sc-PDB

List of CHEMBLId :

This value allows a number of roughly comparable measures of half-maximal response concentration/potency/affinity to be compared on a negative logarithmic scale (e.g., an IC50 measurement of 1nM would have a pChEMBL value of 9).

Uniprot Annotation

Name:	Hypoxanthine-guanine phosphoribosyltransferase
ID:	HPRT_HUMAN
AC:	P00492
Organism:	Homo sapiens
Reign:	Eukaryota
TaxID:	9606
EC Number:	2.4.2.8

---

Chains:

Chain Name:	Percentage of Residues within binding site
B	100 %

---

Ligand binding site composition:

B-Factor:	21.691
Number of residues:	22
Including
Standard Amino Acids:	21
Non Standard Amino Acids:	0
Water Molecules:	1
Cofactors:
Metals:

---

Cavity properties

Ligandability	Volume (Å3)
0.916	904.500

% Hydrophobic	% Polar
42.54	57.46
According to VolSite

HET Code:	25H
Formula:	C9H12N5O5P
Molecular weight:	301.196 g/mol
DrugBank ID:	-
Buried Surface Area:	61.71 %
Polar Surface area:	167.53 Å2

Number of
H-Bond Acceptors:	8
H-Bond Donors:	2
Rings:	2
Aromatic rings:	1
Anionic atoms:	2
Cationic atoms:	0
Rule of Five Violation:	0
Rotatable Bonds:	6

---

Mass center Coordinates

X	Y	Z
17.1617	14.1356	17.7902

• 2D View
• 3D View