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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hfuMEVMevalonate kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hfuMEVMevalonate kinase/1.000
1h74ADPHomoserine kinase2.7.1.390.505
3mk6ACOPantothenate kinase 32.7.1.330.498
4jicFMNGTN Reductase/0.498
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.494
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.493
2x7hPFNProstaglandin reductase 310.491
2a94AP0L-lactate dehydrogenase1.1.1.270.490
1icsFMN12-oxophytodienoate reductase 11.3.1.420.487
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.486
2oapANPType II secretion system protein (GspE-2)/0.485
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.485
4ambDUDPutative glycosyl transferase/0.485
1in5ADPHolliday junction ATP-dependent DNA helicase RuvB/0.484
2rlcCHDCholoylglycine hydrolase3.5.1.240.484
1icqFMN12-oxophytodienoate reductase 11.3.1.420.483
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.483
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.483
2vkeTACTetracycline repressor protein class D/0.483
3tjzGNPADP-ribosylation factor 1/0.483
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.482
2ien017Gag-Pol polyprotein3.4.23.160.482
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.482
3oibFDAPutative acyl-CoA dehydrogenase/0.482
1nlmUD1UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase/0.481
3iaaTYDCalG2/0.480
4dbzNDPPutative ketoacyl reductase1.3.10.480
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.479
2vwqNAPGlucose 1-dehydrogenase/0.477
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.477
3f1kNAPUncharacterized oxidoreductase YciK10.476
3h3t16HCollagen type IV alpha-3-binding protein/0.476
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.476
4dptAGSMevalonate diphosphate decarboxylase/0.476
3b70NAPEnoyl reductase LovC10.475
3p62FMNPentaerythritol tetranitrate reductase/0.475
1n2jPAFPantothenate synthetase6.3.2.10.474
5d3qGDPDynamin-13.6.5.50.474
1h74AGSHomoserine kinase2.7.1.390.473
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
2iyfERYOleandomycin glycosyltransferase2.4.10.473
3wfjNAD2-dehydropantoate 2-reductase/0.473
1h73ANPHomoserine kinase2.7.1.390.472
1kp3ATPArgininosuccinate synthase6.3.4.50.472
2ii6C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.472
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.472
3p74FMNPentaerythritol tetranitrate reductase/0.472
4dpuAGSMevalonate diphosphate decarboxylase/0.472
1u1gBBBUridine phosphorylase2.4.2.30.471
3cib314Beta-secretase 13.4.23.460.471
3qt62P0Mevalonate diphosphate decarboxylase/0.471
1bwsNDPGDP-L-fucose synthase/0.470
1ipeNDPTropinone reductase 21.1.1.2360.470
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.470
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.470
3em3478Gag-Pol polyprotein3.4.23.160.470
3uylTYDProbable NDP-rhamnosyltransferase/0.470
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.470
4kgmATPUncharacterized protein/0.470
1ib0NADNADH-cytochrome b5 reductase 31.6.2.20.469
2eklNADD-3-phosphoglycerate dehydrogenase/0.469
2ephASP_TRP_ASNFructose-bisphosphate aldolase4.1.2.130.469
3qlsNDPDihydrofolate reductase1.5.1.30.469
1nzdUPGDNA beta-glucosyltransferase/0.468
1qo8FADFumarate reductase flavoprotein subunit/0.468
4du82P0Mevalonate diphosphate decarboxylase/0.468
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.468
4i0h1BLBeta-secretase 13.4.23.460.468
1t2cNAIL-lactate dehydrogenase1.1.1.270.467
1xkdNAPIsocitrate dehydrogenase [NADP]/0.467
2j07HDFDeoxyribodipyrimidine photo-lyase4.1.99.30.467
1udbUFGUDP-glucose 4-epimerase5.1.3.20.466
2ahrNAPPyrroline-5-carboxylate reductase/0.466
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
1p0hACOMycothiol acetyltransferase2.3.1.1890.465
1tehNADAlcohol dehydrogenase class-31.1.1.10.465
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.465
