sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ju9 | TZD | Benzoylformate decarboxylase | 4.1.1.7 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ju9 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 1.000 | |
| 4ju8 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.706 | |
| 4mpp | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.669 | |
| 4mq5 | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.664 | |
| 5dgt | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.658 | |
| 2fwn | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.657 | |
| 4k9n | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.635 | |
| 4juf | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.634 | |
| 4qel | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.617 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.602 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.597 | |
| 1bfd | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.593 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.588 | |
| 1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.578 | |
| 4k9p | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.578 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.574 | |
| 4gm4 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.564 | |
| 4juc | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.563 | |
| 4mpr | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.558 | |
| 4mzx | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.533 | |
| 4gg1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.524 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.508 | |
| 4jd5 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.506 | |
| 4gm1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.505 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.504 | |
| 4gm0 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.500 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.500 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.495 | |
| 2v3w | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.495 | |
| 2vhx | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.495 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.495 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.495 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.494 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.493 | |
| 5ftf | ADP | TPR domain protein | / | 0.493 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.491 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.488 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.488 | |
| 4irn | FAD | AnaB | / | 0.487 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.486 | |
| 3eld | SFG | Methyltransferase | / | 0.485 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.485 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.484 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.483 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.483 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.482 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.481 | |
| 3evc | SAH | Genome polyprotein | 2.1.1.56 | 0.481 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.480 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.480 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.479 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.478 | |
| 1qmz | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.478 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.478 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.478 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.477 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.477 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.476 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.476 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.475 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.475 | |
| 4i52 | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.475 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.474 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.474 | |
| 1w5s | ADP | ORC1-type DNA replication protein 2 | / | 0.474 | |
| 2ob0 | ACO | N-alpha-acetyltransferase 50 | / | 0.474 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3pxv | FMN | Nitroreductase | / | 0.474 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.474 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.473 | |
| 3mx2 | TTP | Nucleoprotein | / | 0.473 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.472 | |
| 1ppj | ANY | Cytochrome b | / | 0.472 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.472 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.471 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.471 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.471 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.471 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.471 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.471 | |
| 1nhp | FAD | NADH peroxidase | 1.11.1.1 | 0.470 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.470 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.470 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.470 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.470 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.470 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.469 | |
| 3ieu | GDP | GTPase Era | / | 0.469 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.469 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.469 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.469 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.468 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.468 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.468 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.468 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.468 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.468 | |
| 1iy8 | NAD | Levodione reductase | / | 0.467 | |
| 1vcf | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.467 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.467 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.467 | |
| 3m9v | TYD | FAD-dependent oxidoreductase | / | 0.467 | |
| 3x2w | ATP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.467 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.467 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.466 | |
| 4en4 | ATP | Pyridoxal kinase | 2.7.1.35 | 0.466 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.464 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.464 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.464 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.464 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.464 | |
| 5d4v | YGP | Uncharacterized protein MJ0489 | / | 0.464 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.463 | |
| 1xdp | ATP | Polyphosphate kinase | / | 0.463 | |
| 2d8a | NAD | L-threonine 3-dehydrogenase | / | 0.463 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.463 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.463 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.463 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.463 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.462 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.462 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.462 | |
| 3ely | SAH | Methyltransferase | / | 0.462 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.462 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.462 | |
| 4dju | 0KK | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.462 | |
| 4zp1 | TPP | Pyruvate decarboxylase | 4.1.1.1 | 0.462 | |
| 2uyw | BTN | Avd protein | / | 0.461 | |
| 3eof | FMN | Putative oxidase | / | 0.461 | |
| 3mx5 | UTP | Nucleoprotein | / | 0.461 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.461 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.461 | |
| 4fgr | ADP | Phosphoribosylaminoimidazole-succinocarboxamide synthase | 6.3.2.6 | 0.461 | |
| 5dbg | NAD | Iridoid synthase | 1.3.1.99 | 0.461 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.460 | |
| 1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.460 | |
