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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4a9rRU5Serine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4a9rRU5Serine/threonine-protein kinase Chk22.7.11.11.000
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.619
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.616
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.608
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.583
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.569
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.563
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.563
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.560
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.552
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.550
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.547
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.546
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.534
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.534
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.529
4a9sRU9Serine/threonine-protein kinase Chk22.7.11.10.522
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.520
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.519
4i22IREEpidermal growth factor receptor2.7.10.10.517
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.515
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.515
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.514
4bdeCWSSerine/threonine-protein kinase Chk22.7.11.10.514
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.513
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.513
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.512
4bdaVFBSerine/threonine-protein kinase Chk22.7.11.10.510
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.509
1jpaANPEphrin type-B receptor 22.7.10.10.506
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.505
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.505
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.504
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.503
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.502
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.502
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.501
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.500
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.499
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.499
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.499
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.498
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.498
3gubGUBDeath-associated protein kinase 12.7.11.10.498
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.498
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.498
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.497
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.496
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.495
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.494
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.494
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.494
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.493
2qo9ANPEphrin type-A receptor 32.7.10.10.492
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.492
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.492
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.491
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.491
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.491
1me6IVSPlasmepsin-23.4.23.390.490
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.490
5aacVGHALK tyrosine kinase receptor2.7.10.10.490
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.489
4e8yIHAD-beta-D-heptose 7-phosphate kinase/0.489
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.489
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.488
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.488
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.487
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.487
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.487
2xb7GUIALK tyrosine kinase receptor2.7.10.10.486
1drhNAPDihydrofolate reductase1.5.1.30.485
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.485
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.485
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.485
3s4qNK0Mitogen-activated protein kinase 14/0.484
5e8wSTUTGF-beta receptor type-12.7.11.300.484
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.483
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.483
2xvdAS6Ephrin type-B receptor 42.7.10.10.482
