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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1rx6DDFDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1rx6DDFDihydrofolate reductase1.5.1.31.000
1rx5DDFDihydrofolate reductase1.5.1.30.740
1rx7FOLDihydrofolate reductase1.5.1.30.718
1rx4DDFDihydrofolate reductase1.5.1.30.662
1rc4DDFDihydrofolate reductase1.5.1.30.616
4ej1FOLDihydrofolate reductase1.5.1.30.613
1rf7DHFDihydrofolate reductase1.5.1.30.611
1rx8FOLDihydrofolate reductase1.5.1.30.604
1re7FOLDihydrofolate reductase1.5.1.30.591
3och2MXDihydrofolate reductase1.5.1.30.585
1jomFFODihydrofolate reductase1.5.1.30.584
4i13FOLDihydrofolate reductase1.5.1.30.579
4dfrMTXDihydrofolate reductase1.5.1.30.573
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.570
4x5jFOLDihydrofolate reductase1.5.1.30.568
1dyiFOLDihydrofolate reductase1.5.1.30.564
1jolFFODihydrofolate reductase1.5.1.30.564
4x5hFOLDihydrofolate reductase1.5.1.30.564
5cccDDFDihydrofolate reductase1.5.1.30.564
1tdrMTXDihydrofolate reductase1.5.1.30.561
3eigMTXDihydrofolate reductase1.5.1.30.561
1dyjDDFDihydrofolate reductase1.5.1.30.558
4i1nFOLDihydrofolate reductase1.5.1.30.558
5cc9DDFDihydrofolate reductase1.5.1.30.556
4x5iFOLDihydrofolate reductase1.5.1.30.554
1ra8FOLDihydrofolate reductase1.5.1.30.552
2d0kFOLDihydrofolate reductase1.5.1.30.548
1draMTXDihydrofolate reductase1.5.1.30.545
1ra3MTXDihydrofolate reductase1.5.1.30.545
3s7a684Dihydrofolate reductase1.5.1.30.542
4cd2FOLDihydrofolate reductase1.5.1.30.542
1bzfTMQDihydrofolate reductase1.5.1.30.541
1ddrMTXDihydrofolate reductase1.5.1.30.541
1mvsDTMDihydrofolate reductase1.5.1.30.539
1dyhDZFDihydrofolate reductase1.5.1.30.538
5hi6MTXDihydrofolate reductase/0.537
3s3vTOPDihydrofolate reductase1.5.1.30.536
1ddsMTXDihydrofolate reductase1.5.1.30.535
2drcMTXDihydrofolate reductase1.5.1.30.535
3drcMTXDihydrofolate reductase1.5.1.30.535
1rb2FOLDihydrofolate reductase1.5.1.30.533
3oafOAGDihydrofolate reductase1.5.1.30.532
4g95OAGDihydrofolate reductase1.5.1.30.532
1ia4TQ6Dihydrofolate reductase1.5.1.30.529
1rb3MTXDihydrofolate reductase1.5.1.30.526
1dr3HBIDihydrofolate reductase1.5.1.30.524
2qk8MTXDihydrofolate reductase/0.524
1disBDMDihydrofolate reductase1.5.1.30.523
1ia3TQ5Dihydrofolate reductase1.5.1.30.523
4qi9MTXDihydrofolate reductase/0.522
1dhjMTXDihydrofolate reductase1.5.1.30.521
2w9hTOPDihydrofolate reductase1.5.1.30.518
1diuBDMDihydrofolate reductase1.5.1.30.514
3n0hTOPDihydrofolate reductase1.5.1.30.512
1s3vTQDDihydrofolate reductase1.5.1.30.510
4kne1CYDihydrofolate reductase1.5.1.30.509
1fm4DXCMajor pollen allergen Bet v 1-L/0.508
2uxoTACHTH-type transcriptional regulator TtgR/0.508
1dhfFOLDihydrofolate reductase1.5.1.30.506
1s3uTQDDihydrofolate reductase1.5.1.30.504
4elb34SDihydrofolate reductase/0.499
1drbMTXDihydrofolate reductase1.5.1.30.498
4elb34RDihydrofolate reductase/0.495
4ele31IDihydrofolate reductase/0.495
4lb2DM5Serum albumin/0.494
1dhiMTXDihydrofolate reductase1.5.1.30.493
1pd9CO4Dihydrofolate reductase1.5.1.30.491
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.491
2fr0NDP6-deoxyerythronolide-B synthase EryA1, modules 1 and 2/0.490
3jwcEKBDihydrofolate reductase/0.487
1o9bNAIQuinate/shikimate dehydrogenase/0.486
4boeCLRJapanin/0.486
4jlj1NMDeoxycytidine kinase2.7.1.740.486
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.485
3atzFMNProstaglandin F2a synthase/0.485
2hb7O1CVitamin D3 receptor/0.484
2hk9NAPShikimate dehydrogenase (NADP(+))/0.483
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.483
4iteTEYVitamin D3 receptor/0.483
1drfFOLDihydrofolate reductase1.5.1.30.482
1rd7FOLDihydrofolate reductase1.5.1.30.482
2hasC3OVitamin D3 receptor/0.482
1dz8CAMCamphor 5-monooxygenase1.14.15.10.481
3fl8RARDihydrofolate reductase/0.481
3wsbRWZFarnesyltransferase, putative/0.481
1u71MXADihydrofolate reductase1.5.1.30.480
3c3xNAPEugenol synthase 11.1.1.3180.480
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.480
