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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1pyxANPGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1pyxANPGlycogen synthase kinase-3 beta2.7.11.261.000
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.615
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.613
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.605
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.599
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.598
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.594
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.589
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.581
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.580
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.578
5drdATPAurora kinase A2.7.11.10.577
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.565
1ol5ADPAurora kinase A2.7.11.10.564
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.561
3du8553Glycogen synthase kinase-3 beta2.7.11.260.557
2dwbANPAurora kinase A2.7.11.10.546
3c50ADPRhodopsin kinase/0.543
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.543
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.542
5dt4ATPAurora kinase A2.7.11.10.542
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.541
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.539
1mq4ADPAurora kinase A2.7.11.10.536
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.535
2acxANPG protein-coupled receptor kinase 62.7.11.160.533
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.532
5dt3ATPAurora kinase A2.7.11.10.532
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.530
3qc9ADPRhodopsin kinase/0.530
4deeADPAurora kinase A2.7.11.10.529
3k5uPFQAurora kinase A2.7.11.10.525
2qo9ANPEphrin type-A receptor 32.7.10.10.524
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.523
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.523
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.521
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.519
5dn3ATPAurora kinase A2.7.11.10.519
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.517
1lp4ANPCasein kinase II subunit alpha2.7.11.10.513
2hog710Serine/threonine-protein kinase Chk12.7.11.10.513
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.513
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.512
4utdACPAurora kinase A2.7.11.10.512
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.510
3c4zADPRhodopsin kinase/0.506
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.506
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.506
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.506
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.506
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.505
4jajXU1Aurora kinase A2.7.11.10.504
5dnrATPAurora kinase A2.7.11.10.504
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.503
4qnyANPMitogen activated protein kinase, putative/0.503
2np8CC3Aurora kinase A2.7.11.10.502
3le62BZCyclin-dependent kinase 22.7.11.220.502
1ol7ADPAurora kinase A2.7.11.10.501
3c4wATPRhodopsin kinase/0.501
4ix5ANPUncharacterized protein/0.501
4jbqVX6Aurora kinase A2.7.11.10.501
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.500
1jstATPCyclin-dependent kinase 22.7.11.220.499
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.499
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.499
4oauADP2-5A-dependent ribonuclease3.1.260.499
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.499
1u54ACPActivated CDC42 kinase 1/0.498
4oavACP2-5A-dependent ribonuclease3.1.260.498
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.497
3a7jADPSerine/threonine-protein kinase 242.7.11.10.497
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.497
5dosATPAurora kinase A2.7.11.10.497
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.496
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.496
2j4z626Aurora kinase A2.7.11.10.495
4hvh19RTyrosine-protein kinase JAK32.7.10.20.495
4jqeANPCasein kinase II subunit alpha2.7.11.10.495
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.495
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.494
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.494
3zh8C58Protein kinase C iota type2.7.11.130.494
4b0gVEKAurora kinase A2.7.11.10.494
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.494
3hmm855TGF-beta receptor type-12.7.11.300.493
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.492
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.492
4jbpYPHAurora kinase A2.7.11.10.491
