Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.25

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.251.000
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.579
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.576
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.575
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.567
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.554
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.552
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.546
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.544
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.542
4fv6E57Mitogen-activated protein kinase 12.7.11.240.541
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.538
3sheI85MAP kinase-activated protein kinase 32.7.11.10.533
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.529
3eyhIZATyrosine-protein kinase JAK1/0.527
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.527
1eh4IC1Casein kinase I homolog 12.7.11.10.524
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.524
4f650S9Fibroblast growth factor receptor 1/0.521
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.520
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.518
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.516
2dwbANPAurora kinase A2.7.11.10.516
4hge15VTyrosine-protein kinase JAK2/0.516
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.515
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.515
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.514
3zmmF9JTyrosine-protein kinase JAK2/0.513
3rvg17PTyrosine-protein kinase JAK2/0.512
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.512
2x1nX1NCyclin-dependent kinase 22.7.11.220.511
3hmm855TGF-beta receptor type-12.7.11.300.511
3pxkPXKFocal adhesion kinase 12.7.10.20.511
4aqc88ATyrosine-protein kinase JAK2/0.511
4f081RSTyrosine-protein kinase JAK2/0.510
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.510
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.508
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.508
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.507
5e8wSTUTGF-beta receptor type-12.7.11.300.507
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.506
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.506
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.505
3zh8C58Protein kinase C iota type2.7.11.130.505
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.504
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.504
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.504
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.503
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.503
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.503
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.502
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.502
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.502
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.502
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.501
3gxlQIGTGF-beta receptor type-12.7.11.300.501
3i60E86Mitogen-activated protein kinase 12.7.11.240.501
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.499
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.499
4fod0UVALK tyrosine kinase receptor2.7.10.10.499
4ji91M3Tyrosine-protein kinase JAK2/0.499
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.498
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.498
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.498
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.498
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.498
2b7aIZATyrosine-protein kinase JAK2/0.497
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.497
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.497
1m2rMNYCasein kinase II subunit alpha2.7.11.10.496
1py5PY1TGF-beta receptor type-12.7.11.300.496
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.496
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.496
4jia1K3Tyrosine-protein kinase JAK2/0.496
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.495
4bgg844Activin receptor type-12.7.11.300.495
4hvi19STyrosine-protein kinase JAK32.7.10.20.495
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.495
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.494
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.494
5e8ySTUTGF-beta receptor type-22.7.11.300.494
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.492
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.492
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.491
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.491
3ggfGVDSerine/threonine-protein kinase 26/0.491
4c02TAKActivin receptor type-12.7.11.300.491
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.491
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.490
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.490
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.490
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.490
1u54ACPActivated CDC42 kinase 1/0.489
3r83Z14Cyclin-dependent kinase 22.7.11.220.489