1bwsNDPGDP-L-fucose synthase/0.479
1kl2FONSerine hydroxymethyltransferase/0.479
1rg7MTXDihydrofolate reductase1.5.1.30.479
2dhfDZFDihydrofolate reductase1.5.1.30.479
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.479
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.479
4x5gFOLDihydrofolate reductase1.5.1.30.479
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.478
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.478
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.478
4a81DXCMajor pollen allergen Bet v 1-A/0.478
4a862ANMajor pollen allergen Bet v 1-A/0.478
4elh53IDihydrofolate reductase/0.478
3p67FMNPentaerythritol tetranitrate reductase/0.477
1nq7ARLNuclear receptor ROR-beta/0.476
3nr4PYVAbscisic acid receptor PYL2/0.476
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.476
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
3ixp834Ecdysone receptor/0.475
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.475
4jbtASDCytochrome P450 monooxygenase/0.475
4xe606UDihydrofolate reductase1.5.1.30.475
1m9jCLWNitric oxide synthase, endothelial1.14.13.390.474
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.474
2ij7TPFMycocyclosin synthase1.14.21.90.474
3qm4PN0Cytochrome P450 2D6/0.474
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.474
4a84DXCMajor pollen allergen Bet v 1-A/0.474
4j6bPLOCytochrome P450 monooxygenase/0.474
1blzACVIsopenicillin N synthase1.21.3.10.473
1kkq471Peroxisome proliferator-activated receptor alpha/0.473
2abbFMNPentaerythritol tetranitrate reductase/0.473
3tdaPN0Cytochrome P450 2D6/0.473
1r2jFADFkbI/0.472
1yw2PGJMitogen-activated protein kinase 14/0.472
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.472
2uxpCLMHTH-type transcriptional regulator TtgR/0.472
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.472
3vt65YIVitamin D3 receptor/0.472
4a8v2ANMajor pollen allergen Bet v 1-J/0.472
4dijBLFE3 ubiquitin-protein ligase Mdm26.3.20.472
4e2dFMNDehydrogenase/0.472
4elf35IDihydrofolate reductase/0.472
1e26GPBDihydrofolate reductase1.5.1.30.471
1eioGCHGastrotropin/0.471
2zl9VDAVitamin D3 receptor/0.471
3p74FMNPentaerythritol tetranitrate reductase/0.471
1hvyD16Thymidylate synthase2.1.1.450.470
1vyrFMNPentaerythritol tetranitrate reductase/0.470
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.470
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.470
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.470
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.470
4ryvZEAProtein LlR18A/0.470
4xwtU5PRibonuclease J/0.470
1uydPU8Heat shock protein HSP 90-alpha/0.469
2hb8MVDVitamin D3 receptor/0.469
2idkC2FGlycine N-methyltransferase2.1.1.200.469
2vn0TDZCytochrome P450 2C8/0.469
3p9tTCLRepressor/0.469
3o6o94MHeat shock protein 83/0.468
3vf60H6Glucokinase2.7.1.20.468
4elg52JDihydrofolate reductase/0.468
4lsjLSJGlucocorticoid receptor/0.468
4uymVOR14-alpha sterol demethylase Cyp51B/0.468
4x5fFOLDihydrofolate reductase1.5.1.30.468
1aoeGW3Dihydrofolate reductase1.5.1.30.467
1qzfFOLBifunctional dihydrofolate reductase-thymidylate synthase/0.467
1tvrTB9Gag-Pol polyprotein2.7.7.490.467
1xddAAYIntegrin alpha-L/0.467
2xvq9DSSerum albumin/0.467
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.467
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.467
4e2bFMNDehydrogenase/0.467
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.467
1vi2NADQuinate/shikimate dehydrogenase/0.466
2d29FADAcyl-CoA dehydrogenase/0.466
2zb45OPProstaglandin reductase 21.3.1.480.466
3h3t16HCollagen type IV alpha-3-binding protein/0.466
3oimVZ5Carbonic anhydrase 24.2.1.10.466
4jlk1NODeoxycytidine kinase2.7.1.740.466
1dg5TOPDihydrofolate reductase1.5.1.30.465
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.465
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.465
4a87NARMajor pollen allergen Bet v 1-A/0.465
4bquCLRJapanin/0.465
4g1z0VPVitamin D3 receptor A/0.465
4hnc0UTMandelate racemase/0.465
1h50FMNPentaerythritol tetranitrate reductase/0.464
