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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ywrLI9Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ywrLI9Mitogen-activated protein kinase 14/1.000
1ouk084Mitogen-activated protein kinase 14/0.596
3fln3FNMitogen-activated protein kinase 14/0.577
4ewqMWLMitogen-activated protein kinase 14/0.577
3hl7I47Mitogen-activated protein kinase 14/0.572
2ittAEEEpidermal growth factor receptor2.7.10.10.559
3gc9B45Mitogen-activated protein kinase 112.7.11.240.559
3dt1P40Mitogen-activated protein kinase 14/0.557
3mpaSB2Mitogen-activated protein kinase 14/0.553
3flsFLSMitogen-activated protein kinase 14/0.551
1zyjBI5Mitogen-activated protein kinase 14/0.548
3s4qNK0Mitogen-activated protein kinase 14/0.540
1m7qDQOMitogen-activated protein kinase 14/0.539
4f9wLM4Mitogen-activated protein kinase 14/0.539
3fmjFMJMitogen-activated protein kinase 14/0.538
2ghlLIBMitogen-activated protein kinase 14/0.537
2itqITQEpidermal growth factor receptor2.7.10.10.537
4nks2M2Fibroblast growth factor receptor 1/0.535
3fmkFMKMitogen-activated protein kinase 14/0.534
3gc7B45Mitogen-activated protein kinase 14/0.534
1ouy094Mitogen-activated protein kinase 14/0.533
3uibSB2Putative mitogen-activated protein kinase/0.533
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.532
3roc29AMitogen-activated protein kinase 14/0.532
3fklFKLMitogen-activated protein kinase 14/0.531
1bl6SB6Mitogen-activated protein kinase 14/0.530
3flzFLZMitogen-activated protein kinase 14/0.530
3gubGUBDeath-associated protein kinase 12.7.11.10.530
2ghmLICMitogen-activated protein kinase 14/0.527
3ha85JZMitogen-activated protein kinase 14/0.527
3mvl38PMitogen-activated protein kinase 14/0.527
4lopSB4Mitogen-activated protein kinase 14/0.527
3uvqFS8Mitogen-activated protein kinase 14/0.526
3nww3NWMitogen-activated protein kinase 14/0.525
4jrvKJVEpidermal growth factor receptor2.7.10.10.525
1m17AQ4Epidermal growth factor receptor2.7.10.10.524
3fmn530Mitogen-activated protein kinase 14/0.523
3iphG11Mitogen-activated protein kinase 14/0.523
2itpAEEEpidermal growth factor receptor2.7.10.10.521
3fmh533Mitogen-activated protein kinase 14/0.521
3hllI45Mitogen-activated protein kinase 14/0.521
3kf7L9GMitogen-activated protein kinase 14/0.521
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
4kbk1QGCasein kinase I isoform delta2.7.11.10.520
3igoANPCalmodulin-domain protein kinase 1, putative/0.519
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.519
2balPQAMitogen-activated protein kinase 14/0.518
1oz1FPHMitogen-activated protein kinase 14/0.517
3hvcGG5Mitogen-activated protein kinase 14/0.514
3gfeP37Mitogen-activated protein kinase 14/0.513
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.513
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.512
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.512
3fc152PMitogen-activated protein kinase 14/0.511
3fi4FI4Mitogen-activated protein kinase 14/0.511
4bgg844Activin receptor type-12.7.11.300.510
4ic7ANPMitogen-activated protein kinase 72.7.11.240.510
1w84L12Mitogen-activated protein kinase 14/0.507
3flyFLYMitogen-activated protein kinase 14/0.507
4fob0USALK tyrosine kinase receptor2.7.10.10.507
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.506
4kbc1QJCasein kinase I isoform delta2.7.11.10.506
3fl4FL4Mitogen-activated protein kinase 14/0.505
3fskRO6Mitogen-activated protein kinase 14/0.505
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.505
3w33W19Epidermal growth factor receptor2.7.10.10.505
2qd9LGFMitogen-activated protein kinase 14/0.504
3flwFLWMitogen-activated protein kinase 14/0.504
4aacAAVMitogen-activated protein kinase 14/0.504
5f0a1FBcGMP-dependent protein kinase, putative/0.504
3uvp048Mitogen-activated protein kinase 14/0.503
2itnANPEpidermal growth factor receptor2.7.10.10.502
3hp552PMitogen-activated protein kinase 14/0.502
4eh50OMMitogen-activated protein kinase 14/0.502
4looSB4Mitogen-activated protein kinase 14/0.502
4jr3KJREpidermal growth factor receptor2.7.10.10.501
2fgiPD1Fibroblast growth factor receptor 1/0.500
3obgSB2Mitogen-activated protein kinase 14/0.500
4eym0RXMitogen-activated protein kinase 132.7.11.240.500
3ocgOCGMitogen-activated protein kinase 14/0.499
4aa4QC0Mitogen-activated protein kinase 14/0.499
