sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xtn | GTP | GTPase IMAP family member 2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2xtn | GTP | GTPase IMAP family member 2 | / | 1.000 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.521 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.501 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.493 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.492 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.488 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.487 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.487 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.486 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.485 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.484 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.483 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.482 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.481 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.479 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.479 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.479 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.478 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.478 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.478 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.477 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.477 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.476 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.476 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.474 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.474 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.474 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.474 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.473 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.472 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.472 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.472 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.472 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.471 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.471 | |
| 3t7x | 4SH | Endothiapepsin | 3.4.23.22 | 0.471 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.471 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.470 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.470 | |
| 1vce | SAH | Diphthine synthase | / | 0.470 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.470 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.470 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.470 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.469 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.468 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.468 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.468 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.467 | |
| 4tm4 | FDA | KtzI | / | 0.467 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.467 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.466 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.466 | |
| 3ukf | GDU | UDP-galactopyranose mutase | / | 0.466 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.466 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.466 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.466 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.465 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.465 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.465 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.465 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.465 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.465 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.465 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.465 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.465 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.464 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.464 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.464 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.463 | |
| 2y3s | TIR | TamL | / | 0.463 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.463 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.463 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.463 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.463 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.462 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.462 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.462 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.462 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.462 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.462 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.462 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.462 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.461 | |
| 1zio | AP5 | Adenylate kinase | / | 0.461 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.461 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.461 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.461 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.461 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.460 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.460 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.460 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.460 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.460 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.460 | |
| 3p8z | 36A | Genome polyprotein | 2.1.1.56 | 0.460 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.460 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.460 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.459 | |
| 2ejz | SAH | Diphthine synthase | / | 0.459 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.459 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.459 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.459 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.459 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.459 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.459 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.459 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.458 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.458 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.458 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.458 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.458 | |
| 3ivx | FG6 | Pantothenate synthetase | 6.3.2.1 | 0.458 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.458 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.458 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.457 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.457 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.457 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.457 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.457 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.457 | |
| 2r26 | CMC | Citrate synthase | 2.3.3.16 | 0.457 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.457 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.457 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.457 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.457 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.456 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.456 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.456 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.456 | |
| 3kpb | SAM | Uncharacterized protein MJ0100 | / | 0.456 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.456 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.456 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 4c4o | NAD | SADH | / | 0.456 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.456 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.456 | |
| 4kgm | ATP | Uncharacterized protein | / | 0.456 | |
| 4qec | NAP | ElxO | / | 0.456 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.455 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.455 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.454 | |
| 1c7o | PPG | Hemolysin | / | 0.454 | |
| 2dsh | SAH | Diphthine synthase | / | 0.454 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.454 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.454 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.454 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.454 | |
| 5af7 | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.453 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.453 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.453 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.453 | |
| 2owu | SAH | Diphthine synthase | / | 0.453 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.452 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.452 | |
| 2web | PP4 | Penicillopepsin-1 | 3.4.23.20 | 0.452 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.452 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.452 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.452 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.452 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.452 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.452 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.452 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.452 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.451 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.451 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.451 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.451 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.451 | |
| 3bnk | FMN | Flavoredoxin | / | 0.451 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.451 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.451 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.451 | |
| 4jl5 | ADP | Adenylate kinase | / | 0.451 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 5fsi | 8DG | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.451 | |
| 1iy8 | NAD | Levodione reductase | / | 0.450 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.450 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.450 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.450 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.450 | |
| 3bj7 | COA | Diamine acetyltransferase 1 | / | 0.450 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.450 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.450 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.450 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.450 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.450 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.450 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.450 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.449 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.449 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1w5s | ADP | ORC1-type DNA replication protein 2 | / | 0.449 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.449 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.449 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.449 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.449 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.449 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.449 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.449 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.449 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.449 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.449 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.449 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.448 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.448 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 2h12 | CMX | Citrate synthase | / | 0.448 | |
| 2pck | SAH | Diphthine synthase | / | 0.448 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.448 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.448 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.448 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.448 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.447 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.447 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.447 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.447 | |
| 2p41 | SAH | Genome polyprotein | / | 0.447 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.447 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3eks | CY9 | Actin-5C | / | 0.447 | |
| 3em3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.447 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.447 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.447 | |
| 3pww | ROC | Endothiapepsin | 3.4.23.22 | 0.447 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.447 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.446 | |
| 1yre | COA | Uncharacterized protein | / | 0.446 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.446 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.446 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.446 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.446 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.446 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.446 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.446 | |
| 3zki | WZV | Beta-secretase 2 | 3.4.23.45 | 0.446 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.446 | |
| 4h1v | GNP | Dynamin-1-like protein | 3.6.5.5 | 0.446 | |
| 4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.446 | |
| 1qy5 | NEC | Endoplasmin | / | 0.445 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.445 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.445 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 3bb3 | GDP | Translocase of chloroplast 33, chloroplastic | 3.6.5 | 0.445 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.445 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.445 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.445 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.445 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.445 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.445 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.445 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.445 | |
| 4d0l | GSP | Ras-related protein Rab-11A | / | 0.445 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.445 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.445 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.444 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.444 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.444 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.444 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.444 | |
| 2hux | SAH | Diphthine synthase | / | 0.444 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.444 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.444 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.444 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4b78 | KGG | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.444 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.444 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.444 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.444 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.443 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.443 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.443 | |
| 2e07 | SAH | Diphthine synthase | / | 0.443 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.443 | |
| 2xfi | XFI | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.443 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3eld | SFG | Methyltransferase | / | 0.443 | |
| 3enk | UPG | UDP-glucose 4-epimerase | / | 0.443 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4j2w | FAD | Kynurenine 3-monooxygenase | / | 0.443 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.443 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.443 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.443 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.442 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.442 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.442 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.442 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.442 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.442 | |
| 2dsg | SAH | Diphthine synthase | / | 0.442 | |
| 2emr | SAH | Diphthine synthase | / | 0.442 | |
| 2g9r | G27 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.442 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.442 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.442 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.442 | |
| 3w8q | AGS | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.442 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.442 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.441 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2e15 | SAH | Diphthine synthase | / | 0.441 | |
| 2ejj | SAH | Diphthine synthase | / | 0.441 | |
| 2huq | SAH | Diphthine synthase | / | 0.441 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.441 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2owk | SAH | Diphthine synthase | / | 0.441 | |
| 2p5f | SAH | Diphthine synthase | / | 0.441 | |
| 2ph8 | 35A | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2qjo | NAD | Bifunctional NMN adenylyltransferase/Nudix hydrolase | 2.7.7.1 | 0.441 | |
| 2y4g | TIR | TamL | / | 0.441 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.441 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.441 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3wid | NAP | Glucose 1-dehydrogenase | / | 0.441 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.441 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.441 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.440 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.440 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.440 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.440 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.440 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.440 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.440 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.440 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.440 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.440 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.440 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3qv1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.440 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.440 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.440 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.440 | |
| 4qly | FMN | Enone reductase CLA-ER | / | 0.440 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |