sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ype | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4ype | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 1.000 | |
| 3ooi | SAM | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific | 2.1.1.43 | 0.529 | |
| 2igq | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.523 | |
| 4ypa | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.519 | |
| 3swc | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.504 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.490 | |
| 4ynm | SAM | Histone-lysine N-methyltransferase ASH1L | 2.1.1.43 | 0.488 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.488 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.487 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.485 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.485 | |
| 2rfi | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.484 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.484 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.483 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.482 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.481 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.481 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.481 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.480 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.479 | |
| 2r3a | SAM | Histone-lysine N-methyltransferase SUV39H2 | 2.1.1.43 | 0.478 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.477 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.477 | |
| 1svg | I04 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.476 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.476 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.476 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.475 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.474 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.473 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.473 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.472 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.472 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.471 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.471 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.471 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.471 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.471 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.470 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.470 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.470 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.469 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.469 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.469 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.469 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.468 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.468 | |
| 1rz0 | FAD | Phenol 2-hydroxylase component B | / | 0.468 | |
| 2dsi | SAH | Diphthine synthase | / | 0.468 | |
| 2oah | QIN | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.468 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.467 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.467 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.467 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.467 | |
| 4rcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.467 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.467 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.466 | |
| 2dsh | SAH | Diphthine synthase | / | 0.466 | |
| 2pb5 | SAH | Diphthine synthase | / | 0.466 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.466 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4h12 | SAH | Histone-lysine N-methyltransferase SETD2 | 2.1.1.43 | 0.466 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.466 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.465 | |
| 1sve | I01 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.465 | |
| 2e7r | SAH | Diphthine synthase | / | 0.465 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.465 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.465 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.465 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.465 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.465 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.465 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.464 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.464 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.464 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.464 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.464 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.464 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.464 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.463 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.463 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.462 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.462 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.461 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.461 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.461 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.461 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.461 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.461 | |
| 3u9e | COA | Lmo1369 protein | / | 0.460 | |
| 3w2j | QRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.460 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.460 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.460 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.460 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.460 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.460 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.460 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.459 | |
| 1bp6 | UMP | Thymidylate synthase | / | 0.459 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.459 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.459 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.459 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.459 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.459 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.459 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.459 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.458 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.458 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.458 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.458 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.458 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 2ck3 | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.457 | |
| 2ck3 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.457 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.457 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.457 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.457 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.456 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.456 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.456 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.455 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.455 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.455 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.455 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.455 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.455 | |
| 4frs | 0V6 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 1dj2 | GDP | Adenylosuccinate synthetase, chloroplastic | / | 0.454 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.454 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.454 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.454 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.454 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.454 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.454 | |
| 4mo2 | FAD | UDP-galactopyranose mutase | / | 0.454 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.454 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.453 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.453 | |
| 2ejj | SAH | Diphthine synthase | / | 0.453 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.453 | |
| 2owg | SAH | Diphthine synthase | / | 0.453 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.453 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.453 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.453 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.453 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.453 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.453 | |
| 1dc6 | NAD | Glyceraldehyde-3-phosphate dehydrogenase A | / | 0.452 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.452 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.452 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.452 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.452 | |
| 4ctk | SAM | Genome polyprotein | / | 0.452 | |
| 4ef4 | C2E | Stimulator of interferon genes protein | / | 0.452 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.452 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.452 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.451 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3ixk | 929 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.451 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.451 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.451 | |
| 1i0s | FMN | Ferric-chelate reductase (NAD(P)H) | / | 0.450 | |