4jq7KJQEpidermal growth factor receptor2.7.10.10.499
4i22IREEpidermal growth factor receptor2.7.10.10.498
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.496
2ckeIQUDeath-associated protein kinase 2/0.495
3fknFKNMitogen-activated protein kinase 14/0.495
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.495
4ansVGHALK tyrosine kinase receptor2.7.10.10.495
4wboANWRhodopsin kinase/0.495
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.494
3fkoFKOMitogen-activated protein kinase 14/0.494
4aa5NQBMitogen-activated protein kinase 14/0.494
4f630S7Fibroblast growth factor receptor 1/0.494
2bujSTUSerine/threonine-protein kinase 16/0.493
2ewaSB2Mitogen-activated protein kinase 14/0.493
3mtfA3FActivin receptor type-12.7.11.300.493
3u8w09JMitogen-activated protein kinase 14/0.493
3t8oATPRhodopsin kinase/0.492
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.491
3uyt0CKCasein kinase I isoform delta2.7.11.10.491
3zsh469Mitogen-activated protein kinase 14/0.491
4loqSB4Mitogen-activated protein kinase 14/0.491
4yuqKS1Calmodulin-like domain protein kinase/0.491
1ove358Mitogen-activated protein kinase 14/0.490
1yw2PGJMitogen-activated protein kinase 14/0.490
1zzlTZYMitogen-activated protein kinase 14/0.490
2qocANPEphrin type-A receptor 32.7.10.10.490
4anqVGHALK tyrosine kinase receptor2.7.10.10.490
3hub469Mitogen-activated protein kinase 14/0.488
4hni16WCasein kinase I isoform epsilon2.7.11.10.488
4kin1M8Mitogen-activated protein kinase 14/0.488
4nc3ERM5-hydroxytryptamine receptor 2B/0.488
3q5iANPProtein kinase, putative/0.487
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.487
2itzIREEpidermal growth factor receptor2.7.10.10.486
2pwlACPFibroblast growth factor receptor 2/0.486
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.486
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.486
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.486
4hnf16WCasein kinase I isoform delta2.7.11.10.486
4nk92K5Fibroblast growth factor receptor 1/0.486
3tucFPWTyrosine-protein kinase SYK2.7.10.20.485
4nka2K7Fibroblast growth factor receptor 1/0.485
2itwITQEpidermal growth factor receptor2.7.10.10.484
3fmmXI2Mitogen-activated protein kinase 14/0.484
4g170VNCasein kinase I isoform gamma-32.7.11.10.484
4kiq1RAMitogen-activated protein kinase 14/0.484
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.484
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.484
3mpt1GKMitogen-activated protein kinase 14/0.483
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.482
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.482
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.481
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.481
4f640S8Fibroblast growth factor receptor 1/0.481
4jq8KJ8Epidermal growth factor receptor2.7.10.10.481
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.481
2i0ePDSProtein kinase C beta type2.7.11.130.480
3o8tBMUMitogen-activated protein kinase 14/0.480
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
4kb81QNCasein kinase I isoform delta2.7.11.10.480
4kba1QMCasein kinase I isoform delta2.7.11.10.480
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.479
3vjoANPEpidermal growth factor receptor2.7.10.10.479
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.478
3a7hATPSerine/threonine-protein kinase 242.7.11.10.478
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.478
4xhgADPUncharacterized protein/0.478
2hog710Serine/threonine-protein kinase Chk12.7.11.10.477
2zybKSLTyrosine-protein kinase Lck2.7.10.20.477
3c50ADPRhodopsin kinase/0.477
3l8xN4DMitogen-activated protein kinase 14/0.477
3w2sW2REpidermal growth factor receptor2.7.10.10.477
4iebANPCalmodulin-domain protein kinase 1/0.477
1bl7SB4Mitogen-activated protein kinase 14/0.476
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.476
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.476
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.476
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
2cchATPCyclin-dependent kinase 22.7.11.220.475
2of2547Tyrosine-protein kinase Lck2.7.10.20.475
2zb0GK3Mitogen-activated protein kinase 14/0.475
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.475
3js2VM1Fibroblast growth factor receptor 1/0.475
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.475
