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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4py243EMethionine--tRNA ligase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4py243EMethionine--tRNA ligase/1.000
5k0s0OUMethionine--tRNA ligase/0.605
5k0t415Methionine--tRNA ligase/0.552
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.508
4a81DXCMajor pollen allergen Bet v 1-A/0.503
1kh3ANPArgininosuccinate synthase/0.497
3hyoADPPyridoxal kinase/0.497
1zg32HIIsoflavone 4'-O-methyltransferase/0.496
2webPP4Penicillopepsin-13.4.23.200.495
2v5aLZLBiotin carboxylase6.3.4.140.494
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.493
2y60M8FIsopenicillin N synthase1.21.3.10.493
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.492
3zoiM2WIsopenicillin N synthase1.21.3.10.491
1hb1OCVIsopenicillin N synthase1.21.3.10.490
1l8qADPChromosomal replication initiator protein DnaA/0.489
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.489
5uviZMAAdenosine receptor A2a/0.489
4bis8HQLysine-specific demethylase 4A1.14.110.488
4tx9AMZPhosphoribosyl isomerase A/0.488
2pchSAHDiphthine synthase/0.486
3zkyWT4Isopenicillin N synthase1.21.3.10.486
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.484
2ad5ADPCTP synthase/0.484
2jb4A14Isopenicillin N synthase1.21.3.10.484
3ibqATPPyridoxal kinase/0.483
1zdwFLVPrenyltransferase/0.482
2iviACWIsopenicillin N synthase1.21.3.10.482
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.482
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.479
3pe2E1BCasein kinase II subunit alpha2.7.11.10.479
1nzfUPGDNA beta-glucosyltransferase/0.478
1tj0FADBifunctional protein PutA1.5.5.20.478
4i13FOLDihydrofolate reductase1.5.1.30.478
4v12POGMaoC like domain protein/0.478
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.477
3nmpPYVAbscisic acid receptor PYL2/0.477
5iu86DZAdenosine receptor A2a/0.477
4twnB96Ephrin type-A receptor 32.7.10.10.476
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.475
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.475
2rh9IGPTryptophan synthase alpha chain/0.475
2v0uFMNNPH1-1/0.475
2w06FRVCyclin-dependent kinase 22.7.11.220.475
2yoj8Y6Genome polyprotein2.7.7.480.475
4a83DXCMajor pollen allergen Bet v 1-A/0.475
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.475
1bk0ACVIsopenicillin N synthase1.21.3.10.474
2po7CHDFerrochelatase, mitochondrial4.99.1.10.474
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.474
3c35KAIGlutamate receptor ionotropic, kainate 1/0.474
3qizQI2Botulinum neurotoxin type A3.4.24.690.474
1xddAAYIntegrin alpha-L/0.473
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.473
4la7A1OAbscisic acid receptor PYL2/0.473
1cjkFOKAdenylate cyclase type 2/0.472
1cjkFOKAdenylate cyclase type 5/0.472
1fm4DXCMajor pollen allergen Bet v 1-L/0.472
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.472
2emrSAHDiphthine synthase/0.472
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.472
4a802ANMajor pollen allergen Bet v 1-A/0.472
4mkhAP5Adenylate kinase/0.472
5k2cZMAAdenosine receptor A2a/0.472
1mjbACOHistone acetyltransferase ESA1/0.471
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.471
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.471
4imfSI3N-acetylneuraminate lyase/0.471
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.471
5k2dZMAAdenosine receptor A2a/0.471
1rfvADPPyridoxal kinase2.7.1.350.470
2emuSAHDiphthine synthase/0.470
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.470
2hveADPNucleoside diphosphate kinase A2.7.4.60.470
2ohvNHLGlutamate racemase/0.470
2rhgIGPTryptophan synthase alpha chain/0.470
2ylzFADPhenylacetone monooxygenase1.14.13.920.470
3lqfNADGalactitol dehydrogenase/0.470
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.470
5cyoGDPSeptin-9/0.470
1pd9CO4Dihydrofolate reductase1.5.1.30.469
3fznD7KBenzoylformate decarboxylase4.1.1.70.469
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.469
4a862ANMajor pollen allergen Bet v 1-A/0.469
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.468
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.468
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.468
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2w3aTOPDihydrofolate reductase1.5.1.30.468
2wedPP6Penicillopepsin-13.4.23.200.468