2x0iNAIMalate dehydrogenase/0.465
2z54AB1Gag-Pol polyprotein3.4.23.160.465
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.465
3f03FMNPentaerythritol tetranitrate reductase/0.465
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.465
3lqfNADGalactitol dehydrogenase/0.465
4ajj88RL-lactate dehydrogenase A chain1.1.1.270.465
4yaoFMNNADPH--cytochrome P450 reductase/0.465
1msmJE2Gag-Pol polyprotein3.4.23.160.464
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.464
3v2uATPProtein GAL3/0.464
4a8v2ANMajor pollen allergen Bet v 1-J/0.464
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.464
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.463
2ex1C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.463
3atzFMNProstaglandin F2a synthase/0.463
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.463
3gwfNAPCyclohexanone monooxygenase/0.463
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.463
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.462
1h50FMNPentaerythritol tetranitrate reductase/0.462
2b4qNAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.462
2d29FADAcyl-CoA dehydrogenase/0.462
2ejvNADL-threonine 3-dehydrogenase/0.462
3d3wNAPL-xylulose reductase1.1.1.100.462
3hyoADPPyridoxal kinase/0.462
3kb1ADPIron-sulfur cluster carrier protein/0.462
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.462
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.462
4f3xNADPutative aldehyde dehydrogenase/0.462
2i7pACOPantothenate kinase 32.7.1.330.461
2iko7IGRenin3.4.23.150.461
3c212BADNA integrity scanning protein DisA/0.461
4a802ANMajor pollen allergen Bet v 1-A/0.461
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.461
4m83ERYOleandomycin glycosyltransferase2.4.10.461
4mkhAP5Adenylate kinase/0.461
4qaiFMNNADPH dehydrogenase/0.461
4xguADPPutative pachytene checkpoint protein 2/0.461
1xs7MMIBeta-secretase 13.4.23.460.460
2f81017Gag-Pol polyprotein3.4.23.160.460
2iqgF2IBeta-secretase 13.4.23.460.460
2yd0BESEndoplasmic reticulum aminopeptidase 13.4.110.460
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.460
3imgBZ2Pantothenate synthetase6.3.2.10.460
4i1nFOLDihydrofolate reductase1.5.1.30.460
4j0v1H7Beta-secretase 13.4.23.460.460
4kqrVPPPeptidoglycan D,D-transpeptidase FtsI/0.460
5cyoGDPSeptin-9/0.460
1bsvNDPGDP-L-fucose synthase/0.459
1dr2TAPDihydrofolate reductase1.5.1.30.459
1mj9COAHistone acetyltransferase ESA1/0.459
1udaUFGUDP-glucose 4-epimerase5.1.3.20.459
2c29NAPDihydroflavonol 4-reductase/0.459
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.459
2rcyNAPPyrroline-5-carboxylate reductase/0.459
3drcMTXDihydrofolate reductase1.5.1.30.459
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.459
3gkaFMNN-ethylmaleimide reductase/0.459
3ivxFG6Pantothenate synthetase6.3.2.10.459
3phiNDPShikimate dehydrogenase (NADP(+))/0.459
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.459
1icpFMN12-oxophytodienoate reductase 11.3.1.420.458
1rfuADPPyridoxal kinase2.7.1.350.458
1u1d181Uridine phosphorylase2.4.2.30.458
1xe55FEPlasmepsin-23.4.23.390.458
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.458
2ikuLIYRenin3.4.23.150.458
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.458
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.458
3ox4NADAlcohol dehydrogenase 21.1.1.10.458
4b4dFADFerredoxin-NADP reductase/0.458
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.458
4opgFDAConserved Archaeal protein/0.458
1bim0QBRenin3.4.23.150.457
1hncGDNGlutathione S-transferase Mu 22.5.1.180.457
1q45FMN12-oxophytodienoate reductase 31.3.1.420.457
2cwfNDPDelta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase/0.457
2d4vNADIsocitrate dehydrogenase [NADP]/0.457
2fonFADAcyl-coenzyme A oxidase/0.457
3c1y2BADNA integrity scanning protein DisA/0.457
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.457
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.457