3tm5SFGUncharacterized protein/0.464
4a802ANMajor pollen allergen Bet v 1-A/0.464
4gevCB3Thymidylate synthase/0.464
4gu610NFocal adhesion kinase 12.7.10.20.464
7stdCRPScytalone dehydratase4.2.1.940.464
1fmjRTLRetinol dehydratase/0.463
1mvtDTMDihydrofolate reductase1.5.1.30.463
1txiTX5Vitamin D3 receptor/0.463
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.463
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.463
2po7CHDFerrochelatase, mitochondrial4.99.1.10.463
3csdEMOPutative ketoacyl reductase1.3.10.463
3f03FMNPentaerythritol tetranitrate reductase/0.463
3fl9TOPDihydrofolate reductase/0.463
3g70A5TRenin3.4.23.150.463
3g72A6TRenin3.4.23.150.463
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.463
4x28FDAAcyl-CoA dehydrogenase FadE26/0.463
4x28FDAAcyl-CoA dehydrogenase FadE27/0.463
1sh9RITGag-Pol polyprotein3.4.23.160.462
2aclREARetinoic acid receptor RXR-alpha/0.462
2hm9TRRDihydrofolate reductase1.5.1.30.462
2ywvADPPhosphoribosylaminoimidazole-succinocarboxamide synthase/0.462
3adaNADSubunit alpha of sarocosine oxidase/0.462
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.462
3mnrSD1Heat shock protein HSP 90-alpha/0.462
4cdmFO1Deoxyribodipyrimidine photolyase/0.462
4klaCHDFerrochelatase, mitochondrial4.99.1.10.462
4nh82LCHeat shock protein HSP 90-alpha/0.462
4yaw2AMNADPH--cytochrome P450 reductase/0.462
4zlaBESCytosol aminopeptidase3.4.11.10.462
1m79MQ1Dihydrofolate reductase1.5.1.30.461
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.461
2g263LGRenin3.4.23.150.461
3a783EVVitamin D3 receptor/0.461
3i59N6SCRP-like cAMP-activated global transcriptional regulator/0.461
3kpzZNEVitamin D3 receptor/0.461
3t3r9PLCytochrome P450 2A61.14.130.461
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.461
4bfvZVVPantothenate kinase2.7.1.330.461
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.461
2a9y26AAdenosine kinase2.7.1.200.460
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
2fszOHTEstrogen receptor beta/0.460
2g97DGBNicotinamide phosphoribosyltransferase2.4.2.120.460
2rh9IGPTryptophan synthase alpha chain/0.460
3mdvCL6Cholesterol 24-hydroxylase/0.460
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.460
4gmgNAPYersiniabactin biosynthetic protein YbtU/0.460
1ml6GBXGlutathione S-transferase A22.5.1.180.459
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2cd2FOLDihydrofolate reductase1.5.1.30.459
2uxuNARHTH-type transcriptional regulator TtgR/0.459
3hub469Mitogen-activated protein kinase 14/0.459
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.459
3l6jZ90Alr2278 protein/0.459
3lanKBTGag-Pol polyprotein2.7.7.490.459
3p99LNPLanosterol 14-alpha-demethylase/0.459
3qlrQLRDihydrofolate reductase1.5.1.30.459
3qly55VUncharacterized protein/0.459
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.459
4g2gTDHMycocyclosin synthase1.14.21.90.459
4ixeIXEDihydrofolate reductase1.5.1.30.459
4j6cSTRCytochrome P450 monooxygenase/0.459
5bp9SAHPutative methyltransferase protein/0.459
1cd2FOLDihydrofolate reductase1.5.1.30.458
1hfqMOTDihydrofolate reductase1.5.1.30.458
1m13HYFNuclear receptor subfamily 1 group I member 2/0.458
1tojHCIAspartate aminotransferase2.6.1.10.458
1upw444Oxysterols receptor LXR-beta/0.458
1z6tADPApoptotic protease-activating factor 1/0.458
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
2hamC33Vitamin D3 receptor/0.458
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.458
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.458
2y37A54Nitric oxide synthase, inducible1.14.13.390.458
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.458
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.458
3zeiAWHO-acetylserine sulfhydrylase/0.458
4g3jVNTLanosterol 14-alpha-demethylase/0.458
4hy6FJ1Heat shock protein HSP 90-alpha/0.458
4x2qNADRetinal dehydrogenase 21.2.1.360.458
1d2sDHTSex hormone-binding globulin/0.457
1errRALEstrogen receptor/0.457
1rd4L08Integrin alpha-L/0.457
1uyePU9Heat shock protein HSP 90-alpha/0.457
