Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x20PIDPeridinin-chlorophyll a-binding protein 1, chloroplastic

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
2x20PIDPeridinin-chlorophyll a-binding protein 1, chloroplastic/1.000
3iisPIDPeridinin-chlorophyll a-binding protein 1, chloroplastic/0.617
2x21PIDPeridinin-chlorophyll a-binding protein 1, chloroplastic/0.614
2x1zPIDPeridinin-chlorophyll a-binding protein 1, chloroplastic/0.555
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.520
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.514
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.510
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.509
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.504
4iaq2GM5-hydroxytryptamine receptor 1B/0.503
1q5dEPBEpothilone C/D epoxidase1.140.502
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.501
4kbn25UDihydrofolate reductase1.5.1.30.501
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.499
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.498
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.498
2gjlFMNNitronate monooxygenase1.13.12.160.497
3reoEUG(Iso)eugenol O-methyltransferase2.1.1.1460.495
4dscA8SAbscisic acid receptor PYL3/0.495
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.494
3koo24DBifunctional epoxide hydrolase 23.3.2.100.494
3t8xT8XT-cell surface glycoprotein CD1b/0.493
1xuoLA1Integrin alpha-L/0.492
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.492
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.489
5aajHSCPeroxisomal bifunctional enzyme1.1.1.350.488
1s3uTQDDihydrofolate reductase1.5.1.30.487
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.487
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.487
5bt42LOBromodomain-containing protein 4/0.487
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.486
2fzjDH3Dihydrofolate reductase1.5.1.30.486
3q0gBCOProbable enoyl-CoA hydratase echA84.2.1.170.486
4o71CPBBromodomain-containing protein 4/0.486
3k47D09Dihydrofolate reductase1.5.1.30.485
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.485
5bp9SAHPutative methyltransferase protein/0.485
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.484
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.484
1a4iNDPC-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.483
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.483
4rh10TTSpore photoproduct lyase/0.483
3gwfFADCyclohexanone monooxygenase/0.482
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.482
3um81CYBifunctional dihydrofolate reductase-thymidylate synthase/0.482
2hb8MVDVitamin D3 receptor/0.481
2zb45OPProstaglandin reductase 21.3.1.480.481
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.481
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.481
1g3mPCQEstrogen sulfotransferase2.8.2.40.480
1ly3COGDihydrofolate reductase1.5.1.30.480
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.480
3o73O73Ribosyldihydronicotinamide dehydrogenase [quinone]/0.480
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.479
4h9753SDihydrofolate reductase1.5.1.30.479
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.479
1hfqMOTDihydrofolate reductase1.5.1.30.478
1pd9CO4Dihydrofolate reductase1.5.1.30.478
3lfcZ86Mitogen-activated protein kinase 14/0.478
3qly55VUncharacterized protein/0.478
4h9506UDihydrofolate reductase1.5.1.30.478
4kak06UDihydrofolate reductase1.5.1.30.478
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.477
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.477
3nglNAPBifunctional protein FolD/0.477
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.477
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
3wv9FEGHmd co-occurring protein HcgE/0.476
4ixfIXFDihydrofolate reductase1.5.1.30.476
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.476
1cjcFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.475
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.475
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.475
3fu83DMLaccase-11.10.3.20.475
3njoPYVAbscisic acid receptor PYR1/0.475
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.475
1ezvSMACytochrome b/0.474
1x7hNDPPutative ketoacyl reductase1.3.10.474
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
1yhoTRRDihydrofolate reductase1.5.1.30.474
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
2xvw9NRSerum albumin/0.474
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.474
3s3vTOPDihydrofolate reductase1.5.1.30.474
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.474
4iarERM5-hydroxytryptamine receptor 1B/0.474
4iv21GREstrogen receptor/0.474
1n71COAAac(6')-Ii protein/0.473
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.473
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
2gh6CF3Histone deacetylase-like amidohydrolase3.5.10.473
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.473
3o9lLPNRenin3.4.23.150.473
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.473
3vt7VDXVitamin D3 receptor/0.473
1bwlFMNNADPH dehydrogenase 11.6.99.10.472
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.472
1jxzBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.472
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.472
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.471
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.471
3tkyN7I(Iso)eugenol O-methyltransferase2.1.1.1460.471
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.471
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4k6i9RARetinoic acid receptor RXR-alpha/0.471
4qa0SHHHistone deacetylase 83.5.1.980.471
3gcq1BUMitogen-activated protein kinase 14/0.470
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.470
3kpzZNEVitamin D3 receptor/0.470
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
3vtdTKDVitamin D3 receptor/0.470
1ohkCOPDihydrofolate reductase1.5.1.30.469
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
3w0yDS4Vitamin D3 receptor/0.469
2aclREARetinoic acid receptor RXR-alpha/0.468
2fzhDH1Dihydrofolate reductase1.5.1.30.468
3h18PMSEsterase/lipase/0.468
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.468
4fhf0TTSpore photoproduct lyase/0.468
4ixeIXEDihydrofolate reductase1.5.1.30.468
1ia2TQ4Dihydrofolate reductase1.5.1.30.467
2blbCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.467
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.467
3cd2MTXDihydrofolate reductase1.5.1.30.467
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.467
4j6cSTRCytochrome P450 monooxygenase/0.467
4zasTYDCalS13/0.467
1dr3TAPDihydrofolate reductase1.5.1.30.466
1fcx184Retinoic acid receptor gamma/0.466
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.466
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.466
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.466
2po7CHDFerrochelatase, mitochondrial4.99.1.10.466
2wo7ASVIsopenicillin N synthase1.21.3.10.466
3is9AC7Gag-Pol polyprotein2.7.7.490.466
3k4551PDihydrofolate reductase1.5.1.30.466
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
1fmjRTLRetinol dehydratase/0.465
1ia1TQ3Dihydrofolate reductase1.5.1.30.465
1ie9VDXVitamin D3 receptor/0.465
2vbpVB1Isopenicillin N synthase1.21.3.10.465
3ox1695Ribosyldihydronicotinamide dehydrogenase [quinone]/0.465
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.465
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.465
4haiI23Bifunctional epoxide hydrolase 23.1.3.760.465
1mj3HXCEnoyl-CoA hydratase, mitochondrial4.2.1.170.464
1tl3H20Gag-Pol polyprotein2.7.7.490.464
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
3d80Q22Dihydrofolate reductase1.5.1.30.464
3gieACPSensor histidine kinase DesK2.7.13.30.464