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.488
3uyt0CKCasein kinase I isoform delta2.7.11.10.488
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.488
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.488
4wsqKSAAP2-associated protein kinase 12.7.11.10.488
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.487
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.487
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.487
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.487
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.487
5dr6SKEAurora kinase A2.7.11.10.487
1aq1STUCyclin-dependent kinase 22.7.11.220.486
4jajXU1Aurora kinase A2.7.11.10.486
4qmpDKISerine/threonine-protein kinase 242.7.11.10.486
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.485
1vjy460TGF-beta receptor type-12.7.11.300.485
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.485
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.485
3kc3MK2MAP kinase-activated protein kinase 22.7.11.10.485
4c58824Cyclin-G-associated kinase2.7.11.10.485
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.485
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.485
4y93746Tyrosine-protein kinase/0.485
1h1s4SPCyclin-dependent kinase 22.7.11.220.484
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.484
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.484
2qo9ANPEphrin type-A receptor 32.7.10.10.484
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.484
4btjATPTau-tubulin kinase 12.7.11.10.484
1oirHDYCyclin-dependent kinase 22.7.11.220.483
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.483
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.483
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.483
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.482
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.481
2xneASHAurora kinase A2.7.11.10.481
3sf6FDAGlutaryl-CoA dehydrogenase/0.481
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.481
4dymIYZActivin receptor type-12.7.11.300.481
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.481
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.481
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.481
1bxoPP7Penicillopepsin-13.4.23.200.480
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.480
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.480
4c61LMMTyrosine-protein kinase JAK2/0.480
4dgnLU2Casein kinase II subunit alpha2.7.11.10.480
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.480
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.480
2y6o1N1Ephrin type-A receptor 42.7.10.10.479
3hx4ANPCalmodulin-domain protein kinase 1/0.479
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.478
3zep1NXTyrosine-protein kinase JAK32.7.10.20.478
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.478
2bkzSBCCyclin-dependent kinase 22.7.11.220.477
3be9P04Casein kinase II subunit alpha2.7.11.10.477
3vf80JETyrosine-protein kinase SYK2.7.10.20.477
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.477
4gk3L87Ephrin type-A receptor 32.7.10.10.477
4jqeANPCasein kinase II subunit alpha2.7.11.10.477
2emuSAHDiphthine synthase/0.476
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.476
2np8CC3Aurora kinase A2.7.11.10.476
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.476
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.476
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.475
2xa4AZ5Tyrosine-protein kinase JAK2/0.475
2yn8STUEphrin type-B receptor 42.7.10.10.475
3eljGS7Mitogen-activated protein kinase 82.7.11.240.475
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.474
2pvnP63Casein kinase II subunit alpha2.7.11.10.474
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.474
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.474
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.474
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.474
4dgo0JWCasein kinase II subunit alpha2.7.11.10.474
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
5dt3ATPAurora kinase A2.7.11.10.474
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.473
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.473
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.473
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.473
2w9hTOPDihydrofolate reductase1.5.1.30.473
2wedPP6Penicillopepsin-13.4.23.200.473
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.473
3a62STURibosomal protein S6 kinase beta-12.7.11.10.473
4deeADPAurora kinase A2.7.11.10.473
4dgmAGICasein kinase II subunit alpha2.7.11.10.473
4ewhT77Activated CDC42 kinase 1/0.473
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.473
4i22IREEpidermal growth factor receptor2.7.10.10.473
4y95746Tyrosine-protein kinase/0.473
5dnrATPAurora kinase A2.7.11.10.473
2hog710Serine/threonine-protein kinase Chk12.7.11.10.472
3bhtMFRCyclin-dependent kinase 22.7.11.220.472
3k5uPFQAurora kinase A2.7.11.10.472
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.472
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.472
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.472