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.490
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.490
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.490
4jia1K3Tyrosine-protein kinase JAK2/0.490
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.490
4o0sADNAurora kinase A2.7.11.10.489
3gxlQIGTGF-beta receptor type-12.7.11.300.488
4c3pACPAurora kinase A2.7.11.10.488
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.487
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.487
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.487
1jnkANPMitogen-activated protein kinase 102.7.11.240.486
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.486
4zseANPEpidermal growth factor receptor2.7.10.10.486
3t8oATPRhodopsin kinase/0.485
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.485
4e4m0NHTyrosine-protein kinase JAK2/0.485
4lopSB4Mitogen-activated protein kinase 14/0.485
4o0wADNAurora kinase A2.7.11.10.485
4riyADPEpidermal growth factor receptor2.7.10.10.485
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.484
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.484
4eomATPCyclin-dependent kinase 22.7.11.220.484
4jr7GNPCasein kinase II subunit alpha2.7.11.10.484
4qmzB49Serine/threonine-protein kinase 242.7.11.10.484
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.483
3i60E86Mitogen-activated protein kinase 12.7.11.240.483
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.483
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.483
4uymVOR14-alpha sterol demethylase Cyp51B/0.483
1fvv107Cyclin-dependent kinase 22.7.11.220.482
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.482
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.482
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.482
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.482
5aacVGHALK tyrosine kinase receptor2.7.10.10.482
2henADPEphrin type-B receptor 22.7.10.10.481
4fkv61KCyclin-dependent kinase 22.7.11.220.481
4gk2L66Ephrin type-A receptor 32.7.10.10.481
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.481
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.481
4qmpDKISerine/threonine-protein kinase 242.7.11.10.481
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.480
1unlRRCCyclin-dependent-like kinase 52.7.11.10.480
2qocANPEphrin type-A receptor 32.7.10.10.480
2uzlC94Cyclin-dependent kinase 22.7.11.220.480
4gk3L87Ephrin type-A receptor 32.7.10.10.480
5cnoANPEpidermal growth factor receptor2.7.10.10.480
1csnATPCasein kinase I homolog 12.7.11.10.479
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.479
5dr2ATPAurora kinase A2.7.11.10.479
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.478
2gjlFMNNitronate monooxygenase1.13.12.160.478
2gjnFMNNitronate monooxygenase1.13.12.160.478
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.477
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.477
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.477
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.477
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
4fob0USALK tyrosine kinase receptor2.7.10.10.477
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.477
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.476
4bn1ADPAurora kinase A2.7.11.10.476
4g2fC07Ephrin type-A receptor 32.7.10.10.476
4lfiGNPCasein kinase II subunit alpha2.7.11.10.476
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.476
5dr9SKEAurora kinase A2.7.11.10.476
4z34ON7Lysophosphatidic acid receptor 1/0.476
1dayGNPCasein kinase II subunit alpha2.7.11.10.475
1di8DTQCyclin-dependent kinase 22.7.11.220.475
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.475
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.475
4dgmAGICasein kinase II subunit alpha2.7.11.10.475
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.474
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.474
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
3hx4ANPCalmodulin-domain protein kinase 1/0.474
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.474
4pl3ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.474
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.473
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.473
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.473
2iw84SPCyclin-dependent kinase 22.7.11.220.473
3e5aVX6Aurora kinase A2.7.11.10.473
3eb0DRKUncharacterized protein/0.473
4aotGW8Serine/threonine-protein kinase 102.7.11.10.473
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.473
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.473