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.475
2hk51BMTyrosine-protein kinase HCK2.7.10.20.474
3fmlFMLMitogen-activated protein kinase 14/0.474
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.474
4dymIYZActivin receptor type-12.7.11.300.474
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.474
5auwQUEDeath-associated protein kinase 12.7.11.10.474
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.473
3itzP66Mitogen-activated protein kinase 14/0.473
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.473
4fuxE75Mitogen-activated protein kinase 12.7.11.240.473
4kip1R9Mitogen-activated protein kinase 14/0.473
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.472
2c7xNRBCytochrome P450 monooxygenase PikC/0.472
2o0uC0MMitogen-activated protein kinase 102.7.11.240.472
3mvm39PMitogen-activated protein kinase 14/0.472
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.472
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.471
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.471
4c02TAKActivin receptor type-12.7.11.300.471
4gk3L87Ephrin type-A receptor 32.7.10.10.471
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.471
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.470
2uxuNARHTH-type transcriptional regulator TtgR/0.470
3c4xATPRhodopsin kinase/0.470
3mdvCL6Cholesterol 24-hydroxylase/0.470
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.470
1yqj6NPMitogen-activated protein kinase 14/0.469
2b1pAIZMitogen-activated protein kinase 102.7.11.240.469
2excJNKMitogen-activated protein kinase 102.7.11.240.469
2izsBRQCasein kinase I isoform gamma-32.7.11.10.469
2qa2FADPolyketide oxygenase CabE/0.469
3ormAGSSerine/threonine protein kinase/0.469
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.469
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.468
2vx07X7Ephrin type-B receptor 42.7.10.10.468
3iaeD7KBenzaldehyde lyase/0.468
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.468
3zsgT75Mitogen-activated protein kinase 14/0.468
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.468
4bcqTJFCyclin-dependent kinase 22.7.11.220.468
1vyw292Cyclin-dependent kinase 22.7.11.220.467
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.467
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.467
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.467
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.467
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.467
1zz2B11Mitogen-activated protein kinase 14/0.466
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
2itxANPEpidermal growth factor receptor2.7.10.10.466
2rg5279Mitogen-activated protein kinase 14/0.466
3tmz06XCytochrome P450 2B41.14.14.10.466
1vjy460TGF-beta receptor type-12.7.11.300.465
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
2vwx7X4Ephrin type-B receptor 42.7.10.10.465
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
3hucG97Mitogen-activated protein kinase 14/0.465
3s2pPMUCyclin-dependent kinase 22.7.11.220.465
3w32W32Epidermal growth factor receptor2.7.10.10.465
4i231C9Epidermal growth factor receptor2.7.10.10.465
1blzACVIsopenicillin N synthase1.21.3.10.464
1nzdUPGDNA beta-glucosyltransferase/0.464
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.464
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.464
3vs3VSETyrosine-protein kinase HCK2.7.10.20.464
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.464
5e8xSTUTGF-beta receptor type-12.7.11.300.464
1finATPCyclin-dependent kinase 22.7.11.220.463
2etm7PYFocal adhesion kinase 12.7.10.20.463
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2izuP01Casein kinase I isoform gamma-32.7.11.10.463
2wihP48Cyclin-dependent kinase 22.7.11.220.463
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.463
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4ih8B43Calmodulin-domain protein kinase 1/0.463
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.463
4nj32KDCyclin-dependent kinase 22.7.11.220.463
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.463
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.463
2ituITQEpidermal growth factor receptor2.7.10.10.462
2rg6287Mitogen-activated protein kinase 14/0.462
4cd0AWJALK tyrosine kinase receptor2.7.10.10.462
4enhFVXCholesterol 24-hydroxylase/0.462
4gxs0YSGlutamate receptor 2/0.462
