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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.11.000
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.711
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.696
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.673
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.672
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.648
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.633
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.626
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.605
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.593
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.590
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.589
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.587
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.582
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.582
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.581
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.579
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.579
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.575
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.575
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.570
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.568
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.567
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.567
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.566
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.563
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.562
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.560
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.558
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.558
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.557
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.556
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.555
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.554
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.554
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.554
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.554
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.552
2hog710Serine/threonine-protein kinase Chk12.7.11.10.550
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.548
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.545
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.544
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.543
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.543
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.542
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.542
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.540
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.540
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.539
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.538
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.536
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.536
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.535
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.534
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.534
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.532
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.532
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.532
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.531
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.531
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.529
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.528
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.526
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.525
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.524
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.524
4gk3L87Ephrin type-A receptor 32.7.10.10.524
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.523
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.523
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.523
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.521
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.521
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.518
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.516
3zh8C58Protein kinase C iota type2.7.11.130.516
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.516
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.515
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.515
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.514
1zrzBI1Protein kinase C iota type2.7.11.130.513
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.513
3a62STURibosomal protein S6 kinase beta-12.7.11.10.513
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.513
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.512
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.511
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.511
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.510
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.510
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.509
3c4xATPRhodopsin kinase/0.509
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.509
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.508
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.508
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.508
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.508
4b99R4LMitogen-activated protein kinase 72.7.11.240.508
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.508
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.507
3pxkPXKFocal adhesion kinase 12.7.10.20.507
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.507
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.506
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.505
2qo9ANPEphrin type-A receptor 32.7.10.10.504
2vd5BI8Myotonin-protein kinase2.7.11.10.504
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.504
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.503
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.503
3bheBZNGag-Pol polyprotein3.4.23.160.502
3c4wATPRhodopsin kinase/0.502
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.502
3ggfGVDSerine/threonine-protein kinase 26/0.501
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.501
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.501
4g2fC07Ephrin type-A receptor 32.7.10.10.501
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.500
2xvdAS6Ephrin type-B receptor 42.7.10.10.500
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.500
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.500
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.500
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.500
4fob0USALK tyrosine kinase receptor2.7.10.10.499
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.499
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.499
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.498
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.498
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.497
3t8oATPRhodopsin kinase/0.497
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.497
4fod0UVALK tyrosine kinase receptor2.7.10.10.497
1bygSTUTyrosine-protein kinase CSK/0.496
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.496
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.496
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.496
2ijmATPFocal adhesion kinase 12.7.10.20.495
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.495
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.494
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.494
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.494
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.493
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.493
3sheI85MAP kinase-activated protein kinase 32.7.11.10.493
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.492
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.491
1mqbANPEphrin type-A receptor 22.7.10.10.490
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.490
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.490
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.490
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.490
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.490
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.490
2j0m4STFocal adhesion kinase 12.7.10.20.489
2vwz7X6Ephrin type-B receptor 42.7.10.10.489
2vx07X7Ephrin type-B receptor 42.7.10.10.489
2y6o1N1Ephrin type-A receptor 42.7.10.10.489
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.489
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.488
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.488
3w551FMMitogen-activated protein kinase 12.7.11.240.487
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.487
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.487
2yn8STUEphrin type-B receptor 42.7.10.10.486
3bbrBHYGlutamate receptor 2/0.486
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.486
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.486
2j0lANPFocal adhesion kinase 12.7.10.20.485
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.485
1bwsNDPGDP-L-fucose synthase/0.484
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.484
2y05NAPProstaglandin reductase 1/0.484
3zuyTCHTransporter/0.484
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.484
2acxANPG protein-coupled receptor kinase 62.7.11.160.483
2vwx7X4Ephrin type-B receptor 42.7.10.10.483
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.483
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.482
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.482
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.482
4fv8E63Mitogen-activated protein kinase 12.7.11.240.482
4jia1K3Tyrosine-protein kinase JAK2/0.482
1bw9NADPhenylalanine dehydrogenase/0.481
2etm7PYFocal adhesion kinase 12.7.10.20.481
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.481
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.481
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.481
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.481
2qoqANPEphrin type-A receptor 32.7.10.10.480
4l9i8PRRhodopsin kinase/0.480
1ol6ATPAurora kinase A2.7.11.10.479
2in6839Wee1-like protein kinase2.7.10.20.479
3a7hATPSerine/threonine-protein kinase 242.7.11.10.479
3vjoANPEpidermal growth factor receptor2.7.10.10.479
4fmqANPMitogen-activated protein kinase 12.7.11.240.479
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.479
1xl2189Gag-Pol polyprotein3.4.23.160.478
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.478
2qo7ANPEphrin type-A receptor 32.7.10.10.478
3hx4ANPCalmodulin-domain protein kinase 1/0.478
4bb432WEphrin type-B receptor 42.7.10.10.478
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.478
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.478
4y93746Tyrosine-protein kinase/0.478
1nzdUPGDNA beta-glucosyltransferase/0.477
2xneASHAurora kinase A2.7.11.10.477
3qc9ADPRhodopsin kinase/0.477
4qnaX11Serine/threonine-protein kinase 242.7.11.10.477
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.477
4y95746Tyrosine-protein kinase/0.477
5aaaVGHALK tyrosine kinase receptor2.7.10.10.477
1bxoPP7Penicillopepsin-13.4.23.200.476
3nr4PYVAbscisic acid receptor PYL2/0.476
3qt62P0Mevalonate diphosphate decarboxylase/0.476
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.475
3gu6ADPDeath-associated protein kinase 12.7.11.10.475
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.475
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.474
3gubGUBDeath-associated protein kinase 12.7.11.10.474
4a6cQG9Gag-Pol polyprotein3.4.23.160.474
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.474
4fv6E57Mitogen-activated protein kinase 12.7.11.240.474
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.474
5auwQUEDeath-associated protein kinase 12.7.11.10.474
1aq1STUCyclin-dependent kinase 22.7.11.220.473
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.473
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.473
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.473
2x9fX9FEphrin type-B receptor 42.7.10.10.473
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.473
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.473
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.473
5l8lADPAurora kinase A2.7.11.10.473
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.472
1ppm0P1Penicillopepsin-13.4.23.200.472
2bfyH1NAurora kinase B-A2.7.11.10.472
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.472
2wedPP6Penicillopepsin-13.4.23.200.472
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.472
3i60E86Mitogen-activated protein kinase 12.7.11.240.472
3u9eCOALmo1369 protein/0.472
4c02TAKActivin receptor type-12.7.11.300.472
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.472
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.472
1c1dNAIPhenylalanine dehydrogenase/0.471
2ijmADPFocal adhesion kinase 12.7.10.20.471
4fv9E71Mitogen-activated protein kinase 12.7.11.240.471
4qo9627Serine/threonine-protein kinase 242.7.11.10.471
1u54ACPActivated CDC42 kinase 1/0.470
2izt23DCasein kinase I isoform gamma-32.7.11.10.470
2vx17X8Ephrin type-B receptor 42.7.10.10.470
2xyuQ9GEphrin type-A receptor 42.7.10.10.470
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.470
1culFOKAdenylate cyclase type 2/0.469
1culFOKAdenylate cyclase type 5/0.469
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.469
2xrwANPMitogen-activated protein kinase 82.7.11.240.469
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.469
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.469
3pvuQRWBeta-adrenergic receptor kinase 12.7.11.150.469
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.468
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.468
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.468
3ztxZTXAurora kinase B-A2.7.11.10.468
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.468
2i40BLZCyclin-dependent kinase 22.7.11.220.467
2ituITQEpidermal growth factor receptor2.7.10.10.467
4aguD15Cyclin-dependent kinase-like 1/0.467
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.466
1py5PY1TGF-beta receptor type-12.7.11.300.466
2vwu7X1Ephrin type-B receptor 42.7.10.10.466
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.466
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.466
4wboANWRhodopsin kinase/0.466
1fxsNAPGDP-L-fucose synthase/0.465
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.465
4gmy0X5Tyrosine-protein kinase JAK2/0.465
1bsvNDPGDP-L-fucose synthase/0.464
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.464
2eb3ANPEpidermal growth factor receptor2.7.10.10.464
2vgoAD5Aurora kinase B-A2.7.11.10.464
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
4h3j10WBeta-secretase 13.4.23.460.464
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.464
1j39UPGDNA beta-glucosyltransferase/0.463
2ittAEEEpidermal growth factor receptor2.7.10.10.463
3a4vNADNDP-sugar epimerase/0.463
3c4zADPRhodopsin kinase/0.463
3eyhIZATyrosine-protein kinase JAK1/0.463
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.463
3cgcCOACoenzyme A disulfide reductase/0.462
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.462
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.462
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4fyn0VETyrosine-protein kinase SYK2.7.10.20.462
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.462
4ix6ADPUncharacterized protein/0.462
5auvAGIDeath-associated protein kinase 12.7.11.10.462
1pjkANPCasein kinase II subunit alpha2.7.11.10.461
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.461
2bujSTUSerine/threonine-protein kinase 16/0.461
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.461
3zewSTUEphrin type-B receptor 42.7.10.10.461
4i231C9Epidermal growth factor receptor2.7.10.10.461
4q71FADBifunctional protein PutA/0.461
5aacVGHALK tyrosine kinase receptor2.7.10.10.461
5e8wSTUTGF-beta receptor type-12.7.11.300.461
1c6yMK1Protease/0.460
1xe55FEPlasmepsin-23.4.23.390.460
2y9qANPMitogen-activated protein kinase 12.7.11.240.460
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.460
4brxKGWFocal adhesion kinase 12.7.10.20.460
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.460
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.460
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.460
4ix5ANPUncharacterized protein/0.460
4k8aK8AFocal adhesion kinase 12.7.10.20.460
5av2KMPDeath-associated protein kinase 12.7.11.10.460
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
2itnANPEpidermal growth factor receptor2.7.10.10.459
2itwITQEpidermal growth factor receptor2.7.10.10.459
2vrx447Aurora kinase B-A2.7.11.10.459
2wotZZGTGF-beta receptor type-12.7.11.300.459
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.459
4a6bQG8Gag-Pol polyprotein3.4.23.160.459
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.459
4gk2L66Ephrin type-A receptor 32.7.10.10.459
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.458
1tvoFRZMitogen-activated protein kinase 12.7.11.240.458
2dwbANPAurora kinase A2.7.11.10.458
2nniMTKCytochrome P450 2C8/0.458
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.458
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.458
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.458
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.458
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.458
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.457
1jdzFMBPurine nucleoside phosphorylase/0.457
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.457
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.457
3a1nNADNDP-sugar epimerase/0.457
3sdkP3NProteasome subunit beta type-53.4.25.10.457
3sdkP3NProteasome subunit beta type-63.4.25.10.457
3t3c017Gag-Pol polyprotein3.4.23.160.457
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4fhd0TTSpore photoproduct lyase/0.457
4foc0UUALK tyrosine kinase receptor2.7.10.10.457
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.457
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.457
4gu94GUFocal adhesion kinase 12.7.10.20.457
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.457
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.457
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.457
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
2henADPEphrin type-B receptor 22.7.10.10.456
2jkqVG8Focal adhesion kinase 12.7.10.20.456
3ntaCOAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.456
3vf80JETyrosine-protein kinase SYK2.7.10.20.456
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.456
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.456
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.456
1meiXMPInosine-5'-monophosphate dehydrogenase/0.455
1qy5NECEndoplasmin/0.455
2pwlACPFibroblast growth factor receptor 2/0.455
2wxvWXVCyclin-dependent kinase 22.7.11.220.455
3ibqATPPyridoxal kinase/0.455
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.455
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4hjoAQ4Epidermal growth factor receptor2.7.10.10.455
2oji33AMitogen-activated protein kinase 12.7.11.240.454
2xp2VGHALK tyrosine kinase receptor2.7.10.10.454
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.454
2znq401Peroxisome proliferator-activated receptor delta/0.454
3cgeCOACoenzyme A disulfide reductase/0.454
3s1dZIRCytokinin dehydrogenase 11.5.99.120.454
4a8v2ANMajor pollen allergen Bet v 1-J/0.454
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.454
4i4e1BQFocal adhesion kinase 12.7.10.20.454
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.453
1h74ADPHomoserine kinase2.7.1.390.453
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.453
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.453
2itvANPEpidermal growth factor receptor2.7.10.10.453
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.453
2ojj82AMitogen-activated protein kinase 12.7.11.240.453
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.453
3d8vUD1Bifunctional protein GlmU/0.453
3frqERYErythromycin resistance repressor protein/0.453
3gggNADPrephenate dehydrogenase/0.453
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.453
3sn6P0GBeta-2 adrenergic receptor/0.453
1j4jACOAcetyltransferase2.3.10.452
2cchATPCyclin-dependent kinase 22.7.11.220.452
3cgdCOACoenzyme A disulfide reductase/0.452
3drcMTXDihydrofolate reductase1.5.1.30.452
3fzr3JZProtein-tyrosine kinase 2-beta2.7.10.20.452
3ggu017Gag-Pol polyprotein3.4.23.160.452
3mvqNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.452
4blrUTPNTPase P4/0.452
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.452
4g6oE28Mitogen-activated protein kinase 12.7.11.240.452
4qmzB49Serine/threonine-protein kinase 242.7.11.10.452
4xgxADPFAD:protein FMN transferase/0.452
1dz4CAMCamphor 5-monooxygenase1.14.15.10.451
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.451
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.451
2xa4AZ5Tyrosine-protein kinase JAK2/0.451
3bu5ATPInsulin receptor2.7.10.10.451
3ns2PYVAbscisic acid receptor PYL2/0.451
3vruYS3Vitamin D3 receptor/0.451
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.451
4cd0AWJALK tyrosine kinase receptor2.7.10.10.451
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4gk4L90Ephrin type-A receptor 32.7.10.10.451
4jbqVX6Aurora kinase A2.7.11.10.451
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.451
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.451
