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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.11.000
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.665
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.655
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.644
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.641
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.640
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.628
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.626
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.625
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.617
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.610
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.609
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.607
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.607
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.599
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.599
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.597
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.597
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.596
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.596
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.595
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.592
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.590
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.589
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.589
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.586
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.582
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.581
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.579
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.577
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.577
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.575
3umw596Serine/threonine-protein kinase pim-12.7.11.10.575
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.573
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.570
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.566
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.564
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.557
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.554
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.553
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.552
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.550
4dymIYZActivin receptor type-12.7.11.300.549
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.549
4riyADPEpidermal growth factor receptor2.7.10.10.549
4i22IREEpidermal growth factor receptor2.7.10.10.543
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.539
3a4pDFQHepatocyte growth factor receptor2.7.10.10.536
3uyt0CKCasein kinase I isoform delta2.7.11.10.535
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.528
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.528
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.524
4jq8KJ8Epidermal growth factor receptor2.7.10.10.523
3mtfA3FActivin receptor type-12.7.11.300.521
4bgg844Activin receptor type-12.7.11.300.515
1eh4IC1Casein kinase I homolog 12.7.11.10.514
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.511
2jedLG8Protein kinase C theta type2.7.11.130.510
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.510
4othDRNSerine/threonine-protein kinase N1/0.509
1xjdSTUProtein kinase C theta type2.7.11.130.508
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.506
1u54ACPActivated CDC42 kinase 1/0.504
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.504
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.503
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.501
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
1h1s4SPCyclin-dependent kinase 22.7.11.220.499
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.497
4wboANWRhodopsin kinase/0.497
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.496
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.496
4hgt15GCasein kinase I isoform delta2.7.11.10.496
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.495
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.494
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.494
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.494
2ittAEEEpidermal growth factor receptor2.7.10.10.493
2izrBRKCasein kinase I isoform gamma-32.7.11.10.493
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.493
4b7dQLECytochrome P450 monooxygenase PikC/0.493
2wihP48Cyclin-dependent kinase 22.7.11.220.492
1xl2189Gag-Pol polyprotein3.4.23.160.491
1zys199Serine/threonine-protein kinase Chk12.7.11.10.491
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.491
2izuP01Casein kinase I isoform gamma-32.7.11.10.490
2wpa889Cyclin-dependent kinase 22.7.11.220.490
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.490
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.489
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.489
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.489
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.488
4gw83RASerine/threonine-protein kinase pim-12.7.11.10.488
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.487
2j0m4STFocal adhesion kinase 12.7.10.20.487
2ojg19AMitogen-activated protein kinase 12.7.11.240.487