3lakKR1Gag-Pol polyprotein2.7.7.490.464
1fd0254Retinoic acid receptor gamma/0.463
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.463
3njoP2MAbscisic acid receptor PYR1/0.463
3s7a684Dihydrofolate reductase1.5.1.30.463
3vjcZGASqualene synthase2.5.1.210.463
1mvsDTMDihydrofolate reductase1.5.1.30.462
1s3vTQDDihydrofolate reductase1.5.1.30.462
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
3h1vTK1Glucokinase2.7.1.20.462
4b4vL34Bifunctional protein FolD/0.462
4dsbA8SAbscisic acid receptor PYL3/0.462
4ia1BIVVitamin D3 receptor A/0.462
3qakUKAAdenosine receptor A2a/0.462
1hpzAAPGag-Pol polyprotein2.7.7.490.461
1uhlMEIRetinoic acid receptor RXR-beta/0.461
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
2vcmM11Isopenicillin N synthase1.21.3.10.461
2w3aTOPDihydrofolate reductase1.5.1.30.461
2y37H4BNitric oxide synthase, inducible1.14.13.390.461
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.461
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
3lfeZ84Mitogen-activated protein kinase 14/0.461
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
3wiyLC6Induced myeloid leukemia cell differentiation protein Mcl-1/0.461
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.461
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
4qa2SHHHistone deacetylase 83.5.1.980.461
1dajMOTDihydrofolate reductase1.5.1.30.460
1kkq471Peroxisome proliferator-activated receptor alpha/0.460
2h94FADLysine-specific histone demethylase 1A10.460
2hamC33Vitamin D3 receptor/0.460
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
3negPYVAbscisic acid receptor PYL1/0.460
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4dm6TTBRetinoic acid receptor beta/0.460
4h9614QDihydrofolate reductase1.5.1.30.460
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.460
1dr5NAPDihydrofolate reductase1.5.1.30.459
1m7aMQUDihydrofolate reductase1.5.1.30.459
1olmVTQSEC14-like protein 2/0.459
1tvrTB9Gag-Pol polyprotein2.7.7.490.459
3ctj320Hepatocyte growth factor receptor2.7.10.10.459
3qm4PN0Cytochrome P450 2D6/0.459
3s41S41Glucokinase2.7.1.20.459
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
4qoeFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.459
4u95MIYMultidrug efflux pump subunit AcrB/0.459
1dg5TOPDihydrofolate reductase1.5.1.30.458
1h35R01Squalene--hopene cyclase4.2.1.1290.458
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
2ociTYCValacyclovir hydrolase3.10.458
2op18PCEnoyl-ACP reductase/0.458
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.458
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.458
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.458
3cseN22Uncharacterized protein/0.458
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.458
1o6qR17Squalene--hopene cyclase4.2.1.1290.457
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.457
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.457
2iogIOGEstrogen receptor/0.457
2lbdREARetinoic acid receptor gamma/0.457
2pujHPZ2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.457
2vz0D64Pteridine reductase/0.457
3cxhSMACytochrome b/0.457
3dauMTXDihydrofolate reductase1.5.1.30.457
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.457
3htjETEbrA repressor/0.457
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
4jvnYUGEstrogen sulfotransferase2.8.2.40.457
4qij1HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.457
5c80URIUridine phosphorylase/0.457
1blzACVIsopenicillin N synthase1.21.3.10.456
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
1m8h6NINitric oxide synthase, inducible1.14.13.390.456
2xvv9DNSerum albumin/0.456
3jrxS1AAcetyl-CoA carboxylase 2/0.456
3nhwZXZRibosyldihydronicotinamide dehydrogenase [quinone]/0.456
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
4iw8KN3Estrogen receptor/0.456
4iwv1J9Glucokinase2.7.1.20.456
