Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
4ype | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
4ype | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 1.000 | |
2o8j | SAH | Histone-lysine N-methyltransferase EHMT2 | / | 0.569 | |
3mo0 | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.553 | |
2igq | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.534 | |
3ooi | SAM | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific | 2.1.1.43 | 0.534 | |
4ypa | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.524 | |
4ynp | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.513 | |
3swc | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.508 | |
4qen | SAH | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 | 2.1.1.43 | 0.507 | |
5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.501 | |
5jhn | SAM | Histone-lysine N-methyltransferase EHMT2 | / | 0.500 | |
4ynm | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.498 | |
3d91 | REM | Renin | 3.4.23.15 | 0.497 | |
4ypu | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.497 | |
5jin | SAM | Histone-lysine N-methyltransferase EHMT2 | / | 0.496 | |
3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.494 | |
1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.493 | |
4a6r | TA8 | Probable aminotransferase | / | 0.492 | |
1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.491 | |
1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.491 | |
5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.489 | |
2g1y | 5IG | Renin | 3.4.23.15 | 0.488 | |
3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.488 | |
2rfi | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.487 | |
3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.486 | |
1x1a | SAM | C-20 methyltransferase | / | 0.484 | |
1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.483 | |
4djh | JDC | Kappa-type opioid receptor | / | 0.483 | |
2r3a | SAM | Histone-lysine N-methyltransferase SUV39H2 | 2.1.1.43 | 0.482 | |
4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.482 | |
4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.482 | |
1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.481 | |
2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.480 | |
3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
4h12 | SAH | Histone-lysine N-methyltransferase SETD2 | 2.1.1.43 | 0.479 | |
1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.478 | |
2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.478 | |
3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.475 | |
3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.475 | |
1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.474 | |
1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.474 | |
3hna | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.474 | |
5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.474 | |
1bim | 0QB | Renin | 3.4.23.15 | 0.473 | |
2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.473 | |
2oah | QIN | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.473 | |
3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.473 | |
1cl0 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.472 | |
1j36 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.472 | |
1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.472 | |
2ifa | FMN | Uncharacterized protein | / | 0.472 | |
4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.472 | |
3rpe | FAD | Putative modulator of drug activity | / | 0.471 | |
4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.471 | |
4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.471 | |
4j4n | D44 | Peptidylprolyl isomerase | / | 0.471 | |
1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.470 | |
1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.470 | |
2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.470 | |
2iko | 7IG | Renin | 3.4.23.15 | 0.470 | |
2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.470 | |
3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.469 | |
2fj1 | CTC | Tetracycline repressor protein class D | / | 0.469 | |
2v16 | C47 | Renin | 3.4.23.15 | 0.469 | |
3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.469 | |
3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.469 | |
4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
1bil | 0IU | Renin | 3.4.23.15 | 0.468 | |
1txt | CAA | HMG-CoA synthase | / | 0.468 | |
1x1b | SAH | C-20 methyltransferase | / | 0.468 | |
2g1o | 2IG | Renin | 3.4.23.15 | 0.468 | |
3b70 | NAP | Enoyl reductase LovC | 1 | 0.468 | |
3fpd | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.468 | |
3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.468 | |
3icp | NAD | NAD-dependent epimerase/dehydratase | / | 0.468 | |
4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.468 | |
4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.468 | |
4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.468 | |
1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.467 | |
1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.467 | |
2g1r | 3IG | Renin | 3.4.23.15 | 0.467 | |
2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.467 | |
2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.467 | |
3kmt | SAH | Histone H3K27 methylase | / | 0.467 | |
4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.467 | |
4mo2 | FAD | UDP-galactopyranose mutase | / | 0.467 | |
4q71 | FAD | Bifunctional protein PutA | / | 0.467 | |
1bp6 | UMP | Thymidylate synthase | / | 0.466 | |
3u9e | COA | Lmo1369 protein | / | 0.466 | |
4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.466 | |
4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.466 | |
1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.465 | |
2b58 | COA | Diamine acetyltransferase 1 | / | 0.465 | |
3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.465 | |
3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.465 | |
4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.465 | |
4opg | FDA | Conserved Archaeal protein | / | 0.465 | |
5a9s | NAP | Putative dehydrogenase | / | 0.465 | |
5jj0 | SAM | Histone-lysine N-methyltransferase EHMT2 | / | 0.465 | |
2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.464 | |
2is0 | I03 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.464 | |
3sxj | SAM | Putative methyltransferase | / | 0.464 | |
3vyd | VYD | Renin | 3.4.23.15 | 0.464 | |
1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.463 | |
2bju | IH4 | Plasmepsin-2 | 3.4.23.39 | 0.463 | |
2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.463 | |
3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.463 | |
4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.462 | |
2xhd | 7T9 | Glutamate receptor 2 | / | 0.462 | |
2zz0 | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.462 | |
3cbp | SFG | Histone-lysine N-methyltransferase SETD7 | 2.1.1.43 | 0.462 | |
4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.462 | |
2ck3 | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.461 | |
2ck3 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.461 | |
2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.461 | |
2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.461 | |
3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.461 | |
3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.461 | |
4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.461 | |
1rne | C60 | Renin | 3.4.23.15 | 0.460 | |
1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.460 | |
2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.460 | |
2iku | LIY | Renin | 3.4.23.15 | 0.460 | |
3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.460 | |
3gqv | NAP | Enoyl reductase LovC | 1 | 0.460 | |
3r96 | ACO | MccE protein | / | 0.460 | |
4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.460 | |
4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.460 | |
4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.460 | |
4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.460 | |
4qi5 | FAD | Cellobiose dehydrogenase | / | 0.460 | |
4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.460 | |
4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.460 | |
1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
1svg | I04 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.459 | |
2c20 | NAD | UDP-glucose 4-epimerase | / | 0.459 | |
2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.459 | |
3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.459 | |
3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.459 | |
3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.459 | |
3tr0 | 5GP | Guanylate kinase | / | 0.459 | |
5f8e | SAH | Possible transcriptional regulatory protein | / | 0.459 | |
1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.458 | |
2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.458 | |
2ohj | FMN | Type A flavoprotein FprA | 1 | 0.458 | |
2owg | SAH | Diphthine synthase | / | 0.458 | |
2pj4 | 414 | Carboxypeptidase B | / | 0.458 | |
2wf2 | ZY2 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
3pdn | SFG | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.458 | |
4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
2dsh | SAH | Diphthine synthase | / | 0.457 | |
2i4q | UA4 | Renin | 3.4.23.15 | 0.457 | |
2nr4 | FMN | Conserved protein | / | 0.457 | |
2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.457 | |
3a3g | DLZ | Lumazine protein | / | 0.457 | |
3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.457 | |
3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.457 | |
3tox | NAP | Putative oxidoreductase | / | 0.457 | |
4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.456 | |
1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.456 | |
2ejz | SAH | Diphthine synthase | / | 0.456 | |
3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
3rfa | SAM | Dual-specificity RNA methyltransferase RlmN | / | 0.456 | |
3s7d | LEU_SER_LYS_LYS_MLZ | N-lysine methyltransferase SMYD2 | / | 0.456 | |
5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.456 | |
1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
2g22 | 6IG | Renin | 3.4.23.15 | 0.455 | |
3tjl | FMN | NADPH dehydrogenase | / | 0.455 | |
3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.455 | |
3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
3vsw | R31 | Renin | 3.4.23.15 | 0.455 | |
4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.455 | |
4ef4 | C2E | Stimulator of interferon genes protein | / | 0.455 | |
4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.455 | |
4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.455 | |
4opu | FDA | Conserved Archaeal protein | / | 0.455 | |
5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.455 | |
1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.454 | |
1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.454 | |
2ek7 | SAH | Diphthine synthase | / | 0.454 | |
2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.454 | |
2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.454 | |
2y65 | ADP | Kinesin heavy chain | / | 0.454 | |
3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
3int | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.454 | |
3ixk | 929 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.454 | |
3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.454 | |
3vye | VYE | Renin | 3.4.23.15 | 0.454 | |
4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
4j83 | SAM | Histone-lysine N-methyltransferase SETD7 | 2.1.1.43 | 0.454 | |
1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.453 | |
1i0s | FMN | Ferric-chelate reductase (NAD(P)H) | / | 0.453 | |
1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
2i7n | ACO | Pantothenate kinase 1 | 2.7.1.33 | 0.453 | |
3atz | FMN | Prostaglandin F2a synthase | / | 0.453 | |
3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.453 | |
3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.453 | |
3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.453 | |
3omu | IBD | Heat shock protein 83 | / | 0.453 | |
4bls | APC | NTPase P4 | / | 0.453 | |
4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.453 | |
4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.453 | |
4pzr | COA | Histone acetyltransferase p300 | / | 0.453 | |
4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.453 | |
5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.453 | |
1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.452 | |
1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.452 | |
2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.452 | |
3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.452 | |
3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.452 | |
4blr | UTP | NTPase P4 | / | 0.452 | |
4lut | DCS | Alanine racemase | / | 0.452 | |
5hq8 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.452 | |
1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.451 | |
1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
1sve | I01 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
2e07 | SAH | Diphthine synthase | / | 0.451 | |
2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.451 | |
2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.451 | |
2g1n | 1IG | Renin | 3.4.23.15 | 0.451 | |
2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.451 | |
2gz7 | D3F | Orf1a polyprotein | / | 0.451 | |
2il2 | LIX | Renin | 3.4.23.15 | 0.451 | |
2qln | F59 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.451 | |
3ag6 | PAJ | Pantothenate synthetase | / | 0.451 | |
3ai3 | NDP | NADPH-sorbose reductase | / | 0.451 | |
3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.451 | |
3ziu | LSS | Leucyl-tRNA synthetase | / | 0.451 | |
3zki | WZV | Beta-secretase 2 | 3.4.23.45 | 0.451 | |
4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.451 | |
4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.451 | |
4flk | Y10 | Methionine aminopeptidase 1 | / | 0.451 | |
1kr5 | SAH | Protein-L-isoaspartate(D-aspartate) O-methyltransferase | 2.1.1.77 | 0.450 | |
1pg3 | PRX | Acetyl-coenzyme A synthetase | / | 0.450 | |
2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.450 | |
2e8s | SAH | Diphthine synthase | / | 0.450 | |
2g1s | 4IG | Renin | 3.4.23.15 | 0.450 | |
2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.450 | |
2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.450 | |
3own | 3OW | Renin | 3.4.23.15 | 0.450 | |
3q70 | RIT | Candidapepsin-2 | 3.4.23.24 | 0.450 | |
4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.450 | |
4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
4ca7 | 3EF | Angiotensin-converting enzyme | 3.4.15.1 | 0.450 | |
4de5 | 0JD | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
4jic | FMN | GTN Reductase | / | 0.450 | |
4mlp | 2CX | Cryptochrome-2 | / | 0.450 | |
4r81 | FMN | Predicted NADH dehydrogenase | / | 0.450 | |
1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.449 | |
1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.449 | |
1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.449 | |
1uma | IN2 | Prothrombin | 3.4.21.5 | 0.449 | |
2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.449 | |
2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
3bk2 | U5P | Ribonuclease J | / | 0.449 | |
3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.449 | |
3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
3ko8 | NAD | NAD-dependent epimerase/dehydratase | / | 0.449 | |
3vsx | R32 | Renin | 3.4.23.15 | 0.449 | |
3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.449 | |
4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.449 | |
1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.448 | |
2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
3bgx | TMP | Thymidylate synthase | / | 0.448 | |
3f63 | GTX | Glutathione transferase GST1-4 | / | 0.448 | |
3hl0 | NAD | Maleylacetate reductase | / | 0.448 | |
3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.448 | |
4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
4gdd | NAI | UDP-galactopyranose mutase | / | 0.448 | |
4gsu | DWZ | L,D-transpeptidase 2 | 2.3.2 | 0.448 | |
4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
5dp2 | NAP | CurF | / | 0.448 | |
1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.447 | |
1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.447 | |
2dsg | SAH | Diphthine synthase | / | 0.447 | |
2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.447 | |
2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.447 | |
2g21 | L1B | Renin | 3.4.23.15 | 0.447 | |
2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.447 | |
2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
2xfi | XFI | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
2z3n | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.447 | |
2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.447 | |
3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.447 | |
3tjz | GNP | ADP-ribosylation factor 1 | / | 0.447 | |
3v3m | 0EN | Replicase polyprotein 1a | 3.4.19.12 | 0.447 | |
4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.447 | |
4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.447 | |
4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
4y7c | FAD | NADPH--cytochrome P450 reductase | / | 0.447 | |
5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
1e3l | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.446 | |
1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.446 | |
1l7x | 700 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.446 | |
1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.446 | |
1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.446 | |
1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.446 | |
1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.446 | |
2owu | SAH | Diphthine synthase | / | 0.446 | |
2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.446 | |
2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.446 | |
2wf3 | ZY3 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
2xyt | TC9 | Soluble acetylcholine receptor | / | 0.446 | |
2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.446 | |
3c8b | ARG_ARG_GLY_ILE_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.446 | |
3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
4amb | DUD | Putative glycosyl transferase | / | 0.446 | |
4df2 | FMN | NADPH dehydrogenase | / | 0.446 | |
4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.446 | |
4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.446 | |
4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.446 | |
3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.446 | |
1a59 | COA | 2-methylcitrate synthase | / | 0.445 | |
1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.445 | |
1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
1lbc | CYZ | Glutamate receptor 2 | / | 0.445 | |
1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.445 | |
1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.445 | |
1oxo | IK2 | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.445 | |
1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
2xx9 | 1NF | Glutamate receptor 2 | / | 0.445 | |
