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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1zrzBI1Protein kinase C iota type2.7.11.13

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1zrzBI1Protein kinase C iota type2.7.11.131.000
3zh8C58Protein kinase C iota type2.7.11.130.553
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.550
2vd5BI8Myotonin-protein kinase2.7.11.10.548
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.543
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.539
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.536
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.535
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.532
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.529
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.528
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.526
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.524
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.523
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.523
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.522
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.521
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.521
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.520
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.520
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.518
2hog710Serine/threonine-protein kinase Chk12.7.11.10.513
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.513
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.510
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.510
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.508
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.507
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.506
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.505
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.504
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.504
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.504
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.503
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.503
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.503
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.503
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.502
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.502
4gk3L87Ephrin type-A receptor 32.7.10.10.502
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.502
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.501
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.501
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.501
3zewSTUEphrin type-B receptor 42.7.10.10.500
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.499
3a62STURibosomal protein S6 kinase beta-12.7.11.10.499
3ibqATPPyridoxal kinase/0.499
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.499
4gk2L66Ephrin type-A receptor 32.7.10.10.499
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.497
3il1B5DGlutamate receptor 2/0.497
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.497
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.496
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.496
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.496
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.495
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.494
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.494
1bwsNDPGDP-L-fucose synthase/0.493
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.493
1fxsNAPGDP-L-fucose synthase/0.492
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.492
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.491
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.491
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.491
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.491
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.491
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.490
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.490
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.490
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.490
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.490
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.489
1pjkANPCasein kinase II subunit alpha2.7.11.10.488
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.488
4c62XWWTyrosine-protein kinase JAK2/0.488
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.487
3vjoANPEpidermal growth factor receptor2.7.10.10.487
4fv9E71Mitogen-activated protein kinase 12.7.11.240.487
2yn8STUEphrin type-B receptor 42.7.10.10.486
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.486
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.486
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.485
2i40BLZCyclin-dependent kinase 22.7.11.220.485
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.485
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.485
1bsvNDPGDP-L-fucose synthase/0.484
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.484
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.483
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.483
3pe2E1BCasein kinase II subunit alpha2.7.11.10.483
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.482
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.481
1nzdUPGDNA beta-glucosyltransferase/0.481
2acxANPG protein-coupled receptor kinase 62.7.11.160.481
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.481
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.481