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.487
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
4kbk1QGCasein kinase I isoform delta2.7.11.10.487
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.486
4kba1QMCasein kinase I isoform delta2.7.11.10.485
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.484
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.484
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.484
4b99R4LMitogen-activated protein kinase 72.7.11.240.484
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.484
2etm7PYFocal adhesion kinase 12.7.10.20.483
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.483
3bqr4RBDeath-associated protein kinase 3/0.483
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.482
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.482
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.481
2j0k4STFocal adhesion kinase 12.7.10.20.481
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.481
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.481
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.481
3iw4LW4Protein kinase C alpha type2.7.11.130.481
3sheI85MAP kinase-activated protein kinase 32.7.11.10.481
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.481
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.481
4hni16WCasein kinase I isoform epsilon2.7.11.10.481
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.481
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.481
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.480
1aq1STUCyclin-dependent kinase 22.7.11.220.479
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.479
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.479
4jq7KJQEpidermal growth factor receptor2.7.10.10.479
2c475IDCasein kinase I isoform gamma-2/0.478
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.478
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.478
4bchT7ZCyclin-dependent kinase 92.7.11.220.478
4fob0USALK tyrosine kinase receptor2.7.10.10.478
3zze6XPHepatocyte growth factor receptor2.7.10.10.477
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.476
4erwSTUCyclin-dependent kinase 22.7.11.220.476
4fod0UVALK tyrosine kinase receptor2.7.10.10.476
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.475
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.475
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.475
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.474
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.474
3q9xEMOCasein kinase II subunit alpha2.7.11.10.474
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.474
4wkqIREEpidermal growth factor receptor2.7.10.10.474
1u4dDBQActivated CDC42 kinase 1/0.473
3fzr3JZProtein-tyrosine kinase 2-beta2.7.10.20.473
3t8oATPRhodopsin kinase/0.473
3zh8C58Protein kinase C iota type2.7.11.130.473
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.473
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.473
1f4gTP4Thymidylate synthase/0.472
2cchATPCyclin-dependent kinase 22.7.11.220.472
2iw84SPCyclin-dependent kinase 22.7.11.220.472
3bheBZNGag-Pol polyprotein3.4.23.160.472
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.472
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.472
1k6tXN1Gag-Pol polyprotein3.4.23.160.471
2j0j4STFocal adhesion kinase 12.7.10.20.471
3oom507Activin receptor type-12.7.11.300.471
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.471
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.471
4hnf16WCasein kinase I isoform delta2.7.11.10.471
1j7lADPAminoglycoside 3'-phosphotransferase2.7.1.950.470
1oi9N20Cyclin-dependent kinase 22.7.11.220.470
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.470
2csnCKICasein kinase I homolog 12.7.11.10.470
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.470
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.470
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.470
4hgs15GCasein kinase I isoform gamma-32.7.11.10.470
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.469
3ddpRC8Cyclin-dependent kinase 22.7.11.220.469
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.469
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4jrvKJVEpidermal growth factor receptor2.7.10.10.469
1oirHDYCyclin-dependent kinase 22.7.11.220.468
1oiuN76Cyclin-dependent kinase 22.7.11.220.468
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.468
3gc9B45Mitogen-activated protein kinase 112.7.11.240.468
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
3nynSGVG protein-coupled receptor kinase 62.7.11.160.468
3oqkS52Renin3.4.23.150.468
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.467
1qxlFR8Adenosine deaminase3.5.4.40.467
2b52D42Cyclin-dependent kinase 22.7.11.220.467
2wotZZGTGF-beta receptor type-12.7.11.300.467
4b7sQLECytochrome P450 monooxygenase PikC/0.467
5av2KMPDeath-associated protein kinase 12.7.11.10.467
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.466
2chlDKICasein kinase I isoform gamma-32.7.11.10.466
2izt23DCasein kinase I isoform gamma-32.7.11.10.466
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.466
3vs1VSATyrosine-protein kinase HCK2.7.10.20.466
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.466
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.466
1pkdUCNCyclin-dependent kinase 22.7.11.220.465