3oetNADErythronate-4-phosphate dehydrogenase/0.457
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.456
2b53D23Cyclin-dependent kinase 22.7.11.220.456
2ilvC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.456
2qdxFADFerredoxin--NADP+ reductase/0.456
2wsiFADFAD synthase2.7.7.20.456
3akn11DFatty acid-binding protein, intestinal/0.456
3lpkZ76Beta-secretase 13.4.23.460.456
3oixFMNDihydroorotate dehydrogenase/0.456
4bfvZVVPantothenate kinase2.7.1.330.456
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.456
4df2FMNNADPH dehydrogenase/0.456
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.456
4q71FADBifunctional protein PutA/0.456
4wriOKAOkadaic acid binding protein 2-alpha/0.456
4y9lFADAcyl-CoA dehydrogenase family member 11/0.456
1iy8NADLevodione reductase/0.455
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.455
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.455
2dftADPShikimate kinase2.7.1.710.455
2fnaADPUncharacterized protein/0.455
2fznFADBifunctional protein PutA1.5.5.20.455
2uxoTACHTH-type transcriptional regulator TtgR/0.455
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.455
3k4nFADPyranose 2-oxidase/0.455
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.455
4ktoFADPutative isovaleryl-CoA dehydrogenase protein/0.455
4nesUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.455
4rnwFMNNADPH dehydrogenase 11.6.99.10.455
1dgmADNAdenosine kinase2.7.1.200.454
1kevNDPNADP-dependent isopropanol dehydrogenase1.1.1.800.454
2gv8NDPThiol-specific monooxygenase1.14.130.454
2p83MR0Beta-secretase 13.4.23.460.454
2pauD5M5'-deoxynucleotidase YfbR/0.454
2qn3F55Glycogen phosphorylase, muscle form2.4.1.10.454
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.454
3axkNDPRibulose bisphosphate carboxylase large chain4.1.1.390.454
3e8xNAPBH1520 protein/0.454
3eksCY9Actin-5C/0.454
3fr4F8AFatty acid-binding protein, adipocyte/0.454
3in6FMNUncharacterized protein/0.454
3vsxR32Renin3.4.23.150.454
4i1iNADMalate dehydrogenase/0.454
4tmcFMNOld yellow enzyme/0.454
1dr5NAPDihydrofolate reductase1.5.1.30.453
1mjaCOAHistone acetyltransferase ESA1/0.453
1q6yCOAFormyl-CoA:oxalate CoA-transferase/0.453
1xdpATPPolyphosphate kinase/0.453
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.453
2he5NDPAldo-keto reductase family 1 member C211.1.10.453
2y1tDUDSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.453
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.453
3hx4ANPCalmodulin-domain protein kinase 1/0.453
3iocA5DPantothenate synthetase6.3.2.10.453
3toh079Gag-Pol polyprotein2.7.7.490.453
4d0lGSPRas-related protein Rab-11A/0.453
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.453
4frkDWDBeta-secretase 13.4.23.460.453
4gl4NAIAlcohol dehydrogenase class-3/0.453
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.453
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.452
1g1aNADdTDP-glucose 4,6-dehydratase/0.452
2abbFMNPentaerythritol tetranitrate reductase/0.452
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.452
2i4qUA4Renin3.4.23.150.452
2iviACWIsopenicillin N synthase1.21.3.10.452
2nniMTKCytochrome P450 2C8/0.452
3hlwCE3Beta-lactamase/0.452
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.452
3jzdNADMaleylacetate reductase/0.452
3kpbSAMUncharacterized protein MJ0100/0.452
3r4b74TGag-Pol polyprotein/0.452
4a83DXCMajor pollen allergen Bet v 1-A/0.452
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
4eb7PLPCysteine desulfurase IscS 2/0.452
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.451
1f8wFADNADH peroxidase1.11.1.10.451
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.451
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.451
2j09FMNDeoxyribodipyrimidine photo-lyase4.1.99.30.451
2z1mNDPGDP-mannose 4,6-dehydratase/0.451
3pmy41LEndothiapepsin3.4.23.220.451
3pxvFMNNitroreductase/0.451
4e2bFMNDehydrogenase/0.451
