sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4cb7 | 41G | Polymerase basic protein 2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4cb7 | 41G | Polymerase basic protein 2 | / | 1.000 | |
| 4eqk | MGT | Polymerase basic protein 2 | / | 0.602 | |
| 4nce | MGT | Polymerase basic protein 2 | / | 0.578 | |
| 4cb5 | 93G | Polymerase basic protein 2 | / | 0.556 | |
| 5fmm | MGT | Polymerase basic protein 2 | / | 0.552 | |
| 4cb4 | MGT | Polymerase basic protein 2 | / | 0.533 | |
| 4cb6 | 29R | Polymerase basic protein 2 | / | 0.526 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.525 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.517 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.513 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.513 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.506 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.505 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.503 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.503 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.502 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.499 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.499 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.498 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.496 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.492 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.492 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.492 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.490 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.489 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.486 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.485 | |
| 1rxj | BNI | Streptavidin | / | 0.484 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.482 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.482 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.481 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.481 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.481 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.481 | |
| 4es5 | MGT | Polymerase basic protein 2 | / | 0.481 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.480 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.480 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.478 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.478 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.478 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.476 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.476 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.476 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.475 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.475 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.475 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.474 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.473 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.473 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.473 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.473 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.472 | |
| 4bqw | QNM | Egl nine homolog 1 | / | 0.472 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.471 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.471 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.471 | |
| 4m0e | 1YL | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.471 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
| 1s1r | NAP | Aldo-keto reductase family 1 member C3 | / | 0.470 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.470 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.470 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.470 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.470 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.470 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.469 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
| 2bd0 | BIO | Sepiapterin reductase | / | 0.468 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 3c16 | FOK | Adenylate cyclase type 2 | / | 0.467 | |
| 3c16 | FOK | Adenylate cyclase type 5 | / | 0.467 | |
| 3dzj | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.467 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.467 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.467 | |
| 4a16 | H34 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.467 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.467 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.466 | |
| 2pbz | ATP | Uncharacterized protein | / | 0.466 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.466 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.466 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.466 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.466 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.466 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.465 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.465 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.465 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.465 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.465 | |
| 4qfx | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.465 | |
| 5dp2 | NAP | CurF | / | 0.465 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.464 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.464 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.464 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.464 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.464 | |
| 4ts7 | ADP | Purine phosphoribosyltransferase (GpT-1) | / | 0.464 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.463 | |
| 1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.463 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.463 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.463 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.463 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.463 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.462 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.462 | |
| 1wm1 | PTB | Proline iminopeptidase | 3.4.11.5 | 0.462 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.462 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.462 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.462 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4gv8 | DUP | DUTPase | / | 0.462 | |
| 4ld2 | CTN | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.462 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.461 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.461 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 3o3r | NAP | Aldose reductase-related protein 1 | 1.1.1.21 | 0.461 | |
| 4b66 | FAD | L-ornithine N(5)-monooxygenase | / | 0.461 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.461 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 4j7g | TRH | PCZA361.3 | / | 0.461 | |
| 1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.460 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.460 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.460 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.460 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.460 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.460 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.460 | |
| 4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.460 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.460 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.459 | |
| 2qe2 | 452 | Polyprotein | / | 0.459 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.459 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.459 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.459 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 1lke | DOG | Bilin-binding protein | / | 0.458 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.458 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.458 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.458 | |
| 1x2b | STX | Proline iminopeptidase | 3.4.11.5 | 0.458 | |
| 3lzz | GDP | Uncharacterized protein | / | 0.458 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.457 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.457 | |
| 2hxd | DUP | dCTP deaminase, dUMP-forming | 3.5.4.30 | 0.457 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.457 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.457 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.457 | |
| 5hvn | NAD | 3-dehydroquinate synthase | / | 0.457 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.456 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.456 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.456 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.456 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.456 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.456 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.456 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.456 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.456 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.456 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.456 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.456 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.455 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.455 | |
| 2aj4 | ANP | Galactokinase | 2.7.1.6 | 0.455 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.455 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.455 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3g1l | RF2 | HTH-type transcriptional regulator EthR | / | 0.455 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.455 | |