4ewhT77Activated CDC42 kinase 1/0.465
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
5dr9SKEAurora kinase A2.7.11.10.465
1o5rFR9Adenosine deaminase3.5.4.40.464
1oguST8Cyclin-dependent kinase 22.7.11.220.464
1py5PY1TGF-beta receptor type-12.7.11.300.464
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.464
2a0cCK9Cyclin-dependent kinase 22.7.11.220.464
2bkzSBCCyclin-dependent kinase 22.7.11.220.464
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.464
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.464
2x1nX1NCyclin-dependent kinase 22.7.11.220.464
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.464
3gubGUBDeath-associated protein kinase 12.7.11.10.464
4c02TAKActivin receptor type-12.7.11.300.464
4fkr45KCyclin-dependent kinase 22.7.11.220.464
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
1pjkANPCasein kinase II subunit alpha2.7.11.10.463
2izsBRQCasein kinase I isoform gamma-32.7.11.10.463
2pvmP29Casein kinase II subunit alpha2.7.11.10.463
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.463
3at4CCKCasein kinase II subunit alpha2.7.11.10.463
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.463
3gu7ADPDeath-associated protein kinase 12.7.11.10.463
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.463
3uzp0CKCasein kinase I isoform delta2.7.11.10.463
4fv9E71Mitogen-activated protein kinase 12.7.11.240.463
4fz60VGTyrosine-protein kinase SYK2.7.10.20.463
4kb81QOCasein kinase I isoform delta2.7.11.10.463
4yuqKS1Calmodulin-like domain protein kinase/0.463
1h1r6CPCyclin-dependent kinase 22.7.11.220.462
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.462
2c6hPXICytochrome P450 monooxygenase PikC/0.462
2ckeIQUDeath-associated protein kinase 2/0.462
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.462
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.462
3lltANPProtein serine/threonine kinase-1/0.462
3vspEK8Peroxisome proliferator-activated receptor gamma/0.462
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.462
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.461
1e9hINRCyclin-dependent kinase 22.7.11.220.461
1oiyN41Cyclin-dependent kinase 22.7.11.220.461
2iw94SPCyclin-dependent kinase 22.7.11.220.461
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.461
2xb7GUIALK tyrosine kinase receptor2.7.10.10.461
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.461
3ddqRRCCyclin-dependent kinase 22.7.11.220.461
3nwxKVSGag-Pol polyprotein3.4.23.160.461
3s1h56ZCyclin-dependent kinase 22.7.11.220.461
3sw418KCyclin-dependent kinase 22.7.11.220.461
4aa5NQBMitogen-activated protein kinase 14/0.461
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.461
4foc0UUALK tyrosine kinase receptor2.7.10.10.461
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.461
4o71CPBBromodomain-containing protein 4/0.461
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.461
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.460
2vu3LZECyclin-dependent kinase 22.7.11.220.460
3a7hATPSerine/threonine-protein kinase 242.7.11.10.460
3fzpAGSProtein-tyrosine kinase 2-beta2.7.10.20.460
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.460
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.460
4ix6ADPUncharacterized protein/0.460
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.459
2uzlC94Cyclin-dependent kinase 22.7.11.220.459
3mtlFEFCyclin-dependent kinase 162.7.11.220.459
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.459
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.459
3u4uLNHCasein kinase II subunit alpha2.7.11.10.459
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.459
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.459
4c4jX21Dual specificity protein kinase TTK2.7.12.10.459
4gmy0X5Tyrosine-protein kinase JAK2/0.459
4jia1K3Tyrosine-protein kinase JAK2/0.459
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.458
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.458
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.458
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.458
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.458
3mpaSB2Mitogen-activated protein kinase 14/0.458
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.458
4hge15VTyrosine-protein kinase JAK2/0.458
4o4fATPKinase/0.458
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.457
1wxyFRKAdenosine deaminase3.5.4.40.457
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.457
3rak03ZCyclin-dependent kinase 22.7.11.220.457
3ral04ZCyclin-dependent kinase 22.7.11.220.457
3sqq99ZCyclin-dependent kinase 22.7.11.220.457
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.457
4o4eATPKinase/0.457
5auwQUEDeath-associated protein kinase 12.7.11.10.457
1bygSTUTyrosine-protein kinase CSK/0.456
1csnATPCasein kinase I homolog 12.7.11.10.456
1e7qNAPGDP-L-fucose synthase/0.456
1g5sI17Cyclin-dependent kinase 22.7.11.220.456
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
1zrzBI1Protein kinase C iota type2.7.11.130.456
2itnANPEpidermal growth factor receptor2.7.10.10.456
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.456
2x7gPVBSRSF protein kinase 22.7.11.10.456
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.456
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.456
2znnS44Peroxisome proliferator-activated receptor alpha/0.456
2znq401Peroxisome proliferator-activated receptor delta/0.456
