sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 1.000 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.651 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.593 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.545 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.542 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.527 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.527 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.524 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.520 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.520 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.507 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.506 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.500 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.497 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.496 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.496 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.495 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.493 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.492 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.490 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.484 | |
| 4xr9 | NAD | CalS8 | / | 0.484 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.483 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.481 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.479 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.479 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.479 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.477 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.477 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.476 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.476 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.476 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.476 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.476 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.476 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.476 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.474 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.473 | |
| 1rct | NOS | Purine nucleoside phosphorylase | 2.4.2.1 | 0.472 | |
| 2ejz | SAH | Diphthine synthase | / | 0.472 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.471 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.471 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.470 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.470 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.469 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.469 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.469 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.469 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.469 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.468 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.468 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.468 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.468 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.467 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.467 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.467 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.467 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.466 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.466 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.465 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.465 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.465 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.464 | |
| 1u2y | GOX | Pancreatic alpha-amylase | / | 0.464 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.464 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.463 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.463 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.463 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.463 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.462 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.462 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.462 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 3f8w | ADN | Purine nucleoside phosphorylase | / | 0.461 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.461 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.461 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.461 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.461 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.460 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 1uxy | EPU | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.460 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.460 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.460 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.460 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.460 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.460 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.460 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.460 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.459 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.459 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.459 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.459 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.459 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.458 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.458 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.458 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.457 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.457 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.457 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2j08 | IRF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.457 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.457 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.457 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.457 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.457 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.456 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.456 | |
| 1qrs | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.456 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.456 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.456 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.456 | |
| 3lnc | 5GP | Guanylate kinase | / | 0.456 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.456 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.455 | |
| 1ppj | ANY | Cytochrome b | / | 0.455 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.455 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.455 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.455 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.455 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.455 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.454 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.454 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.454 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.454 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.453 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.453 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.453 | |
| 2dvo | ITT | dITP/XTP pyrophosphatase | 3.6.1.19 | 0.452 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.452 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.452 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 2oo5 | TXD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.452 | |
| 2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.452 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.452 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.452 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.452 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.452 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.452 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.451 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2j09 | FMN | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.451 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.451 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.451 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.451 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.451 | |
| 4lut | DCS | Alanine racemase | / | 0.451 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.451 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.450 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.450 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.450 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.450 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.450 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.450 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.450 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.450 | |
| 4lt6 | 3AT | Poly(A) polymerase gamma | 2.7.7.19 | 0.450 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.450 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.450 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.449 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.449 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3fzf | ATP | Heat shock cognate 71 kDa protein | / | 0.449 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.449 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.449 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.449 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4jic | FMN | GTN Reductase | / | 0.449 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.449 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.448 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.448 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.448 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.448 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.448 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.448 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.448 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.448 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.448 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.448 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.447 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.447 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 2ohv | NHL | Glutamate racemase | / | 0.447 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.447 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.447 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 4e2d | FMN | Dehydrogenase | / | 0.447 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.447 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.447 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.446 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.446 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.446 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.446 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.446 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.446 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.446 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.446 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.446 | |
| 4b78 | KGG | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.446 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.445 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.445 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.445 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.445 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.445 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.445 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.445 | |
| 4ehy | ADP | Tetraacyldisaccharide 4'-kinase | / | 0.445 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.445 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.445 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1eio | GCH | Gastrotropin | / | 0.444 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.444 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.444 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.444 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.444 | |
| 3qvi | K95 | HAP protein | / | 0.444 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.444 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.444 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.444 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.444 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.444 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 2a8x | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.443 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.443 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.443 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.443 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.443 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.443 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.443 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.443 | |
| 4h0x | NAD | Iota toxin component Ia | / | 0.443 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.443 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.442 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 1nec | FMN | Oxygen-insensitive NAD(P)H nitroreductase | 1 | 0.442 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.442 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2ga9 | AGS | Poly(A) polymerase catalytic subunit | 2.7.7.19 | 0.442 | |
| 2gst | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.442 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.442 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.442 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.442 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.442 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.442 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.442 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.442 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.442 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.442 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.442 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.441 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.441 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.441 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.441 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 1w51 | L01 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.441 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.441 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.441 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.441 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.441 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 3ogw | IMN | Lactoperoxidase | 1.11.1.7 | 0.441 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.441 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.441 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.441 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.441 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.441 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.441 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.440 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.440 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1yry | MSG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.440 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.440 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.440 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.440 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.440 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.440 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.440 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.440 |