4fv6E57Mitogen-activated protein kinase 12.7.11.240.481
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.481
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.480
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.480
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.480
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.479
2cchATPCyclin-dependent kinase 22.7.11.220.479
2qo9ANPEphrin type-A receptor 32.7.10.10.479
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.479
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.479
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.478
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.478
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.478
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.478
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.478
4riyADPEpidermal growth factor receptor2.7.10.10.478
1pkdUCNCyclin-dependent kinase 22.7.11.220.477
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.477
2izuP01Casein kinase I isoform gamma-32.7.11.10.476
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.476
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.476
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.476
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.476
4bcmT7ZCyclin-dependent kinase 22.7.11.220.476
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.476
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.475
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.475
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.474
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.474
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.474
1r2jFADFkbI/0.473
1tvoFRZMitogen-activated protein kinase 12.7.11.240.473
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.473
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.473
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.473
4ure1PSCyclohexanol dehydrogenase/0.473
2ejvNADL-threonine 3-dehydrogenase/0.472
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.472
3c4xATPRhodopsin kinase/0.472
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.472
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.472
4qnaX11Serine/threonine-protein kinase 242.7.11.10.472
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.471
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.471
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.471
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.471
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.471
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.471
2x9dITCTetracycline repressor protein class D/0.471
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.471
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.471
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.471
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.470
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.470
2zbaZBATrichothecene 3-O-acetyltransferase/0.470
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.470
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.470
4g7gVFVLanosterol 14-alpha-demethylase/0.470
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.470
4y93746Tyrosine-protein kinase/0.470
2xvdAS6Ephrin type-B receptor 42.7.10.10.469
3c15FOKAdenylate cyclase type 2/0.469
3c15FOKAdenylate cyclase type 5/0.469
3wmxNADNAD dependent epimerase/dehydratase/0.469
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
4aguD15Cyclin-dependent kinase-like 1/0.469
1xddAAYIntegrin alpha-L/0.468
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
2vwx7X4Ephrin type-B receptor 42.7.10.10.468
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.468
4yaoFMNNADPH--cytochrome P450 reductase/0.468
1cjtFOKAdenylate cyclase type 2/0.467
1cjtFOKAdenylate cyclase type 5/0.467
2eb3ANPEpidermal growth factor receptor2.7.10.10.467
4gl4NAIAlcohol dehydrogenase class-3/0.467
1hdgNADGlyceraldehyde-3-phosphate dehydrogenase/0.466
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.466
2ittAEEEpidermal growth factor receptor2.7.10.10.466
2vx07X7Ephrin type-B receptor 42.7.10.10.466
3at4CCKCasein kinase II subunit alpha2.7.11.10.466
3d8bADPFidgetin-like protein 13.6.40.466
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.466
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.466
3tucFPWTyrosine-protein kinase SYK2.7.10.20.466
1tehNADAlcohol dehydrogenase class-31.1.1.10.465
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.465
3f03FMNPentaerythritol tetranitrate reductase/0.465
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.465
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.465
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.464
3ac1KZITyrosine-protein kinase Lck2.7.10.20.464
1culFOKAdenylate cyclase type 2/0.463
1culFOKAdenylate cyclase type 5/0.463
1e3eNAIAlcohol dehydrogenase 41.1.1.10.463
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.463
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.463
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.463
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.463
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.463
4i231C9Epidermal growth factor receptor2.7.10.10.463
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.462
4ji91M3Tyrosine-protein kinase JAK2/0.462
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.462
5e8wSTUTGF-beta receptor type-12.7.11.300.462
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.461
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
2qblCAMCamphor 5-monooxygenase1.14.15.10.461