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.481
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.481
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.481
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.481
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.480
2jkoBIJFocal adhesion kinase 12.7.10.20.480
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.480
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.479
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.479
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.479
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.479
4jq8KJ8Epidermal growth factor receptor2.7.10.10.479
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.478
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.478
2zjwREFCasein kinase II subunit alpha2.7.11.10.478
4brxKGWFocal adhesion kinase 12.7.10.20.478
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.477
3bqr4RBDeath-associated protein kinase 3/0.477
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.477
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.477
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.476
2hog710Serine/threonine-protein kinase Chk12.7.11.10.476
2j0lANPFocal adhesion kinase 12.7.10.20.476
2qo7ANPEphrin type-A receptor 32.7.10.10.476
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.476
4oztP1AEcdysone receptor, putative/0.476
5uviZMAAdenosine receptor A2a/0.476
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.475
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.475
2aa0MTPAdenosine kinase2.7.1.200.475
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.475
3hx4ANPCalmodulin-domain protein kinase 1/0.475
3sp9IL2Peroxisome proliferator-activated receptor delta/0.475
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.474
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.474
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.474
3b9lAZZSerum albumin/0.474
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.474
4fod0UVALK tyrosine kinase receptor2.7.10.10.474
1osvCHCBile acid receptor/0.473
3nbvANPKetohexokinase/0.473
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.473
4anqVGHALK tyrosine kinase receptor2.7.10.10.473
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
1zltHYMSerine/threonine-protein kinase Chk12.7.11.10.472
2xp2VGHALK tyrosine kinase receptor2.7.10.10.472
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.472
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.472
4i02CMPcAMP-activated global transcriptional regulator CRP/0.472
4q71FADBifunctional protein PutA/0.472
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.471
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.471
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.471
3t8oATPRhodopsin kinase/0.471
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.471
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.471
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.471
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.469
2znpK55Peroxisome proliferator-activated receptor delta/0.469
3iaeD7KBenzaldehyde lyase/0.469
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.469
5k2cZMAAdenosine receptor A2a/0.469
2izrBRKCasein kinase I isoform gamma-32.7.11.10.468
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.468
3gbuATPUncharacterized sugar kinase PH14592.7.10.468
3lctADPALK tyrosine kinase receptor2.7.10.10.468
3uvqFS8Mitogen-activated protein kinase 14/0.468
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.468
4g95OAGDihydrofolate reductase1.5.1.30.468
4yuqKS1Calmodulin-like domain protein kinase/0.468
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.467
2fznFADBifunctional protein PutA1.5.5.20.467
2vgoAD5Aurora kinase B-A2.7.11.10.467
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.467
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.467
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.467
3uibSB2Putative mitogen-activated protein kinase/0.467
4bb432WEphrin type-B receptor 42.7.10.10.467
1rx1NAPDihydrofolate reductase1.5.1.30.466
1zys199Serine/threonine-protein kinase Chk12.7.11.10.466
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.466
2qoqANPEphrin type-A receptor 32.7.10.10.466
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.466
2yfxVGHALK tyrosine kinase receptor2.7.10.10.466
3nxe2NCProtease/0.466
3zk5Z18Cytochrome P450 monooxygenase PikC/0.466
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.466
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.465
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.465