4l8u9AZSerum albumin/0.456
4n1gCEIObelin/0.456
4o761M3Bromodomain-containing protein 4/0.456
1dubCAAEnoyl-CoA hydratase, mitochondrial4.2.1.170.455
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
1zz1SHHHistone deacetylase-like amidohydrolase3.5.10.455
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.455
2bakAQZMitogen-activated protein kinase 14/0.455
2hasC3OVitamin D3 receptor/0.455
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.455
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
3bfb9ODPheromone-binding protein ASP1/0.455
3eej53RUncharacterized protein/0.455
3hv3R49Mitogen-activated protein kinase 14/0.455
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
3qlrQLRDihydrofolate reductase1.5.1.30.455
3u8hBHPPhospholipase A2, membrane associated/0.455
4a9yAQZMitogen-activated protein kinase 14/0.455
4dbuBT9Aldo-keto reductase family 1 member C3/0.455
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.455
4jx1CAMCamphor 5-monooxygenase1.14.15.10.455
4k9yK9YFocal adhesion kinase 12.7.10.20.455
4ux6H4BNitric oxide synthase, inducible1.14.13.390.455
1dr2TAPDihydrofolate reductase1.5.1.30.454
1m8hH4BNitric oxide synthase, inducible1.14.13.390.454
1pd8CO4Dihydrofolate reductase1.5.1.30.454
1synF89Thymidylate synthase/0.454
1txiTX5Vitamin D3 receptor/0.454
2g5oDRQEstrogen receptor/0.454
2oz57XYUncharacterized protein/0.454
3antS82Bifunctional epoxide hydrolase 23.3.2.100.454
3cyz9ODPheromone-binding protein ASP1/0.454
3p2oNADBifunctional protein FolD/0.454
3qlzQLZUncharacterized protein/0.454
3saz043Malate synthase G/0.454
3uxhUXHRibosyldihydronicotinamide dehydrogenase [quinone]/0.454
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.454
4a9iP9IBromodomain-containing protein 2/0.454
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.454
4e37NDPCatalase1.11.1.60.454
4jlm1NNDeoxycytidine kinase2.7.1.740.454
4o4eATPKinase/0.454
1fbyREARetinoic acid receptor RXR-alpha/0.453
1m78NDPDihydrofolate reductase1.5.1.30.453
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.453
1z4iUMP5'(3')-deoxyribonucleotidase, mitochondrial3.1.30.453
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2bjsACVIsopenicillin N synthase1.21.3.10.453
2ibzSMACytochrome b/0.453
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
3a0iAJIGlucokinase2.7.1.20.453
3dleGFAGag-Pol polyprotein2.7.7.490.453
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.453
5ctoNTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.453
5dq8FLFTranscriptional enhancer factor TEF-4/0.453
1klkPMDDihydrofolate reductase1.5.1.30.452
1pkfEPDEpothilone C/D epoxidase1.140.452
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.452
2wd8VGFPteridine reductase/0.452
2ykeYKEHeat shock protein HSP 90-alpha/0.452
3fc6REARetinoic acid receptor RXR-alpha/0.452
3gc9B45Mitogen-activated protein kinase 112.7.11.240.452
3l0lHC3Nuclear receptor ROR-gamma/0.452
3up0D7SaceDAF-12/0.452
4ag7COAGlucosamine 6-phosphate N-acetyltransferase/0.452
4b4w9L9Bifunctional protein FolD/0.452
4dhyS41Glucokinase2.7.1.20.452
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4ifvT27Gag-Pol polyprotein2.7.7.490.452
4l1xSTRAldo-keto reductase family 1 member C2/0.452
4lg5A1OAbscisic acid receptor PYL2/0.452
4p66MTXDihydrofolate reductase/0.452
5ahkFADAcetolactate synthase II, large subunit/0.452
1x8lOXRRetinol dehydratase/0.451
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1yqxNAPSinapyl alcohol dehydrogenase/0.451
3dlgGWEGag-Pol polyprotein2.7.7.490.451
3l3rOAGDihydrofolate reductase1.5.1.30.451
3nxvD2FDihydrofolate reductase1.5.1.30.451
3q0gCOAProbable enoyl-CoA hydratase echA84.2.1.170.451
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3vg9ZMAAdenosine receptor A2a/0.451
4jlj1NMDeoxycytidine kinase2.7.1.740.451
4jvlESTEstrogen sulfotransferase2.8.2.40.451
4nh82LCHeat shock protein HSP 90-alpha/0.451