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.457
2hcdBIVVitamin D3 receptor A/0.457
2puiADPMethylthioribose kinase2.7.1.1000.457
3bk2U5PRibonuclease J/0.457
3oom507Activin receptor type-12.7.11.300.457
3p62FMNPentaerythritol tetranitrate reductase/0.457
3vt45YIVitamin D3 receptor/0.457
4b8mVX6Aurora kinase B-A2.7.11.10.457
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.457
1ysx4EBSerum albumin/0.456
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
2jfaRALEstrogen receptor/0.456
2vbdV10Isopenicillin N synthase1.21.3.10.456
3dds26BGlycogen phosphorylase, liver form2.4.1.10.456
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.456
3fwjCAMCamphor 5-monooxygenase1.14.15.10.456
4h9753SDihydrofolate reductase1.5.1.30.456
4ocvANPAminoglycoside phosphotransferase/0.456
4p6wMOFGlucocorticoid receptor/0.456
4r21STRCytochrome P450 family 17 polypeptide 2/0.456
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.455
1obnASVIsopenicillin N synthase1.21.3.10.455
2apgFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.455
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.455
2j9lATPH(+)/Cl(-) exchange transporter 5/0.455
2ykiYKIHeat shock protein HSP 90-alpha/0.455
3ex8AIFRiboflavin biosynthesis protein RibD1.1.1.1930.455
3w0aDS5Vitamin D3 receptor/0.455
4b4gKKTGlucose-1-phosphate thymidylyltransferase/0.455
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.455
4o7uTHFThymidylate synthase/0.455
4xoqF42Coenzyme F420:L-glutamate ligase/0.455
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
1np7FADCryptochrome DASH/0.454
1tlcF89Thymidylate synthase/0.454
1zprCB3Thymidylate synthase/0.454
2cppCAMCamphor 5-monooxygenase1.14.15.10.454
2fzjDH3Dihydrofolate reductase1.5.1.30.454
2iyaZIOOleandomycin glycosyltransferase/0.454
2izsBRQCasein kinase I isoform gamma-32.7.11.10.454
2j9gANPBiotin carboxylase6.3.4.140.454
2lbaCHOFatty acid binding protein 6/0.454
3eej53RUncharacterized protein/0.454
3gwfNAPCyclohexanone monooxygenase/0.454
3qls55VDihydrofolate reductase1.5.1.30.454
4b5bBBEGlucose-1-phosphate thymidylyltransferase/0.454
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.454
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
4ea2RWZDehydrosqualene synthase/0.454
4eji0QACytochrome P450 2A131.14.14.10.454
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4g1y0VOVitamin D3 receptor A/0.454
4g2h0VQVitamin D3 receptor A/0.454
4kbyC2EStimulator of interferon genes protein/0.454
5iu86DZAdenosine receptor A2a/0.454
1aiqCB3Thymidylate synthase/0.453
1dggNDPCatalase1.11.1.60.453
1l2jETCEstrogen receptor beta/0.453
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.453
1rf9DBRCamphor 5-monooxygenase1.14.15.10.453
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.453
3eem53VUncharacterized protein/0.453
3pe6ZYHMonoglyceride lipase/0.453
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.453
3w5tLHPVitamin D3 receptor/0.453
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.453
4g1d0VKVitamin D3 receptor A/0.453
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
4r20AERCytochrome P450 family 17 polypeptide 2/0.453
5iua6DXAdenosine receptor A2a/0.453
1kfbIGPTryptophan synthase alpha chain/0.452
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1tw2ERTCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.452
1uyfPU1Heat shock protein HSP 90-alpha/0.452
1x8lOXRRetinol dehydratase/0.452
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.452
3btjDEQHTH-type transcriptional regulator QacR/0.452
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3hz5Z64Heat shock protein HSP 90-alpha/0.452
3jwm5WBDihydrofolate reductase/0.452
3new3NEMitogen-activated protein kinase 14/0.452
3pl8FADPyranose 2-oxidase/0.452
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.452
4g3rCAMCamphor 5-monooxygenase1.14.15.10.452
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.452
4i8vBHFCytochrome P450 1A11.14.14.10.452
4ia3BIVVitamin D3 receptor A/0.452
4iae1DXAlr2278 protein/0.452
