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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2vezACOGlucosamine 6-phosphate acetyltransferase, putative

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2vezACOGlucosamine 6-phosphate acetyltransferase, putative/1.000
2vxkCOAGlucosamine 6-phosphate acetyltransferase, putative/0.629
1i12ACOGlucosamine 6-phosphate N-acetyltransferase/0.581
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.544
1hb1OCVIsopenicillin N synthase1.21.3.10.539
4hkfACOAlpha-tubulin N-acetyltransferase 1/0.534
2cy2ACOProbable acetyltransferase/0.533
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.526
4phlPILPhosphodiesterase/0.524
2jdcCAOProbable acetyltransferase/0.521
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.520
2iviACWIsopenicillin N synthase1.21.3.10.519
1bk0ACVIsopenicillin N synthase1.21.3.10.512
1hb3SCVIsopenicillin N synthase1.21.3.10.512
3zoiM2WIsopenicillin N synthase1.21.3.10.511
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.509
1ygkRRCPyridoxal kinase2.7.1.350.508
1yhjR6CPyridoxal kinase2.7.1.350.508
1blzACVIsopenicillin N synthase1.21.3.10.507
4bb3KKAIsopenicillin N synthase1.21.3.10.506
4ag9COAGlucosamine 6-phosphate N-acetyltransferase/0.504
5kf2COAPredicted acetyltransferase/0.504
3zkyWT4Isopenicillin N synthase1.21.3.10.503
2ob0ACON-alpha-acetyltransferase 50/0.502
2vcmM11Isopenicillin N synthase1.21.3.10.502
4h6uACOAlpha-tubulin N-acetyltransferase 1/0.502
1d3pBT3Prothrombin3.4.21.50.500
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.500
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.499
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.499
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.497
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.496
1qiqACCIsopenicillin N synthase1.21.3.10.495
3v94WYQPhosphodiesterase/0.495
3zkuHCVIsopenicillin N synthase1.21.3.10.495
1p8dCO1Oxysterols receptor LXR-beta/0.494
2pswCOAN-alpha-acetyltransferase 50/0.494
4cs0ACOPanD regulatory factor/0.493
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.492
3vf60H6Glucokinase2.7.1.20.492
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.492
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.490
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.490
2o28COAGlucosamine 6-phosphate N-acetyltransferase/0.490
3bsyACOUDP-N-acetylbacillosamine N-acetyltransferase2.3.1.2030.490
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.489
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.489
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.488
1oc1ASVIsopenicillin N synthase1.21.3.10.487
3tdaPN0Cytochrome P450 2D6/0.487
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.487
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.487
3c3xNAPEugenol synthase 11.1.1.3180.486
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.485
1pq944BOxysterols receptor LXR-beta/0.485
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.485
3nx4NAPPutative oxidoreductase/0.485
2a4nCOAAac(6')-Ii protein/0.484
3wixLC3Induced myeloid leukemia cell differentiation protein Mcl-1/0.484
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.483
5k2aZMAAdenosine receptor A2a/0.483
1fxuGU7Purine nucleoside phosphorylase2.4.2.10.482
1pqc444Oxysterols receptor LXR-beta/0.482
1puaCOAHAT A1/0.482
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.482
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.482
4iaq2GM5-hydroxytryptamine receptor 1B/0.482
1qsnCOAHAT A1/0.481
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.481
2vbpVB1Isopenicillin N synthase1.21.3.10.481
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.481
4dbw511Aldo-keto reductase family 1 member C3/0.481
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.481
1gtiGTBGlutathione S-transferase P 12.5.1.180.480
1obnASVIsopenicillin N synthase1.21.3.10.480
3s41S41Glucokinase2.7.1.20.480
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.480
1n71COAAac(6')-Ii protein/0.479
2e48FADD-amino-acid oxidase1.4.3.30.479
5g53NECAdenosine receptor A2a/0.479
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.478