5e8wSTUTGF-beta receptor type-12.7.11.300.473
2pziAXXSerine/threonine-protein kinase PknG2.7.11.10.472
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.472
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.472
3nszANPCasein kinase II subunit alpha2.7.11.10.472
3ttiKBIMitogen-activated protein kinase 102.7.11.240.472
4bcmT7ZCyclin-dependent kinase 22.7.11.220.472
4c3rACPAurora kinase A2.7.11.10.472
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
2xa4AZ5Tyrosine-protein kinase JAK2/0.471
3c4xATPRhodopsin kinase/0.471
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.471
3my5RFZCyclin-dependent kinase 22.7.11.220.471
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.471
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.471
4fv7E94Mitogen-activated protein kinase 12.7.11.240.471
4i22IREEpidermal growth factor receptor2.7.10.10.471
4ix4ADPUncharacterized protein/0.471
4qmlANPSerine/threonine-protein kinase 242.7.11.10.471
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
1oi9N20Cyclin-dependent kinase 22.7.11.220.470
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.470
2qo7ANPEphrin type-A receptor 32.7.10.10.470
2w1fL0FAurora kinase A2.7.11.10.470
2zdt46CMitogen-activated protein kinase 102.7.11.240.470
3tnwF18Cyclin-dependent kinase 22.7.11.220.470
4hvg19QTyrosine-protein kinase JAK32.7.10.20.470
4hvi19STyrosine-protein kinase JAK32.7.10.20.470
4ix6ADPUncharacterized protein/0.470
4jboWPHAurora kinase A2.7.11.10.470
5e8xSTUTGF-beta receptor type-12.7.11.300.470
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.469
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.469
3a60STURibosomal protein S6 kinase beta-12.7.11.10.469
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
4c62XWWTyrosine-protein kinase JAK2/0.469
4n57ADPAPH(2'')-Id/0.469
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.468
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.468
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.468
3k9vCPS1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial/0.468
3w32W32Epidermal growth factor receptor2.7.10.10.468
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.468
1bygSTUTyrosine-protein kinase CSK/0.467
1xddAAYIntegrin alpha-L/0.467
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.467
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.467
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.467
3w16P9JAurora kinase A2.7.11.10.467
3wv9FEGHmd co-occurring protein HcgE/0.467
4bgg844Activin receptor type-12.7.11.300.467
4kb81QOCasein kinase I isoform delta2.7.11.10.467
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.467
1e3eNAIAlcohol dehydrogenase 41.1.1.10.466
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.466
1y0s331Peroxisome proliferator-activated receptor delta/0.466
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.466
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.466
3frqERYErythromycin resistance repressor protein/0.466
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.466
3oom507Activin receptor type-12.7.11.300.466
3s2pPMUCyclin-dependent kinase 22.7.11.220.466
4xldBRLPeroxisome proliferator-activated receptor gamma/0.466
1ke6LS2Cyclin-dependent kinase 22.7.11.220.465
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.465
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
3mdvCL6Cholesterol 24-hydroxylase/0.465
4enhFVXCholesterol 24-hydroxylase/0.465
4eor4SPCyclin-dependent kinase 22.7.11.220.465
4erwSTUCyclin-dependent kinase 22.7.11.220.465
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.465
4k33ACPFibroblast growth factor receptor 32.7.10.10.465
4nj32KDCyclin-dependent kinase 22.7.11.220.465
1pmn984Mitogen-activated protein kinase 102.7.11.240.464
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.464
2pvhP19Casein kinase II subunit alpha2.7.11.10.464
2py3ACPFibroblast growth factor receptor 2/0.464
2x1nX1NCyclin-dependent kinase 22.7.11.220.464
2y3rTRKTamL/0.464
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.464
3zonIK1Non-receptor tyrosine-protein kinase TYK22.7.10.20.464
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.464
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.464
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.464
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.464
1zeoC01Peroxisome proliferator-activated receptor gamma/0.463
2c6tDT5Cyclin-dependent kinase 22.7.11.220.463
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.463
5cnnANPEpidermal growth factor receptor2.7.10.10.463
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.462
