sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4de0 | 0JB | Beta-lactamase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4de0 | 0JB | Beta-lactamase | / | 1.000 | |
| 4ddy | DN6 | Beta-lactamase | / | 0.629 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.628 | |
| 4de2 | DN3 | Beta-lactamase | / | 0.608 | |
| 4de3 | DN8 | Beta-lactamase | / | 0.601 | |
| 4de1 | 0J6 | Beta-lactamase | / | 0.598 | |
| 3q1f | YPP | Beta-lactamase | / | 0.522 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.504 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.495 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.495 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.495 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.493 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.491 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.489 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.489 | |
| 3d3x | ARG_ILE_MET_GLU_NH2 | Type E botulinum toxin | / | 0.488 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.486 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.486 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.486 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.484 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.482 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.482 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.480 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.480 | |
| 4u0m | ATP | Cyclic GMP-AMP synthase | / | 0.480 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.479 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.478 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.478 | |
| 3cwq | ADP | ParA family chromosome partitioning protein | / | 0.478 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.478 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.477 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.476 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.475 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.475 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.475 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.475 | |
| 4fdu | IHS | Putative multiple inositol polyphosphate histidine phosphatase 1 | / | 0.475 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.474 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.474 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.474 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.474 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.473 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.472 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.471 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.471 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.471 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.470 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.470 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.469 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.469 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.469 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.469 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.468 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.468 | |
| 3ck7 | ACX | Starch-binding protein SusD | / | 0.468 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.468 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.467 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.467 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.467 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.466 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.466 | |
| 3isi | B88 | Putative dipeptidase | / | 0.466 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.466 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.466 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.466 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.466 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.465 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.465 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.465 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.465 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.465 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.465 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.464 | |
| 2iwh | ANP | Elongation factor 3A | / | 0.464 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 3ieu | GDP | GTPase Era | / | 0.464 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.464 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.464 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.464 | |
| 4gcm | NAP | Thioredoxin reductase | 1.8.1.9 | 0.464 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.463 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.463 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.463 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.463 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.463 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.463 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.463 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.463 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.462 | |
| 2zr9 | DTP | Protein RecA | / | 0.462 | |
| 3gst | GPR | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.462 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.462 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.462 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.461 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.461 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.461 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.461 | |
| 1njf | ADP | DNA polymerase III subunit tau | 2.7.7.7 | 0.460 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.460 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.460 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.459 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.459 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.459 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.459 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.459 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3oix | FMN | Dihydroorotate dehydrogenase | / | 0.459 | |
| 4a0r | DTB | Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial | 6.3.3.3 | 0.459 | |
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 | / | 0.458 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.458 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.458 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.458 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.458 | |
| 3pi5 | 3P5 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.458 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.458 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.458 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.457 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.457 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.457 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.457 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.457 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.457 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.457 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.457 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.457 | |
| 5itz | GTP | Tubulin alpha-1B chain | / | 0.457 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.457 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.456 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.456 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.456 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.456 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.456 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.456 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.456 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.456 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.456 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.456 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.456 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.455 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.455 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.455 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.455 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.455 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.455 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.454 | |
| 1j1z | ATP | Argininosuccinate synthase | / | 0.454 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.454 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.454 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.454 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.454 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.454 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.454 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.453 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.453 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.453 | |
| 4hxy | NDP | Plm1 | / | 0.453 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.453 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.453 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.452 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.452 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.452 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.452 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.452 | |
| 3enk | UPG | UDP-glucose 4-epimerase | / | 0.452 | |
| 3hf3 | FMN | Chromate reductase | / | 0.452 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.452 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.452 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.452 | |
| 4usr | FAD | Monooxygenase | / | 0.452 | |
| 1dor | FMN | Dihydroorotate dehydrogenase A (fumarate) | 1.3.98.1 | 0.451 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.451 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.451 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.451 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.451 | |
| 2j3n | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.451 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.451 | |