4qii2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.451
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.451
1e26GPBDihydrofolate reductase1.5.1.30.450
1e6eFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.450
1gt5BZQOdorant-binding protein/0.450
1kb9SMACytochrome b/0.450
1u1d181Uridine phosphorylase2.4.2.30.450
1uy6PU3Heat shock protein HSP 90-alpha/0.450
1uyfPU1Heat shock protein HSP 90-alpha/0.450
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.450
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.450
2gvcFADThiol-specific monooxygenase1.14.130.450
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.450
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.450
3nmpPYVAbscisic acid receptor PYL2/0.450
3o6o94MHeat shock protein 83/0.450
3p9tTCLRepressor/0.450
3r43ID8Aldo-keto reductase family 1 member C3/0.450
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4ax8ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.450
4fam0SZAldo-keto reductase family 1 member C3/0.450
4fj0HHF17beta-hydroxysteroid dehydrogenase/0.450
4g1nNZTPyruvate kinase PKM2.7.1.400.450
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.450
4kebFOLDihydrofolate reductase1.5.1.30.450
1ai9NDPDihydrofolate reductase1.5.1.30.449
1mczTDPBenzoylformate decarboxylase4.1.1.70.449
1o6rR19Squalene--hopene cyclase4.2.1.1290.449
1v7aFRCAdenosine deaminase3.5.4.40.449
1vrqFONSubunit alpha of sarocosine oxidase/0.449
2jj1ADPATP synthase subunit alpha, mitochondrial/0.449
2jj1ADPATP synthase subunit beta, mitochondrial3.6.3.140.449
2z7gEH9Adenosine deaminase3.5.4.40.449
3bxoUPPdTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose/0.449
3h3r14HCollagen type IV alpha-3-binding protein/0.449
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
3oapREARetinoic acid receptor RXR-alpha/0.449
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.449
3q5kD1UHeat shock protein 83-1/0.449
3qwiCUE17beta-hydroxysteroid dehydrogenase/0.449
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.449
3t9i3T9Serine/threonine-protein kinase pim-12.7.11.10.449
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.449
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.449
4nc3ERM5-hydroxytryptamine receptor 2B/0.449
4yx6FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.449
1dkfBMSRetinoic acid receptor alpha/0.448
1exa394Retinoic acid receptor gamma/0.448
1m78CLZDihydrofolate reductase1.5.1.30.448
1sqqOSTCytochrome b/0.448
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2apgFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.448
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
2p15EZTEstrogen receptor/0.448
2rabNADGlutathione amide reductase/0.448
3jwm5WBDihydrofolate reductase/0.448
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3nn6HNK6-hydroxy-L-nicotine oxidase/0.448
3nxtD2EDihydrofolate reductase1.5.1.30.448
3oafOAGDihydrofolate reductase1.5.1.30.448
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3qlsNDPDihydrofolate reductase1.5.1.30.448
3up3XCAaceDAF-12/0.448
3vt9YI4Vitamin D3 receptor/0.448
4a99MIYTetX family tetracycline inactivation enzyme/0.448
4o701QKBromodomain-containing protein 4/0.448
4y0kNAPAntE/0.448
5bsrCOA4-coumarate--CoA ligase 26.2.1.120.448
1fm69CRRetinoic acid receptor RXR-alpha/0.447
1kl2FONSerine hydroxymethyltransferase/0.447
1kyoSMACytochrome b/0.447
1pq944BOxysterols receptor LXR-beta/0.447
1s9qOHTEstrogen-related receptor gamma/0.447
2bxmIMNSerum albumin/0.447
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.447
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.447
2ykbYKBHeat shock protein HSP 90-alpha/0.447
3d84NDPDihydrofolate reductase1.5.1.30.447
3e5aVX6Aurora kinase A2.7.11.10.447
3eel53TUncharacterized protein/0.447
3nhkVAPRibosyldihydronicotinamide dehydrogenase [quinone]/0.447