3bqr4RBDeath-associated protein kinase 3/0.461
3frqERYErythromycin resistance repressor protein/0.461
3sheI85MAP kinase-activated protein kinase 32.7.11.10.461
3t8oATPRhodopsin kinase/0.461
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.461
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.461
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.461
4iva1J5Tyrosine-protein kinase JAK2/0.461
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.461
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.460
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.460
2izt23DCasein kinase I isoform gamma-32.7.11.10.460
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.460
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.460
2xyuQ9GEphrin type-A receptor 42.7.10.10.460
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.460
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.459
1vyrFMNPentaerythritol tetranitrate reductase/0.459
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.459
3wowANPCasein kinase II subunit alpha2.7.11.10.459
4c58824Cyclin-G-associated kinase2.7.11.10.459
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.459
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.459
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.459
4jia1K3Tyrosine-protein kinase JAK2/0.459
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.459
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.459
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.459
5a3cNADSIR2 family protein/0.459
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.458
2huvSAHDiphthine synthase/0.458
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.458
2qoqANPEphrin type-A receptor 32.7.10.10.458
3hx4ANPCalmodulin-domain protein kinase 1/0.458
3s1dZIRCytokinin dehydrogenase 11.5.99.120.458
4a8v2ANMajor pollen allergen Bet v 1-J/0.458
4a99FADTetX family tetracycline inactivation enzyme/0.458
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.458
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.458
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.457
2in6839Wee1-like protein kinase2.7.10.20.457
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.457
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.457
2uxpCLMHTH-type transcriptional regulator TtgR/0.457
3gw9VNILanosterol 14-alpha-demethylase/0.457
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
4dpuAGSMevalonate diphosphate decarboxylase/0.457
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.456
1jolFFODihydrofolate reductase1.5.1.30.456
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.456
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.456
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.456
3zuyTCHTransporter/0.456
1bygSTUTyrosine-protein kinase CSK/0.455
1jpaANPEphrin type-B receptor 22.7.10.10.455
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.455
2itnANPEpidermal growth factor receptor2.7.10.10.455
2j0m4STFocal adhesion kinase 12.7.10.20.455
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.455
3d84NDPDihydrofolate reductase1.5.1.30.455
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.455
4j97ACPFibroblast growth factor receptor 2/0.455
5cshATPCasein kinase II subunit alpha2.7.11.10.455
5jscFADPutative acyl-CoA dehydrogenase/0.455
1e9hINRCyclin-dependent kinase 22.7.11.220.454
1h63FMNPentaerythritol tetranitrate reductase/0.454
1j39UPGDNA beta-glucosyltransferase/0.454
1nzfUPGDNA beta-glucosyltransferase/0.454
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.454
2itvANPEpidermal growth factor receptor2.7.10.10.454
2rkvZBATrichothecene 3-O-acetyltransferase/0.454
2vu3LZECyclin-dependent kinase 22.7.11.220.454
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.454
3fklFKLMitogen-activated protein kinase 14/0.454
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.454
3i60E86Mitogen-activated protein kinase 12.7.11.240.454
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.454
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.454
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.454
4ez50RSCyclin-dependent kinase 62.7.11.220.454
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.454
4gmy0X5Tyrosine-protein kinase JAK2/0.454
4ivb1J5Tyrosine-protein kinase JAK1/0.454
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.454
4qo9627Serine/threonine-protein kinase 242.7.11.10.454
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.453
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.453
2wipP49Cyclin-dependent kinase 22.7.11.220.453
2y6o1N1Ephrin type-A receptor 42.7.10.10.453
3jpuTY4Transcriptional activator protein LasR/0.453
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.453
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.453
3u9eCOALmo1369 protein/0.453
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.453
4wboANWRhodopsin kinase/0.453
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1finATPCyclin-dependent kinase 22.7.11.220.452
1ipeNDPTropinone reductase 21.1.1.2360.452
1k6tXN1Gag-Pol polyprotein3.4.23.160.452
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
2ckeIQUDeath-associated protein kinase 2/0.452
2d4vNADIsocitrate dehydrogenase [NADP]/0.452
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.452
3ctyFADProbable thioredoxin reductase/0.452
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.452
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.452
4g3jVNTLanosterol 14-alpha-demethylase/0.452
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
1f4fTP3Thymidylate synthase/0.451