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.465
2x9fX9FEphrin type-B receptor 42.7.10.10.465
3flyFLYMitogen-activated protein kinase 14/0.465
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.465
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.465
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.465
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.465
3zh8C58Protein kinase C iota type2.7.11.130.465
1f123HCHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.464
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.464
2ituITQEpidermal growth factor receptor2.7.10.10.464
2j0m4STFocal adhesion kinase 12.7.10.20.464
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.464
3qa2XNAKetohexokinase/0.464
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.464
4gk4L90Ephrin type-A receptor 32.7.10.10.464
4j97ACPFibroblast growth factor receptor 2/0.464
1i8tFADUDP-galactopyranose mutase5.4.99.90.463
2a0cCK9Cyclin-dependent kinase 22.7.11.220.463
2hk9NAPShikimate dehydrogenase (NADP(+))/0.463
3kpkFADSulfide-quinone reductase/0.463
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.463
3pj8404Cyclin-dependent kinase 22.7.11.220.463
3rk507ZCyclin-dependent kinase 22.7.11.220.463
3sheI85MAP kinase-activated protein kinase 32.7.11.10.463
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
4fnyI3KALK tyrosine kinase receptor2.7.10.10.463
5k2bZMAAdenosine receptor A2a/0.463
1ppjANYCytochrome b/0.462
2jcvNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.462
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.462
3qaiXNNKetohexokinase/0.462
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.462
4gk2L66Ephrin type-A receptor 32.7.10.10.462
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.462
4n6hEJ4Delta-type opioid receptor/0.462
4wboANWRhodopsin kinase/0.462
2c29NAPDihydroflavonol 4-reductase/0.461
4ansVGHALK tyrosine kinase receptor2.7.10.10.461
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.461
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.461
4g6oE28Mitogen-activated protein kinase 12.7.11.240.461
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.461
4hjoAQ4Epidermal growth factor receptor2.7.10.10.461
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.461
5iubCLRAdenosine receptor A2a/0.461
1y4lSVRBasic phospholipase A2 homolog 2/0.460
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.460
2nnpROCProtease/0.460
3a62STURibosomal protein S6 kinase beta-12.7.11.10.460
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.460
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.460
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.460
4j54G52Gag-Pol polyprotein3.4.23.160.460
4l4cCAMCamphor 5-monooxygenase1.14.15.10.460
4m9aFDAAcyl-CoA dehydrogenase/0.460
5f0a1FBcGMP-dependent protein kinase, putative/0.460
1mp8ADPFocal adhesion kinase 12.7.10.20.459
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.459
2y05NAPProstaglandin reductase 1/0.459
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.459
2zb3NDPProstaglandin reductase 21.3.1.480.459
3oafOAGDihydrofolate reductase1.5.1.30.459
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.459
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.459
4o701QKBromodomain-containing protein 4/0.459
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.458
2ijmATPFocal adhesion kinase 12.7.10.20.458
2j5xGSPADP-ribosylation factor 6/0.458
2jkqVG8Focal adhesion kinase 12.7.10.20.458
2q9fC3SCholesterol 24-hydroxylase/0.458
2r3lSCWCyclin-dependent kinase 22.7.11.220.458
3q92XNBKetohexokinase/0.458
3t3c017Gag-Pol polyprotein3.4.23.160.458
4e8wIHAD-beta-D-heptose 7-phosphate kinase/0.458
4g2fC07Ephrin type-A receptor 32.7.10.10.458
4qmzB49Serine/threonine-protein kinase 242.7.11.10.458
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
1svmATPLarge T antigen3.6.40.457
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.457
2j0j4STFocal adhesion kinase 12.7.10.20.457
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.457
2r3jSCJCyclin-dependent kinase 22.7.11.220.457
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.457
3nwq2NCGag-Pol polyprotein3.4.23.160.457
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.457
4l4xNDPAmphI/0.457
5k2dZMAAdenosine receptor A2a/0.457
1pjkANPCasein kinase II subunit alpha2.7.11.10.456
1rx8NAPDihydrofolate reductase1.5.1.30.456
2itqITQEpidermal growth factor receptor2.7.10.10.456
2q46NAPUncharacterized protein At5g02240/0.456
2vwqNAPGlucose 1-dehydrogenase/0.456
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.456
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
3iphG11Mitogen-activated protein kinase 14/0.456
