dtpAPUDiphtheria toxin/0.446
1fvpFMANon-fluorescent flavoprotein/0.446
1vbiNADMalate/L-lactate dehydrogenase family protein/0.446
1w06W05Isopenicillin N synthase1.21.3.10.446
1zdwFLVPrenyltransferase/0.446
1zw9H64ATP-dependent molecular chaperone HSP82/0.446
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.446
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4g3jVNTLanosterol 14-alpha-demethylase/0.446
4g47TZFMycocyclosin synthase1.14.21.90.446
4iji99TGlutathione S-transferase-like protein YibF/0.446
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.446
4tmbFMNOld yellow enzyme/0.446
4zqcF6FTryptophan synthase alpha chain/0.446
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.445
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.445
1u3dFADCryptochrome-1/0.445
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.445
2ay3MPPAromatic-amino-acid aminotransferase2.6.1.570.445
2bgjFADNADPH:ferredoxin reductase/0.445
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
2gjnFMNNitronate monooxygenase1.13.12.160.445
2pncCLUPrimary amine oxidase, liver isozyme/0.445
3fknFKNMitogen-activated protein kinase 14/0.445
3p99LNPLanosterol 14-alpha-demethylase/0.445
3q43D66M1 family aminopeptidase3.4.110.445
3vx4ATPPutative ABC transporter, ATP-binding protein ComA/0.445
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.445
4ambDUDPutative glycosyl transferase/0.445
4fhd0TTSpore photoproduct lyase/0.445
4fweFADLysine-specific histone demethylase 1B10.445
4rnuFMNNADPH dehydrogenase 11.6.99.10.445
1hb3SCVIsopenicillin N synthase1.21.3.10.444
1me6IVSPlasmepsin-23.4.23.390.444
1nm6L86Prothrombin3.4.21.50.444
1qrpHH0Pepsin A-43.4.23.10.444
1s3zCOAAminoglycoside N(6')-acetyltransferase type 1/0.444
1zzrDP9Nitric oxide synthase, brain1.14.13.390.444
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.444
2j9lATPH(+)/Cl(-) exchange transporter 5/0.444
2oliIOPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.444
2q153MRBeta-secretase 13.4.23.460.444
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
2uuk897Prothrombin3.4.21.50.444
2v7qATPATP synthase subunit alpha, mitochondrial/0.444
2v7qATPATP synthase subunit beta, mitochondrial3.6.3.140.444
2xszATPRuvB-like 23.6.4.120.444
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.444
3ohh3HHBeta-secretase 13.4.23.460.444
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.444
3r95ACOMccE protein/0.444
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.444
3vt7VDXVitamin D3 receptor/0.444
3wv9FEGHmd co-occurring protein HcgE/0.444
3zkyWT4Isopenicillin N synthase1.21.3.10.444
4b4vL34Bifunctional protein FolD/0.444
4cdmFO1Deoxyribodipyrimidine photolyase/0.444
4dvi2IWTankyrase-12.4.2.300.444
4ktkKTKCytochrome P450/0.444
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.444
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
5dozNDPJamJ/0.444
5dp2NAPCurF/0.444
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.444
5f8eSAHPossible transcriptional regulatory protein/0.444
1fmjRTLRetinol dehydratase/0.443
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
1m13HYFNuclear receptor subfamily 1 group I member 2/0.443
1m9k7NINitric oxide synthase, endothelial1.14.13.390.443
1mczRMNBenzoylformate decarboxylase4.1.1.70.443
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.443
1nhkCMPNucleoside diphosphate kinase2.7.4.60.443
1pd9CO4Dihydrofolate reductase1.5.1.30.443
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.443
1q19SSCCarbapenam-3-carboxylate synthase6.3.3.60.443
1uyePU9Heat shock protein HSP 90-alpha/0.443
1w0kADPATP synthase subunit alpha, mitochondrial/0.443
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.443
1x1dSAHC-20 methyltransferase/0.443
1x8lOXRRetinol dehydratase/0.443
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.443
2cntCOARibosomal-protein-alanine acetyltransferase/0.443
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.443
2lfoGCHFatty acid-binding protein, liver/0.443
2ohvNHLGlutamate racemase/0.443
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.443
2r8oT5XTransketolase 1/0.443
2rlcCHDCholoylglycine hydrolase3.5.1.240.443
2xysSY9Soluble acetylcholine receptor/0.443
2zbaZBATrichothecene 3-O-acetyltransferase/0.443
3adaNADSubunit alpha of sarocosine oxidase/0.443
3bg7FADPyranose 2-oxidase/0.443
3cwqADPParA family chromosome partitioning protein/0.443
3d84NDPDihydrofolate reductase1.5.1.30.443
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.443
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.443
3w8eNAD3-hydroxybutyrate dehydrogenase/0.443
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.443
4bfzZVZPantothenate kinase2.7.1.330.443
4e0u0MVCyclic dipeptide N-prenyltransferase/0.443