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.447
4cdmFO1Deoxyribodipyrimidine photolyase/0.447
4j6dTESCytochrome P450 monooxygenase/0.447
4m8hR4MRetinoic acid receptor RXR-alpha/0.447
4mprTPPBenzoylformate decarboxylase4.1.1.70.447
4x5fFOLDihydrofolate reductase1.5.1.30.447
1cd2FOLDihydrofolate reductase1.5.1.30.446
1crbRTLRetinol-binding protein 1/0.446
1drfFOLDihydrofolate reductase1.5.1.30.446
1s7gNADNAD-dependent protein deacylase 2/0.446
1yc2NADNAD-dependent protein deacylase 2/0.446
2p1v5TNRetinoic acid receptor RXR-alpha/0.446
2rhtC1E2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.446
2w3vTOPDihydrofolate reductase/0.446
2z2w770Wee1-like protein kinase2.7.10.20.446
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3n0hTOPDihydrofolate reductase1.5.1.30.446
3q2mCKISpectinomycin phosphotransferase/0.446
3vrwYS5Vitamin D3 receptor/0.446
4fvxH4BNitric oxide synthase, brain1.14.13.390.446
4gm4TZDBenzoylformate decarboxylase4.1.1.70.446
4j6bPLOCytochrome P450 monooxygenase/0.446
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
1ly4COQDihydrofolate reductase1.5.1.30.445
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.445
1qxlFR8Adenosine deaminase3.5.4.40.445
1vj3TABDihydrofolate reductase1.5.1.30.445
1z1fSTLResveratrol synthase/0.445
2b5j3ACGag-Pol polyprotein2.7.7.490.445
2o7pNAPRiboflavin biosynthesis protein RibD/0.445
2y30SM8Putative repressor SimReg2/0.445
2ykcYKCHeat shock protein HSP 90-alpha/0.445
3dkoIHZEphrin type-A receptor 72.7.10.10.445
3eigMTXDihydrofolate reductase1.5.1.30.445
3fazNOSPurine nucleoside phosphorylase/0.445
3nwe662Catechol O-methyltransferase2.1.1.60.445
3qlhT27Gag-Pol polyprotein2.7.7.490.445
4a84DXCMajor pollen allergen Bet v 1-A/0.445
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.445
4jvmXDIEstrogen sulfotransferase2.8.2.40.445
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
1l2jETCEstrogen receptor beta/0.444
1tkzH16Gag-Pol polyprotein2.7.7.490.444
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.444
2c7gFADNADPH-ferredoxin reductase FprA1.18.1.20.444
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.444
2ykjYKJHeat shock protein HSP 90-alpha/0.444
3bjhNBBOdorant binding protein ASP1/0.444
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3c3dFO12-phospho-L-lactate transferase/0.444
3cz09ODPheromone-binding protein ASP1/0.444
3eon341Glutaryl-CoA dehydrogenase/0.444
3fsuC2F5,10-methylenetetrahydrofolate reductase1.5.1.200.444
3ghvGHCDihydrofolate reductase1.5.1.30.444
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.444
3hz5Z64Heat shock protein HSP 90-alpha/0.444
3nodH4BNitric oxide synthase, inducible1.14.13.390.444
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.444
3td8D2RDihydrofolate reductase1.5.1.30.444
3v94WYQPhosphodiesterase/0.444
4aknS5BBromodomain-containing protein 2/0.444
4i6gFADCryptochrome-2/0.444
4mxeACON-acetyltransferase ESCO12.3.10.444
4xwtU5PRibonuclease J/0.444
1ia4TQ6Dihydrofolate reductase1.5.1.30.443
1klmSPPGag-Pol polyprotein2.7.7.490.443
1ml6GBXGlutathione S-transferase A22.5.1.180.443
1rt4UC1Gag-Pol polyprotein2.7.7.490.443
1uymPU3Heat shock protein HSP 90-beta/0.443
1zgaHMKIsoflavone 4'-O-methyltransferase/0.443
2be2R22Gag-Pol polyprotein2.7.7.490.443
2jkcFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.443
2yatEEUEstrogen receptor/0.443
2zd1T27Gag-Pol polyprotein2.7.7.490.443
3iptEQUSteroid Delta-isomerase5.3.3.10.443
3jt8H4BNitric oxide synthase, brain1.14.13.390.443
3jwcEKBDihydrofolate reductase/0.443
3l8sBFFMitogen-activated protein kinase 14/0.443
3o0iP54Heat shock protein HSP 90-alpha/0.443
3svpH4BNitric oxide synthase, brain1.14.13.390.443
3w0aDS5Vitamin D3 receptor/0.443
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.443
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4dp3MMVBifunctional dihydrofolate reductase-thymidylate synthase/0.443
4ea13RXDehydrosqualene synthase/0.443
4k5dH4BNitric oxide synthase, brain1.14.13.390.443
4m6l21VDihydrofolate reductase1.5.1.30.443
4mr41K0Bromodomain-containing protein 4/0.443
4q0a4OAVitamin D3 receptor A/0.443
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.443
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.442
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
1m8iH4BNitric oxide synthase, inducible1.14.13.390.442
1ndzFR5Adenosine deaminase3.5.4.40.442
2cdcNAPGlucose 1-dehydrogenase/0.442
2cl5BIECatechol O-methyltransferase2.1.1.60.442
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2on6IMHPurine nucleoside phosphorylase2.4.2.10.442
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.442
2w3bNDPDihydrofolate reductase1.5.1.30.442
3acy702Dehydrosqualene synthase/0.442
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.442
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.442
3qlwN22Dihydrofolate reductase1.5.1.30.442
3tqbFOLDihydrofolate reductase/0.442
3vt5YI2Vitamin D3 receptor/0.442
4alhA9PBromodomain-containing protein 2/0.442
4b0j3MQ3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase4.2.1.590.442
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.442
4fhh0U3Vitamin D3 receptor A/0.442
4kfj1R0Dihydrofolate reductase1.5.1.30.442
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.442
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.442
1i58ACPChemotaxis protein CheA2.7.13.30.441
1m8dH4BNitric oxide synthase, inducible1.14.13.390.441
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.441
1upw444Oxysterols receptor LXR-beta/0.441
1z6tADPApoptotic protease-activating factor 1/0.441
2bu9HFVIsopenicillin N synthase1.21.3.10.441
2mm3CHOGastrotropin/0.441
2p1u4TNRetinoic acid receptor RXR-alpha/0.441
2qmzLDPRibosyldihydronicotinamide dehydrogenase [quinone]/0.441
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
3a783EVVitamin D3 receptor/0.441
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3nhfVVVRibosyldihydronicotinamide dehydrogenase [quinone]/0.441
3nj0PYVAbscisic acid receptor PYL2/0.441
3rqlH4BNitric oxide synthase, brain1.14.13.390.441
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
3uk6ADPRuvB-like 23.6.4.120.441
3vt8YI3Vitamin D3 receptor/0.441
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4a9e3PFBromodomain-containing protein 2/0.441
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
3rfmCFFAdenosine receptor A2a/0.441
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
1hfpMOTDihydrofolate reductase1.5.1.30.440
1k2sH4BNitric oxide synthase, brain1.14.13.390.440
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
2a4nCOAAac(6')-Ii protein/0.440
2blaCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
2bzsCB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.440
2cleF6FTryptophan synthase alpha chain/0.440
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.440
2fmn4HF5,10-methylenetetrahydrofolate reductase1.5.1.200.440
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2vf0F89Thymidylate synthase/0.440
3dfrMTXDihydrofolate reductase1.5.1.30.440
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3h4vNAPPteridine reductase 11.5.1.330.440
3imxB84Glucokinase2.7.1.20.440
3irxUDRGag-Pol polyprotein2.7.7.490.440
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3qls55VDihydrofolate reductase1.5.1.30.440
3sl2ATPSensor histidine kinase WalK/0.440
3t8vBTJM1 family aminopeptidase3.4.110.440
4aqlTXCGuanine deaminase3.5.4.30.440
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.440
4dbw511Aldo-keto reductase family 1 member C3/0.440
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
4equG6ISerine/threonine-protein kinase 102.7.11.10.440
4fj2QSO17beta-hydroxysteroid dehydrogenase/0.440
5bp7SAHSAM-dependent methyltransferase/0.440