1a72PADAlcohol dehydrogenase E chain1.1.1.10.450
1nzfUPGDNA beta-glucosyltransferase/0.450
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.450
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.450
1udaUFGUDP-glucose 4-epimerase5.1.3.20.450
1xq6NAPUncharacterized protein At5g02240/0.450
1yliCOAUncharacterized acyl-CoA thioester hydrolase HI_08273.1.20.450
2ghlLIBMitogen-activated protein kinase 14/0.450
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.450
3lm9ADPPutative fructokinase2.7.1.40.450
3s2pPMUCyclin-dependent kinase 22.7.11.220.450
3w16P9JAurora kinase A2.7.11.10.450
4ccuAWFALK tyrosine kinase receptor2.7.10.10.450
4dbzNDPPutative ketoacyl reductase1.3.10.450
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.450
4k28NADShikimate dehydrogenase family protein/0.450
4riyADPEpidermal growth factor receptor2.7.10.10.450
5cp4CAMCamphor 5-monooxygenase1.14.15.10.450
1fwkADPHomoserine kinase2.7.1.390.449
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1llqNADNAD-dependent malic enzyme, mitochondrial1.1.1.380.449
1unlRRCCyclin-dependent-like kinase 52.7.11.10.449
1zltHYMSerine/threonine-protein kinase Chk12.7.11.10.449
2bkzSBCCyclin-dependent kinase 22.7.11.220.449
2yfxVGHALK tyrosine kinase receptor2.7.10.10.449
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3p62FMNPentaerythritol tetranitrate reductase/0.449
3raiX85Cyclin-dependent kinase 22.7.11.220.449
3v3m0ENReplicase polyprotein 1a3.4.19.120.449
3zpuM8BGag-Pol polyprotein3.4.23.160.449
4asjN6AGlucose-1-phosphate thymidylyltransferase/0.449
4h3g10QBeta-secretase 13.4.23.460.449
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.449
4l4cCAMCamphor 5-monooxygenase1.14.15.10.449
4u7wNDPMxaA/0.449
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.449
1geeNADGlucose 1-dehydrogenase1.1.1.470.448
1h51FMNPentaerythritol tetranitrate reductase/0.448
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.448
2cn8DBQSerine/threonine-protein kinase Chk22.7.11.10.448
2panFADGlyoxylate carboligase4.1.1.470.448
2po7CHDFerrochelatase, mitochondrial4.99.1.10.448
2wipP49Cyclin-dependent kinase 22.7.11.220.448
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.448
3a783EVVitamin D3 receptor/0.448
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.448
3oev3OEProteasome subunit beta type-53.4.25.10.448
3oev3OEProteasome subunit beta type-63.4.25.10.448
3t2zFADSulfide-quinone reductase/0.448
4tuvCPZCytochrome P450 1191.140.448
1wvySTUDeath-associated protein kinase 12.7.11.10.447
1xs7MMIBeta-secretase 13.4.23.460.447
2huxSAHDiphthine synthase/0.447
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.447
2izrBRKCasein kinase I isoform gamma-32.7.11.10.447
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.447
2ylxFADPhenylacetone monooxygenase1.14.13.920.447
2ym2FADPhenylacetone monooxygenase1.14.13.920.447
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.447
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.447
4c3pACPAurora kinase A2.7.11.10.447
4c57FEFCyclin-G-associated kinase2.7.11.10.447
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.447
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.447
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.447
4k33ACPFibroblast growth factor receptor 32.7.10.10.447
4ure1PSCyclohexanol dehydrogenase/0.447
4yaiNAIC alpha-dehydrogenase/0.447
1cscCMCCitrate synthase, mitochondrial2.3.3.10.446
1e3eNAIAlcohol dehydrogenase 41.1.1.10.446
1t7i017Gag-Pol polyprotein3.4.23.160.446
1u2yGOXPancreatic alpha-amylase/0.446
2is0I03Beta-secretase 13.4.23.460.446
2of4979Tyrosine-protein kinase Lck2.7.10.20.446
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.446
2py3ACPFibroblast growth factor receptor 2/0.446
2znpK55Peroxisome proliferator-activated receptor delta/0.446
3elcF012-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.446
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.446
3my5RFZCyclin-dependent kinase 22.7.11.220.446
3oibFDAPutative acyl-CoA dehydrogenase/0.446
3qwkX62Cyclin-dependent kinase 22.7.11.220.446
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.446
3wb2YGPUncharacterized protein MJ0488/0.446
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.446
4c58824Cyclin-G-associated kinase2.7.11.10.446
4h3qANPMitogen-activated protein kinase 12.7.11.240.446
4qmlANPSerine/threonine-protein kinase 242.7.11.10.446
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.446
4yntFDAGlucose oxidase, putative/0.446
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.445
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.445
1vjy460TGF-beta receptor type-12.7.11.300.445
1zys199Serine/threonine-protein kinase Chk12.7.11.10.445
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2c27ACOMycothiol acetyltransferase2.3.1.1890.445
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.445
2jcxNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.445
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.445
3a3bRBFLumazine protein/0.445
3a8wATPProtein kinase C iota type2.7.11.130.445
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.445
3g70A5TRenin3.4.23.150.445
3gu83GUDeath-associated protein kinase 12.7.11.10.445
3lxiCAMCytochrome P450/0.445
3pj8404Cyclin-dependent kinase 22.7.11.220.445
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.445
4jq8KJ8Epidermal growth factor receptor2.7.10.10.445
4o0uADNAurora kinase A2.7.11.10.445