3dhcCYKN-acyl homoserine lactonase AiiA3.1.1.810.468
3vyeVYERenin3.4.23.150.468
4m83ERYOleandomycin glycosyltransferase2.4.10.468
1u71MXADihydrofolate reductase1.5.1.30.467
2pmnK51Protein kinase 7/0.467
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.467
3vjoANPEpidermal growth factor receptor2.7.10.10.467
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.467
1rfuADPPyridoxal kinase2.7.1.350.466
2bl4NADLactaldehyde reductase1.1.1.770.466
2bu9HFVIsopenicillin N synthase1.21.3.10.466
2dhfDZFDihydrofolate reductase1.5.1.30.466
2ea2F77Methionine aminopeptidase 2/0.466
2itwITQEpidermal growth factor receptor2.7.10.10.466
2p5uNADUDP-glucose 4-epimerase/0.466
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.466
3fwgCAMCamphor 5-monooxygenase1.14.15.10.466
3isjA8DPantothenate synthetase6.3.2.10.466
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.466
3pdqKC6Lysine-specific demethylase 4A1.14.110.466
3wv9FEGHmd co-occurring protein HcgE/0.466
4a0rDTBBifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial6.3.3.30.466
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.466
5k2bZMAAdenosine receptor A2a/0.466
1hb3SCVIsopenicillin N synthase1.21.3.10.465
1nzdUPGDNA beta-glucosyltransferase/0.465
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.465
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.465
2flhZEACytokinin-specific binding protein/0.465
2ghlLIBMitogen-activated protein kinase 14/0.465
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3h3qH13Collagen type IV alpha-3-binding protein/0.465
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.465
4a8v2ANMajor pollen allergen Bet v 1-J/0.465
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
4dpuAGSMevalonate diphosphate decarboxylase/0.465
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.465
1zapA70Candidapepsin-23.4.23.240.464
2ab8MTPAdenosine kinase2.7.1.200.464
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.464
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.464
2qfvNAPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.464
2x06NADL-sulfolactate dehydrogenase/0.464
3pqbVGPPutative oxidoreductase/0.464
3qge26FGenome polyprotein2.7.7.480.464
4a84DXCMajor pollen allergen Bet v 1-A/0.464
5c1mCLRMu-type opioid receptor/0.464
3sn6P0GBeta-2 adrenergic receptor/0.464
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.463
1h60STRPentaerythritol tetranitrate reductase/0.463
1pjcNADAlanine dehydrogenase/0.463
1ve3SAMUncharacterized protein/0.463
2g5cNADPrephenate dehydrogenase/0.463
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.463
3iodA6DPantothenate synthetase6.3.2.10.463
4mv8ACPBiotin carboxylase6.3.4.140.463
2rc4ACOHistone acetyltransferase KAT6A/0.462
2vbpVB1Isopenicillin N synthase1.21.3.10.462
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.462
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.462
4e0u0MVCyclic dipeptide N-prenyltransferase/0.462
4rpgFADUDP-galactopyranose mutase5.4.99.90.462
1zgaHMKIsoflavone 4'-O-methyltransferase/0.461
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.461
2xlrFADPutative flavin-containing monooxygenase/0.461
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.461
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3p67FMNPentaerythritol tetranitrate reductase/0.461
3qpvADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.461
3raiX85Cyclin-dependent kinase 22.7.11.220.461
3sl2ATPSensor histidine kinase WalK/0.461
4du82P0Mevalonate diphosphate decarboxylase/0.461
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.461
5k2aZMAAdenosine receptor A2a/0.461
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.460
1g28FMNPHY3/0.460
1kfbIGPTryptophan synthase alpha chain/0.460
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.460
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
2v1aFMNNPH1-1/0.460
2vbdV10Isopenicillin N synthase1.21.3.10.460
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.460
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.460
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3gep24HHypoxanthine-guanine phosphoribosyltransferase2.4.2.80.460
3h3r14HCollagen type IV alpha-3-binding protein/0.460
3q43D66M1 family aminopeptidase3.4.110.460
4g8bHL6Alpha/beta hydrolase fold protein/0.460
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.460
