Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.740 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.718 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.662 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.616 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.613 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.611 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.604 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.591 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.585 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.584 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.579 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.573 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.570 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.568 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.564 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.561 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.561 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.558 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.558 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.556 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.554 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.552 | |
| 2d0k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.548 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.545 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.542 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.541 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.539 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 5hi6 | MTX | Dihydrofolate reductase | / | 0.537 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.536 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.535 | |
| 1rb2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.533 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.532 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.529 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.526 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.524 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.524 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.523 | |
| 4qi9 | MTX | Dihydrofolate reductase | / | 0.522 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.521 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.518 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.514 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.510 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.508 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.508 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.499 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.495 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.495 | |
| 4lb2 | DM5 | Serum albumin | / | 0.494 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.493 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.491 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.490 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.487 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.486 | |
| 4boe | CLR | Japanin | / | 0.486 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.486 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.485 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.485 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.484 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.483 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.483 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.483 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.482 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.481 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.481 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.481 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.480 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.480 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.479 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.479 | |
| 1rg7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.479 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.479 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.478 | |
| 2bla | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.478 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.478 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.478 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.478 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 1nq7 | ARL | Nuclear receptor ROR-beta | / | 0.476 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.476 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.476 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.475 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.475 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.475 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1m9j | CLW | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.474 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.474 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.474 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.474 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.474 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.474 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.474 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.473 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.473 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.473 | |
| 1r2j | FAD | FkbI | / | 0.472 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.472 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.472 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.472 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.472 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.472 | |
| 4dij | BLF | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.472 | |
| 4e2d | FMN | Dehydrogenase | / | 0.472 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.472 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1eio | GCH | Gastrotropin | / | 0.471 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.471 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.471 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.470 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.470 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.470 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.470 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.470 | |
| 4xwt | U5P | Ribonuclease J | / | 0.470 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.469 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.469 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.469 | |
| 3p9t | TCL | Repressor | / | 0.469 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.468 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.468 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.468 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.468 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.468 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1aoe | GW3 | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1qzf | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.467 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.467 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.467 | |
| 2xvq | 9DS | Serum albumin | / | 0.467 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.467 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.467 | |
| 4e2b | FMN | Dehydrogenase | / | 0.467 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.467 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.466 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.466 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.466 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.466 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.466 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.466 | |
| 1dg5 | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.465 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.465 | |
| 4bqu | CLR | Japanin | / | 0.465 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.465 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.465 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.464 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.464 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.464 | |
| 4gu6 | 10N | Focal adhesion kinase 1 | 2.7.10.2 | 0.464 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.464 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.463 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.463 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.463 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.463 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.463 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.463 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.463 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.463 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.463 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.463 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.463 | |
