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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ypeSAMHistone-lysine N-methyltransferase ASH1L2.1.1.43

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4ypeSAMHistone-lysine N-methyltransferase ASH1L2.1.1.431.000
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.569
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.553
2igqSAHHistone-lysine N-methyltransferase EHMT1/0.534
3ooiSAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific2.1.1.430.534
4ypaSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.524
4ynpSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.513
3swcSAHHistone-lysine N-methyltransferase EHMT1/0.508
4qenSAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH42.1.1.430.507
5czySAMEukaryotic huntingtin interacting protein B/0.501
5jhnSAMHistone-lysine N-methyltransferase EHMT2/0.500
4ynmSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.498
3d91REMRenin3.4.23.150.497
4ypuSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.497
5jinSAMHistone-lysine N-methyltransferase EHMT2/0.496
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.494
1w6hTITPlasmepsin-23.4.23.390.493
4a6rTA8Probable aminotransferase/0.492
1lf2R37Plasmepsin-23.4.23.390.491
1xe55FEPlasmepsin-23.4.23.390.491
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.489
2g1y5IGRenin3.4.23.150.488
3lqsPSZD-alanine aminotransferase2.6.1.210.488
2rfiSAHHistone-lysine N-methyltransferase EHMT1/0.487
3udn09BBeta-secretase 13.4.23.460.486
1x1aSAMC-20 methyltransferase/0.484
1xvaSAMGlycine N-methyltransferase2.1.1.200.483
4djhJDCKappa-type opioid receptor/0.483
2r3aSAMHistone-lysine N-methyltransferase SUV39H22.1.1.430.482
4dh60KNBeta-secretase 13.4.23.460.482
4twrNADNAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase/0.482
1xe65FPPlasmepsin-23.4.23.390.481
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.480
3duyAFJBeta-secretase 13.4.23.460.479
4h12SAHHistone-lysine N-methyltransferase SETD22.1.1.430.479
1f8fNADBenzyl alcohol dehydrogenase/0.478
2ilvC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.478
3cib314Beta-secretase 13.4.23.460.478
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.475
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.475
1gcoNADGlucose 1-dehydrogenase1.1.1.470.474
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.474
3hnaSAHHistone-lysine N-methyltransferase EHMT1/0.474
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.474
1bim0QBRenin3.4.23.150.473
2iibC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.473
2oahQINBeta-secretase 13.4.23.460.473
3k5c0BIBeta-secretase 13.4.23.460.473
3lpjZ75Beta-secretase 13.4.23.460.473
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.473
3wqmB29Diterpene synthase3.1.7.80.473
1cl0FADThioredoxin reductase1.8.1.90.472
1j36LPRAngiotensin-converting enzyme3.4.15.10.472
1w34FADFerredoxin--NADP reductase1.18.1.20.472
2ifaFMNUncharacterized protein/0.472
4z4pSAHHistone-lysine N-methyltransferase 2D2.1.1.430.472
3rpeFADPutative modulator of drug activity/0.471
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.471
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.471
4j4nD44Peptidylprolyl isomerase/0.471
1kp3ATPArgininosuccinate synthase6.3.4.50.470
1vbiNADMalate/L-lactate dehydrogenase family protein/0.470
2i3gNAPN-acetyl-gamma-glutamyl-phosphate reductase1.2.1.380.470
2iko7IGRenin3.4.23.150.470
2z3lPHE_ARG_TYR_LEU_GLYLeucyl/phenylalanyl-tRNA--protein transferase2.3.2.60.470
3qlsNDPDihydrofolate reductase1.5.1.30.470
2cndFADNitrate reductase [NADH]1.7.1.10.469
2fj1CTCTetracycline repressor protein class D/0.469
2v16C47Renin3.4.23.150.469
3q9bB3NAcetylpolyamine amidohydrolase/0.469
3zksWZVBeta-secretase 23.4.23.450.469
4ewo996Beta-secretase 13.4.23.460.469
1bil0IURenin3.4.23.150.468
1txtCAAHMG-CoA synthase/0.468