4qmlANPSerine/threonine-protein kinase 242.7.11.10.462
4riyADPEpidermal growth factor receptor2.7.10.10.462
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.461
2wouZZFTGF-beta receptor type-12.7.11.300.461
3cgoJNOMitogen-activated protein kinase 102.7.11.240.461
4gk2L66Ephrin type-A receptor 32.7.10.10.461
1ie4T44Transthyretin/0.460
1kgjFL8Transthyretin/0.460
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.460
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.460
2q0bACPFibroblast growth factor receptor 2/0.460
3oom507Activin receptor type-12.7.11.300.460
3ttjJBIMitogen-activated protein kinase 102.7.11.240.460
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.460
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.460
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.460
2jedLG8Protein kinase C theta type2.7.11.130.459
2vd5BI8Myotonin-protein kinase2.7.11.10.459
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.459
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.459
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.459
4cy8FDA2-hydroxybiphenyl-3-monooxygenase/0.459
4gu94GUFocal adhesion kinase 12.7.10.20.459
4izy1J2Mitogen-activated protein kinase 82.7.11.240.459
5aaaVGHALK tyrosine kinase receptor2.7.10.10.459
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.458
2eb3ANPEpidermal growth factor receptor2.7.10.10.458
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.458
3iw5DF3Mitogen-activated protein kinase 14/0.458
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.458
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.458
4ubsDIFPentalenic acid synthase1.14.15.110.458
1agwSU2Fibroblast growth factor receptor 1/0.457
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
1s6qTPBGag-Pol polyprotein2.7.7.490.457
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.457
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.457
2py3ACPFibroblast growth factor receptor 2/0.457
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.457
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.457
3blqATPCyclin-dependent kinase 92.7.11.220.457
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.457
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
3lltANPProtein serine/threonine kinase-1/0.457
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.457
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.457
3uwqU5POrotidine 5'-phosphate decarboxylase/0.457
4bchT7ZCyclin-dependent kinase 92.7.11.220.457
4eh60ONMitogen-activated protein kinase 14/0.457
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4hyu1BKMitogen-activated protein kinase 82.7.11.240.457
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.457
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.457
1xjdSTUProtein kinase C theta type2.7.11.130.456
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
2pv7NADT-protein1.3.1.120.456
3d8vUD1Bifunctional protein GlmU/0.456
3du8553Glycogen synthase kinase-3 beta2.7.11.260.456
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4dce0JFALK tyrosine kinase receptor2.7.10.10.456
4i4e1BQFocal adhesion kinase 12.7.10.20.456
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.456
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.456
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.455
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.455
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.455
2j7t274Serine/threonine-protein kinase 102.7.11.10.455
2qo9ANPEphrin type-A receptor 32.7.10.10.455
3hmm855TGF-beta receptor type-12.7.11.300.455
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.455
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.455
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4qmzB49Serine/threonine-protein kinase 242.7.11.10.455
1zrzBI1Protein kinase C iota type2.7.11.130.454
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.454
2vwz7X6Ephrin type-B receptor 42.7.10.10.454
2xvdAS6Ephrin type-B receptor 42.7.10.10.454
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.454
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.454
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.454
4eh70OOMitogen-activated protein kinase 14/0.454
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.454
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.453