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.452
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1fmlRTLRetinol dehydratase/0.451
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.451
1uzwCDHIsopenicillin N synthase1.21.3.10.451
2g226IGRenin3.4.23.150.451
2gv8NDPThiol-specific monooxygenase1.14.130.451
2rhrEMOPutative ketoacyl reductase1.3.10.451
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.451
3cseN22Uncharacterized protein/0.451
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.451
3nj0PYVAbscisic acid receptor PYL2/0.451
3tm4SAMUncharacterized protein/0.451
3w0c6DSVitamin D3 receptor/0.451
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.451
4bfuZVUPantothenate kinase2.7.1.330.451
4bfxZVXPantothenate kinase2.7.1.330.451
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4fhh0U3Vitamin D3 receptor A/0.451
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.451
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.451
1dghNDPCatalase1.11.1.60.450
1rkhVD2Vitamin D3 receptor/0.450
1toiHCIAspartate aminotransferase2.6.1.10.450
1xuoLA1Integrin alpha-L/0.450
1y4sADPChaperone protein HtpG/0.450
2a94AP0L-lactate dehydrogenase1.1.1.270.450
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.450
2c9dPHR6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2ftoCB3Thymidylate synthase/0.450
2oapANPType II secretion system protein (GspE-2)/0.450
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.450
2q9fC3SCholesterol 24-hydroxylase/0.450
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.450
2zaxCAMCamphor 5-monooxygenase1.14.15.10.450
2zbaZBATrichothecene 3-O-acetyltransferase/0.450
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.450
3d78NBBPheromone-binding protein ASP1/0.450
3fwgCAMCamphor 5-monooxygenase1.14.15.10.450
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.450
3p8iFMNPentaerythritol tetranitrate reductase/0.450
3wrhCAMCamphor 5-monooxygenase1.14.15.10.450
4e5yNDPGDP-L-fucose synthase1.1.1.2710.450
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.450
4o701QKBromodomain-containing protein 4/0.450
4pkwGM6Lethal factor3.4.24.830.450
4py6R78Bromodomain protein, putative/0.450
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.450
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.450
1dz6CAMCamphor 5-monooxygenase1.14.15.10.449
1e7qNAPGDP-L-fucose synthase/0.449
1q5dEPBEpothilone C/D epoxidase1.140.449
1rfqLARActin, alpha skeletal muscle/0.449
1s4dSAHUroporphyrinogen-III C-methyltransferase2.1.1.1070.449
1tduCB3Thymidylate synthase/0.449
2gjnFMNNitronate monooxygenase1.13.12.160.449
2hc4VDXVitamin D3 receptor A/0.449
2ojg19AMitogen-activated protein kinase 12.7.11.240.449
2q7vFADThioredoxin reductase/0.449
2wd8VGFPteridine reductase/0.449
3b9lAZZSerum albumin/0.449
3dxjNE6DNA-directed RNA polymerase subunit beta/0.449
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.449
3irxUDRGag-Pol polyprotein2.7.7.490.449
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.449
3wrmCAMCamphor 5-monooxygenase1.14.15.10.449
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4fogC2FThymidylate synthase ThyA/0.449
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4hni16WCasein kinase I isoform epsilon2.7.11.10.449
4iw8KN3Estrogen receptor/0.449
1dduCB3Thymidylate synthase/0.448
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
1m7aMQUDihydrofolate reductase1.5.1.30.448
1zdwFLVPrenyltransferase/0.448
2jb4A14Isopenicillin N synthase1.21.3.10.448
2w02ATPAcsD/0.448
2xtbKRMAdenosine kinase, putative/0.448
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.448
3e7gAT2Nitric oxide synthase, inducible1.14.13.390.448
3g5hYTTMycocyclosin synthase1.14.21.90.448
3h3qH13Collagen type IV alpha-3-binding protein/0.448
3k1wBFXRenin3.4.23.150.448
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.448
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.448
4b4bGJBGlucose-1-phosphate thymidylyltransferase/0.448