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.472
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.472
5dpvSKEAurora kinase A2.7.11.10.472
1xjdSTUProtein kinase C theta type2.7.11.130.471
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.471
2znq401Peroxisome proliferator-activated receptor delta/0.471
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.471
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.471
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.471
4u0mGTPCyclic GMP-AMP synthase/0.471
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.470
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.470
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.470
2x9fX9FEphrin type-B receptor 42.7.10.10.470
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.470
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.470
3pj8404Cyclin-dependent kinase 22.7.11.220.470
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.470
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.470
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.470
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.470
1mq4ADPAurora kinase A2.7.11.10.469
2feuCAMCamphor 5-monooxygenase1.14.15.10.469
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.469
2xnbY8LCyclin-dependent kinase 22.7.11.220.469
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.469
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.469
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.469
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.469
1g5sI17Cyclin-dependent kinase 22.7.11.220.468
1jpaANPEphrin type-B receptor 22.7.10.10.468
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.468
2j0m4STFocal adhesion kinase 12.7.10.20.468
2w1fL0FAurora kinase A2.7.11.10.468
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.468
4c62XWWTyrosine-protein kinase JAK2/0.468
4deaNHIAurora kinase A2.7.11.10.468
4iva1J5Tyrosine-protein kinase JAK2/0.468
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.468
5e92ANPTGF-beta receptor type-22.7.11.300.468
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.467
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.467
2vttLZDCyclin-dependent kinase 22.7.11.220.467
2wotZZGTGF-beta receptor type-12.7.11.300.467
2xikJ60Serine/threonine-protein kinase 252.7.11.10.467
4bb432WEphrin type-B receptor 42.7.10.10.467
5dr9SKEAurora kinase A2.7.11.10.467
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.466
2p5fSAHDiphthine synthase/0.466
2qbmCAMCamphor 5-monooxygenase1.14.15.10.466
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.466
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.466
3iok1P6Tyrosine-protein kinase JAK2/0.466
4gk2L66Ephrin type-A receptor 32.7.10.10.466
5e8xSTUTGF-beta receptor type-12.7.11.300.466
1xelUPGUDP-glucose 4-epimerase5.1.3.20.465
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.465
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.465
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.465
3gubGUBDeath-associated protein kinase 12.7.11.10.465
3zewSTUEphrin type-B receptor 42.7.10.10.465
4g2fC07Ephrin type-A receptor 32.7.10.10.465
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.464
3lpbNVBTyrosine-protein kinase JAK2/0.464
3ukuC69Actin-related protein 3/0.464
4btjADPTau-tubulin kinase 12.7.11.10.464
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.464
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.464
4iwd1JCHepatocyte growth factor receptor2.7.10.10.464
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.464
6cp4CAMCamphor 5-monooxygenase1.14.15.10.464
3cgfJNFMitogen-activated protein kinase 102.7.11.240.463
3q43D66M1 family aminopeptidase3.4.110.463
4anmWULCasein kinase II subunit alpha2.7.11.10.463
4e6d0NUTyrosine-protein kinase JAK2/0.463
1dhrNADDihydropteridine reductase1.5.1.340.462
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.462
2qblCAMCamphor 5-monooxygenase1.14.15.10.462
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.462
3akzGSUGlutamate--tRNA ligase 2/0.462
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.462
5drdATPAurora kinase A2.7.11.10.462
2v7a627Tyrosine-protein kinase ABL12.7.10.20.461
3uo50BXAurora kinase A2.7.11.10.461
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.461
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.461
4gmy0X5Tyrosine-protein kinase JAK2/0.461
1y91CT9Cyclin-dependent kinase 22.7.11.220.460
2ed3SAHDiphthine synthase/0.460
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
3biz61EWee1-like protein kinase2.7.10.20.460
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.460
3rni21ZCyclin-dependent kinase 22.7.11.220.460
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.460
4g160VMCasein kinase I isoform gamma-32.7.11.10.460
1bwsNDPGDP-L-fucose synthase/0.459
1orrNADCDP-paratose 2-epimerase/0.459
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.459
2owkSAHDiphthine synthase/0.459
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.459
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.459
3oqkS52Renin3.4.23.150.459