| 1nj5 | P5A | Proline--tRNA ligase | / | 0.450 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.450 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.450 | |
| 2bju | IH4 | Plasmepsin-2 | 3.4.23.39 | 0.450 | |
| 2eeq | SAH | Diphthine synthase | / | 0.450 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.450 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.450 | |
| 2nr4 | FMN | Conserved protein | / | 0.450 | |
| 2wf2 | ZY2 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.450 | |
| 3lzx | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.450 | |
| 3mt8 | 17T | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.450 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 3q70 | RIT | Candidapepsin-2 | 3.4.23.24 | 0.450 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.450 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.450 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.450 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.449 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.449 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.449 | |
| 2e8s | SAH | Diphthine synthase | / | 0.449 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.449 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.449 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.449 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.449 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.449 | |
| 3kxw | 1ZZ | Saframycin Mx1 synthetase B | / | 0.449 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.449 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.449 | |
| 4jic | FMN | GTN Reductase | / | 0.449 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.449 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.449 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.449 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 5hq8 | SAH | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.449 | |
| 1cl0 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.448 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.448 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.448 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.448 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.448 | |
| 2g94 | ZPQ | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3tjl | FMN | NADPH dehydrogenase | / | 0.448 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.448 | |
| 4wzh | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.448 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.448 | |
| 5ilw | URI | Ribosome inactivating protein | / | 0.448 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1qy5 | NEC | Endoplasmin | / | 0.447 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 2e07 | SAH | Diphthine synthase | / | 0.447 | |
| 2ejz | SAH | Diphthine synthase | / | 0.447 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.447 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.447 | |
| 3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.447 | |
| 3s7d | LEU_SER_LYS_LYS_MLZ | N-lysine methyltransferase SMYD2 | / | 0.447 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.447 | |
| 4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 1daa | PLP | D-alanine aminotransferase | 2.6.1.21 | 0.446 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1wng | SAH | Diphthine synthase | / | 0.446 | |
| 1ydr | IQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 2e8r | SAH | Diphthine synthase | / | 0.446 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.446 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.446 | |
| 2j5b | TYE | Tyrosine--tRNA ligase | 6.1.1.1 | 0.446 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.446 | |
| 2wf3 | ZY3 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.446 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.446 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.446 | |
| 3pdn | SFG | Histone-lysine N-methyltransferase SMYD3 | 2.1.1.43 | 0.446 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.446 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.446 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.446 | |
| 4opu | FDA | Conserved Archaeal protein | / | 0.446 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.446 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.445 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.445 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.445 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2gn6 | UD1 | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.445 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 2owu | SAH | Diphthine synthase | / | 0.445 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.445 | |
| 2vkv | TDC | Tetracycline repressor protein class D | / | 0.445 | |
| 3exo | 5MS | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.445 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 4bls | APC | NTPase P4 | / | 0.445 | |
| 4e2d | FMN | Dehydrogenase | / | 0.445 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.444 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.444 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.444 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.444 | |
| 3r2f | PB0 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.444 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4blr | UTP | NTPase P4 | / | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.444 | |
| 4j1k | 1HG | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.443 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.443 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.443 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.443 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.443 | |
| 1umk | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 1vc2 | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.443 | |
| 2is0 | I03 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2p6k | SAH | Diphthine synthase | / | 0.443 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.443 | |
| 2z3n | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.443 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.443 | |
| 3ag6 | PAJ | Pantothenate synthetase | / | 0.443 | |
| 3l5l | FMN | Xenobiotic reductase | / | 0.443 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.443 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.443 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4de5 | 0JD | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.443 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.443 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.442 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.442 | |
| 1r6t | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.442 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1xjw | PAL | Aspartate carbamoyltransferase catalytic subunit | 2.1.3.2 | 0.442 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.442 | |
| 2cbr | A80 | Cellular retinoic acid-binding protein 1 | / | 0.442 | |
| 2dsg | SAH | Diphthine synthase | / | 0.442 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.442 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.442 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.442 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.442 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.442 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.442 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.442 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.442 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.441 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.441 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.441 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 3pnd | FAD | FAD:protein FMN transferase | / | 0.441 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 4fnc | HMU | G/T mismatch-specific thymine DNA glycosylase | 3.2.2.29 | 0.441 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.441 | |
| 4nv1 | TYD | Formyl transferase | / | 0.441 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.441 | |
| 4wxx | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.441 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.441 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.441 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.441 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.441 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.440 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.440 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.440 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.440 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.440 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 2dxv | SAH | Diphthine synthase | / | 0.440 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.440 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.440 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.440 | |
| 2p6d | SAH | Diphthine synthase | / | 0.440 | |
| 2pck | SAH | Diphthine synthase | / | 0.440 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 2r8p | T6F | Transketolase 1 | / | 0.440 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.440 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3kkz | SAM | Uncharacterized protein | / | 0.440 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.440 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.440 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.440 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4js1 | CTN | Beta-galactoside alpha-2,6-sialyltransferase 1 | 2.4.99.1 | 0.440 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.440 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.440 |