4lcjNADC-terminal-binding protein 2/0.451
5ftfADPTPR domain protein/0.451
5idwNAPShort-chain dehydrogenase/reductase SDR/0.451
1hb3SCVIsopenicillin N synthase1.21.3.10.450
1ia1NDPDihydrofolate reductase1.5.1.30.450
1lbcCYZGlutamate receptor 2/0.450
1nzfUPGDNA beta-glucosyltransferase/0.450
1vikBAYGag-Pol polyprotein/0.450
1xddAAYIntegrin alpha-L/0.450
2c27ACOMycothiol acetyltransferase2.3.1.1890.450
2y0mACOHistone acetyltransferase KAT8/0.450
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.450
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.450
3ixk929Beta-secretase 13.4.23.460.450
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.450
3o0o5ADVitamin B12-dependent ribonucleotide reductase/0.450
3pgxNADUncharacterized NAD-dependent oxidoreductase MAP_4146/0.450
4m4922YL-lactate dehydrogenase A chain1.1.1.270.450
5cwa0GAAnthranilate synthase component 14.1.3.270.450
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.449
2daaDCSD-alanine aminotransferase2.6.1.210.449
2ejzSAHDiphthine synthase/0.449
2freFMNNAD(P)H-flavin oxidoreductase/0.449
2i5bADPPyridoxine kinase/0.449
2j08IRFDeoxyribodipyrimidine photo-lyase4.1.99.30.449
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.449
3h06VBPGlutamate receptor 2/0.449
3isjA8DPantothenate synthetase6.3.2.10.449
3lsiFADPyranose 2-oxidase/0.449
3ohh3HHBeta-secretase 13.4.23.460.449
3sj7NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative/0.449
3tdj3TJGlutamate receptor 2/0.449
4i9h1E4L-lactate dehydrogenase A chain1.1.1.270.449
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.449
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.449
4loi1YCStimulator of interferon genes protein/0.449
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.449
4nxxGDPMitochondrial dynamics protein MID51/0.449
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
1fm4DXCMajor pollen allergen Bet v 1-L/0.448
1fy7COAHistone acetyltransferase ESA1/0.448
2jb4A14Isopenicillin N synthase1.21.3.10.448
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.448
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.448
2ql6ADPNicotinamide riboside kinase 1/0.448
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.448
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.448
3ixj586Beta-secretase 13.4.23.460.448
3p67FMNPentaerythritol tetranitrate reductase/0.448
3sxpNADADP-L-glycero-D-mannoheptose-6-epimerase/0.448
4a862ANMajor pollen allergen Bet v 1-A/0.448
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.448
1e3eNAIAlcohol dehydrogenase 41.1.1.10.447
1h51FMNPentaerythritol tetranitrate reductase/0.447
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1j1zATPArgininosuccinate synthase/0.447
1jolFFODihydrofolate reductase1.5.1.30.447
1meiXMPInosine-5'-monophosphate dehydrogenase/0.447
2e1mFADL-glutamate oxidase/0.447
2gmjFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.447
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.447
2ylzFADPhenylacetone monooxygenase1.14.13.920.447
2yxuATPPyridoxal kinase2.7.1.350.447
3coy53HPantothenate synthetase6.3.2.10.447
3f3sNADLambda-crystallin homolog/0.447
3h3qH13Collagen type IV alpha-3-binding protein/0.447
3nutSAHPrecorrin-3 methylase/0.447
4a6nFADTetX family tetracycline inactivation enzyme/0.447
4fqsLYAThymidylate synthase ThyA/0.447
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.447
4xbjIN5Alanine racemase, biosynthetic/0.447
5cflC2EStimulator of interferon genes protein/0.447
1foaUD1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase2.4.1.1010.446
1hb1OCVIsopenicillin N synthase1.21.3.10.446
1p31EPUUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.446
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.446
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.446
2dvoITTdITP/XTP pyrophosphatase3.6.1.190.446
2gjlFMNNitronate monooxygenase1.13.12.160.446
2nmtNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.446
2rhgIGPTryptophan synthase alpha chain/0.446
2v5aLZLBiotin carboxylase6.3.4.140.446
3dmeFADPutative conserved exported protein/0.446
3ekuCY9Actin-5C/0.446
3fhyATPPyridoxal kinase2.7.1.350.446
3fktSIIBeta-secretase 13.4.23.460.446
3iodA6DPantothenate synthetase6.3.2.10.446
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
4an4DUDPutative glycosyl transferase/0.446
4eb5PLPCysteine desulfurase IscS 2/0.446
4h1e10JBeta-secretase 13.4.23.460.446
4k8s1QTBeta-secretase 13.4.23.460.446
4yaiNAIC alpha-dehydrogenase/0.446
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.446
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.446
1gilGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.445
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1mjbACOHistone acetyltransferase ESA1/0.445
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.445
2iypNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.445
2qbuSAHPrecorrin-2 methyltransferase/0.445
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
2xpuTDCTetracycline repressor protein class D/0.445
3c15FOKAdenylate cyclase type 2/0.445
3c15FOKAdenylate cyclase type 5/0.445
3dk1G05Gag-Pol polyprotein3.4.23.160.445
3gw9VNILanosterol 14-alpha-demethylase/0.445
3junAKDPhenazine biosynthesis protein A/B/0.445
3mknDNBPyrimidine-specific ribonucleoside hydrolase RihB/0.445
3opdHIEHeat shock protein 83/0.445
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.445
4askK0ILysine-specific demethylase 6B1.14.110.445
4fse0VABeta-secretase 13.4.23.460.445
4m5pFMNNADPH dehydrogenase/0.445
4p63NADProbable deoxyhypusine synthase2.5.1.460.445
4q73FADBifunctional protein PutA/0.445
4u0mATPCyclic GMP-AMP synthase/0.445
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.445
1a72PADAlcohol dehydrogenase E chain1.1.1.10.444
1d7aAIRN5-carboxyaminoimidazole ribonucleotide mutase/0.444
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1omoNADAlanine dehydrogenase/0.444
1tqf32PBeta-secretase 13.4.23.460.444
1w6hTITPlasmepsin-23.4.23.390.444
2dvlFADAcyl-CoA dehydrogenase/0.444
2g226IGRenin3.4.23.150.444
2p3b3TLV-1 PROTEASE protein/0.444
2p3b3TLV-1 protease/0.444
2q7vFADThioredoxin reductase/0.444
2rc4ACOHistone acetyltransferase KAT6A/0.444
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.444
2yvgNADFerredoxin reductase/0.444
3b2sB2STrichothecene 3-O-acetyltransferase/0.444
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
3p82FMNPentaerythritol tetranitrate reductase/0.444
3wmxNADNAD dependent epimerase/dehydratase/0.444
4dfg0JVGag-Pol polyprotein3.4.23.160.444
4egbNADdTDP-glucose 4,6-dehydratase/0.444
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.444
4fxy0W2Neurolysin, mitochondrial3.4.24.160.444
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.444
4h1vGNPDynamin-1-like protein3.6.5.50.444
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.444
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.444
4mihFADPyranose 2-oxidase1.1.3.100.444
4qxaGTPRas-related protein Rab-9A/0.444
5dozNDPJamJ/0.444
1i5cADPChemotaxis protein CheA2.7.13.30.443
1jmhUMPThymidylate synthase/0.443
1n77ATPGlutamate--tRNA ligase6.1.1.170.443
1nytNAPShikimate dehydrogenase (NADP(+))/0.443
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
2fj1CTCTetracycline repressor protein class D/0.443
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.443
2jahNDPClavaldehyde dehydrogenase/0.443
2ji6TPWOxalyl-CoA decarboxylase4.1.1.80.443
2ozuACOHistone acetyltransferase KAT6A/0.443
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.443
3d4pNADL-lactate dehydrogenase 11.1.1.270.443
3gy0NAPNAD(P)-dependent oxidoreductase/0.443
3h3cP1EProtein-tyrosine kinase 2-beta2.7.10.20.443
3h3jNADL-lactate dehydrogenase 11.1.1.270.443
3lzs017Gag-Pol polyprotein3.4.23.160.443
3qe2FMNNADPH--cytochrome P450 reductase/0.443