3qm4PN0Cytochrome P450 2D6/0.478
3up0D7SaceDAF-12/0.478
4j6bPLOCytochrome P450 monooxygenase/0.478
5dozNDPJamJ/0.478
1dqaCOA3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.477
1drfFOLDihydrofolate reductase1.5.1.30.477
1gsfEAAGlutathione S-transferase A12.5.1.180.477
2ydoADNAdenosine receptor A2a/0.477
4ua3COAN-alpha-acetyltransferase 402.3.10.477
4x28FDAAcyl-CoA dehydrogenase FadE26/0.477
4x28FDAAcyl-CoA dehydrogenase FadE27/0.477
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.477
5kf9COAPredicted acetyltransferase/0.477
1ra3NAPDihydrofolate reductase1.5.1.30.476
2gzl2AA2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase4.6.1.120.476
2jb4A14Isopenicillin N synthase1.21.3.10.476
3k9uACOSpermidine N(1)-acetyltransferase/0.476
4y1bNAPAntE/0.476
5uviZMAAdenosine receptor A2a/0.476
1yc2NADNAD-dependent protein deacylase 2/0.475
3ckqUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.475
2dhfDZFDihydrofolate reductase1.5.1.30.474
2f3815MAldo-keto reductase family 1 member C3/0.474
2vbdV10Isopenicillin N synthase1.21.3.10.474
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.474
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.474
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.474
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.474
1aqxGTDGlutathione S-transferase P2.5.1.180.473
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.473
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.473
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.473
3tfyCOAN-alpha-acetyltransferase 502.3.10.473
4ttjFMCPurine nucleoside phosphorylase DeoD-type/0.473
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.473
1qjfACSIsopenicillin N synthase1.21.3.10.472
2iyaZIOOleandomycin glycosyltransferase/0.472
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.472
4zm6ACON-acetyl-beta-D glucosaminidase/0.472
1d3dBZTProthrombin3.4.21.50.471
1s7gNADNAD-dependent protein deacylase 2/0.471
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.471
2cf8ESHProthrombin3.4.21.50.471
3d7zGK5Mitogen-activated protein kinase 14/0.471
3wqmB29Diterpene synthase3.1.7.80.471
4twnB96Ephrin type-A receptor 32.7.10.10.471
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.470
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.470
2idkC2FGlycine N-methyltransferase2.1.1.200.470
2r0pK2CPutative FAD-monooxygenase/0.470
2wo7ASVIsopenicillin N synthase1.21.3.10.470
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.470
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.470
4cryACOPanD regulatory factor/0.470
4kbn25UDihydrofolate reductase1.5.1.30.470
1jwtBLIProthrombin3.4.21.50.469
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.469
1txtCAAHMG-CoA synthase/0.469
2bjsACVIsopenicillin N synthase1.21.3.10.469
2bu9HFVIsopenicillin N synthase1.21.3.10.469
2geuCOKPantothenate kinase2.7.1.330.469
4b5pACOAlpha-tubulin N-acetyltransferase 1/0.469
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
5bt42LOBromodomain-containing protein 4/0.469
7catNDPCatalase1.11.1.60.469
1hfqMOTDihydrofolate reductase1.5.1.30.468
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.468
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
2pksG44Prothrombin3.4.21.50.468
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.468
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
3lfeZ84Mitogen-activated protein kinase 14/0.468
3sl2ATPSensor histidine kinase WalK/0.468
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.468
4b4w9L9Bifunctional protein FolD/0.468
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
4mxeACON-acetyltransferase ESCO12.3.10.468
5epvACPBlue-light-activated histidine kinase2.7.13.30.468
1c7oPPGHemolysin/0.467
1s3uTQDDihydrofolate reductase1.5.1.30.467
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.467
3gusN11Glutathione S-transferase P2.5.1.180.467
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.467
3thrC2FGlycine N-methyltransferase2.1.1.200.467
2p15EZTEstrogen receptor/0.466
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.466
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.466