| 2pci | SAH | Diphthine synthase | / | 0.451 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.451 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.451 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.451 | |
| 4kc4 | WS3 | Histo-blood group ABO system transferase | / | 0.451 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.451 | |
| 5c4n | NAP | Precorrin-6A reductase | 1.3.1.54 | 0.451 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.450 | |
| 3dk9 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.450 | |
| 3ggc | H26 | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.450 | |
| 3int | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.450 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.450 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.450 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.449 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.449 | |
| 1zio | AP5 | Adenylate kinase | / | 0.449 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.449 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.449 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.449 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.449 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.449 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.449 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.449 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.449 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.449 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.449 | |
| 3rv9 | RVD | Salicylate synthase | / | 0.449 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.449 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.449 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.449 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.448 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.448 | |
| 1rjd | SAM | Leucine carboxyl methyltransferase 1 | 2.1.1.233 | 0.448 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.448 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2abj | PLP | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.448 | |
| 2idv | M7G | Eukaryotic translation initiation factor 4E-1 | / | 0.448 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.448 | |
| 3fvl | BHK | Carboxypeptidase A1 | 3.4.17.1 | 0.448 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.448 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.448 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.447 | |
| 1uxy | EPU | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.447 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.447 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.447 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 3cne | FMN | Putative protease I | / | 0.447 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.447 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.447 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.447 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4mfe | BTN | Pyruvate carboxylase | / | 0.447 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.447 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.447 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.447 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.446 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.446 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.446 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.446 | |
| 2q0k | NAP | Thioredoxin reductase | 1.8.1.9 | 0.446 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.446 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.446 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.446 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.446 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.446 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.446 | |
| 4qbg | AP5 | Adenylate kinase | / | 0.446 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.445 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.445 | |
| 1ohh | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.445 | |
| 1ohh | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.445 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.445 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.445 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.445 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.445 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.445 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.445 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.445 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.445 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.445 | |
| 4kvm | SER_ALA_SER_GLU_1XE | N-terminal acetyltransferase A complex catalytic subunit ard1 | 2.3.1.88 | 0.445 | |
| 4nau | AGS | Phosphopantetheine adenylyltransferase | / | 0.445 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.445 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.445 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.445 | |
| 5dp2 | NAP | CurF | / | 0.445 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 1gsn | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.444 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.444 | |
| 1l2s | STC | Beta-lactamase | 3.5.2.6 | 0.444 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.444 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.444 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.444 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.444 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.444 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.444 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3qdl | FMN | Oxygen-insensitive NADPH nitroreductase | / | 0.444 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.444 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.444 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.444 | |
| 4k81 | GTP | GTPase HRas | / | 0.444 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.444 | |
| 4rv9 | SAH | D-mycarose 3-C-methyltransferase | / | 0.444 | |
| 1feb | FAD | Trypanothione reductase | 1.8.1.12 | 0.443 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.443 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.443 | |
| 1vjt | NAD | Alpha-glucosidase, putative | / | 0.443 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.443 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.443 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.443 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.443 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.443 | |
| 2owf | SAH | Diphthine synthase | / | 0.443 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2udp | UPP | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 3e23 | SAM | Uncharacterized protein | / | 0.443 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4blr | UTP | NTPase P4 | / | 0.443 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.443 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.443 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.442 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.442 | |
| 1vhz | APR | ADP compounds hydrolase NudE | 3.6.1 | 0.442 | |
| 1zdw | FLV | Prenyltransferase | / | 0.442 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.442 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 2p0r | LEU_LEU_ACE_AR7 | Calpain-9 | / | 0.442 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2v7q | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.442 | |
| 2v7q | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3a3g | DLZ | Lumazine protein | / | 0.442 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.442 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.442 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.442 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.442 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.442 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.442 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.442 | |
| 3uax | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.442 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.442 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.442 | |
| 5c41 | ACP | Ribokinase | / | 0.442 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.441 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.441 | |
| 1rje | SAH | Leucine carboxyl methyltransferase 1 | 2.1.1.233 | 0.441 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.441 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.441 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3bj7 | COA | Diamine acetyltransferase 1 | / | 0.441 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.441 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.441 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.441 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.441 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.440 | |
| 1c7o | PPG | Hemolysin | / | 0.440 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 1i6k | TYM | Tryptophan--tRNA ligase | 6.1.1.2 | 0.440 | |
| 2emu | SAH | Diphthine synthase | / | 0.440 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.440 | |
| 2h6i | CYS_VAL_LEU_SER_GER | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.440 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.440 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.440 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.440 | |
| 3e6e | DCS | Alanine racemase | / | 0.440 | |
| 3eku | CY9 | Actin-5C | / | 0.440 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.440 | |
| 3em3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 3int | FDA | UDP-galactopyranose mutase | 5.4.99.9 | 0.440 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.440 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.440 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4fnc | HMU | G/T mismatch-specific thymine DNA glycosylase | 3.2.2.29 | 0.440 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.440 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.440 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.440 | |
| 4wzh | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.440 |