sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4fll | YZ6 | Methionine aminopeptidase 1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 1.000 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.791 | |
| 4flj | Y08 | Methionine aminopeptidase 1 | / | 0.762 | |
| 4fli | Y16 | Methionine aminopeptidase 1 | / | 0.685 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.678 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.659 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.649 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.646 | |
| 4ikr | PVP | Methionine aminopeptidase 1 | / | 0.640 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.617 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.612 | |
| 4iku | SHX | Methionine aminopeptidase 1 | / | 0.604 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.598 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.597 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.595 | |
| 4hxx | 1AY | Methionine aminopeptidase 1 | / | 0.594 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.594 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.589 | |
| 2nq7 | HM5 | Methionine aminopeptidase 1 | / | 0.585 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.584 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.569 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.568 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.568 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.566 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.565 | |
| 1c23 | MPH | Methionine aminopeptidase | / | 0.564 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.564 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.562 | |
| 3pkc | Y08 | Methionine aminopeptidase 2 | / | 0.562 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.559 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.553 | |
| 3d27 | W29 | Methionine aminopeptidase | / | 0.551 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.535 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.532 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.532 | |
| 2gg2 | U12 | Methionine aminopeptidase | / | 0.531 | |
| 1xnz | FCD | Methionine aminopeptidase | / | 0.528 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.527 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.527 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.523 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.523 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.517 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.514 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.514 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.509 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.507 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.506 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.505 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.502 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.502 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.501 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.497 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.497 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.497 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.496 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.492 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.492 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.491 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.490 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.490 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.490 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.490 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.489 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.488 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.488 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.487 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.487 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.487 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.486 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.486 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.485 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.483 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.483 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.482 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 4kxj | P34 | Nucleoprotein | / | 0.482 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.481 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.480 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.480 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.479 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.479 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.478 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.478 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.477 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.477 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.477 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.477 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.475 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.475 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.475 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.474 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.474 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.473 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.473 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.473 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.473 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.472 | |
| 2idv | M7G | Eukaryotic translation initiation factor 4E-1 | / | 0.472 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.472 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.472 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.472 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.471 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.471 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.470 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.470 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 4e2y | JHZ | Methyltransferase | / | 0.470 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.469 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.469 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.468 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.468 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.468 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.467 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.467 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.467 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.466 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.466 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.466 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.466 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.465 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.465 | |
| 4bb2 | STR | Corticosteroid-binding globulin | / | 0.465 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.465 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.464 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.464 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.464 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.464 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.463 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.463 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.463 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.463 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.463 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3ny9 | JSZ | Beta-2 adrenergic receptor | / | 0.463 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.462 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.462 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4drn | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.462 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.462 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1gax | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.461 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.461 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3e6e | DCS | Alanine racemase | / | 0.461 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.461 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.461 | |
| 4qfz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.461 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.460 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.460 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.460 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 3c1o | NAP | Eugenol synthase | / | 0.460 | |
| 3lzz | GDP | Uncharacterized protein | / | 0.460 | |
| 4aza | MGO | Eukaryotic translation initiation factor 4E | / | 0.460 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.460 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 2hej | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.459 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4hcy | 0YN | Transketolase | / | 0.459 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.459 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.458 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.458 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.458 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.458 | |
| 5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.458 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.458 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.457 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.457 | |
| 3pz4 | 3PZ | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.457 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 1jf0 | CZH | Obelin | / | 0.456 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.456 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.456 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.455 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.454 | |
| 3v2u | ATP | Protein GAL3 | / | 0.454 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.454 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.454 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.453 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.453 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.453 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.453 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.453 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.453 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.453 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.452 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.452 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.452 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.452 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.452 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.452 | |
| 3hgg | CHD | CmeR | / | 0.452 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.451 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.451 | |
| 1kwc | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.451 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.451 | |
| 2gmu | PDG | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.451 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.451 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.451 | |
| 3i0o | SMI | Spectinomycin phosphotransferase | / | 0.451 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.451 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.451 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.451 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.451 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.450 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.450 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.450 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.450 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.450 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.450 | |
| 4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.450 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.449 | |
| 1qs2 | NAD | Vip2Ac | / | 0.449 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 2jiz | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.449 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.449 | |
| 4rxr | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.449 | |
| 1c7o | PPG | Hemolysin | / | 0.448 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.448 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 2z4w | 749 | Geranylgeranyl pyrophosphate synthase | / | 0.448 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.448 | |
| 4rxp | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.448 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.448 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.447 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.447 | |
| 4b1c | 1B1 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4dh0 | MR8 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.447 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.447 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.447 | |
| 2y04 | 68H | Beta-1 adrenergic receptor | / | 0.447 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.447 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.447 | |
| 1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.446 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2bf4 | FAD | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.446 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.446 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.446 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.446 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.446 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.446 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.445 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.445 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.445 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.445 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.445 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4bfq | 083 | Soluble acetylcholine receptor | / | 0.445 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.445 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.445 | |
| 4xwt | U5P | Ribonuclease J | / | 0.445 | |
| 5d7o | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.445 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.444 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.444 | |
| 2po3 | T4K | 4-dehydrase | / | 0.444 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.444 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.444 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.444 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.444 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.444 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.443 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.443 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.443 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.443 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.443 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.443 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.443 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.443 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.443 | |
| 1fkb | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 1kru | IPT | Galactoside O-acetyltransferase | 2.3.1.18 | 0.442 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.442 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.442 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.442 | |
| 2v57 | PRL | TetR family transcriptional regulator | / | 0.442 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3g5m | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3mw0 | BHR | Nickel-binding periplasmic protein | / | 0.442 | |
| 3vjl | W94 | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.442 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.442 | |
| 1jf2 | CZH | Obelin | / | 0.441 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.441 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.441 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.441 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2r8p | T6F | Transketolase 1 | / | 0.441 | |
| 3mz9 | BHN | Nickel-binding periplasmic protein | / | 0.441 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3s8p | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.441 | |
| 3tfy | MET_LEU_GLY_PRO | N-alpha-acetyltransferase 50 | 2.3.1 | 0.441 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.441 | |
| 4g5d | NDP | Prostaglandin F synthase | 1.1.1.188 | 0.441 | |
| 4lcw | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.441 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.441 | |
| 5fmm | MGT | Polymerase basic protein 2 | / | 0.441 | |
| 1amo | NAP | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 1gvr | TNL | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.440 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.440 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 2r8o | T5X | Transketolase 1 | / | 0.440 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.440 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.440 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.440 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.440 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.440 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.440 | |
| 4j1c | 1HO | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.440 | |
| 4lut | DCS | Alanine racemase | / | 0.440 | |
| 4rxq | DUT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.440 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.440 |