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
2mwgFMNBlue-light photoreceptor/0.451
2znq401Peroxisome proliferator-activated receptor delta/0.451
3drcMTXDihydrofolate reductase1.5.1.30.451
3gwfFADCyclohexanone monooxygenase/0.451
3r0tFU9Casein kinase II subunit alpha2.7.11.10.451
3rak03ZCyclin-dependent kinase 22.7.11.220.451
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.451
4e730NRMitogen-activated protein kinase 82.7.11.240.451
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.451
4i22IREEpidermal growth factor receptor2.7.10.10.451
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.451
1eupASD6-deoxyerythronolide B hydroxylase/0.450
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.450
1u54ACPActivated CDC42 kinase 1/0.450
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.450
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.450
2wxvWXVCyclin-dependent kinase 22.7.11.220.450
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.450
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.450
3p67FMNPentaerythritol tetranitrate reductase/0.450
3zdu38RCyclin-dependent kinase-like 32.7.11.220.450
5a3bAPRSIR2 family protein/0.450
2po7CHDFerrochelatase, mitochondrial4.99.1.10.449
3bi6396Wee1-like protein kinase2.7.10.20.449
3d7kD7KBenzaldehyde lyase/0.449
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.449
3q5kD1UHeat shock protein 83-1/0.449
4dgo0JWCasein kinase II subunit alpha2.7.11.10.449
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.449
4gk4L90Ephrin type-A receptor 32.7.10.10.449
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.449
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1y0s331Peroxisome proliferator-activated receptor delta/0.448
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.448
2nq8ZIDEnoyl-ACP reductase/0.448
2q7vFADThioredoxin reductase/0.448
2xa4AZ5Tyrosine-protein kinase JAK2/0.448
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.448
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.448
3k981RCHeat shock protein HSP 90-alpha/0.448
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
3p62FMNPentaerythritol tetranitrate reductase/0.448
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.448
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.448
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.448
4grb0XGCasein kinase II subunit alpha2.7.11.10.448
5e92ANPTGF-beta receptor type-22.7.11.300.448
1drhNAPDihydrofolate reductase1.5.1.30.447
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.447
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.447
2fvdLIACyclin-dependent kinase 22.7.11.220.447
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.447
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.447
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.447
2vnaNAPProstaglandin reductase 21.3.1.480.447
2x9fX9FEphrin type-B receptor 42.7.10.10.447
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.447
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4b99R4LMitogen-activated protein kinase 72.7.11.240.447
4dt9GMPAPH(2'')-Id/0.447
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.447
4g2fC07Ephrin type-A receptor 32.7.10.10.447
4hvh19RTyrosine-protein kinase JAK32.7.10.20.447
4ix5ANPUncharacterized protein/0.447
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.447
4o701QKBromodomain-containing protein 4/0.447
4q71FADBifunctional protein PutA/0.447
4qms1N1Serine/threonine-protein kinase 242.7.11.10.447
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
5cvhADPCasein kinase II subunit alpha2.7.11.10.447
5dg3U21Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.447
1g5sI17Cyclin-dependent kinase 22.7.11.220.446
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.446
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.446
2izrBRKCasein kinase I isoform gamma-32.7.11.10.446
2lbaCHOFatty acid binding protein 6/0.446
2uxoTACHTH-type transcriptional regulator TtgR/0.446
2vwz7X6Ephrin type-B receptor 42.7.10.10.446
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.446
3igoANPCalmodulin-domain protein kinase 1, putative/0.446
3ih0ANPUncharacterized sugar kinase PH14592.7.10.446
3tqhNDPQuinone oxidoreductase/0.446
3zuxTCHTransporter/0.446
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.446
4erwSTUCyclin-dependent kinase 22.7.11.220.446
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.446
4qmzB49Serine/threonine-protein kinase 242.7.11.10.446
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.445
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2wihP48Cyclin-dependent kinase 22.7.11.220.445
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.445
3a8wATPProtein kinase C iota type2.7.11.130.445
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.445
3c4wATPRhodopsin kinase/0.445
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.445
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.445
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3w3oROEDihydroorotate dehydrogenase (fumarate)1.3.98.10.445
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.445
4eok4SPCyclin-dependent kinase 22.7.11.220.445
4fgrADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.445
4lcg1WMUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.445
4tmcFMNOld yellow enzyme/0.445
1g1aNADdTDP-glucose 4,6-dehydratase/0.444
1kc1NDPdTDP-4-dehydrorhamnose reductase1.1.1.1330.444
1rfvADPPyridoxal kinase2.7.1.350.444
1vrwNAIEnoyl-ACP reductase/0.444
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.444
2itpAEEEpidermal growth factor receptor2.7.10.10.444