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.453
2hw1ANPKetohexokinase/0.453
2pvyACPFibroblast growth factor receptor 2/0.453
2vww7X2Ephrin type-B receptor 42.7.10.10.453
2xp2VGHALK tyrosine kinase receptor2.7.10.10.453
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.453
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3miaANPCyclin-dependent kinase 92.7.11.220.453
3w2rW2REpidermal growth factor receptor2.7.10.10.453
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.453
4f650S9Fibroblast growth factor receptor 1/0.453
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.453
4fnzNZFALK tyrosine kinase receptor2.7.10.10.453
1v0pPVBCell division control protein 2 homolog2.7.11.220.452
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.452
2j0k4STFocal adhesion kinase 12.7.10.20.452
2q4wFADCytokinin dehydrogenase 71.5.99.120.452
2vwu7X1Ephrin type-B receptor 42.7.10.10.452
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.452
2y6o1N1Ephrin type-A receptor 42.7.10.10.452
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.452
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.452
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.452
3ddpRC8Cyclin-dependent kinase 22.7.11.220.452
3fwjCAMCamphor 5-monooxygenase1.14.15.10.452
3h9f92MDual specificity protein kinase TTK2.7.12.10.452
3rm719ZCyclin-dependent kinase 22.7.11.220.452
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4b99R4LMitogen-activated protein kinase 72.7.11.240.452
4hgt15GCasein kinase I isoform delta2.7.11.10.452
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.452
1wvxBD4Death-associated protein kinase 12.7.11.10.451
1xkkFMMEpidermal growth factor receptor2.7.10.10.451
1yinCM3Estrogen receptor/0.451
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.451
2fzhDH1Dihydrofolate reductase1.5.1.30.451
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.451
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3swrSFGDNA (cytosine-5)-methyltransferase 12.1.1.370.451
3zk5Z18Cytochrome P450 monooxygenase PikC/0.451
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.451
4ccbOFGALK tyrosine kinase receptor2.7.10.10.451
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.451
4gk4L90Ephrin type-A receptor 32.7.10.10.451
5auzGENDeath-associated protein kinase 12.7.11.10.451
1ir3ANPInsulin receptor2.7.10.10.450
1oiyN41Cyclin-dependent kinase 22.7.11.220.450
1uy7PU4Heat shock protein HSP 90-alpha/0.450
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.450
2o2u738Mitogen-activated protein kinase 102.7.11.240.450
2vn0TDZCytochrome P450 2C8/0.450
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.450
3l8p0CEAngiopoietin-1 receptor2.7.10.10.450
3lctADPALK tyrosine kinase receptor2.7.10.10.450
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.450
3zokNAD3-dehydroquinate synthase, chloroplastic4.2.3.40.450
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.450
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.450
4eh3NARMitogen-activated protein kinase 14/0.450
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4s34ANPMitogen-activated protein kinase 12.7.11.240.450
1dkfBMSRetinoic acid receptor alpha/0.449
1g67TZPThiamine-phosphate synthase/0.449
1oecAA2Fibroblast growth factor receptor 2/0.449
2c6hPXICytochrome P450 monooxygenase PikC/0.449
2chlDKICasein kinase I isoform gamma-32.7.11.10.449
2i40BLZCyclin-dependent kinase 22.7.11.220.449
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
2izrBRKCasein kinase I isoform gamma-32.7.11.10.449
2j0lANPFocal adhesion kinase 12.7.10.20.449
2of4979Tyrosine-protein kinase Lck2.7.10.20.449
2vwy7X5Ephrin type-B receptor 42.7.10.10.449
2x9fX9FEphrin type-B receptor 42.7.10.10.449
2xclANPPhosphoribosylamine--glycine ligase/0.449
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.449
3q9yTXQCasein kinase II subunit alpha2.7.11.10.449
3ttiKBIMitogen-activated protein kinase 102.7.11.240.449
4bcoT6QCyclin-dependent kinase 22.7.11.220.449
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.449
5aacVGHALK tyrosine kinase receptor2.7.10.10.449
5av4GENDeath-associated protein kinase 12.7.11.10.449
5jqbIBPEnvelope glycoprotein/0.449
1phgMYTCamphor 5-monooxygenase1.14.15.10.448
1u4dDBQActivated CDC42 kinase 1/0.448