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.466
5ab6CAANonspecific lipid-transfer protein, putative/0.466
1dljUGAUDP-glucose 6-dehydrogenase/0.465
1nzyBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.465
1pwyAC2Purine nucleoside phosphorylase2.4.2.10.465
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.465
1w06W05Isopenicillin N synthase1.21.3.10.465
2ejzSAHDiphthine synthase/0.465
2g1n1IGRenin3.4.23.150.465
2y6fM9FIsopenicillin N synthase1.21.3.10.465
2zs9ADPPantothenate kinase2.7.1.330.465
4jbtASDCytochrome P450 monooxygenase/0.465
1rpwDIDHTH-type transcriptional regulator QacR/0.464
1ygjRMCPyridoxal kinase2.7.1.350.464
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.464
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.464
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.464
3gncQQQGlutaryl-CoA dehydrogenase/0.464
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.464
4bftZVTPantothenate kinase2.7.1.330.464
4pgtGBXGlutathione S-transferase P2.5.1.180.464
1ej3CZHAequorin-2/0.463
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.463
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
2cdcNAPGlucose 1-dehydrogenase/0.463
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.463
2y60M8FIsopenicillin N synthase1.21.3.10.463
3h3r14HCollagen type IV alpha-3-binding protein/0.463
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.463
3pg3DG7Mitogen-activated protein kinase 14/0.463
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.463
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4jdcNADProbable pyrroline-5-carboxylate dehydrogenase RocA/0.463
4jlk1NODeoxycytidine kinase2.7.1.740.463
5jtbZMAAdenosine receptor A2a/0.463
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.462
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.462
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
3l0lHC3Nuclear receptor ROR-gamma/0.462
4dhyS41Glucokinase2.7.1.20.462
4p9dTMPDeoxycytidylate deaminase/0.462
4rh10TTSpore photoproduct lyase/0.462
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.461
1pt8ACOFormyl-CoA:oxalate CoA-transferase/0.461
1uydPU8Heat shock protein HSP 90-alpha/0.461
1wp4NDP3-hydroxyisobutyrate dehydrogenase/0.461
3pm1ETHTH-type transcriptional regulator QacR/0.461
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.461
4boeCLRJapanin/0.461
4jjiNADAlcohol dehydrogenase class-3/0.461
5dbfNDPIridoid synthase1.3.1.990.461
1cm0COAHistone acetyltransferase KAT2B2.3.1.480.460
2a0yDIHPurine nucleoside phosphorylase2.4.2.10.460
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.460
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
3eigMTXDihydrofolate reductase1.5.1.30.460
3l6jZ90Alr2278 protein/0.460
3q9bB3NAcetylpolyamine amidohydrolase/0.460
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.460
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
4j6cSTRCytochrome P450 monooxygenase/0.460
3uzcT4EAdenosine receptor A2a/0.460
1ezfIN0Squalene synthase2.5.1.210.459
3f0aACOSpermidine N(1)-acetyltransferase/0.459
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.459
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.459
1pkfEPDEpothilone C/D epoxidase1.140.458
1u0wSTLChalcone synthase 22.3.1.740.458
1uzwCDHIsopenicillin N synthase1.21.3.10.458
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.458
2wksCB63-dehydroquinate dehydratase4.2.1.100.458
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.458
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.458
3g6zA7TRenin3.4.23.150.458
3iktNADRedox-sensing transcriptional repressor Rex/0.458
3rsv3RSBeta-secretase 13.4.23.460.458
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
5emhNAPIridoid synthase1.3.1.990.458
1dghNDPCatalase1.11.1.60.457
1mu6CDAProthrombin3.4.21.50.457
1uhhCZPAequorin-2/0.457
1z7yAA5Cysteine synthase 12.5.1.470.457
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.457
2in6839Wee1-like protein kinase2.7.10.20.457
2msdGNPMHC class I alpha chain/0.457
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.457
3a1l2CCCytochrome P450/0.457
3c1oNAPEugenol synthase/0.457
3d4bDZDNAD-dependent protein deacetylase/0.457