4mv4ACPBiotin carboxylase6.3.4.140.460
4rr6A3SProbable threonine--tRNA ligase 26.1.1.30.460
4wucANPDNA gyrase subunit B/0.460
1bwsNDPGDP-L-fucose synthase/0.459
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.459
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.459
2tprFADTrypanothione reductase1.8.1.120.459
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.459
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.459
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.459
1fy7COAHistone acetyltransferase ESA1/0.458
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.458
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.458
2y3rTRKTamL/0.458
3tscNADUncharacterized protein/0.458
3vtdTKDVitamin D3 receptor/0.458
3vyfVYFRenin3.4.23.150.458
3zh8C58Protein kinase C iota type2.7.11.130.458
3zxzKRWHepatocyte growth factor receptor2.7.10.10.458
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.457
1t85CAMCamphor 5-monooxygenase1.14.15.10.457
2a5kAZPReplicase polyprotein 1ab3.4.220.457
2e8sSAHDiphthine synthase/0.457
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.457
2ji9TPWOxalyl-CoA decarboxylase4.1.1.80.457
2y6fM9FIsopenicillin N synthase1.21.3.10.457
2yphQQY2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.457
3ckqUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.457
3eej53RUncharacterized protein/0.457
3ibdCPZCytochrome P450 2B61.14.130.457
3imgBZ2Pantothenate synthetase6.3.2.10.457
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3oafOAGDihydrofolate reductase1.5.1.30.457
3tdaPN0Cytochrome P450 2D6/0.457
4ey6GNTAcetylcholinesterase3.1.1.70.457
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.457
4wsoNADProbable nicotinate-nucleotide adenylyltransferase/0.457
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.457
1gky5GPGuanylate kinase2.7.4.80.456
1kfcIPLTryptophan synthase alpha chain/0.456
1rzuADPGlycogen synthase 12.4.1.210.456
2acwUPGGlycosyltransferase/0.456
2b53D23Cyclin-dependent kinase 22.7.11.220.456
2bsxNOSPurine nucleoside phosphorylase/0.456
2gr1FADFerredoxin reductase/0.456
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.456
4a87NARMajor pollen allergen Bet v 1-A/0.456
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
4opgFDAConserved Archaeal protein/0.456
5jtbZMAAdenosine receptor A2a/0.456
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
1dliUDXUDP-glucose 6-dehydrogenase/0.455
1dr3HBIDihydrofolate reductase1.5.1.30.455
1me6IVSPlasmepsin-23.4.23.390.455
1qiqACCIsopenicillin N synthase1.21.3.10.455
1qjfACSIsopenicillin N synthase1.21.3.10.455
2dvlFADAcyl-CoA dehydrogenase/0.455
2igoFADPyranose 2-oxidase/0.455
3csoXNIGenome polyprotein2.7.7.480.455
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.455
3qt62P0Mevalonate diphosphate decarboxylase/0.455
3qttANPPantothenate synthetase/0.455
3uyk0CXProbable NDP-rhamnosyltransferase/0.455
3vsxR32Renin3.4.23.150.455
4bfxZVXPantothenate kinase2.7.1.330.455
4gd40WSLysine-specific demethylase 4A1.14.110.455
4m5pFMNNADPH dehydrogenase/0.455
4oqyNDP(S)-imine reductase/0.455
4q0kGA3Phytohormone-binding protein/0.455
4qe6JN3Bile acid receptor/0.455
5djtFMNNPH1-2/0.455
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.454
1cqp803Integrin alpha-L/0.454
1dhfFOLDihydrofolate reductase1.5.1.30.454
1di8DTQCyclin-dependent kinase 22.7.11.220.454
1j1zATPArgininosuccinate synthase/0.454
1t2cNAIL-lactate dehydrogenase1.1.1.270.454
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.454
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.454
2ejzSAHDiphthine synthase/0.454
2wo7ASVIsopenicillin N synthase1.21.3.10.454
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
3bw4FMNPutative 2-nitropropane dioxygenase/0.454
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.454
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.454
3gfbNADL-threonine 3-dehydrogenase/0.454
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.454
3jziJZLBiotin carboxylase6.3.4.140.454
3phiNDPShikimate dehydrogenase (NADP(+))/0.454
3vg9ZMAAdenosine receptor A2a/0.454
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4y9lFADAcyl-CoA dehydrogenase family member 11/0.454
5efwFMNNPH1-1/0.454
1h51FMNPentaerythritol tetranitrate reductase/0.453
1h65GDPTranslocase of chloroplast 343.6.50.453
1yvfPH7Polyprotein/0.453
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.453
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.453
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.453
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3kjgADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.453
3sf6FDAGlutaryl-CoA dehydrogenase/0.453
3t3r9PLCytochrome P450 2A61.14.130.453
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.453
4m4922YL-lactate dehydrogenase A chain1.1.1.270.453
1ivsVAAValine--tRNA ligase6.1.1.90.452
1mvtDTMDihydrofolate reductase1.5.1.30.452
1u1cBAUUridine phosphorylase2.4.2.30.452
1vi2NADQuinate/shikimate dehydrogenase/0.452
1w06W05Isopenicillin N synthase1.21.3.10.452
2btsU32Cyclin-dependent kinase 22.7.11.220.452
2bxmIMNSerum albumin/0.452
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2c3qGTXGlutathione S-transferase theta-12.5.1.180.452
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.452
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.452
2rqfJH3Hemolymph juvenile hormone binding protein/0.452
2vkeTACTetracycline repressor protein class D/0.452
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3eblGA4Gibberellin receptor GID1/0.452
3ivgFG5Pantothenate synthetase6.3.2.10.452
3own3OXRenin3.4.23.150.452
3psyRB9Endothiapepsin3.4.23.220.452
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.452
4drp0MDPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.452
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.452
4relKMPGlycosyltransferase/0.452
3emlZMAAdenosine receptor A2a/0.452
2ekaSAHDiphthine synthase/0.451
2pb4SAHDiphthine synthase/0.451
2rlcCHDCholoylglycine hydrolase3.5.1.240.451
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.451
2vn0TDZCytochrome P450 2C8/0.451
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.451
3gw9VNILanosterol 14-alpha-demethylase/0.451
3hk1B64Fatty acid-binding protein, adipocyte/0.451
3mknDNBPyrimidine-specific ribonucleoside hydrolase RihB/0.451
3oibFDAPutative acyl-CoA dehydrogenase/0.451
3rdqDTBStreptavidin/0.451
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.451
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3vri1KXHLA class I histocompatibility antigen, B-57 alpha chain/0.451
3zuyTCHTransporter/0.451
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.451
4dptAGSMevalonate diphosphate decarboxylase/0.451
4eiyZMAAdenosine receptor A2a/0.451
4ytnFD8Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.451
4ytnFD8Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial/0.451
4ytnFD8Succinate dehydrogenase cytochrome b560/0.451
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.451
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.451
1dssNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.450
1i91INQCarbonic anhydrase 24.2.1.10.450
1rj6AZMCarbonic anhydrase 144.2.1.10.450
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.450
2w3wVG9Dihydrofolate reductase/0.450
2w9hTOPDihydrofolate reductase1.5.1.30.450
2xyuQ9GEphrin type-A receptor 42.7.10.10.450
2zscBTNTamavidin2/0.450
3fhxPXLPyridoxal kinase2.7.1.350.450
3ggj25HHypoxanthine-guanine phosphoribosyltransferase2.4.2.80.450
3hx4ANPCalmodulin-domain protein kinase 1/0.450
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
3rqqBA3ADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.450
4aosNAPSteroid monooxygenase/0.450
4bb3KKAIsopenicillin N synthase1.21.3.10.450
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.450
5c8yACPTubulin tyrosine ligase/0.450
1adfTADAlcohol dehydrogenase E chain1.1.1.10.449
1h50FMNPentaerythritol tetranitrate reductase/0.449
1n2hPAJPantothenate synthetase6.3.2.10.449
1r2jFADFkbI/0.449
1stdBFSScytalone dehydratase4.2.1.940.449
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.449
1xr2C2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase2.1.1.140.449
1zgv501Prothrombin3.4.21.50.449
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.449
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
2pcgSAHDiphthine synthase/0.449
2v58LZJBiotin carboxylase6.3.4.140.449
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.449
2xpuTDCTetracycline repressor protein class D/0.449
3ak4NADNADH-dependent quinuclidinone reductase/0.449
3junAKDPhenazine biosynthesis protein A/B/0.449
3s1dZIRCytokinin dehydrogenase 11.5.99.120.449
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3t7x4SHEndothiapepsin3.4.23.220.449
4b5dSW4Achbp/0.449
4g67SAHUncharacterized ACR, COG1565 superfamily/0.449
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/0.449
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.448
1h74ADPHomoserine kinase2.7.1.390.448
1hbvGANGag-Pol polyprotein/0.448
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.448
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.448
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.448
2d4h5GPGuanylate-binding protein 1/0.448
2dxwSAHDiphthine synthase/0.448
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.448
2pauD5M5'-deoxynucleotidase YfbR/0.448
2rm2W43Genome polyprotein/0.448
2xvw9NRSerum albumin/0.448
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3e6eDCSAlanine racemase/0.448
3t6iNC8Endothiapepsin3.4.23.220.448
4fvqATPTyrosine-protein kinase JAK2/0.448
4fxy0W2Neurolysin, mitochondrial3.4.24.160.448
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4la1FADThioredoxin glutathione reductase/0.448
4oztP1AEcdysone receptor, putative/0.448
4qbjNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.448
4yusFMNFamily 3 adenylate cyclase/0.448
3vw7VPXProteinase-activated receptor 1/0.448
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1txtCAAHMG-CoA synthase/0.447
2bf4FMNNADPH--cytochrome P450 reductase/0.447
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.447
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.447
2ilvC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.447
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.447
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.447
2w6oOA3Biotin carboxylase6.3.4.140.447
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.447
3b9lAZZSerum albumin/0.447
3ba6AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.447
3dogNNNCyclin-dependent kinase 22.7.11.220.447
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3nxvD2FDihydrofolate reductase1.5.1.30.447
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.447
4b13NHWGlycylpeptide N-tetradecanoyltransferase/0.447
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.447
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.447
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4tvbNADHomospermidine synthase2.5.1.440.447
4xq9NADHomospermidine synthase2.5.1.440.447
4y380A9Endothiapepsin3.4.23.220.447
4yqfGDPSeptin-9/0.447
4zowCLMMultidrug transporter MdfA/0.447
4zj8SUVOrexin receptor type 1/0.447
1e81M91Endothiapepsin3.4.23.220.446
1fmjRTLRetinol dehydratase/0.446
1jqdSAHHistamine N-methyltransferase2.1.1.80.446
1kqwRTLCellular retinol-binding protein type II/0.446
1o97FADElectron transfer flavoprotein subunit alpha/0.446
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1w51L01Beta-secretase 13.4.23.460.446
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2cdaNAPGlucose 1-dehydrogenase/0.446
2ikuLIYRenin3.4.23.150.446
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
2p2xSAHDiphthine synthase/0.446
2rs1W84Genome polyprotein/0.446
2v00V15Endothiapepsin3.4.23.220.446
2vcmM11Isopenicillin N synthase1.21.3.10.446
2xvfFADPutative flavin-containing monooxygenase/0.446
2zbaZBATrichothecene 3-O-acetyltransferase/0.446
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
3pd4A3GThreonine--tRNA ligase6.1.1.30.446
3u9eCOALmo1369 protein/0.446
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.446
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.446
4cdmFO1Deoxyribodipyrimidine photolyase/0.446
4nieNBHNuclear receptor ROR-gamma/0.446
1eagA70Candidapepsin-23.4.23.240.445
1gveNAPAflatoxin B1 aldehyde reductase member 310.445
1hfqMOTDihydrofolate reductase1.5.1.30.445
1jmgUMPThymidylate synthase/0.445
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.445
1nvtNAPShikimate dehydrogenase (NADP(+))/0.445
1o76CAMCamphor 5-monooxygenase1.14.15.10.445
1osvCHCBile acid receptor/0.445
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.445
1y9dTPPPyruvate oxidase1.2.3.30.445
2c7gFADNADPH-ferredoxin reductase FprA1.18.1.20.445
2cjfRP43-dehydroquinate dehydratase4.2.1.100.445
2dvoITTdITP/XTP pyrophosphatase3.6.1.190.445
2ek3SAHDiphthine synthase/0.445
2g1n1IGRenin3.4.23.150.445
2g1s4IGRenin3.4.23.150.445