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.443
4q73FADBifunctional protein PutA/0.443
4xiwAZMCarbonic anhydrase, alpha type/0.443
5itzLOCTubulin beta-2B chain/0.443
1bsvNDPGDP-L-fucose synthase/0.442
1nvtNAPShikimate dehydrogenase (NADP(+))/0.442
1oc1ASVIsopenicillin N synthase1.21.3.10.442
1qjfACSIsopenicillin N synthase1.21.3.10.442
1rc4DDFDihydrofolate reductase1.5.1.30.442
1rd4L08Integrin alpha-L/0.442
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.442
2gevCOKPantothenate kinase2.7.1.330.442
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.442
2j83BATUlilysin3.4.240.442
2ok7FADFerredoxin--NADP reductase, apicoplast/0.442
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.442
2uxpCLMHTH-type transcriptional regulator TtgR/0.442
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.442
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3e5aVX6Aurora kinase A2.7.11.10.442
3ensENSCoagulation factor X3.4.21.60.442
3gqvNAPEnoyl reductase LovC10.442
3lpjZ75Beta-secretase 13.4.23.460.442
3nt5NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.442
3p3zP3ZPutative cytochrome P450/0.442
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.442
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.442
4e2dFMNDehydrogenase/0.442
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.442
4jicFMNGTN Reductase/0.442
4qaiFMNNADPH dehydrogenase/0.442
4qg1DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.442
4uyf73BBromodomain-containing protein 2/0.442
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.442
5hs1VORLanosterol 14-alpha demethylase/0.442
7stdCRPScytalone dehydratase4.2.1.940.442
1culFOKAdenylate cyclase type 2/0.441
1culFOKAdenylate cyclase type 5/0.441
1dnaCB3Thymidylate synthase/0.441
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1kfbIGPTryptophan synthase alpha chain/0.441
1psa0ZLPepsin A3.4.23.10.441
1uy8PU5Heat shock protein HSP 90-alpha/0.441
1uydPU8Heat shock protein HSP 90-alpha/0.441
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.441
2bktRPFRenin3.4.23.150.441
2c31ADPOxalyl-CoA decarboxylase4.1.1.80.441
2ctsCOACitrate synthase, mitochondrial2.3.3.10.441
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.441
2g226IGRenin3.4.23.150.441
2gfsPQBMitogen-activated protein kinase 14/0.441
2hizLIJBeta-secretase 13.4.23.460.441
2ji6ADPOxalyl-CoA decarboxylase4.1.1.80.441
2jl1NAPTriphenylmethane reductase/0.441
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.441
2q4wFADCytokinin dehydrogenase 71.5.99.120.441
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.441
2z0x5CAUncharacterized protein/0.441
3atyFMNProstaglandin F2a synthase/0.441
3g70A5TRenin3.4.23.150.441
3hqdANPKinesin-like protein KIF11/0.441
3iktNADRedox-sensing transcriptional repressor Rex/0.441
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3l63CAMCamphor 5-monooxygenase1.14.15.10.441
3nz2ACOHexapeptide-repeat containing-acetyltransferase/0.441
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.441
3v0o4GWHisto-blood group ABO system transferase/0.441
3zhuTD8Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.441
4ead0NPThymidine phosphorylase2.4.2.40.441
4fqsLYAThymidylate synthase ThyA/0.441
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.441
4n4v2GYTankyrase-12.4.2.300.441
4o1mNADEnoyl-acyl carrier reductase/0.441
1cqp803Integrin alpha-L/0.440
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.440
1kzjCB3Thymidylate synthase/0.440
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
1ma0NADAlcohol dehydrogenase class-31.1.1.10.440
1o9bNAIQuinate/shikimate dehydrogenase/0.440
1p0hACOMycothiol acetyltransferase2.3.1.1890.440
1qy5NECEndoplasmin/0.440
1x1cSAHC-20 methyltransferase/0.440
2bu9HFVIsopenicillin N synthase1.21.3.10.440
2eixFADNADH-cytochrome b5 reductase/0.440
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2x9dITCTetracycline repressor protein class D/0.440
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.440
3bk2U5PRibonuclease J/0.440
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.440
3hyg099A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.440
3lqfNADGalactitol dehydrogenase/0.440
3nxxNDPDihydrofolate reductase1.5.1.30.440
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.440
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.440
3vtbTKAVitamin D3 receptor/0.440
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.440
4a6rTA8Probable aminotransferase/0.440
4a9mP9MBromodomain-containing protein 2/0.440
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.440
4nxuADPMitochondrial dynamics protein MID51/0.440
4nxxGDPMitochondrial dynamics protein MID51/0.440
4y7cNAPNADPH--cytochrome P450 reductase/0.440