1zeoC01Peroxisome proliferator-activated receptor gamma/0.448
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.448
2pzpACPFibroblast growth factor receptor 2/0.448
3eek53SUncharacterized protein/0.448
3fi3JK2Mitogen-activated protein kinase 102.7.11.240.448
3gu83GUDeath-associated protein kinase 12.7.11.10.448
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.448
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.448
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.448
4qnaX11Serine/threonine-protein kinase 242.7.11.10.448
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.447
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1v0oINRCell division control protein 2 homolog2.7.11.220.447
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.447
2c4g514Cyclin-dependent kinase 22.7.11.220.447
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.447
2x7gPVBSRSF protein kinase 22.7.11.10.447
3a7jADPSerine/threonine-protein kinase 242.7.11.10.447
3bu5ATPInsulin receptor2.7.10.10.447
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4ib4ERM5-hydroxytryptamine receptor 2B/0.447
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.447
5dc5B3NHistone deacetylase 83.5.1.980.447
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
2g44T3OEstrogen receptor/0.446
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.446
2vx17X8Ephrin type-B receptor 42.7.10.10.446
2wxvWXVCyclin-dependent kinase 22.7.11.220.446
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.446
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.446
3au8NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.446
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.446
3oriAGSSerine/threonine protein kinase/0.446
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.446
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
4b7dQLECytochrome P450 monooxygenase PikC/0.446
4j97ACPFibroblast growth factor receptor 2/0.446
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.446
4nfn2KCTau-tubulin kinase 12.7.11.10.446
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.446
4tuvCPZCytochrome P450 1191.140.446
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.446
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.446
1jpaANPEphrin type-B receptor 22.7.10.10.445
1uomPTIEstrogen receptor/0.445
2p33J07Mitogen-activated protein kinase 102.7.11.240.445
2vzmNRBCytochrome P450 monooxygenase PikC/0.445
2w3vTOPDihydrofolate reductase/0.445
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.445
3a60STURibosomal protein S6 kinase beta-12.7.11.10.445
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.445
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.445
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.445
4g2fC07Ephrin type-A receptor 32.7.10.10.445
4gmy0X5Tyrosine-protein kinase JAK2/0.445
4nt03DUOrotidine 5'-phosphate decarboxylase4.1.1.230.445
4o701QKBromodomain-containing protein 4/0.445
1bygSTUTyrosine-protein kinase CSK/0.444
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.444
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.444
2vcmM11Isopenicillin N synthase1.21.3.10.444
2w4iVGAGlutamate racemase/0.444
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.444
2xru400Aurora kinase A2.7.11.10.444
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.444
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.444
3cv9VDXVitamin D3 dihydroxylase/0.444
3flq891Mitogen-activated protein kinase 14/0.444
3nbwTR4Ketohexokinase/0.444
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.444
4b7sQLECytochrome P450 monooxygenase PikC/0.444
4b8zNAPGDP-L-fucose synthase1.1.1.2710.444
4g1wG1WMitogen-activated protein kinase 82.7.11.240.444
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.444
4icyFADPgaE/0.444
4l4bCAMCamphor 5-monooxygenase1.14.15.10.444
1eh4IC1Casein kinase I homolog 12.7.11.10.443
1j39UPGDNA beta-glucosyltransferase/0.443
1sn5T3Transthyretin/0.443
1v9aSAHUncharacterized protein/0.443
2itvANPEpidermal growth factor receptor2.7.10.10.443
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.443
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.443
2woeAR6ADP-ribosyl-[dinitrogen reductase] glycohydrolase3.2.2.240.443
2zazGK1Mitogen-activated protein kinase 14/0.443
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.443