2g2zCOZMalonyl CoA-acyl carrier protein transacylase2.3.1.390.445
2gqwFADFerredoxin reductase/0.445
2j3qTFLAcetylcholinesterase3.1.1.70.445
2pg0FADAcyl-CoA dehydrogenase/0.445
2v2vV124-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.445
3fr5I4AFatty acid-binding protein, adipocyte/0.445
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3qbwADPAnhydro-N-acetylmuramic acid kinase/0.445
3sfeFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.445
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
3x2fNAIAdenosylhomocysteinase/0.445
4g95OAGDihydrofolate reductase1.5.1.30.445
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.445
4jlj1NMDeoxycytidine kinase2.7.1.740.445
4klrCHDFerrochelatase, mitochondrial4.99.1.10.445
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.445
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.445
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.445
1j7uANPAminoglycoside 3'-phosphotransferase2.7.1.950.444
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.444
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.444
2rehFADNitroalkane oxidase1.7.3.10.444
3akm11DFatty acid-binding protein, intestinal/0.444
3c3xNAPEugenol synthase 11.1.1.3180.444
3clrFADElectron transfer flavoprotein subunit alpha/0.444
3ictFADCoenzyme A disulfide reductase/0.444
3s79ASDAromatase1.14.14.140.444
3wrmCAMCamphor 5-monooxygenase1.14.15.10.444
4hjoAQ4Epidermal growth factor receptor2.7.10.10.444
4kbn25UDihydrofolate reductase1.5.1.30.444
4ke11R6Beta-secretase 13.4.23.460.444
4l0qNADAlcohol dehydrogenase class-3/0.444
4lzwTHMUridine phosphorylase/0.444
4n57ADPAPH(2'')-Id/0.444
4x7vMIVMycinamicin III 3''-O-methyltransferase2.1.1.2370.444
4xrgNADHomospermidine synthase2.5.1.440.444
1ay0TPPTransketolase 12.2.1.10.443
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.443
1ja0FADNADPH--cytochrome P450 reductase/0.443
1mjaCOAHistone acetyltransferase ESA1/0.443
1n3rGTPGTP cyclohydrolase 13.5.4.160.443
1t86CAMCamphor 5-monooxygenase1.14.15.10.443
1t87CAMCamphor 5-monooxygenase1.14.15.10.443
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.443
2e15SAHDiphthine synthase/0.443
2xvq9DSSerum albumin/0.443
3c15GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.443
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.443
3fhxPLPPyridoxal kinase2.7.1.350.443
3lpgZ78Beta-glucuronidase3.2.1.310.443
3oev3OEProteasome subunit beta type-53.4.25.10.443
3oev3OEProteasome subunit beta type-63.4.25.10.443
3p0fBAUUridine phosphorylase 22.4.2.30.443
3rvhHQ2Lysine-specific demethylase 4A1.14.110.443
3uylTYDProbable NDP-rhamnosyltransferase/0.443
4a86H35Major pollen allergen Bet v 1-A/0.443
4dshFDAUncharacterized protein/0.443
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4klaCHDFerrochelatase, mitochondrial4.99.1.10.443
4mr51K0Bromodomain-containing protein 2/0.443
4qofFMNRibosyldihydronicotinamide dehydrogenase [quinone]/0.443
4z36ON3Lysophosphatidic acid receptor 1/0.443
1dgmADNAdenosine kinase2.7.1.200.442
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.442
1knpFADL-aspartate oxidase1.4.3.160.442
1p0pBCHCholinesterase3.1.1.80.442
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.442
1yrdCAMCamphor 5-monooxygenase1.14.15.10.442
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.442
2ek2SAHDiphthine synthase/0.442
2imlFMNUncharacterized protein/0.442
2pcmSAHDiphthine synthase/0.442
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.442
2vesGVRUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.442
2x8gFADThioredoxin glutathione reductase/0.442
2zynBCDPeriplasmic binding protein/0.442
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3d8vUD1Bifunctional protein GlmU/0.442
3djjFADGlutathione reductase, mitochondrial1.8.1.70.442
3havATPAminoglycoside phosphotransferase/0.442
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.442
3lb8FADPutidaredoxin reductase1.18.1.50.442
3lzs017Gag-Pol polyprotein3.4.23.160.442
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.442
3qeoLLTDeoxycytidine kinase2.7.1.740.442
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.442
3r1rATPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.442
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.442
3zv7NHGAcetylcholinesterase3.1.1.70.442
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.442