| 4to2 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.455 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.454 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.454 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.454 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.454 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.454 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.454 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 3s8p | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.454 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.453 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.453 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.453 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.453 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.453 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.453 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.453 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.453 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.453 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4to4 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.453 | |
| 1u2r | SO1 | Elongation factor 2 | / | 0.452 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3anl | SYC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.452 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.452 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.452 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.452 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.451 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1e64 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.451 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.451 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.451 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.451 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.451 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.451 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.451 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.451 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.451 | |
| 1e2l | TMC | Thymidine kinase | / | 0.450 | |
| 1n5v | NOM | ActVA 6 protein | / | 0.450 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.450 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.450 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.450 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.450 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.450 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.450 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.450 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.450 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.450 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.450 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.449 | |
| 1c3r | TSN | Acetoin utilization protein | / | 0.449 | |
| 1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.449 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.449 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.449 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.449 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.449 | |
| 2uuo | LK3 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.449 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.449 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.449 | |
| 3biv | 11U | Prothrombin | 3.4.21.5 | 0.449 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.449 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.448 | |
| 1qtq | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.448 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.448 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.448 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.448 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.448 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 1g60 | SAM | Modification methylase MboII | 2.1.1.72 | 0.447 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.447 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.447 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 2apc | UDM | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.447 | |
| 2c42 | TPP | Pyruvate synthase | / | 0.447 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.447 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.447 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.447 | |
| 3e4v | FMN | Uncharacterized protein | / | 0.447 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 4hrq | AZG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.447 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.447 | |
| 1ahg | TYR_PLP | Aspartate aminotransferase | 2.6.1.1 | 0.446 | |
| 1cjv | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cjv | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1j8q | FMN | Flavodoxin | / | 0.446 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.446 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.446 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.446 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2ejz | SAH | Diphthine synthase | / | 0.446 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.446 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.446 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.446 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.446 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.446 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.446 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.446 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.446 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.446 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.446 | |
| 4j7h | TRH | PCZA361.3 | / | 0.446 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.446 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.446 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.445 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.445 | |
| 3c0z | SHH | Histone deacetylase 7 | 3.5.1.98 | 0.445 | |
| 3ccb | B2Y | Dipeptidyl peptidase 4 | / | 0.445 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.445 | |
| 4a1o | AMZ | Bifunctional purine biosynthesis protein PurH | 2.1.2.3 | 0.445 | |
| 4aws | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.445 | |
| 4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.445 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4itx | IN5 | Cystathionine beta-lyase MetC | 4.4.1.8 | 0.445 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.445 | |
| 1az2 | NAP | Aldose reductase | 1.1.1.21 | 0.444 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.444 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.444 | |
| 2pda | TPP | Pyruvate synthase | / | 0.444 | |
| 2v57 | PRL | TetR family transcriptional regulator | / | 0.444 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.444 | |
| 3dv0 | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.444 | |
| 3dv0 | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.444 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.444 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.444 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.444 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.444 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.444 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.444 | |
| 4phl | PIL | Phosphodiesterase | / | 0.444 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.444 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.444 | |
| 5cto | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.444 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.443 | |
| 1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.443 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.443 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 3cv6 | HXS | Aldo-keto reductase family 1 member C21 | / | 0.443 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.443 | |
| 3w5u | FAD | Ferredoxin | / | 0.443 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4dxl | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.443 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.443 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.443 | |
| 5cku | FAD | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2dg3 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.442 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2xs4 | ALA_PHE_THR | Karilysin | 3.4.24 | 0.442 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.442 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.442 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.442 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.442 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 5c4n | NAP | Precorrin-6A reductase | 1.3.1.54 | 0.442 | |
| 1kek | HTL | Pyruvate synthase | / | 0.441 | |
| 1krr | ACO | Galactoside O-acetyltransferase | 2.3.1.18 | 0.441 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.441 | |
| 1xk9 | P34 | Exotoxin A | 2.4.2.36 | 0.441 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.441 | |
| 2jgs | BTN | Avidin | / | 0.441 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.441 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3dr4 | G4M | GDP-perosamine synthase | / | 0.441 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.441 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4bzb | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.441 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.441 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.441 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.440 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.440 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.440 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.440 | |
| 3hgg | CHD | CmeR | / | 0.440 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.440 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.440 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4iei | ADP | Gene 2 protein | / | 0.440 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.440 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.440 |