2zzc | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.445 | |
3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.445 | |
3pft | FMN | Flavin reductase | / | 0.445 | |
3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.445 | |
4f5y | C2E | Stimulator of interferon genes protein | / | 0.445 | |
4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.445 | |
5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.445 | |
1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.444 | |
1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.444 | |
1qy5 | NEC | Endoplasmin | / | 0.444 | |
2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.444 | |
2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.444 | |
2pb4 | SAH | Diphthine synthase | / | 0.444 | |
2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.444 | |
3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.444 | |
4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.444 | |
4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.444 | |
4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.444 | |
4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.444 | |
5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.444 | |
3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.444 | |
1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.443 | |
1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.443 | |
1x1c | SAH | C-20 methyltransferase | / | 0.443 | |
2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
2g24 | 7IG | Renin | 3.4.23.15 | 0.443 | |
2g94 | ZPQ | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.443 | |
2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.443 | |
2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.443 | |
2vj6 | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
2vke | TAC | Tetracycline repressor protein class D | / | 0.443 | |
2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.443 | |
3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.443 | |
3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
3r2f | PB0 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
3r9u | FAD | Thioredoxin reductase | / | 0.443 | |
3ukf | GDU | UDP-galactopyranose mutase | / | 0.443 | |
4dna | FAD | Probable glutathione reductase | / | 0.443 | |
4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.443 | |
4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.443 | |
5cyo | GDP | Septin-9 | / | 0.443 | |
8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
1cne | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.442 | |
1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.442 | |
1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
1r6t | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.442 | |
1t4u | 81A | Prothrombin | 3.4.21.5 | 0.442 | |
1zrq | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.442 | |
2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.442 | |
2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.442 | |
2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.442 | |
2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.442 | |
2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
2zhq | 27U | Prothrombin | 3.4.21.5 | 0.442 | |
2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
3bnk | FMN | Flavoredoxin | / | 0.442 | |
3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.442 | |
3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.442 | |
3oqf | S51 | Renin | 3.4.23.15 | 0.442 | |
3p5p | A3C | Taxadiene synthase | 4.2.3.17 | 0.442 | |
3pnd | FAD | FAD:protein FMN transferase | / | 0.442 | |
3qwp | SAM | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.442 | |
3ru0 | SFG | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.442 | |
3zcs | CAW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.442 | |
4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.442 | |
4asu | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.442 | |
4nv1 | 0FX | Formyl transferase | / | 0.442 | |
4pzs | ACO | Histone acetyltransferase p300 | / | 0.442 | |
4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.442 | |
5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
1bid | UMP | Thymidylate synthase | / | 0.441 | |
1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
2ed3 | SAH | Diphthine synthase | / | 0.441 | |
2eh5 | SAH | Diphthine synthase | / | 0.441 | |
2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.441 | |
2p20 | PRX | Acetyl-coenzyme A synthetase | / | 0.441 | |
2p2b | PRX | Acetyl-coenzyme A synthetase | / | 0.441 | |
2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
3itj | FAD | Thioredoxin reductase 1 | 1.8.1.9 | 0.441 | |
3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
3vyf | VYF | Renin | 3.4.23.15 | 0.441 | |
4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
4lcj | NAD | C-terminal-binding protein 2 | / | 0.441 | |
4m55 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.441 | |
4m5p | FMN | NADPH dehydrogenase | / | 0.441 | |
4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.440 | |
1n2j | PAF | Pantothenate synthetase | 6.3.2.1 | 0.440 | |
1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.440 | |
2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 | |
2dsi | SAH | Diphthine synthase | / | 0.440 | |
2dv7 | SAH | Diphthine synthase | / | 0.440 | |
2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.440 | |
2ign | FAD | Pyranose 2-oxidase | / | 0.440 | |
2ii6 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.440 | |
2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.440 | |
2pb6 | SAH | Diphthine synthase | / | 0.440 | |
2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.440 | |
2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.440 | |
2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
3c1k | T15 | Prothrombin | 3.4.21.5 | 0.440 | |
3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.440 | |
3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.440 | |
3sm2 | 478 | Putative gag-pro-pol polyprotein | / | 0.440 | |
4hh4 | SAH | CcbJ | / | 0.440 | |
4la1 | FAD | Thioredoxin glutathione reductase | / | 0.440 | |
4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.440 | |
5cfl | C2E | Stimulator of interferon genes protein | / | 0.440 | |
5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.440 | |
5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 |