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.459
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.459
3r9hZ67Cyclin-dependent kinase 22.7.11.220.459
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.459
4foc0UUALK tyrosine kinase receptor2.7.10.10.459
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.459
4ix6ADPUncharacterized protein/0.459
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
1lp4ANPCasein kinase II subunit alpha2.7.11.10.458
1m2pHNACasein kinase II subunit alpha2.7.11.10.458
1ol5ADPAurora kinase A2.7.11.10.458
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.458
2pvhP19Casein kinase II subunit alpha2.7.11.10.458
2x9dITCTetracycline repressor protein class D/0.458
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.458
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.458
4ivc1J6Tyrosine-protein kinase JAK1/0.458
4k771Q4Tyrosine-protein kinase JAK1/0.458
1fvv107Cyclin-dependent kinase 22.7.11.220.457
1om1IQACasein kinase II subunit alpha2.7.11.10.457
2is0I03Beta-secretase 13.4.23.460.457
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.457
2pvlP55Casein kinase II subunit alpha2.7.11.10.457
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.457
2zdt46CMitogen-activated protein kinase 102.7.11.240.457
3bbrBHYGlutamate receptor 2/0.457
3gu83GUDeath-associated protein kinase 12.7.11.10.457
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.457
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.457
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.457
4lfiGNPCasein kinase II subunit alpha2.7.11.10.457
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.456
2hckQUETyrosine-protein kinase HCK2.7.10.20.456
2vu3LZECyclin-dependent kinase 22.7.11.220.456
3ijoB4DGlutamate receptor 2/0.456
3mtfA3FActivin receptor type-12.7.11.300.456
3umw596Serine/threonine-protein kinase pim-12.7.11.10.456
4ix5ANPUncharacterized protein/0.456
4kbk1QGCasein kinase I isoform delta2.7.11.10.456
4o0wADNAurora kinase A2.7.11.10.456
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.456
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.456
4y3jHICEndothiapepsin3.4.23.220.456
1ay0TPPTransketolase 12.2.1.10.455
1m2qMNXCasein kinase II subunit alpha2.7.11.10.455
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.455
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.455
2btrU73Cyclin-dependent kinase 22.7.11.220.455
2c6tDT5Cyclin-dependent kinase 22.7.11.220.455
2gjlFMNNitronate monooxygenase1.13.12.160.455
3oafOAGDihydrofolate reductase1.5.1.30.455
4bgh3I6Cyclin-dependent kinase 22.7.11.220.455
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.455
4i5cC5ITyrosine-protein kinase JAK1/0.455
5dn3ATPAurora kinase A2.7.11.10.455
1ia1NDPDihydrofolate reductase1.5.1.30.454
1ppm0P1Penicillopepsin-13.4.23.200.454
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2itpAEEEpidermal growth factor receptor2.7.10.10.454
2j0lANPFocal adhesion kinase 12.7.10.20.454
2xrwANPMitogen-activated protein kinase 82.7.11.240.454
2y9qANPMitogen-activated protein kinase 12.7.11.240.454
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4fi1ATPCasein kinase II subunit alpha2.7.11.10.454
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.454
4ivd15TTyrosine-protein kinase JAK1/0.454
4ocvANPAminoglycoside phosphotransferase/0.454
4q71FADBifunctional protein PutA/0.454
4qmzB49Serine/threonine-protein kinase 242.7.11.10.454
4ux9ANPMitogen-activated protein kinase 82.7.11.240.454
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.454
1pxlCK4Cyclin-dependent kinase 22.7.11.220.453
2dv4SAHDiphthine synthase/0.453
2ejzSAHDiphthine synthase/0.453
2owfSAHDiphthine synthase/0.453
2w06FRVCyclin-dependent kinase 22.7.11.220.453
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.453
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.453
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.453
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3nxe2NCProtease/0.453
3v3m0ENReplicase polyprotein 1a3.4.19.120.453
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.453
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.453
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.453
5dp2NAPCurF/0.453
1bxqPP8Penicillopepsin-13.4.23.200.452
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
2eufLQQCyclin-dependent kinase 62.7.11.220.452
3fwfCAMCamphor 5-monooxygenase1.14.15.10.452
3rk507ZCyclin-dependent kinase 22.7.11.220.452
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4fkt48KCyclin-dependent kinase 22.7.11.220.452
1dirNADDihydropteridine reductase1.5.1.340.451
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1t85CAMCamphor 5-monooxygenase1.14.15.10.451
1yrcCAMCamphor 5-monooxygenase1.14.15.10.451
2egbSAHDiphthine synthase/0.451
2huvSAHDiphthine synthase/0.451
2iw94SPCyclin-dependent kinase 22.7.11.220.451
2pmoHMDProtein kinase 7/0.451
2xru400Aurora kinase A2.7.11.10.451
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.451
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.451
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.451
3nwxKVSGag-Pol polyprotein3.4.23.160.451