2rh9IGPTryptophan synthase alpha chain/0.444
2wedPP6Penicillopepsin-13.4.23.200.444
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.444
3a1nNADNDP-sugar epimerase/0.444
3hekBD0Heat shock protein HSP 90-alpha/0.444
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.444
3lu8IQXSerum albumin/0.444
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.444
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.444
4bcqTJFCyclin-dependent kinase 22.7.11.220.444
4dbzNDPPutative ketoacyl reductase1.3.10.444
4dtaADNAPH(2'')-Id/0.444
4e5yNDPGDP-L-fucose synthase1.1.1.2710.444
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.444
4g74FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.444
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
4jr7GNPCasein kinase II subunit alpha2.7.11.10.444
1ia3TQ5Dihydrofolate reductase1.5.1.30.443
1mp0NADAlcohol dehydrogenase class-31.1.1.10.443
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2d29FADAcyl-CoA dehydrogenase/0.443
2ejzSAHDiphthine synthase/0.443
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.443
2oji33AMitogen-activated protein kinase 12.7.11.240.443
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.443
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.443
3c1y2BADNA integrity scanning protein DisA/0.443
3my5RFZCyclin-dependent kinase 22.7.11.220.443
3r9uFADThioredoxin reductase/0.443
3tnwF18Cyclin-dependent kinase 22.7.11.220.443
3w551FMMitogen-activated protein kinase 12.7.11.240.443
4b7sQLECytochrome P450 monooxygenase PikC/0.443
4fuxE75Mitogen-activated protein kinase 12.7.11.240.443
4fv8E63Mitogen-activated protein kinase 12.7.11.240.443
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.443
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.443
4ly91YYGlucokinase regulatory protein/0.443
1dz6CAMCamphor 5-monooxygenase1.14.15.10.442
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.442
1uy7PU4Heat shock protein HSP 90-alpha/0.442
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.442
2abbFMNPentaerythritol tetranitrate reductase/0.442
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.442
2ejjSAHDiphthine synthase/0.442
2ituITQEpidermal growth factor receptor2.7.10.10.442
2qboCAMCamphor 5-monooxygenase1.14.15.10.442
2uxuNARHTH-type transcriptional regulator TtgR/0.442
2vkeTACTetracycline repressor protein class D/0.442
2vn0TDZCytochrome P450 2C8/0.442
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.442
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.442
3gobHXXDdmC/0.442
3l63CAMCamphor 5-monooxygenase1.14.15.10.442
3lpbNVBTyrosine-protein kinase JAK2/0.442
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.442
3w4yFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.442
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.442
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4fob0USALK tyrosine kinase receptor2.7.10.10.442
4l8u9AZSerum albumin/0.442
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.442
5cvfATPCasein kinase II subunit alpha2.7.11.10.442
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.441
2c475IDCasein kinase I isoform gamma-2/0.441
2fypRDEEndoplasmin/0.441
2huqSAHDiphthine synthase/0.441
2igoFADPyranose 2-oxidase/0.441
2itwITQEpidermal growth factor receptor2.7.10.10.441
2vwqNAPGlucose 1-dehydrogenase/0.441
2wi72KLHeat shock protein HSP 90-alpha/0.441
2wotZZGTGF-beta receptor type-12.7.11.300.441
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.441
3gu7ADPDeath-associated protein kinase 12.7.11.10.441
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.441
3mb601ICasein kinase II subunit alpha2.7.11.10.441
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.441
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.441
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.441
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.441
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.441
4kugNAD3-hydroxybutyryl-CoA dehydrogenase/0.441
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.441
4wkqIREEpidermal growth factor receptor2.7.10.10.441
1dyjDDFDihydrofolate reductase1.5.1.30.440
1e7qNAPGDP-L-fucose synthase/0.440
1eh4IC1Casein kinase I homolog 12.7.11.10.440
1h74ADPHomoserine kinase2.7.1.390.440
1ia4TQ6Dihydrofolate reductase1.5.1.30.440
1ma0NADAlcohol dehydrogenase class-31.1.1.10.440
1qoqIGPTryptophan synthase alpha chain/0.440
1t86CAMCamphor 5-monooxygenase1.14.15.10.440
1vyw292Cyclin-dependent kinase 22.7.11.220.440
2balPQAMitogen-activated protein kinase 14/0.440
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2j3iNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.440
2owb626Serine/threonine-protein kinase PLK12.7.11.210.440
2pauD5M5'-deoxynucleotidase YfbR/0.440
2x0rNADMalate dehydrogenase/0.440
2x1nX1NCyclin-dependent kinase 22.7.11.220.440
3b895GP16S rRNA methylase/0.440
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.440
3cf0ADPTransitional endoplasmic reticulum ATPase3.6.4.60.440
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.440
3dfrMTXDihydrofolate reductase1.5.1.30.440
3dogNNNCyclin-dependent kinase 22.7.11.220.440
3fcjFADNitroalkane oxidase1.7.3.10.440
3junAJDPhenazine biosynthesis protein A/B/0.440
3k4nFADPyranose 2-oxidase/0.440
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.440
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.440
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.440
3syiFADSulfide-quinone reductase/0.440
4fx360KCyclin-dependent kinase 22.7.11.220.440
4ryvZEAProtein LlR18A/0.440
4xwtU5PRibonuclease J/0.440
5cu6ATPCasein kinase II subunit alpha2.7.11.10.440