| 1vza | UMP | Thymidylate synthase | / | 0.460 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.460 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.460 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.460 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.460 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.460 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.460 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.459 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.459 | |
| 1w78 | PD8 | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.459 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.459 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.459 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.459 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.459 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.459 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.459 | |
| 4ctj | SAM | Genome polyprotein | / | 0.459 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.459 | |
| 4gah | 0ET | Acyl-coenzyme A thioesterase THEM4 | 3.1.2.2 | 0.459 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.459 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.459 | |
| 5cfp | C2E | Stimulator of interferon genes protein | / | 0.459 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.458 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.458 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.458 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.458 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.458 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.458 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.458 | |
| 3uce | NDP | Dehydrogenase | / | 0.458 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.458 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.458 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.457 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.457 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.457 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.457 | |
| 2rc3 | NAD | CBS domain | / | 0.457 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.457 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.457 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.457 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.457 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.457 | |
| 5i39 | FAD | L-amino acid deaminase | / | 0.457 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.456 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.456 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 1bp6 | UMP | Thymidylate synthase | / | 0.455 | |
| 1e2n | RCA | Thymidine kinase | / | 0.455 | |
| 2eg5 | SAH | 7-methylxanthosine synthase 1 | / | 0.455 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.455 | |
| 3u9e | COA | Lmo1369 protein | / | 0.455 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.455 | |
| 1pl1 | ABY | Glutathione S-transferase A1 | 2.5.1.18 | 0.454 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.454 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3nbv | ANP | Ketohexokinase | / | 0.454 | |
| 3nl6 | ACP | Uncharacterized protein | / | 0.454 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.454 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 4h12 | SAH | Histone-lysine N-methyltransferase SETD2 | 2.1.1.43 | 0.454 | |
| 4qtu | SAM | 18S rRNA (guanine(1575)-N(7))-methyltransferase | / | 0.454 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.453 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.453 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.453 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.453 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.453 | |
| 2cnt | COA | Ribosomal-protein-alanine acetyltransferase | / | 0.453 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.453 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.453 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 3p8z | 36A | Genome polyprotein | 2.1.1.56 | 0.453 | |
| 3s1s | SAH | Restriction endonuclease BpuSI | / | 0.453 | |
| 3t7x | 4SH | Endothiapepsin | 3.4.23.22 | 0.453 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.453 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.453 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.453 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.452 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.452 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.452 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.452 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.452 | |
| 3cx4 | ADP | Glycogen synthase | 2.4.1.21 | 0.452 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.452 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.452 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.452 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.452 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.452 | |
| 4xwt | U5P | Ribonuclease J | / | 0.452 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.452 | |
| 5kj1 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1fml | RTL | Retinol dehydratase | / | 0.451 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.451 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.451 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.451 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.451 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.451 | |
| 3pnd | FAD | FAD:protein FMN transferase | / | 0.451 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.451 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.451 | |
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 | / | 0.450 | |
| 1zdw | FLV | Prenyltransferase | / | 0.450 | |
| 2eq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.450 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.450 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.450 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.450 | |
| 3fnl | SHA | Lactoperoxidase | / | 0.450 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.450 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.450 | |
| 4bl5 | GFB | GDP-L-fucose synthase | 1.1.1.271 | 0.450 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.450 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.450 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.450 | |
| 4l03 | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.450 | |
| 4ohw | ATP | Protein clpf-1 | / | 0.450 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.450 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.449 | |
| 1e94 | ANP | ATP-dependent protease ATPase subunit HslU | / | 0.449 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.449 | |
| 1kh2 | ATP | Argininosuccinate synthase | / | 0.449 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.449 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.449 | |
| 2e93 | B29 | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.449 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.449 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3w8q | AGS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.449 | |
| 4dja | FAD | (6-4) photolyase | / | 0.449 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.449 | |
| 4wq5 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.449 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.448 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.448 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.448 | |
| 1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.448 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.448 | |
| 2vhv | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.448 | |
| 2wks | CB6 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.448 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.448 | |
| 4h4u | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.448 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.448 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.448 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.447 | |