1x1bSAHC-20 methyltransferase/0.468
2g1o2IGRenin3.4.23.150.468
3b70NAPEnoyl reductase LovC10.468
3fpdSAHHistone-lysine N-methyltransferase EHMT1/0.468
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.468
3icpNADNAD-dependent epimerase/dehydratase/0.468
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.468
4eb7PLPCysteine desulfurase IscS 2/0.468
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.468
1ndhFADNADH-cytochrome b5 reductase 31.6.2.20.467
1s20NAD2,3-diketo-L-gulonate reductase1.1.1.1300.467
2g1r3IGRenin3.4.23.150.467
2gv8NDPThiol-specific monooxygenase1.14.130.467
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.467
3kmtSAHHistone H3K27 methylase/0.467
4b68NAPL-ornithine N(5)-monooxygenase/0.467
4mo2FADUDP-galactopyranose mutase/0.467
4q71FADBifunctional protein PutA/0.467
1bp6UMPThymidylate synthase/0.466
3u9eCOALmo1369 protein/0.466
4hmz18TdTDP-4-dehydro-6-deoxyglucose 3-epimerase5.1.3.270.466
4m83ERYOleandomycin glycosyltransferase2.4.10.466
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.465
2b58COADiamine acetyltransferase 1/0.465
3ixj586Beta-secretase 13.4.23.460.465
3m1vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.465
3m1vCOMMethyl-coenzyme M reductase I subunit beta2.8.4.10.465
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.465
4opgFDAConserved Archaeal protein/0.465
5a9sNAPPutative dehydrogenase/0.465
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.465
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.464
2is0I03Beta-secretase 13.4.23.460.464
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.464
3sxjSAMPutative methyltransferase/0.464
3vydVYDRenin3.4.23.150.464
1geeNADGlucose 1-dehydrogenase1.1.1.470.463
2bjuIH4Plasmepsin-23.4.23.390.463
2iyfERYOleandomycin glycosyltransferase2.4.10.463
3wb2YGPUncharacterized protein MJ0488/0.463
4lxk1YTBeta-secretase 13.4.23.460.463
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
2c12FADNitroalkane oxidase1.7.3.10.462
2xhd7T9Glutamate receptor 2/0.462
2zz0FADThioredoxin reductase 1, cytoplasmic1.8.1.90.462
3cbpSFGHistone-lysine N-methyltransferase SETD72.1.1.430.462
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.462
2ck3ANPATP synthase subunit alpha, mitochondrial/0.461
2ck3ANPATP synthase subunit beta, mitochondrial3.6.3.140.461
2ex1C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.461
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.461
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.461
3m2vCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.461
4lxa1YSBeta-secretase 13.4.23.460.461
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.461
1rneC60Renin3.4.23.150.460
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.460
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.460
2ikuLIYRenin3.4.23.150.460
3eheNADUDP-glucose 4-epimerase (GalE-1)/0.460
3gqvNAPEnoyl reductase LovC10.460
3r96ACOMccE protein/0.460
4bfxZVXPantothenate kinase2.7.1.330.460
4bfzZVZPantothenate kinase2.7.1.330.460
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.460
4dd8BATDisintegrin and metalloproteinase domain-containing protein 83.4.240.460
4qi5FADCellobiose dehydrogenase/0.460
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.460
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.460
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.459
2c20NADUDP-glucose 4-epimerase/0.459
2yd0BESEndoplasmic reticulum aminopeptidase 13.4.110.459
3o0o5ADVitamin B12-dependent ribonucleotide reductase/0.459
3pfdFDAAcyl-CoA dehydrogenase FadE25/0.459
3rufNADUDP-N-acetylglucosamine 4-epimerase/0.459
3tr05GPGuanylate kinase/0.459
5f8eSAHPossible transcriptional regulatory protein/0.459
1cnfFADNitrate reductase [NADH]1.7.1.10.458
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.458
2ohjFMNType A flavoprotein FprA10.458
2owgSAHDiphthine synthase/0.458
2pj4414Carboxypeptidase B/0.458
2wf2ZY2Beta-secretase 13.4.23.460.458
3dm6757Beta-secretase 13.4.23.460.458
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.458
4dbzNDPPutative ketoacyl reductase1.3.10.458
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.457
2dshSAHDiphthine synthase/0.457
2i4qUA4Renin3.4.23.150.457
2nr4FMNConserved protein/0.457
2zcvNDPQuinone oxidoreductase 21.6.5.20.457
3a3gDLZLumazine protein/0.457
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3nsh957Beta-secretase 13.4.23.460.457
3phiNDPShikimate dehydrogenase (NADP(+))/0.457
3rsv3RSBeta-secretase 13.4.23.460.457
3skgPB8Beta-secretase 13.4.23.460.457
3slz3TLPutative gag-pro-pol polyprotein/0.457
3toxNAPPutative oxidoreductase/0.457
4i0i957Beta-secretase 13.4.23.460.457
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.456
1lc3NADBiliverdin reductase A1.3.1.240.456
2ejzSAHDiphthine synthase/0.456
3cic316Beta-secretase 13.4.23.460.456
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.456
3rfaSAMDual-specificity RNA methyltransferase RlmN/0.456
3s7dLEU_SER_LYS_LYS_MLZN-lysine methyltransferase SMYD2/0.456
5d3qGDPDynamin-13.6.5.50.456
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.455
2g226IGRenin3.4.23.150.455
3tjlFMNNADPH dehydrogenase/0.455
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.455
3veu0GOBeta-secretase 13.4.23.460.455
3vswR31Renin3.4.23.150.455
4d89BXDBeta-secretase 13.4.23.460.455
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.455
4ef4C2EStimulator of interferon genes protein/0.455
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.455
4i0h1BLBeta-secretase 13.4.23.460.455
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.455
4opuFDAConserved Archaeal protein/0.455
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
5irnADPNucleotide binding oligomerization domain containing 2/0.455
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.454
1qx4FADNADH-cytochrome b5 reductase 31.6.2.20.454
2ek7SAHDiphthine synthase/0.454
2iqgF2IBeta-secretase 13.4.23.460.454
2rlcCHDCholoylglycine hydrolase3.5.1.240.454
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.454
2y65ADPKinesin heavy chain/0.454
3d84NDPDihydrofolate reductase1.5.1.30.454
3intGDUUDP-galactopyranose mutase5.4.99.90.454
3ixk929Beta-secretase 13.4.23.460.454
3mt817TGlycogen phosphorylase, muscle form2.4.1.10.454
3qwbNDPProbable quinone oxidoreductase1.6.5.50.454
3vyeVYERenin3.4.23.150.454
4h3i10VBeta-secretase 13.4.23.460.454
4j83SAMHistone-lysine N-methyltransferase SETD72.1.1.430.454
1cf3FADGlucose oxidase1.1.3.40.453
1i0sFMNFerric-chelate reductase (NAD(P)H)/0.453
1odcA8BAcetylcholinesterase3.1.1.70.453
1xs7MMIBeta-secretase 13.4.23.460.453
2i7nACOPantothenate kinase 12.7.1.330.453
3atzFMNProstaglandin F2a synthase/0.453
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.453
3m30COMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.453
3m30COMMethyl-coenzyme M reductase I subunit beta2.8.4.10.453
3omuIBDHeat shock protein 83/0.453
4blsAPCNTPase P4/0.453
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.453
4i8zG08Gag-Pol polyprotein3.4.23.160.453
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.453
4pzrCOAHistone acetyltransferase p300/0.453
4yaoFMNNADPH--cytochrome P450 reductase/0.453
5eioNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.453
1h51FMNPentaerythritol tetranitrate reductase/0.452
1szgFNSCytochrome b2, mitochondrial1.1.2.30.452
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2oapANPType II secretion system protein (GspE-2)/0.452
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.452
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3m2uCOMMethyl-coenzyme M reductase I subunit alpha2.8.4.10.452
3nxxNDPDihydrofolate reductase1.5.1.30.452
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.452
4blrUTPNTPase P4/0.452
4lutDCSAlanine racemase/0.452