| 1sh9 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.462 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2ywv | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | / | 0.462 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.462 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.462 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.462 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.462 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.462 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.461 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.461 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.461 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.461 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.461 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.461 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.461 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.461 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.460 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.460 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.460 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.460 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.460 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 4gmg | NAP | Yersiniabactin biosynthetic protein YbtU | / | 0.460 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.459 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 2cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.459 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.459 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.459 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.459 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3qly | 55V | Uncharacterized protein | / | 0.459 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.459 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.459 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.459 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.459 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.458 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.458 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.458 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.458 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.458 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.458 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.458 | |
| 2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.458 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.458 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 4x2q | NAD | Retinal dehydrogenase 2 | 1.2.1.36 | 0.458 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.457 | |
| 1err | RAL | Estrogen receptor | / | 0.457 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.457 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.457 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.457 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.457 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.457 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.457 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.457 | |
| 4b8m | VX6 | Aurora kinase B-A | 2.7.11.1 | 0.457 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 1ysx | 4EB | Serum albumin | / | 0.456 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 2jfa | RAL | Estrogen receptor | / | 0.456 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.456 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.456 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.456 | |
| 4p6w | MOF | Glucocorticoid receptor | / | 0.456 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.456 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.455 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2apg | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.455 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.455 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.455 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3ex8 | AIF | Riboflavin biosynthesis protein RibD | 1.1.1.193 | 0.455 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.455 | |
| 4b4g | KKT | Glucose-1-phosphate thymidylyltransferase | / | 0.455 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.455 | |
| 4o7u | THF | Thymidylate synthase | / | 0.455 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.455 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.454 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.454 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.454 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.454 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.454 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.454 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.454 | |
| 3eej | 53R | Uncharacterized protein | / | 0.454 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.454 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4b5b | BBE | Glucose-1-phosphate thymidylyltransferase | / | 0.454 | |
| 4czt | CPS | CBL-interacting serine/threonine-protein kinase 23 | 2.7.11.1 | 0.454 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.454 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.454 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.454 | |
| 4g2h | 0VQ | Vitamin D3 receptor A | / | 0.454 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.454 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.454 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.453 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.453 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.453 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 3eem | 53V | Uncharacterized protein | / | 0.453 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.453 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.453 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.453 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.453 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.453 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.453 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.452 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1tw2 | ERT | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.452 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.452 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.452 | |
| 3btj | DEQ | HTH-type transcriptional regulator QacR | / | 0.452 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3jwm | 5WB | Dihydrofolate reductase | / | 0.452 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.452 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.452 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.452 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.452 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4iae | 1DX | Alr2278 protein | / | 0.452 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.452 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 1fml | RTL | Retinol dehydratase | / | 0.451 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.451 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.451 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.451 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 3cse | N22 | Uncharacterized protein | / | 0.451 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.451 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.451 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.451 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.451 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.451 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.451 | |
| 4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.451 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.451 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.450 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.450 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.450 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.450 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.450 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.450 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.450 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.450 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.450 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.450 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.450 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.450 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.450 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.450 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.450 | |
| 4j1r | I5R | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.450 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.450 | |
| 4pkw | GM6 | Lethal factor | 3.4.24.83 | 0.450 | |
| 4py6 | R78 | Bromodomain protein, putative | / | 0.450 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.450 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.449 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.449 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.449 | |
| 1s4d | SAH | Uroporphyrinogen-III C-methyltransferase | 2.1.1.107 | 0.449 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.449 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.449 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.449 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.449 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.449 | |
| 3b9l | AZZ | Serum albumin | / | 0.449 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.449 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.449 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4fog | C2F | Thymidylate synthase ThyA | / | 0.449 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.449 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.449 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.448 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1zdw | FLV | Prenyltransferase | / | 0.448 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2w02 | ATP | AcsD | / | 0.448 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.448 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.448 | |
| 3e7g | AT2 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.448 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.448 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.448 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.448 | |
| 4b4b | GJB | Glucose-1-phosphate thymidylyltransferase | / | 0.448 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.448 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.448 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.448 | |
| 4ivy | 1GT | Estrogen receptor | / | 0.448 | |
| 4j7x | SAS | Sepiapterin reductase | 1.1.1.153 | 0.448 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.447 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.447 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.447 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.447 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.447 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.447 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.447 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 3nbz | GTP | GTP-binding nuclear protein Ran | / | 0.447 | |