3ndxRITGag-Pol polyprotein3.4.23.160.456
3r8lZ30Cyclin-dependent kinase 22.7.11.220.456
3stv3HOMethylketone synthase I/0.456
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.456
4d58BI9Focal adhesion kinase 12.7.10.20.456
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.456
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.456
5dr6SKEAurora kinase A2.7.11.10.456
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.455
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.455
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.455
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.455
3qlrNDPDihydrofolate reductase1.5.1.30.455
4gu610NFocal adhesion kinase 12.7.10.20.455
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.455
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.455
1hpoUNIGag-Pol polyprotein3.4.23.160.454
1nhhANPDNA mismatch repair protein MutL/0.454
1oirHDYCyclin-dependent kinase 22.7.11.220.454
1rkdADPRibokinase/0.454
2c7xNRBCytochrome P450 monooxygenase PikC/0.454
2dvlFADAcyl-CoA dehydrogenase/0.454
2f3kRO1Protease/0.454
2pwcG3GGag-Pol polyprotein3.4.23.160.454
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.454
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.454
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
4eh60ONMitogen-activated protein kinase 14/0.454
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.454
4gh5NADShort-chain dehydrogenase/reductase SDR/0.454
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.454
1ia4TQ6Dihydrofolate reductase1.5.1.30.453
1juvNDPDihydrofolate reductase1.5.1.30.453
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2bxqIMNSerum albumin/0.453
2f02ATPTagatose-6-phosphate kinase/0.453
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.453
2of2547Tyrosine-protein kinase Lck2.7.10.20.453
2qhcAB1Protease/0.453
2w1hL0FCyclin-dependent kinase 22.7.11.220.453
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.453
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.453
3d7kD7KBenzaldehyde lyase/0.453
3p7nFMNLight-activated DNA-binding protein EL222/0.453
3vquO22Dual specificity protein kinase TTK2.7.12.10.453
4fkpLS5Cyclin-dependent kinase 22.7.11.220.453
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.453
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.453
4fv9E71Mitogen-activated protein kinase 12.7.11.240.453
4gk3L87Ephrin type-A receptor 32.7.10.10.453
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.453
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.453
4hj6FMNLOV protein/0.453
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.453
4xgxADPFAD:protein FMN transferase/0.453
5f8eSAHPossible transcriptional regulatory protein/0.453
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.452
1pxlCK4Cyclin-dependent kinase 22.7.11.220.452
2b53D23Cyclin-dependent kinase 22.7.11.220.452
3d1yROCGag-Pol polyprotein3.4.23.160.452
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.452
4a6bQG8Gag-Pol polyprotein3.4.23.160.452
4c02TAKActivin receptor type-12.7.11.300.452
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.452
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.452
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.452
5iua6DXAdenosine receptor A2a/0.452
1bvgDMPGag-Pol polyprotein3.4.23.160.451
1pxpCK8Cyclin-dependent kinase 22.7.11.220.451
1py5PY1TGF-beta receptor type-12.7.11.300.451
1xjdSTUProtein kinase C theta type2.7.11.130.451
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.451
2c6o4SPCyclin-dependent kinase 22.7.11.220.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.451
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.451
2zazGK1Mitogen-activated protein kinase 14/0.451
3flzFLZMitogen-activated protein kinase 14/0.451
3gc9B45Mitogen-activated protein kinase 112.7.11.240.451
3nxxNDPDihydrofolate reductase1.5.1.30.451
3oibFDAPutative acyl-CoA dehydrogenase/0.451
3t2zFADSulfide-quinone reductase/0.451
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.451
4bgh3I6Cyclin-dependent kinase 22.7.11.220.451
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.451
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.451
5eccNAPDehydrofolate reductase type I/0.451
1ia1NDPDihydrofolate reductase1.5.1.30.450
1ju9NADAlcohol dehydrogenase E chain1.1.1.10.450
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.450
1m78NDPDihydrofolate reductase1.5.1.30.450
1oecAA2Fibroblast growth factor receptor 2/0.450
1s6qTPBGag-Pol polyprotein2.7.7.490.450
2henADPEphrin type-B receptor 22.7.10.10.450
2jkkBI9Focal adhesion kinase 12.7.10.20.450
2ou2ACOHistone acetyltransferase KAT5/0.450
2pym1UNGag-Pol polyprotein3.4.23.160.450