3a60STURibosomal protein S6 kinase beta-12.7.11.10.456
3be9P04Casein kinase II subunit alpha2.7.11.10.456
3qfvNM7Serine/threonine-protein kinase MRCK beta2.7.11.10.456
3vetADPnebramycin 5' synthase6.1.2.20.456
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.456
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.456
5aabVGHALK tyrosine kinase receptor2.7.10.10.456
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.456
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.455
1kkq471Peroxisome proliferator-activated receptor alpha/0.455
1pyePM1Cyclin-dependent kinase 22.7.11.220.455
2jkoBIJFocal adhesion kinase 12.7.10.20.455
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.455
3dfcANPDeath-associated protein kinase 12.7.11.10.455
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4iaq2GM5-hydroxytryptamine receptor 1B/0.455
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.455
1bwsNDPGDP-L-fucose synthase/0.454
1urwI1PCyclin-dependent kinase 22.7.11.220.454
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.454
2pvlP55Casein kinase II subunit alpha2.7.11.10.454
2uzbC75Cyclin-dependent kinase 22.7.11.220.454
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.454
3bu5ATPInsulin receptor2.7.10.10.454
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
3emg685Tyrosine-protein kinase SYK2.7.10.20.454
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.454
3pxkPXKFocal adhesion kinase 12.7.10.20.454
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.454
5cvhADPCasein kinase II subunit alpha2.7.11.10.454
2xa4AZ5Tyrosine-protein kinase JAK2/0.453
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.453
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
3w551FMMitogen-activated protein kinase 12.7.11.240.453
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.453
4fv6E57Mitogen-activated protein kinase 12.7.11.240.453
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.453
5f0a1FBcGMP-dependent protein kinase, putative/0.453
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.452
1w0xOLOCyclin-dependent kinase 22.7.11.220.452
1wvxBD4Death-associated protein kinase 12.7.11.10.452
1zgaHMKIsoflavone 4'-O-methyltransferase/0.452
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.452
2ovhAS0Progesterone receptor/0.452
2q9fC3SCholesterol 24-hydroxylase/0.452
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3kf7L9GMitogen-activated protein kinase 14/0.452
3mqe416Prostaglandin G/H synthase 21.14.99.10.452
3zk5Z18Cytochrome P450 monooxygenase PikC/0.452
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.452
4fyn0VETyrosine-protein kinase SYK2.7.10.20.452
4hvg19QTyrosine-protein kinase JAK32.7.10.20.452
4jlj1NMDeoxycytidine kinase2.7.1.740.452
1m2pHNACasein kinase II subunit alpha2.7.11.10.451
1ndzFR5Adenosine deaminase3.5.4.40.451
2r64740Cyclin-dependent kinase 22.7.11.220.451
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3vf80JETyrosine-protein kinase SYK2.7.10.20.451
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.451
4c4g7RODual specificity protein kinase TTK2.7.12.10.451
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4i2q1BTGag-Pol polyprotein2.7.7.490.451
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.451
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.451
1jpaANPEphrin type-B receptor 22.7.10.10.450
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.450
2c7xNRBCytochrome P450 monooxygenase PikC/0.450
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.450
2vagV25Dual specificity protein kinase CLK12.7.12.10.450
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.450
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.450
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.450
4a9iP9IBromodomain-containing protein 2/0.450
4erkOLOMitogen-activated protein kinase 12.7.11.240.450
4ewqMWLMitogen-activated protein kinase 14/0.450
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.450
4gu610NFocal adhesion kinase 12.7.10.20.450
4ib4ERM5-hydroxytryptamine receptor 2B/0.450
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.450
4o761M3Bromodomain-containing protein 4/0.450
4qmlANPSerine/threonine-protein kinase 242.7.11.10.450
5auvAGIDeath-associated protein kinase 12.7.11.10.450
1jklANPDeath-associated protein kinase 12.7.11.10.449
1om1IQACasein kinase II subunit alpha2.7.11.10.449
1umlFR4Adenosine deaminase3.5.4.40.449
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.449
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.449
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.449
2itqITQEpidermal growth factor receptor2.7.10.10.449
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.449
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.449
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.449
3du8553Glycogen synthase kinase-3 beta2.7.11.260.449
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.449
3mdvCL6Cholesterol 24-hydroxylase/0.449
3njoP2MAbscisic acid receptor PYR1/0.449
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
3qaiXNNKetohexokinase/0.449
3rni21ZCyclin-dependent kinase 22.7.11.220.449
3s2pPMUCyclin-dependent kinase 22.7.11.220.449
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.449
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.449
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.449