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.462
3a62STURibosomal protein S6 kinase beta-12.7.11.10.462
3cgfJNFMitogen-activated protein kinase 102.7.11.240.462
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.462
4mwhATPCasein kinase II subunit alpha2.7.11.10.462
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.461
1ol6ATPAurora kinase A2.7.11.10.461
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.461
2qoqANPEphrin type-A receptor 32.7.10.10.461
3nizADPCdc2-like CDK2/CDC28 like protein kinase/0.461
3oroAGSSerine/threonine protein kinase/0.461
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.461
4c02TAKActivin receptor type-12.7.11.300.461
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.461
4xlvACPInsulin receptor2.7.10.10.461
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.460
2bhhRYUCyclin-dependent kinase 22.7.11.220.460
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.460
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.460
2i51FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding/0.460
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.460
2xngA0HAurora kinase A2.7.11.10.460
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.460
4qnaX11Serine/threonine-protein kinase 242.7.11.10.460
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
1a72PADAlcohol dehydrogenase E chain1.1.1.10.459
1bw9NADPhenylalanine dehydrogenase/0.459
1gij2PUCyclin-dependent kinase 22.7.11.220.459
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.459
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.459
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.459
3be9P04Casein kinase II subunit alpha2.7.11.10.459
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.459
3ijdC2FMethylenetetrahydrofolate reductase/0.459
3tqhNDPQuinone oxidoreductase/0.459
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.459
3wowANPCasein kinase II subunit alpha2.7.11.10.459
4eooATPCyclin-dependent kinase 22.7.11.220.459
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.458
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
1vjy460TGF-beta receptor type-12.7.11.300.458
2cchATPCyclin-dependent kinase 22.7.11.220.458
2csnCKICasein kinase I homolog 12.7.11.10.458
2wotZZGTGF-beta receptor type-12.7.11.300.458
2xru400Aurora kinase A2.7.11.10.458
3clyACPFibroblast growth factor receptor 2/0.458
3efwAK8Aurora kinase A2.7.11.10.458
3ggfGVDSerine/threonine-protein kinase 26/0.458
3r9hZ67Cyclin-dependent kinase 22.7.11.220.458
3so9017Pol protein/0.458
4c4jX21Dual specificity protein kinase TTK2.7.12.10.458
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.458
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.458
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4qi5FADCellobiose dehydrogenase/0.458
5e92ANPTGF-beta receptor type-22.7.11.300.458
1pxlCK4Cyclin-dependent kinase 22.7.11.220.457
1rw8580TGF-beta receptor type-12.7.11.300.457
2excJNKMitogen-activated protein kinase 102.7.11.240.457
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.457
3qwkX62Cyclin-dependent kinase 22.7.11.220.457
3ttjJBIMitogen-activated protein kinase 102.7.11.240.457
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.457
4j95ACPFibroblast growth factor receptor 2/0.457
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.456
2c5yMTWCyclin-dependent kinase 22.7.11.220.456
2pvnP63Casein kinase II subunit alpha2.7.11.10.456
2vd5BI8Myotonin-protein kinase2.7.11.10.456
2w1gL0GAurora kinase A2.7.11.10.456
2xikJ60Serine/threonine-protein kinase 252.7.11.10.456
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.456
3zep1NXTyrosine-protein kinase JAK32.7.10.20.456
4eok4SPCyclin-dependent kinase 22.7.11.220.456
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.456
4j97ACPFibroblast growth factor receptor 2/0.456
4ktc1X3Genome polyprotein3.4.21.980.456
1aq1STUCyclin-dependent kinase 22.7.11.220.455
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1v0pPVBCell division control protein 2 homolog2.7.11.220.455
1x2hLPALipoate-protein ligase A6.3.1.200.455
1zltHYMSerine/threonine-protein kinase Chk12.7.11.10.455
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.455
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.455
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.455
3bheBZNGag-Pol polyprotein3.4.23.160.455
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.455
4bcnT9NCyclin-dependent kinase 22.7.11.220.455
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.455
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.455