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.451
3wrjCAMCamphor 5-monooxygenase1.14.15.10.451
4ek816KCyclin-dependent kinase 22.7.11.220.451
4ele31IDihydrofolate reductase/0.451
4jr7GNPCasein kinase II subunit alpha2.7.11.10.451
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.451
5dosATPAurora kinase A2.7.11.10.451
1bygSTUTyrosine-protein kinase CSK/0.450
1ol7ADPAurora kinase A2.7.11.10.450
1q1rFADPutidaredoxin reductase1.18.1.50.450
1t86CAMCamphor 5-monooxygenase1.14.15.10.450
1x8b824Wee1-like protein kinase2.7.10.20.450
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.450
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.450
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.450
3bi6396Wee1-like protein kinase2.7.10.20.450
3cr0809Wee1-like protein kinase2.7.10.20.450
3qt62P0Mevalonate diphosphate decarboxylase/0.450
3r9oZ71Cyclin-dependent kinase 22.7.11.220.450
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
4wkqIREEpidermal growth factor receptor2.7.10.10.450
1zrzBI1Protein kinase C iota type2.7.11.130.449
2a0cCK9Cyclin-dependent kinase 22.7.11.220.449
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.449
2h96893Mitogen-activated protein kinase 82.7.11.240.449
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
2w1gL0GAurora kinase A2.7.11.10.449
2w1hL0FCyclin-dependent kinase 22.7.11.220.449
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.449
3lfqA28Cyclin-dependent kinase 22.7.11.220.449
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.449
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.449
4fv7E94Mitogen-activated protein kinase 12.7.11.240.449
5dt4ATPAurora kinase A2.7.11.10.449
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1c1dNAIPhenylalanine dehydrogenase/0.448
1vsoAT1Glutamate receptor ionotropic, kainate 1/0.448
2qo7ANPEphrin type-A receptor 32.7.10.10.448
2wxvWXVCyclin-dependent kinase 22.7.11.220.448
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.448
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.448
3r8lZ30Cyclin-dependent kinase 22.7.11.220.448
3zdu38RCyclin-dependent kinase-like 32.7.11.220.448
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.448
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.448
4e4m0NHTyrosine-protein kinase JAK2/0.448
4f09JAKTyrosine-protein kinase JAK2/0.448
4fkv61KCyclin-dependent kinase 22.7.11.220.448
4qnaX11Serine/threonine-protein kinase 242.7.11.10.448
4riyADPEpidermal growth factor receptor2.7.10.10.448
5auuLU2Death-associated protein kinase 12.7.11.10.448
1di8DTQCyclin-dependent kinase 22.7.11.220.447
1ek6UPGUDP-glucose 4-epimerase/0.447
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
1zemNADXylitol dehydrogenase/0.447
2a1oCAMCamphor 5-monooxygenase1.14.15.10.447
2csnCKICasein kinase I homolog 12.7.11.10.447
2dxvSAHDiphthine synthase/0.447
2henADPEphrin type-B receptor 22.7.10.10.447
2j9mPY8Cyclin-dependent kinase 22.7.11.220.447
2wecPP5Penicillopepsin-13.4.23.200.447
3eb0DRKUncharacterized protein/0.447
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.447
3rn8RN8Glutamate receptor 2/0.447
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.447
3w33W19Epidermal growth factor receptor2.7.10.10.447
3wrhCAMCamphor 5-monooxygenase1.14.15.10.447
4ivb1J5Tyrosine-protein kinase JAK1/0.447
4jboWPHAurora kinase A2.7.11.10.447
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.447
5dr2ATPAurora kinase A2.7.11.10.447
1bw9NADPhenylalanine dehydrogenase/0.446
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1nhhANPDNA mismatch repair protein MutL/0.446
1nooCAHCamphor 5-monooxygenase1.14.15.10.446
1rx1NAPDihydrofolate reductase1.5.1.30.446
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.446
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.446
2bunFADAppA protein/0.446
2ed5SAHDiphthine synthase/0.446
2in6839Wee1-like protein kinase2.7.10.20.446
2itnANPEpidermal growth factor receptor2.7.10.10.446
2j2pSC2Ficolin-2/0.446
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.446
2qboCAMCamphor 5-monooxygenase1.14.15.10.446
2qoqANPEphrin type-A receptor 32.7.10.10.446
2uzbC75Cyclin-dependent kinase 22.7.11.220.446
2wipP49Cyclin-dependent kinase 22.7.11.220.446
3fwjCAMCamphor 5-monooxygenase1.14.15.10.446
3ibqATPPyridoxal kinase/0.446
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.446
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.446
3w8qAGSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.446
4elg52JDihydrofolate reductase/0.446
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.446
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.446
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.446
4ure1PSCyclohexanol dehydrogenase/0.446
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.446
1pxpCK8Cyclin-dependent kinase 22.7.11.220.445
1t88CAMCamphor 5-monooxygenase1.14.15.10.445
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.445
1zys199Serine/threonine-protein kinase Chk12.7.11.10.445
2pb4SAHDiphthine synthase/0.445
2pvmP29Casein kinase II subunit alpha2.7.11.10.445
2wihP48Cyclin-dependent kinase 22.7.11.220.445