4xx0COASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial6.2.1.40.445
5a9sNAPPutative dehydrogenase/0.445
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1me8RVPInosine-5'-monophosphate dehydrogenase/0.444
2b7aIZATyrosine-protein kinase JAK2/0.444
2cppCAMCamphor 5-monooxygenase1.14.15.10.444
2j0j4STFocal adhesion kinase 12.7.10.20.444
2rh9IGPTryptophan synthase alpha chain/0.444
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2xh9J01Uncharacterized protein/0.444
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
3ctyFADProbable thioredoxin reductase/0.444
3fwgCAMCamphor 5-monooxygenase1.14.15.10.444
3hllI45Mitogen-activated protein kinase 14/0.444
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.444
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.444
3zptM8YGag-Pol polyprotein3.4.23.160.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.444
4jboWPHAurora kinase A2.7.11.10.444
4wkqIREEpidermal growth factor receptor2.7.10.10.444
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.444
5bsfNADPyrroline-5-carboxylate reductase/0.444
1dnpMHFDeoxyribodipyrimidine photo-lyase4.1.99.30.443
1g1aNADdTDP-glucose 4,6-dehydratase/0.443
1h63FMNPentaerythritol tetranitrate reductase/0.443
1hdrNADDihydropteridine reductase1.5.1.340.443
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.443
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
1txiTX5Vitamin D3 receptor/0.443
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.443
2zdt46CMitogen-activated protein kinase 102.7.11.240.443
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.443
3ge1ADPGlycerol kinase/0.443
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.443
3lctADPALK tyrosine kinase receptor2.7.10.10.443
3s56ROCProtease/0.443
3wsbRWZFarnesyltransferase, putative/0.443
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
4aicNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.443
4b8zNAPGDP-L-fucose synthase1.1.1.2710.443
4c62XWWTyrosine-protein kinase JAK2/0.443
4ccbOFGALK tyrosine kinase receptor2.7.10.10.443
4du82P0Mevalonate diphosphate decarboxylase/0.443
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.443
4jqeANPCasein kinase II subunit alpha2.7.11.10.443
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.443
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.443
1beuIPLTryptophan synthase alpha chain/0.442
1dirNADDihydropteridine reductase1.5.1.340.442
1mp0NADAlcohol dehydrogenase class-31.1.1.10.442
2b53D23Cyclin-dependent kinase 22.7.11.220.442
2fy4COACholine O-acetyltransferase2.3.1.60.442
2vwy7X5Ephrin type-B receptor 42.7.10.10.442
2y3rTRKTamL/0.442
3fwfCAMCamphor 5-monooxygenase1.14.15.10.442
3op5REBSerine/threonine-protein kinase VRK12.7.11.10.442
3p8jFMNPentaerythritol tetranitrate reductase/0.442
3tnwF18Cyclin-dependent kinase 22.7.11.220.442
3ttiKBIMitogen-activated protein kinase 102.7.11.240.442
4njsG08Protease/0.442
5aabVGHALK tyrosine kinase receptor2.7.10.10.442
4xnw2IDP2Y purinoceptor 1/0.442
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.441
1gqtACPRibokinase/0.441
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.441
1u3dFADCryptochrome-1/0.441
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.441
2bb9AKCGag-Pol polyprotein3.4.23.160.441
2c4g514Cyclin-dependent kinase 22.7.11.220.441
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.441
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.441
2gjlFMNNitronate monooxygenase1.13.12.160.441
2qbuSAHPrecorrin-2 methyltransferase/0.441
2x1nX1NCyclin-dependent kinase 22.7.11.220.441
3cscACOCitrate synthase, mitochondrial2.3.3.10.441
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.441
3qbhQBHBeta-secretase 13.4.23.460.441
3rvg17PTyrosine-protein kinase JAK2/0.441
3tucFPWTyrosine-protein kinase SYK2.7.10.20.441
3uyt0CKCasein kinase I isoform delta2.7.11.10.441
3vfa031Gag-Pol polyprotein3.4.23.160.441
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4gt3ATPMitogen-activated protein kinase 12.7.11.240.441
4k9oTPPBenzoylformate decarboxylase4.1.1.70.441
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4nj32KDCyclin-dependent kinase 22.7.11.220.441
5av4GENDeath-associated protein kinase 12.7.11.10.441
1e7qNAPGDP-L-fucose synthase/0.440
1g63FMNEpidermin decarboxylase4.1.10.440
1o76CAMCamphor 5-monooxygenase1.14.15.10.440
1pkdUCNCyclin-dependent kinase 22.7.11.220.440
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.440
1s19MC9Vitamin D3 receptor/0.440
2dfvNADL-threonine 3-dehydrogenase/0.440
2g8yNADHydroxycarboxylate dehydrogenase B/0.440
2r43G3GGag-Pol polyprotein3.4.23.160.440
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2xb7GUIALK tyrosine kinase receptor2.7.10.10.440
2yaaATPDeath-associated protein kinase 2/0.440
3cisATPUniversal stress protein Rv2623/0.440
3cr0809Wee1-like protein kinase2.7.10.20.440
3dds26BGlycogen phosphorylase, liver form2.4.1.10.440
3ekp478Gag-Pol polyprotein3.4.23.160.440
3el01UNGag-Pol polyprotein3.4.23.160.440
3gfbNADL-threonine 3-dehydrogenase/0.440
3lqfNADGalactitol dehydrogenase/0.440
3nx4NAPPutative oxidoreductase/0.440
3uli1N3Cyclin-dependent kinase 22.7.11.220.440
4dc0NDPPutative ketoacyl reductase1.3.10.440
4eudCOASuccinyl-CoA:acetate CoA-transferase/0.440
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.440
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.440
4kkyCAMCamphor 5-monooxygenase1.14.15.10.440
5e8ySTUTGF-beta receptor type-22.7.11.300.440