3rucNADUDP-N-acetylglucosamine 4-epimerase/0.443
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.443
3t64DU3Deoxyuridine 5'-triphosphate nucleotidohydrolase/0.443
3toxNAPPutative oxidoreductase/0.443
3w1tWRODihydroorotate dehydrogenase (fumarate)1.3.98.10.443
4bkqNAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.443
4fn4NADShort chain dehydrogenase/0.443
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.443
4q72FADBifunctional protein PutA/0.443
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.443
1a5bIGPTryptophan synthase alpha chain/0.442
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.442
1pqc444Oxysterols receptor LXR-beta/0.442
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.442
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.442
2ab8MTPAdenosine kinase2.7.1.200.442
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.442
2hm1LIQBeta-secretase 13.4.23.460.442
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.442
2o23NAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
2vceU2FUDP-glycosyltransferase 72B1/0.442
3b6pTMPThree-prime repair exonuclease 13.1.11.20.442
3bgbLJGGag-Pol polyprotein3.4.23.160.442
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3fp0FP015-O-acetyltransferase/0.442
3h3r14HCollagen type IV alpha-3-binding protein/0.442
3rk1ATPN-type ATP pyrophosphatase superfamily/0.442
3u9eCOALmo1369 protein/0.442
3ukoNADAlcohol dehydrogenase class-3/0.442
3wqmB29Diterpene synthase3.1.7.80.442
4a99FADTetX family tetracycline inactivation enzyme/0.442
4bfxZVXPantothenate kinase2.7.1.330.442
4g7gVFVLanosterol 14-alpha-demethylase/0.442
4hi0GDPUrease accessory protein UreG/0.442
4jldADPAdenylate kinase/0.442
4zohFADPutative oxidoreductase FAD-binding subunit/0.442
5c1mCLRMu-type opioid receptor/0.442
5eoyADPType 4 fimbrial biogenesis protein PilM/0.442
1culFOKAdenylate cyclase type 2/0.441
1culFOKAdenylate cyclase type 5/0.441
1gcoNADGlucose 1-dehydrogenase1.1.1.470.441
1h72ANPHomoserine kinase2.7.1.390.441
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1obbNADAlpha-glucosidase3.2.1.200.441
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.441
2draATPCCA-adding enzyme2.7.7.720.441
2g76NADD-3-phosphoglycerate dehydrogenase1.1.1.950.441
2il2LIXRenin3.4.23.150.441
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.441
3atyFMNProstaglandin F2a synthase/0.441
3dm5GDPSignal recognition particle 54 kDa protein/0.441
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.441
3pm9FADPutative oxidoreductase/0.441
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.441
3ty3GGGHomoisocitrate dehydrogenase1.1.1.870.441
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4ead0NPThymidine phosphorylase2.4.2.40.441
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.441
4oagADPMitochondrial dynamics protein MID51/0.441
5a3bAPRSIR2 family protein/0.441
5jjsSAHGenome polyprotein/0.441
1ezvUQ6Cytochrome b/0.440
1fmlRTLRetinol dehydratase/0.440
1fxsNAPGDP-L-fucose synthase/0.440
1ma0NADAlcohol dehydrogenase class-31.1.1.10.440
1mokFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.440
1psa0ZLPepsin A3.4.23.10.440
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.440
1w4zNAPPutative ketoacyl reductase1.3.10.440
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2v2qNVG4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.440
2y6o1N1Ephrin type-A receptor 42.7.10.10.440
3ai3NDPNADPH-sorbose reductase/0.440
3bg7FADPyranose 2-oxidase/0.440
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
3k5gBJCBeta-secretase 13.4.23.460.440
3lu1NADUDP-N-acetylglucosamine 4-epimerase/0.440
4bfzZVZPantothenate kinase2.7.1.330.440
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.440
4f9fGDPPutative glycosyltransferase/0.440
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4ke11R6Beta-secretase 13.4.23.460.440
4tqgNDPPutative dTDP-d-glucose 4 6-dehydratase/0.440