3gkjHC3Niemann-Pick C1 protein/0.457
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
4stdBFSScytalone dehydratase4.2.1.940.457
5k2cZMAAdenosine receptor A2a/0.457
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.456
1kt3RTLRetinol-binding protein 4/0.456
1ry8RUTAldo-keto reductase family 1 member C3/0.456
1trgCB3Thymidylate synthase/0.456
1zdwFLVPrenyltransferase/0.456
1zgcA2EAcetylcholinesterase3.1.1.70.456
3eta351Insulin receptor2.7.10.10.456
3v4eCOAPutative acetyltransferase SACOL25702.3.10.456
4at0FADPossible succinate dehydrogenase/0.456
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.456
4bfxZVXPantothenate kinase2.7.1.330.456
4bquCLRJapanin/0.456
4l5b1UXDeoxycytidine kinase2.7.1.740.456
4wasCOOEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.456
7stdCRPScytalone dehydratase4.2.1.940.456
1rd4L08Integrin alpha-L/0.455
2jn3JN3Fatty acid-binding protein, liver/0.455
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.455
3fhxPXLPyridoxal kinase2.7.1.350.455
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3gw9VNILanosterol 14-alpha-demethylase/0.455
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3o9lLPNRenin3.4.23.150.455
4irnFADAnaB/0.455
12gs0HHGlutathione S-transferase P2.5.1.180.454
1dhfFOLDihydrofolate reductase1.5.1.30.454
1o6qR17Squalene--hopene cyclase4.2.1.1290.454
1ypeUIPProthrombin3.4.21.50.454
2zevB71Geranylgeranyl pyrophosphate synthase/0.454
3abaFLICytochrome P450/0.454
3jynNDPQuinone oxidoreductase/0.454
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3tyvHI3Genome polyprotein2.7.7.480.454
4iarERM5-hydroxytryptamine receptor 1B/0.454
4ku5DCC3-oxoacyl-[ACP] synthase III/0.454
4n3l2FNProthrombin3.4.21.50.454
1g63FMNEpidermin decarboxylase4.1.10.453
1lf2R37Plasmepsin-23.4.23.390.453
1pgtGTXGlutathione S-transferase P2.5.1.180.453
1qo8FADFumarate reductase flavoprotein subunit/0.453
2clfF6FTryptophan synthase alpha chain/0.453
2clmF6FTryptophan synthase alpha chain/0.453
2fjaFADAdenylylsulfate reductase, subunit A (AprA)/0.453
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.453
2jh0701Prothrombin3.4.21.50.453
3aosJH2Hemolymph juvenile hormone binding protein/0.453
3hkyIX6Genome polyprotein2.7.7.480.453
3pqbVGPPutative oxidoreductase/0.453
3sytNADGlutamine-dependent NAD(+) synthetase6.3.5.10.453
3tfn2CJDehydrosqualene synthase/0.453
3tubFPUTyrosine-protein kinase SYK2.7.10.20.453
3zsh469Mitogen-activated protein kinase 14/0.453
4eqrCOACoenzyme A disulfide reductase/0.453
5k2bZMAAdenosine receptor A2a/0.453
1bx9GLY_GGL_FOEGlutathione S-transferase F22.5.1.180.452
1gnwGTXGlutathione S-transferase F22.5.1.180.452
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.452
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.452
1ta6177Prothrombin3.4.21.50.452
1thz326Bifunctional purine biosynthesis protein PURH2.1.2.30.452
1txzAPRProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.452
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.452
2g1o2IGRenin3.4.23.150.452
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2v0mKLNCytochrome P450 3A4/0.452
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
3ie3N11Glutathione S-transferase P2.5.1.180.452
3qri919Tyrosine-protein kinase ABL12.7.10.20.452
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
4crzACOPanD regulatory factor/0.452
4ej1FOLDihydrofolate reductase1.5.1.30.452
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4uohADPNucleoside diphosphate kinase/0.452
4xbjIN5Alanine racemase, biosynthetic/0.452
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.452
8catNDPCatalase1.11.1.60.452
5iua6DXAdenosine receptor A2a/0.452
1mvtDTMDihydrofolate reductase1.5.1.30.451
1q63AIQQueuine tRNA-ribosyltransferase2.4.2.290.451
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.451
3c4aFADProtodeoxyviolaceinate monooxygenase10.451
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.451
3qe2FMNNADPH--cytochrome P450 reductase/0.451
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4b4vL34Bifunctional protein FolD/0.451
4jv41ORcAMP-dependent protein kinase type I-alpha regulatory subunit/0.451
4relKMPGlycosyltransferase/0.451