4qo9627Serine/threonine-protein kinase 242.7.11.10.449
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
5av3KMPDeath-associated protein kinase 12.7.11.10.449
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1nq7ARLNuclear receptor ROR-beta/0.448
2b55D31Cyclin-dependent kinase 22.7.11.220.448
2pvhP19Casein kinase II subunit alpha2.7.11.10.448
2uxoTACHTH-type transcriptional regulator TtgR/0.448
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.448
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.448
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.448
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.448
3qtzX42Cyclin-dependent kinase 22.7.11.220.448
3rmf20ZCyclin-dependent kinase 22.7.11.220.448
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.448
4aacAAVMitogen-activated protein kinase 14/0.448
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.448
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.448
4gg50J3Hepatocyte growth factor receptor2.7.10.10.448
4xwtU5PRibonuclease J/0.448
5e8wSTUTGF-beta receptor type-12.7.11.300.448
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
1zeoC01Peroxisome proliferator-activated receptor gamma/0.447
2duv371Cyclin-dependent kinase 22.7.11.220.447
2ijmADPFocal adhesion kinase 12.7.10.20.447
2jkqVG8Focal adhesion kinase 12.7.10.20.447
2w1hL0FCyclin-dependent kinase 22.7.11.220.447
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.447
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.447
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.447
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.447
3m8qDJZGag-Pol polyprotein2.7.7.490.447
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.447
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.447
3vryB43Tyrosine-protein kinase HCK2.7.10.20.447
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.447
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.447
4ansVGHALK tyrosine kinase receptor2.7.10.10.447
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.447
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.447
4kb81QNCasein kinase I isoform delta2.7.11.10.447
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.447
5cvfATPCasein kinase II subunit alpha2.7.11.10.447
1k6pXN3Gag-Pol polyprotein3.4.23.160.446
1rfvADPPyridoxal kinase2.7.1.350.446
1vjy460TGF-beta receptor type-12.7.11.300.446
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.446
2p33J07Mitogen-activated protein kinase 102.7.11.240.446
2w05FRTCyclin-dependent kinase 22.7.11.220.446
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.446
2xikJ60Serine/threonine-protein kinase 252.7.11.10.446
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3blrCPBCyclin-dependent kinase 92.7.11.220.446
3ggfGVDSerine/threonine-protein kinase 26/0.446
3lfnA27Cyclin-dependent kinase 22.7.11.220.446
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.446
3qqkX02Cyclin-dependent kinase 22.7.11.220.446
3rk708ZCyclin-dependent kinase 22.7.11.220.446
3tdvGDPGentamicin resistance protein/0.446
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.446
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.446
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4a9mP9MBromodomain-containing protein 2/0.446
4brxKGWFocal adhesion kinase 12.7.10.20.446
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.446
4g160VMCasein kinase I isoform gamma-32.7.11.10.446
4g1qT27Gag-Pol polyprotein2.7.7.490.446
4j95ACPFibroblast growth factor receptor 2/0.446
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.446
4lxhC1EAlpha/beta hydrolase fold/0.446
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.446
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1gih1PUCyclin-dependent kinase 22.7.11.220.445
1tqmANPRIO-type serine/threonine-protein kinase Rio22.7.11.10.445
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.445
2hog710Serine/threonine-protein kinase Chk12.7.11.10.445
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.445
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.445
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.445
2yn8STUEphrin type-B receptor 42.7.10.10.445
2zoq5IDMitogen-activated protein kinase 32.7.11.240.445
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.445
3hllI45Mitogen-activated protein kinase 14/0.445
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
3tucFPWTyrosine-protein kinase SYK2.7.10.20.445
3vt7VDXVitamin D3 receptor/0.445
4bcmT7ZCyclin-dependent kinase 22.7.11.220.445
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4h9614QDihydrofolate reductase1.5.1.30.445
4i8vBHFCytochrome P450 1A11.14.14.10.445
4jqeANPCasein kinase II subunit alpha2.7.11.10.445
4m6p20RNicotinamide phosphoribosyltransferase2.4.2.120.445
1ir3ANPInsulin receptor2.7.10.10.444
1m13HYFNuclear receptor subfamily 1 group I member 2/0.444
1ppm0P1Penicillopepsin-13.4.23.200.444
1yvj4STTyrosine-protein kinase JAK32.7.10.20.444
1zaoATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.444
1zhwHC2Oxysterol-binding protein homolog 4/0.444
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.444
2c3qGTXGlutathione S-transferase theta-12.5.1.180.444
2hw2RFPRifampin ADP-ribosyl transferase/0.444
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.444
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.444