4b4vL34Bifunctional protein FolD/0.448
4eqwCOACoenzyme A disulfide reductase/0.448
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.448
4ivy1GTEstrogen receptor/0.448
4j7xSASSepiapterin reductase1.1.1.1530.448
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1ek2CDUBifunctional epoxide hydrolase 2/0.447
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
1hb1OCVIsopenicillin N synthase1.21.3.10.447
1qoqIGPTryptophan synthase alpha chain/0.447
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.447
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2e0nSAHPrecorrin-2 C20-methyltransferase/0.447
2feuCAMCamphor 5-monooxygenase1.14.15.10.447
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.447
2qblCAMCamphor 5-monooxygenase1.14.15.10.447
2rhgIGPTryptophan synthase alpha chain/0.447
2zynBCDPeriplasmic binding protein/0.447
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3nbzGTPGTP-binding nuclear protein Ran/0.447
3qfvNM7Serine/threonine-protein kinase MRCK beta2.7.11.10.447
3sa16DRDihydrofolate reductase/0.447
3vt8YI3Vitamin D3 receptor/0.447
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.447
4g47TZFMycocyclosin synthase1.14.21.90.447
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.447
4jlt8PRCytochrome P450 2B41.14.14.10.447
5stdUNNScytalone dehydratase4.2.1.940.447
1ao8MTXDihydrofolate reductase1.5.1.30.446
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1fm69CRRetinoic acid receptor RXR-alpha/0.446
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1t88CAMCamphor 5-monooxygenase1.14.15.10.446
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2ptfFMNUncharacterized protein MTH_863/0.446
3bfb9ODPheromone-binding protein ASP1/0.446
3bgxMEFThymidylate synthase/0.446
3bw4FMNPutative 2-nitropropane dioxygenase/0.446
3datMTXDihydrofolate reductase/0.446
3hwxTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.446
3junAKDPhenazine biosynthesis protein A/B/0.446
3vtbTKAVitamin D3 receptor/0.446
3vtdTKDVitamin D3 receptor/0.446
3wrlCAMCamphor 5-monooxygenase1.14.15.10.446
3wv9FEGHmd co-occurring protein HcgE/0.446
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.446
4cgd8P3Integrase/0.446
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4jnc1LFBifunctional epoxide hydrolase 23.1.3.760.446
4u7wNDPMxaA/0.446
4xymCOAAcyl-CoA synthetase (NDP forming)/0.446
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1f5fDHTSex hormone-binding globulin/0.445
1i5aACPChemotaxis protein CheA2.7.13.30.445
1kquBR4Phospholipase A2, membrane associated/0.445
1l8qADPChromosomal replication initiator protein DnaA/0.445
1n83CLRNuclear receptor ROR-alpha/0.445
1o97FADElectron transfer flavoprotein subunit alpha/0.445
1rjkVDZVitamin D3 receptor/0.445
1rk3VDXVitamin D3 receptor/0.445
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.445
2bu9HFVIsopenicillin N synthase1.21.3.10.445
2hl0A3SThreonine--tRNA ligase6.1.1.30.445
2jlbUDMUncharacterized protein/0.445
2qimZEAClass 10 plant pathogenesis-related protein/0.445
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
2xtnGTPGTPase IMAP family member 2/0.445
2zb8IMNProstaglandin reductase 21.3.1.480.445
2zlcVDXVitamin D3 receptor/0.445
3fp0FP015-O-acetyltransferase/0.445
3gwfFADCyclohexanone monooxygenase/0.445
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.445
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.445
3qdqCOA4-Hydroxybutyrate CoA-transferase/0.445
3ua506XCytochrome P450 2B61.14.130.445
4a6bQG8Gag-Pol polyprotein3.4.23.160.445
4a83DXCMajor pollen allergen Bet v 1-A/0.445
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.445
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.445
4l9kEHFSerum albumin/0.445
4xoiGTPTransforming protein RhoA/0.445
5cwa0GAAnthranilate synthase component 14.1.3.270.445
1m9m6NINitric oxide synthase, endothelial1.14.13.390.444
1osvCHCBile acid receptor/0.444
1uyuCAMCamphor 5-monooxygenase1.14.15.10.444
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.444