2vwu7X1Ephrin type-B receptor 42.7.10.10.450
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.450
3itzP66Mitogen-activated protein kinase 14/0.450
3k145352-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.450
3nbwTR4Ketohexokinase/0.450
3rni21ZCyclin-dependent kinase 22.7.11.220.450
3uleC69Actin-related protein 3/0.450
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.450
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.450
4c717RD3-oxoacyl-ACP synthase/0.450
4e9aQAPPeptide deformylase/0.450
4foc0UUALK tyrosine kinase receptor2.7.10.10.450
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.450
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.450
4kqwNAPKetol-acid reductoisomerase (NADP(+))/0.450
4nifANPMitogen-activated protein kinase 12.7.11.240.450
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.450
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.450
4ea30NNNociceptin receptor/0.450
3emlZMAAdenosine receptor A2a/0.450
1cbqRE9Cellular retinoic acid-binding protein 2/0.449
1ckpPVBCyclin-dependent kinase 22.7.11.220.449
1ec2BEJGag-Pol polyprotein3.4.23.160.449
1fwkADPHomoserine kinase2.7.1.390.449
2c27ACOMycothiol acetyltransferase2.3.1.1890.449
2c475IDCasein kinase I isoform gamma-2/0.449
2qd7065Gag-Pol polyprotein3.4.23.160.449
2yaaATPDeath-associated protein kinase 2/0.449
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.449
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.449
3el9DR7Gag-Pol polyprotein3.4.23.160.449
3p3zP3ZPutative cytochrome P450/0.449
3pxkPXKFocal adhesion kinase 12.7.10.20.449
3s0o50ZCyclin-dependent kinase 22.7.11.220.449
3sw719KCyclin-dependent kinase 22.7.11.220.449
4aa4QC0Mitogen-activated protein kinase 14/0.449
4c57FEFCyclin-G-associated kinase2.7.11.10.449
4dzzADPPlasmid partitioning protein ParF/0.449
4eoi1ROCyclin-dependent kinase 22.7.11.220.449
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.449
4ib4ERM5-hydroxytryptamine receptor 2B/0.449
4k8aK8AFocal adhesion kinase 12.7.10.20.449
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.449
5k2aZMAAdenosine receptor A2a/0.449
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.448
2cig1DGDihydrofolate reductase1.5.1.30.448
2ojj82AMitogen-activated protein kinase 12.7.11.240.448
2qocANPEphrin type-A receptor 32.7.10.10.448
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.448
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.448
2xf3J01Uncharacterized protein/0.448
3ds6A17Mitogen-activated protein kinase 14/0.448
3ekqROCGag-Pol polyprotein3.4.23.160.448
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.448
3sw1FMNSensory box protein/0.448
4aotGW8Serine/threonine-protein kinase 102.7.11.10.448
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4njt017Protease/0.448
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.448
4wsqKSAAP2-associated protein kinase 12.7.11.10.448
5auuLU2Death-associated protein kinase 12.7.11.10.448
5auwQUEDeath-associated protein kinase 12.7.11.10.448
5da9AGSUncharacterized protein/0.448
6cp4CAMCamphor 5-monooxygenase1.14.15.10.448
1d4yTPVGag-Pol polyprotein3.4.23.160.447
1k6cMK1Gag-Pol polyprotein3.4.23.160.447
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.447
2acxANPG protein-coupled receptor kinase 62.7.11.160.447
2aquDR7Gag-Pol polyprotein3.4.23.160.447
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2ieo017Protease/0.447
2r3wG3GGag-Pol polyprotein3.4.23.160.447
2x1nX1NCyclin-dependent kinase 22.7.11.220.447
3sdkP3NProteasome subunit beta type-53.4.25.10.447
3sdkP3NProteasome subunit beta type-63.4.25.10.447
3slkNDPPolyketide synthase extender module 2/0.447
3tqaNDPDihydrofolate reductase/0.447
4b99R4LMitogen-activated protein kinase 72.7.11.240.447
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.447
4kb81QNCasein kinase I isoform delta2.7.11.10.447
4l9i8PRRhodopsin kinase/0.447
4nks2M2Fibroblast growth factor receptor 1/0.447
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1f0xFADD-lactate dehydrogenase1.1.1.280.446
1g6nCMPcAMP-activated global transcriptional regulator CRP/0.446
1m17AQ4Epidermal growth factor receptor2.7.10.10.446
1s7nCOAAcetyl transferase/0.446
1wvxBD4Death-associated protein kinase 12.7.11.10.446
1zrzBI1Protein kinase C iota type2.7.11.130.446
2c9ePIDPeridinin-chlorophyll a protein, high-salt form/0.446
2ci01CMLanosterol 14-alpha demethylase1.14.13.700.446
2d4vNADIsocitrate dehydrogenase [NADP]/0.446
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.446
2gfsPQBMitogen-activated protein kinase 14/0.446
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.446
2pziAXXSerine/threonine-protein kinase PknG2.7.11.10.446
2y5kYCUFructose-1,6-bisphosphatase 13.1.3.110.446