5fitAP2Bis(5'-adenosyl)-triphosphatase3.6.1.290.451
1dr3HBIDihydrofolate reductase1.5.1.30.450
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.450
1nhkCMPNucleoside diphosphate kinase2.7.4.60.450
1qrpHH0Pepsin A-43.4.23.10.450
1rftPXMPyridoxal kinase2.7.1.350.450
1stdBFSScytalone dehydratase4.2.1.940.450
1uhjCZBAequorin-2/0.450
2fzwNADAlcohol dehydrogenase class-31.1.1.10.450
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2pdaTPPPyruvate synthase/0.450
2yoj8Y6Genome polyprotein2.7.7.480.450
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.450
3nalDBKCalcium-transporting ATPase/0.450
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.450
4hfp15UProthrombin3.4.21.50.450
4j6dTESCytochrome P450 monooxygenase/0.450
5cc9DDFDihydrofolate reductase1.5.1.30.450
6stdMS2Scytalone dehydratase4.2.1.940.450
1jtuLYBThymidylate synthase/0.449
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.449
1nm6L86Prothrombin3.4.21.50.449
1v48HA1Purine nucleoside phosphorylase2.4.2.10.449
1w7kADPDihydrofolate synthase/folylpolyglutamate synthase6.3.2.120.449
2imkGTXAGAP009194-PA/0.449
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.449
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4dvi2IWTankyrase-12.4.2.300.449
4h7zGUNQueuine tRNA-ribosyltransferase2.4.2.290.449
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.449
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.449
4uhrNGIAdenosine receptor A2a/0.449
1dgfNDPCatalase1.11.1.60.448
1digL37C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.448
1diuBDMDihydrofolate reductase1.5.1.30.448
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.448
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.448
1mvsDTMDihydrofolate reductase1.5.1.30.448
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.448
2bsxNOSPurine nucleoside phosphorylase/0.448
2po7CHDFerrochelatase, mitochondrial4.99.1.10.448
2wetFADTryptophan 5-halogenase/0.448
3cic316Beta-secretase 13.4.23.460.448
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4ag7COAGlucosamine 6-phosphate N-acetyltransferase/0.448
4at4T6EBDNF/NT-3 growth factors receptor2.7.10.10.448
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.448
4y6gF6FTryptophan synthase alpha chain/0.448
1h36R88Squalene--hopene cyclase4.2.1.1290.447
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.447
1kquBR4Phospholipase A2, membrane associated/0.447
1mapKETAspartate aminotransferase, mitochondrial2.6.1.10.447
1upw444Oxysterols receptor LXR-beta/0.447
1y6qTDI5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase3.2.2.90.447
2bxqIMNSerum albumin/0.447
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.447
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.447
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.447
3eksCY9Actin-5C/0.447
3ntgD72Prostaglandin G/H synthase 21.14.99.10.447
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.447
13gsSASGlutathione S-transferase P2.5.1.180.446
1a8t061Metallo-beta-lactamase type 2/0.446
1lwlDSOCamphor 5-monooxygenase1.14.15.10.446
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
20gsCBDGlutathione S-transferase P2.5.1.180.446
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2ozuACOHistone acetyltransferase KAT6A/0.446
3p9tTCLRepressor/0.446
4r20AERCytochrome P450 family 17 polypeptide 2/0.446
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.445
1jnrFADAdenylylsulfate reductase, subunit A (AprA)/0.445
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.445
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.445
3kr6UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
3zeiAWHO-acetylserine sulfhydrylase/0.445
4jqh1MFAlr2278 protein/0.445
4nieNBHNuclear receptor ROR-gamma/0.445
4nqgCZHMitrocomin/0.445
5c4nNAPPrecorrin-6A reductase1.3.1.540.445
5dp2NAPCurF/0.445
5kf2ACOPredicted acetyltransferase/0.445
1efaNPFLactose operon repressor/0.444
1pj7FFODimethylglycine oxidase1.5.3.100.444
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.444
1z71L17Prothrombin3.4.21.50.444
2e94364Geranylgeranyl pyrophosphate synthase/0.444
2ed3SAHDiphthine synthase/0.444