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3i8aN22Dihydrofolate reductase1.5.1.30.444
3nwq2NCGag-Pol polyprotein3.4.23.160.444
3qlxQLRUncharacterized protein/0.444
3r7vZ02Cyclin-dependent kinase 22.7.11.220.444
3r9dX6BCyclin-dependent kinase 22.7.11.220.444
3uvqFS8Mitogen-activated protein kinase 14/0.444
4acm7YGCyclin-dependent kinase 22.7.11.220.444
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.444
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.444
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4cfnJYMCyclin-dependent kinase 22.7.11.220.444
4enhFVXCholesterol 24-hydroxylase/0.444
4hvh19RTyrosine-protein kinase JAK32.7.10.20.444
4jrnANPRhoptry kinase family protein/0.444
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.444
5aacVGHALK tyrosine kinase receptor2.7.10.10.444
5cu6ATPCasein kinase II subunit alpha2.7.11.10.444
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.443
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.443
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.443
2b7aIZATyrosine-protein kinase JAK2/0.443
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.443
2c5nCK8Cyclin-dependent kinase 22.7.11.220.443
2f3mGTDGlutathione S-transferase Mu 12.5.1.180.443
2i40BLZCyclin-dependent kinase 22.7.11.220.443
2wipP49Cyclin-dependent kinase 22.7.11.220.443
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.443
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3at3ATKCasein kinase II subunit alpha2.7.11.10.443
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.443
3rpv26ZCyclin-dependent kinase 22.7.11.220.443
3srwQ27Dihydrofolate reductase1.5.1.30.443
3unj0BXCyclin-dependent kinase 22.7.11.220.443
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.443
4fmqANPMitogen-activated protein kinase 12.7.11.240.443
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.443
4fuxE75Mitogen-activated protein kinase 12.7.11.240.443
4iarERM5-hydroxytryptamine receptor 1B/0.443
4ifvT27Gag-Pol polyprotein2.7.7.490.443
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4wa9AXITyrosine-protein kinase ABL12.7.10.20.443
4xlvACPInsulin receptor2.7.10.10.443
1bsvNDPGDP-L-fucose synthase/0.442
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
1m2rMNYCasein kinase II subunit alpha2.7.11.10.442
1yinCM3Estrogen receptor/0.442
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.442
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.442
3adaNADSubunit alpha of sarocosine oxidase/0.442
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.442
3poz03PEpidermal growth factor receptor2.7.10.10.442
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.442
3qyw6PBMitogen-activated protein kinase 12.7.11.240.442
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
4bcoT6QCyclin-dependent kinase 22.7.11.220.442
4eon1ROCyclin-dependent kinase 22.7.11.220.442
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.442
4jx1CAMCamphor 5-monooxygenase1.14.15.10.442
4o0wADNAurora kinase A2.7.11.10.442
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.442
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.442
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.441
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.441
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.441
2h96893Mitogen-activated protein kinase 82.7.11.240.441
2j7t274Serine/threonine-protein kinase 102.7.11.10.441
2pywADPMethylthioribose kinase2.7.1.1000.441
2uzeC95Cyclin-dependent kinase 22.7.11.220.441
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.441
3a62STURibosomal protein S6 kinase beta-12.7.11.10.441
3oroAGSSerine/threonine protein kinase/0.441
3pj8404Cyclin-dependent kinase 22.7.11.220.441
3rjc06ZCyclin-dependent kinase 22.7.11.220.441
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4c57FEFCyclin-G-associated kinase2.7.11.10.441
4ixgIXGDihydrofolate reductase1.5.1.30.441
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.441
4pkl1GHUncharacterized protein/0.441
1ie4T44Transthyretin/0.440
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.440
2ca0PXICytochrome P450 monooxygenase PikC/0.440
2of2547Tyrosine-protein kinase Lck2.7.10.20.440
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.440
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.440
2r3lSCWCyclin-dependent kinase 22.7.11.220.440
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3eek53SUncharacterized protein/0.440
3gu6ADPDeath-associated protein kinase 12.7.11.10.440
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.440
3pm0BHFCytochrome P450 1B1/0.440
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.440
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4c61LMMTyrosine-protein kinase JAK2/0.440
4dgnLU2Casein kinase II subunit alpha2.7.11.10.440
4ez50RSCyclin-dependent kinase 62.7.11.220.440
4fkv61KCyclin-dependent kinase 22.7.11.220.440
4fnyI3KALK tyrosine kinase receptor2.7.10.10.440
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.440
4g6oE28Mitogen-activated protein kinase 12.7.11.240.440
4h3qANPMitogen-activated protein kinase 12.7.11.240.440
4jazSTLPeroxisome proliferator-activated receptor gamma/0.440
4kbc1QJCasein kinase I isoform delta2.7.11.10.440
4kd11QKCyclin-dependent kinase 22.7.11.220.440
4nk92K5Fibroblast growth factor receptor 1/0.440
4o701QKBromodomain-containing protein 4/0.440
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.440