| 1g6o | ADP | Cag alpha | / | 0.447 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.447 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 2vhw | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.447 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.447 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 3csc | ACO | Citrate synthase, mitochondrial | 2.3.3.1 | 0.447 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.447 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.447 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 4ctk | SAM | Genome polyprotein | / | 0.447 | |
| 1a5b | IGP | Tryptophan synthase alpha chain | / | 0.446 | |
| 1h6d | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.446 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.446 | |
| 1t0l | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.446 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.446 | |
| 2rhq | GAX | Phenylalanine--tRNA ligase alpha subunit | / | 0.446 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.446 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.446 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.446 | |
| 3eku | CY9 | Actin-5C | / | 0.446 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.446 | |
| 3idb | ANP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 3ll9 | ADP | Isopentenyl phosphate kinase | / | 0.446 | |
| 3qcx | 3Q2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.446 | |
| 4ki8 | ADP | 60 kDa chaperonin | / | 0.446 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.445 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.445 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.445 | |
| 3int | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.445 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3m31 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.445 | |
| 3tza | TZG | Glutamate receptor 2 | / | 0.445 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4h1v | GNP | Dynamin-1-like protein | 3.6.5.5 | 0.445 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.445 | |
| 4l7g | 1W0 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.444 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.444 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.444 | |
| 1n75 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.444 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.444 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.444 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.444 | |
| 2igy | A2T | Plasmepsin 2 | / | 0.444 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2rl1 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.444 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.444 | |
| 3zhz | FM7 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.444 | |
| 4a2b | AGS | Cell division protein FtsA | / | 0.444 | |
| 4ap3 | FAD | Steroid monooxygenase | / | 0.444 | |
| 4c3x | FAD | 3-ketosteroid dehydrogenase | / | 0.444 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.444 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.444 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.444 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.444 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.444 | |
| 5eg3 | ACP | Fibroblast growth factor receptor 2 | / | 0.444 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.443 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.443 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.443 | |
| 1kp3 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.443 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.443 | |
| 2j9g | ANP | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 2jt2 | C90 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.443 | |
| 2pak | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.443 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.443 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3axb | FAD | Putative oxidoreductase | / | 0.443 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.443 | |
| 4c3y | FAD | 3-ketosteroid dehydrogenase | / | 0.443 | |
| 4dna | FAD | Probable glutathione reductase | / | 0.443 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.443 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.443 | |
| 5fl3 | ADP | Pili retraction protein PilT | / | 0.443 | |
| 5l3r | GCP | Cell division protein FtsY homolog, chloroplastic | / | 0.443 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.442 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.442 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.442 | |
| 2e1z | B4P | Propionate kinase | / | 0.442 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.442 | |
| 2j8z | NAP | Quinone oxidoreductase PIG3 | 1 | 0.442 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.442 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 3aho | 3A2 | Oligopeptidase | / | 0.442 | |
| 3akd | CDP | Cytidylate kinase | / | 0.442 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3elu | SAM | Methyltransferase | / | 0.442 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.442 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 3ov7 | ATP | CCA-adding enzyme | 2.7.7.72 | 0.442 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 4b0q | GMF | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.442 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.442 | |
| 4mkh | AP5 | Adenylate kinase | / | 0.442 | |
| 4tlz | NAP | KtzI | / | 0.442 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.442 | |
| 5hxw | FAD | L-amino acid deaminase | / | 0.442 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.441 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 1glf | ADP | Glycerol kinase | / | 0.441 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.441 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.441 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.441 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.441 | |
| 2udp | UPP | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 2wa2 | SAM | Genome polyprotein | / | 0.441 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.441 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.441 | |
| 2yg6 | FAD | Putrescine oxidase | / | 0.441 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.441 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.441 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.441 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.441 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.441 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.441 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.441 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 4i42 | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.441 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.441 | |
| 5kj6 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.441 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.441 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.440 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 1hpx | KNI | Gag-Pol polyprotein | / | 0.440 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.440 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.440 | |
| 1udc | UFM | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 1yre | COA | Uncharacterized protein | / | 0.440 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.440 | |
| 2eer | NAD | NAD-dependent alcohol dehydrogenase | 1.1.1.1 | 0.440 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.440 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.440 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 2vj6 | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.440 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.440 | |
| 2xvu | 9DN | Serum albumin | / | 0.440 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.440 | |
| 3cwq | ADP | ParA family chromosome partitioning protein | / | 0.440 | |
| 3enk | UPG | UDP-glucose 4-epimerase | / | 0.440 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.440 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.440 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 4biz | ADP | Sensor histidine kinase CpxA | / | 0.440 | |
| 4gyi | ADP | Uncharacterized protein | / | 0.440 | |
| 4hb9 | FAD | Uncharacterized protein | / | 0.440 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.440 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.440 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.440 |