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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eqcXR1Serine/threonine-protein kinase PAK 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4eqcXR1Serine/threonine-protein kinase PAK 12.7.11.11.000
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.538
4i22IREEpidermal growth factor receptor2.7.10.10.531
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.527
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.519
4y95746Tyrosine-protein kinase/0.514
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.512
2c6eHPMAurora kinase A2.7.11.10.511
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.509
2vrx447Aurora kinase B-A2.7.11.10.509
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.509
4aotGW8Serine/threonine-protein kinase 102.7.11.10.508
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.504
2vgpAD6Aurora kinase B-A2.7.11.10.504
3ttjJBIMitogen-activated protein kinase 102.7.11.240.504
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.503
3w2o03PEpidermal growth factor receptor2.7.10.10.502
2qocANPEphrin type-A receptor 32.7.10.10.501
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.500
4nka2K7Fibroblast growth factor receptor 1/0.499
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.498
3erkSB4Mitogen-activated protein kinase 12.7.11.240.498
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.496
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.494
4hjfC2EGGDEF family protein/0.494
2zmd537Dual specificity protein kinase TTK2.7.12.10.491
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.491
3w2sW2REpidermal growth factor receptor2.7.10.10.491
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.490
3w33W19Epidermal growth factor receptor2.7.10.10.490
4c4iX20Dual specificity protein kinase TTK2.7.12.10.490
3l8p0CEAngiopoietin-1 receptor2.7.10.10.487
4c4h7RODual specificity protein kinase TTK2.7.12.10.487
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.486
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.486
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.485
2yfxVGHALK tyrosine kinase receptor2.7.10.10.485
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.485
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.485
5ap57RODual specificity protein kinase TTK2.7.12.10.485
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.484
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.484
2ba9FADPutative aminooxidase/0.483
4s33ANPMitogen-activated protein kinase 12.7.11.240.483
4s34ANPMitogen-activated protein kinase 12.7.11.240.483
2o0uC0MMitogen-activated protein kinase 102.7.11.240.482
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.482
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.482
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.482
3vs1VSATyrosine-protein kinase HCK2.7.10.20.482
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.482
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.481
4jbqVX6Aurora kinase A2.7.11.10.481
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.480
2zybKSLTyrosine-protein kinase Lck2.7.10.20.480
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.480
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.479
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.479
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
3vqvANPPyrrolysine--tRNA ligase/0.479
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.479
2xvdAS6Ephrin type-B receptor 42.7.10.10.478
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.478
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.478
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.478
2bfyH1NAurora kinase B-A2.7.11.10.477
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.477
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.477
4c4g7RODual specificity protein kinase TTK2.7.12.10.477
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.477
2i0ePDSProtein kinase C beta type2.7.11.130.476
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.476
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.476
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.476
2pzpACPFibroblast growth factor receptor 2/0.475
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.475
4hjoAQ4Epidermal growth factor receptor2.7.10.10.475
4qms1N1Serine/threonine-protein kinase 242.7.11.10.475
2py3ACPFibroblast growth factor receptor 2/0.474
3n8wFLPProstaglandin G/H synthase 11.14.99.10.474
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.474
4crsAGSSerine/threonine-protein kinase N22.7.11.130.474
4id71G0Activated CDC42 kinase 1/0.474
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.473
3orn3ORDual specificity mitogen-activated protein kinase kinase 12.7.12.20.473
3vjoANPEpidermal growth factor receptor2.7.10.10.473
4b1fKRHGlutamate racemase/0.473
1mabATPATP synthase subunit alpha, mitochondrial/0.472
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.472
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.472
3e9hKAALysine--tRNA ligase6.1.1.60.472
3hx4ANPCalmodulin-domain protein kinase 1/0.472
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
4pd6URINucleoside permease/0.472
2gs7ANPEpidermal growth factor receptor2.7.10.10.471
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.471
3ttiKBIMitogen-activated protein kinase 102.7.11.240.471
4bvaT3Ketimine reductase mu-crystallin1.5.1.250.471
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.471
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.471
4iebANPCalmodulin-domain protein kinase 1/0.471
4qo9627Serine/threonine-protein kinase 242.7.11.10.471
4anqVGHALK tyrosine kinase receptor2.7.10.10.470
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.470
2b9wFADPutative aminooxidase/0.469
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.469
3hp552PMitogen-activated protein kinase 14/0.469
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.469
3mpaSB2Mitogen-activated protein kinase 14/0.469
3n8zFLPProstaglandin G/H synthase 11.14.99.10.469
5jqbIBPEnvelope glycoprotein/0.469
2itzIREEpidermal growth factor receptor2.7.10.10.468
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.468
2wqeADPAurora kinase A2.7.11.10.468
3gu7ADPDeath-associated protein kinase 12.7.11.10.468
3ha85JZMitogen-activated protein kinase 14/0.468