5hq8SAHHistone-lysine N-methyltransferase SMYD32.1.1.430.452
1e3eNAIAlcohol dehydrogenase 41.1.1.10.451
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2e07SAHDiphthine synthase/0.451
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.451
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.451
2g1n1IGRenin3.4.23.150.451
2gjlFMNNitronate monooxygenase1.13.12.160.451
2gz7D3FOrf1a polyprotein/0.451
2il2LIXRenin3.4.23.150.451
2qlnF59Glycogen phosphorylase, muscle form2.4.1.10.451
3ag6PAJPantothenate synthetase/0.451
3ai3NDPNADPH-sorbose reductase/0.451
3pm1ETHTH-type transcriptional regulator QacR/0.451
3ziuLSSLeucyl-tRNA synthetase/0.451
3zkiWZVBeta-secretase 23.4.23.450.451
4bbyFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.451
4bftZVTPantothenate kinase2.7.1.330.451
4flkY10Methionine aminopeptidase 1/0.451
1kr5SAHProtein-L-isoaspartate(D-aspartate) O-methyltransferase2.1.1.770.450
1pg3PRXAcetyl-coenzyme A synthetase/0.450
2a94AP0L-lactate dehydrogenase1.1.1.270.450
2e8sSAHDiphthine synthase/0.450
2g1s4IGRenin3.4.23.150.450
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.450
2p4j23IBeta-secretase 13.4.23.460.450
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.450
3own3OWRenin3.4.23.150.450
3q70RITCandidapepsin-23.4.23.240.450
4a83DXCMajor pollen allergen Bet v 1-A/0.450
4b722FBBeta-secretase 13.4.23.460.450
4ca73EFAngiotensin-converting enzyme3.4.15.10.450
4de50JDPantothenate synthetase6.3.2.10.450
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4j0v1H7Beta-secretase 13.4.23.460.450
4jicFMNGTN Reductase/0.450
4mlp2CXCryptochrome-2/0.450
4r81FMNPredicted NADH dehydrogenase/0.450
1j9zFADNADPH--cytochrome P450 reductase/0.449
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.449
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.449
1umaIN2Prothrombin3.4.21.50.449
2f3rG5PGuanylate kinase2.7.4.80.449
2hm1LIQBeta-secretase 13.4.23.460.449
2viyVG3Beta-secretase 13.4.23.460.449
3bk2U5PRibonuclease J/0.449
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3hekBD0Heat shock protein HSP 90-alpha/0.449
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.449
3ko8NADNAD-dependent epimerase/dehydratase/0.449
3vsxR32Renin3.4.23.150.449
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.449
4b68FADL-ornithine N(5)-monooxygenase/0.449
1f20FADNitric oxide synthase, brain1.14.13.390.448
1n7hNDPGDP-mannose 4,6 dehydratase 24.2.1.470.448
2ha6SCKAcetylcholinesterase3.1.1.70.448
3bgxTMPThymidylate synthase/0.448
3f63GTXGlutathione transferase GST1-4/0.448
3hl0NADMaleylacetate reductase/0.448
3qt62P0Mevalonate diphosphate decarboxylase/0.448
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.448
4gddNAIUDP-galactopyranose mutase/0.448
4gsuDWZL,D-transpeptidase 22.3.20.448
4ke11R6Beta-secretase 13.4.23.460.448
5dp2NAPCurF/0.448
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1owe675Urokinase-type plasminogen activator3.4.21.730.447
1umkFADNADH-cytochrome b5 reductase 31.6.2.20.447
2dsgSAHDiphthine synthase/0.447
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.447
2fxv5GPXanthine phosphoribosyltransferase2.4.2.220.447
2g21L1BRenin3.4.23.150.447
2qimZEAClass 10 plant pathogenesis-related protein/0.447
2wxvWXVCyclin-dependent kinase 22.7.11.220.447
2xfiXFIBeta-secretase 13.4.23.460.447
2z3nPHE_ARG_TYR_LEU_GLYLeucyl/phenylalanyl-tRNA--protein transferase2.3.2.60.447
2zjmF1MBeta-secretase 13.4.23.460.447
3af1GDPPantothenate kinase2.7.1.330.447
3f1kNAPUncharacterized oxidoreductase YciK10.447
3ru7NADUDP-N-acetylglucosamine 4-epimerase/0.447
3tjzGNPADP-ribosylation factor 1/0.447
3v3m0ENReplicase polyprotein 1a3.4.19.120.447
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.447
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.447
4j1k1HGBeta-secretase 13.4.23.460.447
4y7cFADNADPH--cytochrome P450 reductase/0.447