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3oibFDAPutative acyl-CoA dehydrogenase/0.445
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.445
3qu0X40Cyclin-dependent kinase 22.7.11.220.445
4du82P0Mevalonate diphosphate decarboxylase/0.445
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.445
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
1dz8CAMCamphor 5-monooxygenase1.14.15.10.444
1pmn984Mitogen-activated protein kinase 102.7.11.240.444
1tqf32PBeta-secretase 13.4.23.460.444
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.444
2a94AP0L-lactate dehydrogenase1.1.1.270.444
2egsSAHDiphthine synthase/0.444
2el0SAHDiphthine synthase/0.444
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.444
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.444
3cid318Beta-secretase 13.4.23.460.444
3cukFADD-amino-acid oxidase1.4.3.30.444
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.444
4g3rCAMCamphor 5-monooxygenase1.14.15.10.444
4zohFADPutative oxidoreductase FAD-binding subunit/0.444
1dz6CAMCamphor 5-monooxygenase1.14.15.10.443
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.443
2dxxSAHDiphthine synthase/0.443
2excJNKMitogen-activated protein kinase 102.7.11.240.443
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.443
2xhd7T9Glutamate receptor 2/0.443
2xyuQ9GEphrin type-A receptor 42.7.10.10.443
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.443
4r1lADPPhenylacetate-coenzyme A ligase/0.443
1diuBDMDihydrofolate reductase1.5.1.30.442
1dr3TAPDihydrofolate reductase1.5.1.30.442
1udaUFGUDP-glucose 4-epimerase5.1.3.20.442
1w0xOLOCyclin-dependent kinase 22.7.11.220.442
2dsiSAHDiphthine synthase/0.442
2of4979Tyrosine-protein kinase Lck2.7.10.20.442
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.442
2p33J07Mitogen-activated protein kinase 102.7.11.240.442
2qd8065Gag-Pol polyprotein3.4.23.160.442
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.442
2xb7GUIALK tyrosine kinase receptor2.7.10.10.442
2xvdAS6Ephrin type-B receptor 42.7.10.10.442
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.442
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.442
3s1h56ZCyclin-dependent kinase 22.7.11.220.442
3t8oATPRhodopsin kinase/0.442
3w16P9JAurora kinase A2.7.11.10.442
4c57FEFCyclin-G-associated kinase2.7.11.10.442
4fko20KCyclin-dependent kinase 22.7.11.220.442
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.442
4grb0XGCasein kinase II subunit alpha2.7.11.10.442
4hvg19QTyrosine-protein kinase JAK32.7.10.20.442
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.442
1csnATPCasein kinase I homolog 12.7.11.10.441
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1dr3HBIDihydrofolate reductase1.5.1.30.441
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1kfbIGPTryptophan synthase alpha chain/0.441
1me6IVSPlasmepsin-23.4.23.390.441
1o76CAMCamphor 5-monooxygenase1.14.15.10.441
1rx8NAPDihydrofolate reductase1.5.1.30.441
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.441
2c5yMTWCyclin-dependent kinase 22.7.11.220.441
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.441
2g2zCOZMalonyl CoA-acyl carrier protein transacylase2.3.1.390.441
2nniMTKCytochrome P450 2C8/0.441
2owuSAHDiphthine synthase/0.441
2wouZZFTGF-beta receptor type-12.7.11.300.441
3d84NDPDihydrofolate reductase1.5.1.30.441
3dogNNNCyclin-dependent kinase 22.7.11.220.441
3gggNADPrephenate dehydrogenase/0.441
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.441
3orfNADDihydropteridine reductase1.5.1.340.441
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.441
3slz3TLPutative gag-pro-pol polyprotein/0.441
3upf0BUPolyprotein/0.441
3vucHHERenin3.4.23.150.441
3w32W32Epidermal growth factor receptor2.7.10.10.441
4bbfO19Tyrosine-protein kinase JAK2/0.441
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.441
4e5yNDPGDP-L-fucose synthase1.1.1.2710.441
4l9i8PRRhodopsin kinase/0.441
4q73FADBifunctional protein PutA/0.441
5dt0SKEAurora kinase A2.7.11.10.441
1a9zUPGUDP-glucose 4-epimerase5.1.3.20.440
1lbcCYZGlutamate receptor 2/0.440
1pmv537Mitogen-activated protein kinase 102.7.11.240.440
1tehNADAlcohol dehydrogenase class-31.1.1.10.440
1xddAAYIntegrin alpha-L/0.440
1yrdCAMCamphor 5-monooxygenase1.14.15.10.440
2gjnFMNNitronate monooxygenase1.13.12.160.440
2ntrL00Beta-secretase 13.4.23.460.440
2r3iSCFCyclin-dependent kinase 22.7.11.220.440
3a1nNADNDP-sugar epimerase/0.440
3cgdCOACoenzyme A disulfide reductase/0.440
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.440
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.440
3nxxNDPDihydrofolate reductase1.5.1.30.440
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.440
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.440
3rq6APRADP-dependent (S)-NAD(P)H-hydrate dehydratase/0.440
3sufSUEPolyprotein/0.440
3ttjJBIMitogen-activated protein kinase 102.7.11.240.440
3wrmCAMCamphor 5-monooxygenase1.14.15.10.440
4cegADPAurora kinase A2.7.11.10.440
4g6oE28Mitogen-activated protein kinase 12.7.11.240.440
4jbpYPHAurora kinase A2.7.11.10.440
4l4fCAMCamphor 5-monooxygenase1.14.15.10.440
4o0uADNAurora kinase A2.7.11.10.440
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.440