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2cchATPCyclin-dependent kinase 22.7.11.220.444
2qbmCAMCamphor 5-monooxygenase1.14.15.10.444
2qc8ADPGlutamine synthetase6.3.1.20.444
2vcmM11Isopenicillin N synthase1.21.3.10.444
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.444
2ykcYKCHeat shock protein HSP 90-alpha/0.444
3ebf332Nitric oxide synthase, inducible1.14.13.390.444
3ed1GA3Gibberellin receptor GID1/0.444
3gw9VNILanosterol 14-alpha-demethylase/0.444
3h3r14HCollagen type IV alpha-3-binding protein/0.444
3k9uACOSpermidine N(1)-acetyltransferase/0.444
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.444
3phiNDPShikimate dehydrogenase (NADP(+))/0.444
3rf7NADIron-containing alcohol dehydrogenase/0.444
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.444
3ufsHW6Nitric oxide synthase, brain1.14.13.390.444
4b1fKRHGlutamate racemase/0.444
4deg0JJHepatocyte growth factor receptor2.7.10.10.444
4jazSTLPeroxisome proliferator-activated receptor gamma/0.444
4kwhNAPReductase homolog/0.444
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.444
6cp4CAMCamphor 5-monooxygenase1.14.15.10.444
5k2dZMAAdenosine receptor A2a/0.444
1bk0ACVIsopenicillin N synthase1.21.3.10.443
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.443
1ie9VDXVitamin D3 receptor/0.443
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
1oc1ASVIsopenicillin N synthase1.21.3.10.443
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
1uy9PU6Heat shock protein HSP 90-alpha/0.443
2bvs2CEProthrombin3.4.21.50.443
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
2i40BLZCyclin-dependent kinase 22.7.11.220.443
2iviACWIsopenicillin N synthase1.21.3.10.443
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.443
2nr4FMNConserved protein/0.443
2pg0FADAcyl-CoA dehydrogenase/0.443
2uxhQUEHTH-type transcriptional regulator TtgR/0.443
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.443
2y6fM9FIsopenicillin N synthase1.21.3.10.443
3abaFLICytochrome P450/0.443
3acw651Dehydrosqualene synthase/0.443
3akm11DFatty acid-binding protein, intestinal/0.443
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.443
3fbuCOAAcetyltransferase, GNAT family/0.443
3ft8MOJHeat shock protein HSP 90-alpha/0.443
3fwiCAMCamphor 5-monooxygenase1.14.15.10.443
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.443
3tvuB37Acetyl-CoA carboxylase/0.443
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.443
3w0gW07Vitamin D3 receptor/0.443
3zuxTCHTransporter/0.443
4awq592Heat shock protein HSP 90-alpha/0.443
4ax8ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.443
4b3aTACTetracycline repressor protein class D/0.443
4bb3KKAIsopenicillin N synthase1.21.3.10.443
4c717RD3-oxoacyl-ACP synthase/0.443
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4ejh0QACytochrome P450 2A131.14.14.10.443
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.443
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.443
4rbs0RVMetallo-beta-lactamase type 2/0.443
5choFADFlavin reductase/0.443
5iubCLRAdenosine receptor A2a/0.443
1ay0TPPTransketolase 12.2.1.10.442
1ju6LYAThymidylate synthase2.1.1.450.442
1kh3ANPArgininosuccinate synthase/0.442
1kzjCB3Thymidylate synthase/0.442
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.442
1pkfEPDEpothilone C/D epoxidase1.140.442
1ty9FMNPhenazine biosynthesis protein PhzG1.40.442
1y6oMJIPhospholipase A2, major isoenzyme3.1.1.40.442
2a1nCAMCamphor 5-monooxygenase1.14.15.10.442
2b51UTPRNA editing complex protein MP57/0.442
2g5oDRQEstrogen receptor/0.442
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.442
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.442
3h3sH15Collagen type IV alpha-3-binding protein/0.442
3hx4ANPCalmodulin-domain protein kinase 1/0.442
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3kytHC2Nuclear receptor ROR-gamma/0.442
3l0lHC3Nuclear receptor ROR-gamma/0.442
3p84FMNPentaerythritol tetranitrate reductase/0.442
3pd3A3TThreonine--tRNA ligase6.1.1.30.442
3vt7VDXVitamin D3 receptor/0.442