2ydoADNAdenosine receptor A2a/0.446
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3lzu017Gag-Pol polyprotein3.4.23.160.446
3pwrROCGag-Pol polyprotein3.4.23.160.446
3sw418KCyclin-dependent kinase 22.7.11.220.446
3tucFPWTyrosine-protein kinase SYK2.7.10.20.446
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.446
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4e0iFADMitochondrial FAD-linked sulfhydryl oxidase ERV11.8.3.20.446
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.446
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.446
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.446
4xx0COASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial6.2.1.40.446
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.445
1eagA70Candidapepsin-23.4.23.240.445
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.445
1t88CAMCamphor 5-monooxygenase1.14.15.10.445
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.445
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.445
2etm7PYFocal adhesion kinase 12.7.10.20.445
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.445
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.445
2r43G3GGag-Pol polyprotein3.4.23.160.445
2w9hTOPDihydrofolate reductase1.5.1.30.445
2wotZZGTGF-beta receptor type-12.7.11.300.445
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.445
2y6o1N1Ephrin type-A receptor 42.7.10.10.445
2ym1FADPhenylacetone monooxygenase1.14.13.920.445
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.445
3gqvNAPEnoyl reductase LovC10.445
3qbfJHGGag-Pol polyprotein3.4.23.160.445
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.445
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
4tuvCPZCytochrome P450 1191.140.445
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.445
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.445
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1meuDMPGag-Pol polyprotein3.4.23.160.444
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.444
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.444
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.444
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2xvv9DNSerum albumin/0.444
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.444
2z3uCRRCytochrome P450/0.444
2zb1GK4Mitogen-activated protein kinase 14/0.444
3btsNADGalactose/lactose metabolism regulatory protein GAL80/0.444
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.444
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.444
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.444
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3l8xN4DMitogen-activated protein kinase 14/0.444
3pm4F5NEndothiapepsin3.4.23.220.444
3s2pPMUCyclin-dependent kinase 22.7.11.220.444
3ufnROCGag-Pol polyprotein/0.444
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.444
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.444
4dbzNDPPutative ketoacyl reductase1.3.10.444
4dshFDAUncharacterized protein/0.444
4e4m0NHTyrosine-protein kinase JAK2/0.444
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.444
4fv7E94Mitogen-activated protein kinase 12.7.11.240.444
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.444
4lhtCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.444
4qgiROCGag-Pol polyprotein3.4.23.160.444
4tvbNADHomospermidine synthase2.5.1.440.444
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.444
5cnoANPEpidermal growth factor receptor2.7.10.10.444
1bk0ACVIsopenicillin N synthase1.21.3.10.443
1bygSTUTyrosine-protein kinase CSK/0.443
1dhrNADDihydropteridine reductase1.5.1.340.443
1dr2TAPDihydrofolate reductase1.5.1.30.443
1fvt106Cyclin-dependent kinase 22.7.11.220.443
1ohr1UNV-1 PROTEASE protein/0.443
1orrNADCDP-paratose 2-epimerase/0.443
1ot7CHCBile acid receptor/0.443
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
1tvoFRZMitogen-activated protein kinase 12.7.11.240.443
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.443
2cvjFADThioredoxin reductase related protein/0.443
2r3tG4GGag-Pol polyprotein3.4.23.160.443
2r64740Cyclin-dependent kinase 22.7.11.220.443
2zb0GK3Mitogen-activated protein kinase 14/0.443
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.443
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.443
3e2sFADBifunctional protein PutA1.5.5.20.443
3ggfGVDSerine/threonine-protein kinase 26/0.443
3k4nFADPyranose 2-oxidase/0.443
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3ol5SAWCamphor 5-monooxygenase1.14.15.10.443
3qu0X40Cyclin-dependent kinase 22.7.11.220.443
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.443
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.443