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.443
3le62BZCyclin-dependent kinase 22.7.11.220.443
3nga3NGCasein kinase II subunit alpha2.7.11.10.443
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
3vewADPnebramycin 5' synthase6.1.2.20.443
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.443
4dlj6RGMitogen-activated protein kinase 14/0.443
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.443
4ez50RSCyclin-dependent kinase 62.7.11.220.443
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.443
4foc0UUALK tyrosine kinase receptor2.7.10.10.443
4fyn0VETyrosine-protein kinase SYK2.7.10.20.443
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.443
4ogrADNCyclin-dependent kinase 92.7.11.220.443
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.443
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.443
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.442
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.442
2ftoCB3Thymidylate synthase/0.442
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.442
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.442
2x1nX1NCyclin-dependent kinase 22.7.11.220.442
3cseN22Uncharacterized protein/0.442
3vjnANPEpidermal growth factor receptor2.7.10.10.442
4btkDTQTau-tubulin kinase 12.7.11.10.442
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.442
4erkOLOMitogen-activated protein kinase 12.7.11.240.442
4jx1CAHCamphor 5-monooxygenase1.14.15.10.442
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
4l4cCAMCamphor 5-monooxygenase1.14.15.10.442
5cvhADPCasein kinase II subunit alpha2.7.11.10.442
1sj0E4DEstrogen receptor/0.441
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.441
2bkzSBCCyclin-dependent kinase 22.7.11.220.441
2cahNDPCatalase1.11.1.60.441
2fumMIXSerine/threonine-protein kinase PknB2.7.11.10.441
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
2pz5ACPFibroblast growth factor receptor 2/0.441
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.441
2w4kADPDeath-associated protein kinase 12.7.11.10.441
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.441
2x4zX4ZSerine/threonine-protein kinase PAK 42.7.11.10.441
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.441
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.441
3bqr4RBDeath-associated protein kinase 3/0.441
3ezvEZVCyclin-dependent kinase 22.7.11.220.441
3hx4ANPCalmodulin-domain protein kinase 1/0.441
3iw4LW4Protein kinase C alpha type2.7.11.130.441
3oibFDAPutative acyl-CoA dehydrogenase/0.441
3pe2E1BCasein kinase II subunit alpha2.7.11.10.441
3w0rANPHygromycin-B 4-O-kinase2.7.1.1630.441
4h50NAPBiphenyl dioxygenase ferredoxin reductase subunit/0.441
4i8vBHFCytochrome P450 1A11.14.14.10.441
4in44IDKelch-like ECH-associated protein 1/0.441
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.441
4qms1N1Serine/threonine-protein kinase 242.7.11.10.441
4xlvACPInsulin receptor2.7.10.10.441
1nq7ARLNuclear receptor ROR-beta/0.440
1p4fDRGDeath-associated protein kinase 12.7.11.10.440
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.440
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.440
2w03ADNAcsD/0.440
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.440
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.440
3bhy7CPDeath-associated protein kinase 3/0.440
3emg685Tyrosine-protein kinase SYK2.7.10.20.440
3hz5Z64Heat shock protein HSP 90-alpha/0.440
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3poz03PEpidermal growth factor receptor2.7.10.10.440
3q92XNBKetohexokinase/0.440
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.440
3vquO22Dual specificity protein kinase TTK2.7.12.10.440
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4appN53Serine/threonine-protein kinase PAK 42.7.11.10.440
4bgq38RCyclin-dependent kinase-like 52.7.11.220.440
4dgnLU2Casein kinase II subunit alpha2.7.11.10.440
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.440
4g160VMCasein kinase I isoform gamma-32.7.11.10.440
4gg70J8Hepatocyte growth factor receptor2.7.10.10.440
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4mxaBK7Calmodulin-like domain protein kinase isoenzyme gamma, related/0.440
5auvAGIDeath-associated protein kinase 12.7.11.10.440
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.440
5dt3ATPAurora kinase A2.7.11.10.440