3w6hAZMCarbonic anhydrase 14.2.1.10.442
3zep1NXTyrosine-protein kinase JAK32.7.10.20.442
4b8zNAPGDP-L-fucose synthase1.1.1.2710.442
4g48PZBMycocyclosin synthase1.14.21.90.442
4giu636Anthranilate phosphoribosyltransferase/0.442
4h9814QUncharacterized protein/0.442
4jqh1MFAlr2278 protein/0.442
4l4eCAMCamphor 5-monooxygenase1.14.15.10.442
4nieNBHNuclear receptor ROR-gamma/0.442
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.442
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
1axwMTXThymidylate synthase/0.441
1dgbNDPCatalase1.11.1.60.441
1iyzNDPProbable quinone oxidoreductase/0.441
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1klkPMDDihydrofolate reductase1.5.1.30.441
1pq6965Oxysterols receptor LXR-beta/0.441
1s0zEB1Vitamin D3 receptor/0.441
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.441
2ban357Gag-Pol polyprotein2.7.7.490.441
2dwpACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.441
2giuFBREstrogen receptor beta/0.441
2gjlFMNNitronate monooxygenase1.13.12.160.441
2jfz003Glutamate racemase/0.441
2kceD16Thymidylate synthase/0.441
2oliIOPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.441
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
2vu3LZECyclin-dependent kinase 22.7.11.220.441
2yeiXQIHeat shock protein HSP 90-alpha/0.441
3a6qFMNFMN-binding protein/0.441
3otwCOAPhosphopantetheine adenylyltransferase/0.441
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.441
3stv3HOMethylketone synthase I/0.441
3tk3CPZCytochrome P450 2B41.14.14.10.441
3zcnATPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.441
3zoiM2WIsopenicillin N synthase1.21.3.10.441
4a6cQG9Gag-Pol polyprotein3.4.23.160.441
4at2ASDPossible succinate dehydrogenase/0.441
4b2wBZ0Glucose-1-phosphate thymidylyltransferase/0.441
4cp4CAMCamphor 5-monooxygenase1.14.15.10.441
4fvqATPTyrosine-protein kinase JAK2/0.441
4g210VPVitamin D3 receptor A/0.441
4h9506UDihydrofolate reductase1.5.1.30.441
4h9614QDihydrofolate reductase1.5.1.30.441
4iah1DXAlr2278 protein/0.441
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.441
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.441
4oztP1AEcdysone receptor, putative/0.441
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
5ifiPRXAcetyl-coenzyme A synthetase/0.441
1dnaCB3Thymidylate synthase/0.440
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.440
1m8h6NINitric oxide synthase, inducible1.14.13.390.440
1m9k7NINitric oxide synthase, endothelial1.14.13.390.440
1nooCAHCamphor 5-monooxygenase1.14.15.10.440
1nvtNAPShikimate dehydrogenase (NADP(+))/0.440
1rx3MTXDihydrofolate reductase1.5.1.30.440
1xiuREARetinoic acid receptor RXR/0.440
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.440
2c27ACOMycothiol acetyltransferase2.3.1.1890.440
2d3aADPGlutamine synthetase root isozyme 36.3.1.20.440
2izrBRKCasein kinase I isoform gamma-32.7.11.10.440
2oazI96Methionine aminopeptidase 2/0.440
2ph5NADHomospermidine synthase/0.440
2xweAMFGlucosylceramidase3.2.1.450.440
2zlaVDBVitamin D3 receptor/0.440
3apwDP0Alpha-1-acid glycoprotein 2/0.440
3bl7DD1m7GpppX diphosphatase3.6.1.590.440
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.440
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3eai328Nitric oxide synthase, inducible1.14.13.390.440
3fwfCAMCamphor 5-monooxygenase1.14.15.10.440
3inwJZBHeat shock protein HSP 90-alpha/0.440
3owaFADAcyl-CoA dehydrogenase/0.440
3r324CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.440
3s56ROCProtease/0.440
3v2uATPProtein GAL3/0.440
3vt5YI2Vitamin D3 receptor/0.440
3vtcTK3Vitamin D3 receptor/0.440
3w0jT08Vitamin D3 receptor/0.440
4a9e3PFBromodomain-containing protein 2/0.440
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.440
4lt63ATPoly(A) polymerase gamma2.7.7.190.440
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.440
4rh10TTSpore photoproduct lyase/0.440
4tuvCPZCytochrome P450 1191.140.440
5im3DTPRibonucleoside-diphosphate reductase/0.440
6stdMS2Scytalone dehydratase4.2.1.940.440