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.447
1e3lNADAlcohol dehydrogenase 41.1.1.10.446
1icpFMN12-oxophytodienoate reductase 11.3.1.420.446
1l7x700Glycogen phosphorylase, liver form2.4.1.10.446
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.446
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.446
1sb1165Prothrombin3.4.21.50.446
1tehNADAlcohol dehydrogenase class-31.1.1.10.446
2owuSAHDiphthine synthase/0.446
2p83MR0Beta-secretase 13.4.23.460.446
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.446
2qn3F55Glycogen phosphorylase, muscle form2.4.1.10.446
2wf3ZY3Beta-secretase 13.4.23.460.446
2xytTC9Soluble acetylcholine receptor/0.446
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.446
3c8bARG_ARG_GLY_ILE_NH2Botulinum neurotoxin type A3.4.24.690.446
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3w5hFADNADH-cytochrome b5 reductase 31.6.2.20.446
4ambDUDPutative glycosyl transferase/0.446
4df2FMNNADPH dehydrogenase/0.446
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.446
4fxy0W2Neurolysin, mitochondrial3.4.24.160.446
4o1mNADEnoyl-acyl carrier reductase/0.446
3vw7VPXProteinase-activated receptor 1/0.446
1a59COA2-methylcitrate synthase/0.445
1h60STRPentaerythritol tetranitrate reductase/0.445
1h61PDNPentaerythritol tetranitrate reductase/0.445
1lbcCYZGlutamate receptor 2/0.445
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.445
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.445
1o9bNAIQuinate/shikimate dehydrogenase/0.445
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.445
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.445
1udaUFGUDP-glucose 4-epimerase5.1.3.20.445
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2b4tAESGlyceraldehyde-3-phosphate dehydrogenase/0.445
2fdpFRPBeta-secretase 13.4.23.460.445
2xx91NFGlutamate receptor 2/0.445
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.445
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3oetNADErythronate-4-phosphate dehydrogenase/0.445
3pftFMNFlavin reductase/0.445
3v0o4GWHisto-blood group ABO system transferase/0.445
4f5yC2EStimulator of interferon genes protein/0.445
4frjDWBBeta-secretase 13.4.23.460.445
4m9aFDAAcyl-CoA dehydrogenase/0.445
5einNAP[LysW]-L-2-aminoadipate 6-phosphate reductase/0.445
1ja1FMNNADPH--cytochrome P450 reductase/0.444
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1me6IVSPlasmepsin-23.4.23.390.444
1psa0ZLPepsin A3.4.23.10.444
1qy5NECEndoplasmin/0.444
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.444
2i7pACOPantothenate kinase 32.7.1.330.444
2pb4SAHDiphthine synthase/0.444
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3ig6438Urokinase-type plasminogen activator3.4.21.730.444
3kxw1ZZSaframycin Mx1 synthetase B/0.444
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.444
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.444
4egbNADdTDP-glucose 4,6-dehydratase/0.444
4fco0U4Beta-secretase 13.4.23.460.444
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
5c77SAHProtein arginine N-methyltransferase SFM1/0.444
5e7oMD1DMSO reductase family type II enzyme, molybdopterin subunit/0.444
3sn6P0GBeta-2 adrenergic receptor/0.444
1f8wFADNADH peroxidase1.11.1.10.443
1v0jFADUDP-galactopyranose mutase5.4.99.90.443
1x1cSAHC-20 methyltransferase/0.443
2cy0NAPShikimate dehydrogenase (NADP(+))/0.443
2g247IGRenin3.4.23.150.443
2g94ZPQBeta-secretase 13.4.23.460.443
2hizLIJBeta-secretase 13.4.23.460.443
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.443
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.443
2rcyNAPPyrroline-5-carboxylate reductase/0.443
2vj6VG5Beta-secretase 13.4.23.460.443
2vkeTACTetracycline repressor protein class D/0.443
2w3bNDPDihydrofolate reductase1.5.1.30.443
2wf1ZY1Beta-secretase 13.4.23.460.443
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
3adaNADSubunit alpha of sarocosine oxidase/0.443