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.442
4fvrATPTyrosine-protein kinase JAK2/0.442
4hxyNDPPlm1/0.442
4kfj1R0Dihydrofolate reductase1.5.1.30.442
4knjE1FCarbonic anhydrase 24.2.1.10.442
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.442
4y17LAETranscriptional regulator of ftsQAZ gene cluster/0.442
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
4zseANPEpidermal growth factor receptor2.7.10.10.442
5cb4ACPTubulin tyrosine ligase/0.442
5hs1VORLanosterol 14-alpha demethylase/0.442
5irnADPNucleotide binding oligomerization domain containing 2/0.442
4z34ON7Lysophosphatidic acid receptor 1/0.442
1cs4GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.441
1culFOKAdenylate cyclase type 2/0.441
1culFOKAdenylate cyclase type 5/0.441
1dhrNADDihydropteridine reductase1.5.1.340.441
1eioGCHGastrotropin/0.441
1k7fIAVTryptophan synthase alpha chain/0.441
1k8y13PTryptophan synthase alpha chain/0.441
1p0hACOMycothiol acetyltransferase2.3.1.1890.441
1sxjAGSReplication factor C subunit 1/0.441
1udaUFGUDP-glucose 4-epimerase5.1.3.20.441
1uxjNADMalate dehydrogenase/0.441
1z7yAA5Cysteine synthase 12.5.1.470.441
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.441
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.441
2en5SAHDiphthine synthase/0.441
2g1r3IGRenin3.4.23.150.441
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.441
2hk9NAPShikimate dehydrogenase (NADP(+))/0.441
2huxSAHDiphthine synthase/0.441
2pb6SAHDiphthine synthase/0.441
2qimZEAClass 10 plant pathogenesis-related protein/0.441
2qn7HBZGlycogen phosphorylase, muscle form2.4.1.10.441
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.441
3bj7COADiamine acetyltransferase 1/0.441
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.441
3eft3BSCarbonic anhydrase 24.2.1.10.441
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3l3rOAGDihydrofolate reductase1.5.1.30.441
3lnbCOAN-acetyltransferase family protein/0.441
3mytEQUSteroid Delta-isomerase5.3.3.10.441
3nmhPYVAbscisic acid receptor PYL2/0.441
3o3jBB4Peptide deformylase 1B, chloroplastic/mitochondrial3.5.1.880.441
3oqfS51Renin3.4.23.150.441
3up0D7SaceDAF-12/0.441
3vf60H6Glucokinase2.7.1.20.441
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.441
4dc0NDPPutative ketoacyl reductase1.3.10.441
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.441
1cjvFOKAdenylate cyclase type 2/0.440
1cjvFOKAdenylate cyclase type 5/0.440
1cnxEG2Carbonic anhydrase 24.2.1.10.440
1dnpMHFDeoxyribodipyrimidine photo-lyase4.1.99.30.440
1f5fDHTSex hormone-binding globulin/0.440
1n77ATPGlutamate--tRNA ligase6.1.1.170.440
1rctNOSPurine nucleoside phosphorylase2.4.2.10.440
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.440
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
1wuaAP8Actin, alpha skeletal muscle/0.440
1y6oMJIPhospholipase A2, major isoenzyme3.1.1.40.440
1zsbAZMCarbonic anhydrase 24.2.1.10.440
2c4iBTNAvidin/0.440
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2d29FADAcyl-CoA dehydrogenase/0.440
2dsiSAHDiphthine synthase/0.440
2fl2ADPKinesin-like protein KIF11/0.440
2ft9CHDFatty acid-binding protein 2, liver/0.440
2gtbAZPOrf1ab polyprotein/0.440
2onmADPAldehyde dehydrogenase, mitochondrial1.2.1.30.440
2q59240Peroxisome proliferator-activated receptor gamma/0.440
2whqHI6Acetylcholinesterase3.1.1.70.440
2xvv9DNSerum albumin/0.440
2z0x5CAUncharacterized protein/0.440
2zshGA3Gibberellin receptor GID1A30.440
3bgbLJGGag-Pol polyprotein3.4.23.160.440
3cr7PPSAdenylyl-sulfate kinase2.7.1.250.440
3fwyADPLight-independent protochlorophyllide reductase iron-sulfur ATP-binding protein/0.440
3hazFADBifunctional protein PutA/0.440
3kxw1ZZSaframycin Mx1 synthetase B/0.440
3pd3A3TThreonine--tRNA ligase6.1.1.30.440
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.440
4bfuZVUPantothenate kinase2.7.1.330.440
4bfzZVZPantothenate kinase2.7.1.330.440
4df2FMNNADPH dehydrogenase/0.440
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.440
4fw43P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.440
4g3jVNTLanosterol 14-alpha-demethylase/0.440
4g7gVFVLanosterol 14-alpha-demethylase/0.440
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.440
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.440
4jicFMNGTN Reductase/0.440
4pnmNU1Tankyrase-22.4.2.300.440