4dpwAGSMevalonate diphosphate decarboxylase/0.443
4dxd9PCCell division protein FtsZ/0.443
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.443
4hvh19RTyrosine-protein kinase JAK32.7.10.20.443
4ienCOAPutative acyl-CoA hydrolase/0.443
4kl9NDPDihydrofolate reductase1.5.1.30.443
4r20AERCytochrome P450 family 17 polypeptide 2/0.443
5fl3ADPPili retraction protein PilT/0.443
1dr3HBIDihydrofolate reductase1.5.1.30.442
1gebCAMCamphor 5-monooxygenase1.14.15.10.442
1gii1PUCyclin-dependent kinase 22.7.11.220.442
1hvlA76Gag-Pol polyprotein/0.442
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.442
1k6pXN3Gag-Pol polyprotein3.4.23.160.442
1oitHDTCyclin-dependent kinase 22.7.11.220.442
1xddAAYIntegrin alpha-L/0.442
2ahcVNLChorismate pyruvate-lyase/0.442
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.442
2qi4MZ6Gag-Pol polyprotein/0.442
2rhrEMOPutative ketoacyl reductase1.3.10.442
2z6dFMNPhototropin-22.7.11.10.442
3djkG55Gag-Pol polyprotein3.4.23.160.442
3gi4K60Gag-Pol polyprotein/0.442
3lzs017Gag-Pol polyprotein3.4.23.160.442
3ndtROCGag-Pol polyprotein3.4.23.160.442
3qftNAPNADPH--cytochrome P450 reductase/0.442
3vetADPnebramycin 5' synthase6.1.2.20.442
3w2o03PEpidermal growth factor receptor2.7.10.10.442
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.442
4f630S7Fibroblast growth factor receptor 1/0.442
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.442
4hdbG52Gag-Pol polyprotein3.4.23.160.442
4ih8B43Calmodulin-domain protein kinase 1/0.442
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.442
4kbk1QGCasein kinase I isoform delta2.7.11.10.442
4l4dCAMCamphor 5-monooxygenase1.14.15.10.442
4lopSB4Mitogen-activated protein kinase 14/0.442
4n0sDHCMitogen-activated protein kinase 12.7.11.240.442
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.442
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
1cjcFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.441
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.441
1lf2R37Plasmepsin-23.4.23.390.441
1pzfA3DLactate dehydrogenase/0.441
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.441
2fdd385Pol protein/0.441
2givACOHistone acetyltransferase KAT8/0.441
2q7hYLYPyrrolysine--tRNA ligase/0.441
2wedPP6Penicillopepsin-13.4.23.200.441
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.441
2z97CAMCamphor 5-monooxygenase1.14.15.10.441
2znq401Peroxisome proliferator-activated receptor delta/0.441
3bv2P38Mitogen-activated protein kinase 14/0.441
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3el1DR7Gag-Pol polyprotein3.4.23.160.441
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.441
3pxyJWSCyclin-dependent kinase 22.7.11.220.441
3qlsNDPDihydrofolate reductase1.5.1.30.441
3r9uFADThioredoxin reductase/0.441
3sacAF8Protease/0.441
3vryB43Tyrosine-protein kinase HCK2.7.10.20.441
4ewhT77Activated CDC42 kinase 1/0.441
4jbqVX6Aurora kinase A2.7.11.10.441
4zohFADPutative oxidoreductase FAD-binding subunit/0.441
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.441
5upjUINGag-Pol polyprotein/0.441
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.440
1hviA77Protease/0.440
1hvkA79Gag-Pol polyprotein/0.440
1ia3TQ5Dihydrofolate reductase1.5.1.30.440
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.440
1sivPSIGag-Pol polyprotein/0.440
1um0FMNChorismate synthase/0.440
2b5vNAPGlucose 1-dehydrogenase/0.440
2cn8DBQSerine/threonine-protein kinase Chk22.7.11.10.440
2f81017Gag-Pol polyprotein3.4.23.160.440
2hs2017Protease/0.440
2iviACWIsopenicillin N synthase1.21.3.10.440
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.440
2jd0NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.440
2rc6NAPFerredoxin--NADP reductase/0.440
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.440
3a2oKNJGag-Pol polyprotein3.4.23.160.440
3cbsR12Cellular retinoic acid-binding protein 2/0.440
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.440
3d84NDPDihydrofolate reductase1.5.1.30.440
3h0aD30Peroxisome proliferator-activated receptor gamma/0.440
3h65I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.440
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.440
3kvxFMYMitogen-activated protein kinase 102.7.11.240.440
3q3cNADNAD-dependent L-serine dehydrogenase/0.440
3r73X87Cyclin-dependent kinase 22.7.11.220.440
3s1dZIRCytokinin dehydrogenase 11.5.99.120.440
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4gmy0X5Tyrosine-protein kinase JAK2/0.440
4nka2K7Fibroblast growth factor receptor 1/0.440
4wa9AXITyrosine-protein kinase ABL12.7.10.20.440
4yt5H4MH(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338/0.440
5iu86DZAdenosine receptor A2a/0.440
4ug2NGIAdenosine receptor A2a/0.440