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.455
5dt0SKEAurora kinase A2.7.11.10.455
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1oiyN41Cyclin-dependent kinase 22.7.11.220.454
1vyw292Cyclin-dependent kinase 22.7.11.220.454
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.454
2ft9CHDFatty acid-binding protein 2, liver/0.454
2pzpACPFibroblast growth factor receptor 2/0.454
2r64740Cyclin-dependent kinase 22.7.11.220.454
2wihP48Cyclin-dependent kinase 22.7.11.220.454
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.454
3ddpRC8Cyclin-dependent kinase 22.7.11.220.454
3lfqA28Cyclin-dependent kinase 22.7.11.220.454
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.454
4wboANWRhodopsin kinase/0.454
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1ha3MAUElongation factor Tu-A/0.453
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.453
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.453
2uzdC85Cyclin-dependent kinase 22.7.11.220.453
2x6dX6DAurora kinase A2.7.11.10.453
2xuuADPDeath-associated protein kinase 12.7.11.10.453
3zmmF9JTyrosine-protein kinase JAK2/0.453
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.453
5dr6SKEAurora kinase A2.7.11.10.453
1e9hINRCyclin-dependent kinase 22.7.11.220.452
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.452
1pkdUCNCyclin-dependent kinase 22.7.11.220.452
1yw2PGJMitogen-activated protein kinase 14/0.452
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2d29FADAcyl-CoA dehydrogenase/0.452
2ejvNADL-threonine 3-dehydrogenase/0.452
2f2cAP9Cyclin-dependent kinase 62.7.11.220.452
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.452
2j9mPY8Cyclin-dependent kinase 22.7.11.220.452
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.452
3gcnTYR_GLN_PHESerine endoprotease DegS3.4.21.1070.452
3nux3NVCyclin-dependent kinase 62.7.11.220.452
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.452
3zewSTUEphrin type-B receptor 42.7.10.10.452
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.452
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.452
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.452
4gmy0X5Tyrosine-protein kinase JAK2/0.452
4loqSB4Mitogen-activated protein kinase 14/0.452
1yb5NAPQuinone oxidoreductase1.6.5.50.451
1yvj4STTyrosine-protein kinase JAK32.7.10.20.451
2pvlP55Casein kinase II subunit alpha2.7.11.10.451
2q5g1FAPeroxisome proliferator-activated receptor delta/0.451
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.451
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.451
3ddqRRCCyclin-dependent kinase 22.7.11.220.451
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.451
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.451
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.451
4g6oE28Mitogen-activated protein kinase 12.7.11.240.451
4l9i8PRRhodopsin kinase/0.451
5l8lADPAurora kinase A2.7.11.10.451
1lbcCYZGlutamate receptor 2/0.450
2b55D31Cyclin-dependent kinase 22.7.11.220.450
2bheBRYCyclin-dependent kinase 22.7.11.220.450
2c6dANPAurora kinase A2.7.11.10.450
2w1eL0EAurora kinase A2.7.11.10.450
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.450
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
3js2VM1Fibroblast growth factor receptor 1/0.450
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3sdi3SDProteasome subunit beta type-53.4.25.10.450
3sdi3SDProteasome subunit beta type-63.4.25.10.450
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.450
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.450
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1phgMYTCamphor 5-monooxygenase1.14.15.10.449
1v9aSAHUncharacterized protein/0.449
1w2xRCPAcetyl-CoA carboxylase/0.449
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.449
2wxvWXVCyclin-dependent kinase 22.7.11.220.449
2x9fX9FEphrin type-B receptor 42.7.10.10.449
2y6o1N1Ephrin type-A receptor 42.7.10.10.449
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.449
3hl7I47Mitogen-activated protein kinase 14/0.449
3pgqGY3Acetyl-CoA carboxylase/0.449
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3zxtACPDeath-associated protein kinase 12.7.11.10.449
4btkDTQTau-tubulin kinase 12.7.11.10.449
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4lrjANPUncharacterized protein/0.449
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.448
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.448
2izrBRKCasein kinase I isoform gamma-32.7.11.10.448
2y3sTIRTamL/0.448
3bbrBHYGlutamate receptor 2/0.448
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.448
3gcoVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.448