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.444
3dv0TPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.444
3dv0TPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.444
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.444
4b6r3DQ3-dehydroquinate dehydratase4.2.1.100.444
4frkDWDBeta-secretase 13.4.23.460.444
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.444
4k4eK4ETankyrase-12.4.2.300.444
4kwhNAPReductase homolog/0.444
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
1mr9ACOStreptogramin A acetyltransferase2.3.10.443
1odnAPVIsopenicillin N synthase1.21.3.10.443
1pu9COAHAT A1/0.443
1v2hGUNPurine nucleoside phosphorylase2.4.2.10.443
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1ypgUIRProthrombin3.4.21.50.443
2cjfRP43-dehydroquinate dehydratase4.2.1.100.443
2dteNAIGlucose 1-dehydrogenase related protein/0.443
2io6330Wee1-like protein kinase2.7.10.20.443
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.443
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.443
3nxyD2HDihydrofolate reductase1.5.1.30.443
4ax9N5NProthrombin3.4.21.50.443
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.443
4equG6ISerine/threonine-protein kinase 102.7.11.10.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4j7hTRHPCZA361.3/0.443
4jlj1NMDeoxycytidine kinase2.7.1.740.443
4li81XQTankyrase-12.4.2.300.443
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.443
4nv14TGFormyl transferase/0.443
4tyj0LIFibroblast growth factor receptor 42.7.10.10.443
4wbdADPPutative cysteine ligase BshC/0.443
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.442
1kl2FONSerine hydroxymethyltransferase/0.442
1ohkCOPDihydrofolate reductase1.5.1.30.442
1qv1CZHObelin/0.442
1v5z2HCMajor NAD(P)H-flavin oxidoreductase1.6.990.442
1yryMSGPurine nucleoside phosphorylase2.4.2.10.442
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.442
2m3z1HFGag-Pol polyprotein/0.442
3seqNXXGlutamine-dependent NAD(+) synthetase6.3.5.10.442
3u4r08FGenome polyprotein2.7.7.480.442
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.442
4bfpSWYTankyrase-22.4.2.300.442
4bfzZVZPantothenate kinase2.7.1.330.442
4dsbA8SAbscisic acid receptor PYL3/0.442
5k2dZMAAdenosine receptor A2a/0.442
1dgbNDPCatalase1.11.1.60.441
1muuGDXGDP-mannose 6-dehydrogenase1.1.1.1320.441
1nceCB3Thymidylate synthase/0.441
1rszDIHPurine nucleoside phosphorylase2.4.2.10.441
1s1rNAPAldo-keto reductase family 1 member C3/0.441
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1tllFMNNitric oxide synthase, brain1.14.13.390.441
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.441
2d29FADAcyl-CoA dehydrogenase/0.441
2gciMRRProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.441
2og81N8Tyrosine-protein kinase Lck2.7.10.20.441
2xdaJPS3-dehydroquinate dehydratase4.2.1.100.441
3bsc2PDGenome polyprotein2.7.7.480.441
3n5xXFKNitric oxide synthase, brain1.14.13.390.441
4bubADPUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase/0.441
4fam0SZAldo-keto reductase family 1 member C3/0.441
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
5cmx0G6Prothrombin3.4.21.50.441
5d5aCAUBeta-2 adrenergic receptor/0.441
3emlZMAAdenosine receptor A2a/0.441
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.440
1pz1NAPGeneral stress protein 69/0.440
1rf7DHFDihydrofolate reductase1.5.1.30.440
1xddAAYIntegrin alpha-L/0.440
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2bdyUNBProthrombin3.4.21.50.440
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2v59LZKBiotin carboxylase6.3.4.140.440
2yyeAPCSelenide, water dikinase2.7.9.30.440
2zhf49UProthrombin3.4.21.50.440
3ekuCY9Actin-5C/0.440
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
3h59H59Genome polyprotein2.7.7.480.440
3n76CA23-dehydroquinate dehydratase4.2.1.100.440
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
3qwc98PProthrombin3.4.21.50.440
3r7kFDAProbable acyl CoA dehydrogenase/0.440
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.440
4eqsCOACoenzyme A disulfide reductase/0.440
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.440
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.440
4mka2AYGenome polyprotein2.7.7.480.440