3f7bAG5Carbonic anhydrase 44.2.1.10.443
3ohh3HHBeta-secretase 13.4.23.460.443
3r2fPB0Beta-secretase 13.4.23.460.443
3r9uFADThioredoxin reductase/0.443
3ukfGDUUDP-galactopyranose mutase/0.443
4dnaFADProbable glutathione reductase/0.443
4dpf0LGBeta-secretase 13.4.23.460.443
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.443
5cyoGDPSeptin-9/0.443
8dfrNDPDihydrofolate reductase1.5.1.30.443
1cneFADNitrate reductase [NADH]1.7.1.10.442
1g6kNADGlucose 1-dehydrogenase1.1.1.470.442
1ia1NDPDihydrofolate reductase1.5.1.30.442
1r6tTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.442
1t4u81AProthrombin3.4.21.50.442
1zrqFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.442
2cv2GSUGlutamate--tRNA ligase6.1.1.170.442
2freFMNNAD(P)H-flavin oxidoreductase/0.442
2g8yNADHydroxycarboxylate dehydrogenase B/0.442
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.442
2v59LZKBiotin carboxylase6.3.4.140.442
2vyqFADFerredoxin--NADP reductase1.18.1.20.442
2zhq27UProthrombin3.4.21.50.442
2znnS44Peroxisome proliferator-activated receptor alpha/0.442
3bnkFMNFlavoredoxin/0.442
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.442
3hyg099A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.442
3oqfS51Renin3.4.23.150.442
3p5pA3CTaxadiene synthase4.2.3.170.442
3pndFADFAD:protein FMN transferase/0.442
3qwpSAMHistone-lysine N-methyltransferase SMYD32.1.1.430.442
3ru0SFGHistone-lysine N-methyltransferase SMYD32.1.1.430.442
3zcsCAWGlycogen phosphorylase, muscle form2.4.1.10.442
4a8v2ANMajor pollen allergen Bet v 1-J/0.442
4asuADPATP synthase subunit alpha, mitochondrial/0.442
4nv10FXFormyl transferase/0.442
4pzsACOHistone acetyltransferase p300/0.442
4yp6NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.442
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.442
1bidUMPThymidylate synthase/0.441
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.441
2ed3SAHDiphthine synthase/0.441
2eh5SAHDiphthine synthase/0.441
2eklNADD-3-phosphoglycerate dehydrogenase/0.441
2p20PRXAcetyl-coenzyme A synthetase/0.441
2p2bPRXAcetyl-coenzyme A synthetase/0.441
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3itjFADThioredoxin reductase 11.8.1.90.441
3k5fAYHBeta-secretase 13.4.23.460.441
3ojwFMNNADPH--cytochrome P450 reductase/0.441
3vyfVYFRenin3.4.23.150.441
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.441
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.441
4i1c1BEBeta-secretase 13.4.23.460.441
4k8s1QTBeta-secretase 13.4.23.460.441
4lcjNADC-terminal-binding protein 2/0.441
4m55NADUDP-glucuronic acid decarboxylase 14.1.1.350.441
4m5pFMNNADPH dehydrogenase/0.441
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
1h73ANPHomoserine kinase2.7.1.390.440
1n2jPAFPantothenate synthetase6.3.2.10.440
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
2a87FADThioredoxin reductase1.8.1.90.440
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.440
2dsiSAHDiphthine synthase/0.440
2dv7SAHDiphthine synthase/0.440
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.440
2ignFADPyranose 2-oxidase/0.440
2ii6C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.440
2jfgUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
2pb6SAHDiphthine synthase/0.440
2uxoTACHTH-type transcriptional regulator TtgR/0.440
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.440
2xuqTZ4Acetylcholinesterase3.1.1.70.440
3c1kT15Prothrombin3.4.21.50.440
3ensENSCoagulation factor X3.4.21.60.440
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.440
3sm2478Putative gag-pro-pol polyprotein/0.440
4hh4SAHCcbJ/0.440
4la1FADThioredoxin glutathione reductase/0.440
4xguADPPutative pachytene checkpoint protein 2/0.440
5cflC2EStimulator of interferon genes protein/0.440
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.440
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.440