3lu7IPXSerum albumin/0.448
3r7iX9ICyclin-dependent kinase 22.7.11.220.448
3r83Z14Cyclin-dependent kinase 22.7.11.220.448
4fi1ATPCasein kinase II subunit alpha2.7.11.10.448
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.448
4g1wG1WMitogen-activated protein kinase 82.7.11.240.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
4yvz3ATDNA integrity scanning protein DisA/0.448
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.448
5l8kADPAurora kinase A2.7.11.10.448
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.447
2b52D42Cyclin-dependent kinase 22.7.11.220.447
2bkzSBCCyclin-dependent kinase 22.7.11.220.447
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
2j0m4STFocal adhesion kinase 12.7.10.20.447
2uzeC95Cyclin-dependent kinase 22.7.11.220.447
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.447
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.447
3kvxFMYMitogen-activated protein kinase 102.7.11.240.447
3mdmFJZCholesterol 24-hydroxylase/0.447
3nieANPMitogen-activated protein kinase/0.447
3t2yFADSulfide-quinone reductase/0.447
4c61LMMTyrosine-protein kinase JAK2/0.447
4qi7FADCellobiose dehydrogenase/0.447
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.447
4qo9627Serine/threonine-protein kinase 242.7.11.10.447
1gih1PUCyclin-dependent kinase 22.7.11.220.446
1nyxDRFPeroxisome proliferator-activated receptor gamma/0.446
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.446
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.446
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.446
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.446
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.446
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.446
2panFADGlyoxylate carboligase4.1.1.470.446
3blqATPCyclin-dependent kinase 92.7.11.220.446
3il1B5DGlutamate receptor 2/0.446
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.446
3ormAGSSerine/threonine protein kinase/0.446
3r9oZ71Cyclin-dependent kinase 22.7.11.220.446
4anqVGHALK tyrosine kinase receptor2.7.10.10.446
4fod0UVALK tyrosine kinase receptor2.7.10.10.446
4gxs0YSGlutamate receptor 2/0.446
4i2q1BTGag-Pol polyprotein2.7.7.490.446
5cvhADPCasein kinase II subunit alpha2.7.11.10.446
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.445
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.445
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.445
2a7r5GPGMP reductase 2/0.445
2ds11CDCyclin-dependent kinase 22.7.11.220.445
2gs7ANPEpidermal growth factor receptor2.7.10.10.445
2iw94SPCyclin-dependent kinase 22.7.11.220.445
2nq8ZIDEnoyl-ACP reductase/0.445
2pmlANPUncharacterized protein/0.445
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.445
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.445
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
3b70NAPEnoyl reductase LovC10.445
3igoANPCalmodulin-domain protein kinase 1, putative/0.445
3k6l2BBPeptide deformylase3.5.1.880.445
3oriAGSSerine/threonine protein kinase/0.445
3roy22ZCyclin-dependent kinase 22.7.11.220.445
3t113T1Gag-Pol polyprotein3.4.23.160.445
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.445
4cfnJYMCyclin-dependent kinase 22.7.11.220.445
4fkg4CKCyclin-dependent kinase 22.7.11.220.445
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.445
4tuvCPZCytochrome P450 1191.140.445
5auwQUEDeath-associated protein kinase 12.7.11.10.445
1eh4IC1Casein kinase I homolog 12.7.11.10.444
1u4dDBQActivated CDC42 kinase 1/0.444
2eufLQQCyclin-dependent kinase 62.7.11.220.444
2izsBRQCasein kinase I isoform gamma-32.7.11.10.444
2om9AJAPeroxisome proliferator-activated receptor gamma/0.444
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2vttLZDCyclin-dependent kinase 22.7.11.220.444
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.444
2xneASHAurora kinase A2.7.11.10.444
2xvu9DNSerum albumin/0.444
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.444
3b6zCO7Enoyl reductase LovC10.444
3c1y2BADNA integrity scanning protein DisA/0.444
3friSAH16S rRNA methylase/0.444
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.444
3nynSGVG protein-coupled receptor kinase 62.7.11.160.444
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.444
3vspEK8Peroxisome proliferator-activated receptor gamma/0.444
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.444
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.444
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.444
4r20AERCytochrome P450 family 17 polypeptide 2/0.444
4ww0ADPATP-dependent zinc metalloprotease FtsH/0.444
1kkq471Peroxisome proliferator-activated receptor alpha/0.443