| 3qfv | NM7 | Serine/threonine-protein kinase MRCK beta | 2.7.11.1 | 0.447 | |
| 3sa1 | 6DR | Dihydrofolate reductase | / | 0.447 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.447 | |
| 4a33 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.447 | |
| 4jlt | 8PR | Cytochrome P450 2B4 | 1.14.14.1 | 0.447 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.447 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.446 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2ptf | FMN | Uncharacterized protein MTH_863 | / | 0.446 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.446 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.446 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.446 | |
| 3dat | MTX | Dihydrofolate reductase | / | 0.446 | |
| 3hwx | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.446 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.446 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.446 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.446 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.446 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 4cgd | 8P3 | Integrase | / | 0.446 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4jnc | 1LF | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.446 | |
| 4u7w | NDP | MxaA | / | 0.446 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.446 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.445 | |
| 1i5a | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.445 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.445 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.445 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.445 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.445 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.445 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.445 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.445 | |
| 2jlb | UDM | Uncharacterized protein | / | 0.445 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.445 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.445 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.445 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.445 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.445 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.445 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.445 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.445 | |
| 3qdq | COA | 4-Hydroxybutyrate CoA-transferase | / | 0.445 | |
| 3ua5 | 06X | Cytochrome P450 2B6 | 1.14.13 | 0.445 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.445 | |
| 4i0t | 1B6 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.445 | |
| 4l9k | EHF | Serum albumin | / | 0.445 | |
| 4xoi | GTP | Transforming protein RhoA | / | 0.445 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.445 | |
| 1m9m | 6NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.444 | |
| 1osv | CHC | Bile acid receptor | / | 0.444 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2qc8 | ADP | Glutamine synthetase | 6.3.1.2 | 0.444 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.444 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3ebf | 332 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.444 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.444 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3k9u | ACO | Spermidine N(1)-acetyltransferase | / | 0.444 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.444 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 3rf7 | NAD | Iron-containing alcohol dehydrogenase | / | 0.444 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.444 | |
| 3ufs | HW6 | Nitric oxide synthase, brain | 1.14.13.39 | 0.444 | |
| 4b1f | KRH | Glutamate racemase | / | 0.444 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.444 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 4kwh | NAP | Reductase homolog | / | 0.444 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.443 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.443 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.443 | |
| 2gnf | Y27 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 2nr4 | FMN | Conserved protein | / | 0.443 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.443 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3aba | FLI | Cytochrome P450 | / | 0.443 | |
| 3acw | 651 | Dehydrosqualene synthase | / | 0.443 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.443 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3fbu | COA | Acetyltransferase, GNAT family | / | 0.443 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.443 | |
| 3tvu | B37 | Acetyl-CoA carboxylase | / | 0.443 | |
| 3uim | ANP | BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 | 2.7.10.1 | 0.443 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.443 | |
| 3zux | TCH | Transporter | / | 0.443 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4ax8 | ADP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.443 | |
| 4b3a | TAC | Tetracycline repressor protein class D | / | 0.443 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.443 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.443 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.443 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.443 | |
| 5cho | FAD | Flavin reductase | / | 0.443 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.443 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.442 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.442 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.442 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.442 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.442 | |
| 1ty9 | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.442 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2b51 | UTP | RNA editing complex protein MP57 | / | 0.442 | |
| 2g5o | DRQ | Estrogen receptor | / | 0.442 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.442 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.442 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.442 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.442 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.442 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3pd3 | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.442 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.442 | |
| 3zep | 1NX | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.442 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.442 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.442 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.442 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.442 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.442 | |
| 4x81 | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 1axw | MTX | Thymidylate synthase | / | 0.441 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.441 | |
| 1wvg | APR | CDP-glucose 4,6-dehydratase | 4.2.1.45 | 0.441 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 2dwp | ACP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.441 | |
| 2giu | FBR | Estrogen receptor beta | / | 0.441 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2jfz | 003 | Glutamate racemase | / | 0.441 | |
| 2kce | D16 | Thymidylate synthase | / | 0.441 | |
| 2oli | IOP | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.441 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3a6q | FMN | FMN-binding protein | / | 0.441 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.441 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.441 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.441 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.441 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4at2 | ASD | Possible succinate dehydrogenase | / | 0.441 | |
| 4b2w | BZ0 | Glucose-1-phosphate thymidylyltransferase | / | 0.441 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4fvq | ATP | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.441 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4iah | 1DX | Alr2278 protein | / | 0.441 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.441 | |
| 4n6z | 2HW | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.441 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 5ifi | PRX | Acetyl-coenzyme A synthetase | / | 0.441 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.440 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.440 | |
| 1m8h | 6NI | Nitric oxide synthase, inducible | 1.14.13.39 | 0.440 | |
| 1m9k | 7NI | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.440 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 1rx3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.440 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.440 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.440 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.440 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.440 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.440 | |
| 2xwe | AMF | Glucosylceramidase | 3.2.1.45 | 0.440 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.440 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.440 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.440 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3eai | 328 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.440 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.440 | |
| 3r32 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.440 | |
| 3s56 | ROC | Protease | / | 0.440 | |
| 3v2u | ATP | Protein GAL3 | / | 0.440 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.440 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.440 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.440 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.440 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.440 | |
| 4lt6 | 3AT | Poly(A) polymerase gamma | 2.7.7.19 | 0.440 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.440 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.440 | |
| 5im3 | DTP | Ribonucleoside-diphosphate reductase | / | 0.440 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.440 |