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.443
3fklFKLMitogen-activated protein kinase 14/0.443
3l0lHC3Nuclear receptor ROR-gamma/0.443
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.443
3rni21ZCyclin-dependent kinase 22.7.11.220.443
4bcpT3CCyclin-dependent kinase 22.7.11.220.443
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
4iarERM5-hydroxytryptamine receptor 1B/0.443
4ienCOAPutative acyl-CoA hydrolase/0.443
4o0uADNAurora kinase A2.7.11.10.443
4q73FADBifunctional protein PutA/0.443
4qmySTUSerine/threonine-protein kinase 242.7.11.10.443
4r21STRCytochrome P450 family 17 polypeptide 2/0.443
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1h1r6CPCyclin-dependent kinase 22.7.11.220.442
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1rfuADPPyridoxal kinase2.7.1.350.442
1v0oINRCell division control protein 2 homolog2.7.11.220.442
1vrwNAIEnoyl-ACP reductase/0.442
2pywADPMethylthioribose kinase2.7.1.1000.442
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.442
2vv9IM9Cyclin-dependent kinase 22.7.11.220.442
3a4vNADNDP-sugar epimerase/0.442
3a7hATPSerine/threonine-protein kinase 242.7.11.10.442
3ezrEZRCyclin-dependent kinase 22.7.11.220.442
3qn8NI7Gag-Pol polyprotein3.4.23.160.442
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.442
3zcw4A2Kinesin-like protein KIF11/0.442
4b1fKRHGlutamate racemase/0.442
4bcoT6QCyclin-dependent kinase 22.7.11.220.442
4e730NRMitogen-activated protein kinase 82.7.11.240.442
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.442
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.442
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.442
4nka2K7Fibroblast growth factor receptor 1/0.442
4q72FADBifunctional protein PutA/0.442
4zohFADPutative oxidoreductase FAD-binding subunit/0.442
1gy3ATPCyclin-dependent kinase 22.7.11.220.441
1hiiC20Gag-Pol polyprotein/0.441
1i3mUD1UDP-glucose 4-epimerase/0.441
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.441
1pyePM1Cyclin-dependent kinase 22.7.11.220.441
1rfvADPPyridoxal kinase2.7.1.350.441
1ykr628Cyclin-dependent kinase 22.7.11.220.441
2bxoOPBSerum albumin/0.441
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.441
2fy4COACholine O-acetyltransferase2.3.1.60.441
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.441
2pmoHMDProtein kinase 7/0.441
2q9fC3SCholesterol 24-hydroxylase/0.441
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.441
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.441
3ajrNADNDP-sugar epimerase/0.441
3emg685Tyrosine-protein kinase SYK2.7.10.20.441
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.441
3p8jFMNPentaerythritol tetranitrate reductase/0.441
3qu0X40Cyclin-dependent kinase 22.7.11.220.441
3rk507ZCyclin-dependent kinase 22.7.11.220.441
3tjsD0RCytochrome P450 3A4/0.441
3tvuB37Acetyl-CoA carboxylase/0.441
4a8v2ANMajor pollen allergen Bet v 1-J/0.441
4a9mP9MBromodomain-containing protein 2/0.441
4c57FEFCyclin-G-associated kinase2.7.11.10.441
4fk8FADFerredoxin--NADP reductase/0.441
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.441
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4gk4L90Ephrin type-A receptor 32.7.10.10.441
4kba1QMCasein kinase I isoform delta2.7.11.10.441
4nb6444Nuclear receptor ROR-gamma/0.441
4o1pANPRibonuclease L/0.441
1aj8COACitrate synthase/0.440
1knuYPAPeroxisome proliferator-activated receptor gamma/0.440
1qrpHH0Pepsin A-43.4.23.10.440
1tl7FOKAdenylate cyclase type 2/0.440
1tl7FOKAdenylate cyclase type 5/0.440
1wlvCOAPhenylacetic acid degradation protein PaaI/0.440
1wvxBD4Death-associated protein kinase 12.7.11.10.440
2bfyH1NAurora kinase B-A2.7.11.10.440
2chlDKICasein kinase I isoform gamma-32.7.11.10.440
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.440
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.440
2jlbUDMUncharacterized protein/0.440
2pvmP29Casein kinase II subunit alpha2.7.11.10.440
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.440
3rk909ZCyclin-dependent kinase 22.7.11.220.440
3t2kFADSulfide-quinone reductase/0.440
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
4ansVGHALK tyrosine kinase receptor2.7.10.10.440
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.440
4dgnLU2Casein kinase II subunit alpha2.7.11.10.440
4fkr45KCyclin-dependent kinase 22.7.11.220.440
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.440
4l9kEHFSerum albumin/0.440
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
4yaoFMNNADPH--cytochrome P450 reductase/0.440
5hwsNAP2-dehydropantoate 2-reductase/0.440
5jlaNADPutative short-chain dehydrogenase/reductase/0.440