3hub469Mitogen-activated protein kinase 14/0.468
3mvm39PMitogen-activated protein kinase 14/0.468
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.468
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
1ht834CProstaglandin G/H synthase 11.14.99.10.467
3kk6CELProstaglandin G/H synthase 11.14.99.10.467
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.467
4y93746Tyrosine-protein kinase/0.467
1a5uATPPyruvate kinase PKM2.7.1.400.466
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.466
2v51LABActin, alpha skeletal muscle/0.466
2y6o1N1Ephrin type-A receptor 42.7.10.10.466
3pcfFHBProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.466
3uwqU5POrotidine 5'-phosphate decarboxylase/0.466
4coxIMNProstaglandin G/H synthase 21.14.99.10.466
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.465
3qlsNDPDihydrofolate reductase1.5.1.30.465
4oavACP2-5A-dependent ribonuclease3.1.260.465
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.465
5k2aZMAAdenosine receptor A2a/0.465
1jkkANPDeath-associated protein kinase 12.7.11.10.464
1ml6GBXGlutathione S-transferase A22.5.1.180.464
1psdNADD-3-phosphoglycerate dehydrogenase1.1.1.950.464
1xkkFMMEpidermal growth factor receptor2.7.10.10.464
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.464
3r9dX6BCyclin-dependent kinase 22.7.11.220.464
4fob0USALK tyrosine kinase receptor2.7.10.10.464
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.464
5j3wFMNSensory box protein/0.464
1osvCHCBile acid receptor/0.463
2j7t274Serine/threonine-protein kinase 102.7.11.10.463
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.463
4an35Y0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.463
4b8mVX6Aurora kinase B-A2.7.11.10.463
4bwxAGSPAB-dependent poly(A)-specific ribonuclease subunit pan3/0.463
4c4f7CEDual specificity protein kinase TTK2.7.12.10.463
4ek816KCyclin-dependent kinase 22.7.11.220.463
4hee14RPeroxisome proliferator-activated receptor gamma/0.463
4hys1BJMitogen-activated protein kinase 82.7.11.240.463
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.463
4z35ON9Lysophosphatidic acid receptor 1/0.463
1yinCM3Estrogen receptor/0.462
2fgiPD1Fibroblast growth factor receptor 1/0.462
3ac2KSETyrosine-protein kinase Lck2.7.10.20.462
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4pl3ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.462
5aaaVGHALK tyrosine kinase receptor2.7.10.10.462
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.461
2cciATPCyclin-dependent kinase 22.7.11.220.461
2itnANPEpidermal growth factor receptor2.7.10.10.461
2ituITQEpidermal growth factor receptor2.7.10.10.461
3zsh469Mitogen-activated protein kinase 14/0.461
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.461
5j4eFMNSensory box protein/0.461
1m17AQ4Epidermal growth factor receptor2.7.10.10.460
2nomDUTPoly(A) polymerase, putative/0.460
3aoxEMHALK tyrosine kinase receptor2.7.10.10.460
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.460
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.460
4eooATPCyclin-dependent kinase 22.7.11.220.460
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.460
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.460
5aut2ANDeath-associated protein kinase 12.7.11.10.460
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.459
1qo8FADFumarate reductase flavoprotein subunit/0.459
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.459
2ittAEEEpidermal growth factor receptor2.7.10.10.459
2of4979Tyrosine-protein kinase Lck2.7.10.20.459
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.459
2xyuQ9GEphrin type-A receptor 42.7.10.10.459
3c5uP41Mitogen-activated protein kinase 14/0.459
3pjuC2EDiguanylate cyclase/phosphodiesterase/0.459
3s4qNK0Mitogen-activated protein kinase 14/0.459
4ansVGHALK tyrosine kinase receptor2.7.10.10.459
4g2fC07Ephrin type-A receptor 32.7.10.10.459
4hgt15GCasein kinase I isoform delta2.7.11.10.459
4hvh19RTyrosine-protein kinase JAK32.7.10.20.459
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.459
1eqgIBPProstaglandin G/H synthase 11.14.99.10.458
1ot7CHCBile acid receptor/0.458
1uomPTIEstrogen receptor/0.458
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
2cbsR13Cellular retinoic acid-binding protein 2/0.458
2cjmATPCyclin-dependent kinase 22.7.11.220.458
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.458
2hk51BMTyrosine-protein kinase HCK2.7.10.20.458
2qo9ANPEphrin type-A receptor 32.7.10.10.458
3hv6R39Mitogen-activated protein kinase 14/0.458
3lfcZ86Mitogen-activated protein kinase 14/0.458
3nc9TR3Ketohexokinase/0.458
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
3vryB43Tyrosine-protein kinase HCK2.7.10.20.458
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
5ej7TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.458
2og81N8Tyrosine-protein kinase Lck2.7.10.20.457
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.457
3dk4NDPGlutathione reductase, mitochondrial1.8.1.70.457
3dt1P40Mitogen-activated protein kinase 14/0.457
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
3zcw4A2Kinesin-like protein KIF11/0.457
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.457
4f630S7Fibroblast growth factor receptor 1/0.457
4gyiADPUncharacterized protein/0.457
4joa3DKALK tyrosine kinase receptor2.7.10.10.457
1lriCLRBeta-elicitin cryptogein/0.456
1ywrLI9Mitogen-activated protein kinase 14/0.456
2b9xFADPutative aminooxidase/0.456
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.456
3mec65BGag-Pol polyprotein2.7.7.490.456
4at8ATPInterleukin enhancer-binding factor 2/0.456
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.456
4gk2L66Ephrin type-A receptor 32.7.10.10.456
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.456
1hk2T44Serum albumin/0.455
1pjkANPCasein kinase II subunit alpha2.7.11.10.455
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.455
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
1ztfXYARIO-type serine/threonine-protein kinase Rio12.7.11.10.455
2pzrACPFibroblast growth factor receptor 2/0.455
2q61SF1Peroxisome proliferator-activated receptor gamma/0.455
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.455
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.455
3clyACPFibroblast growth factor receptor 2/0.455
3w18N13Aurora kinase A2.7.11.10.455
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.455
4jboWPHAurora kinase A2.7.11.10.455
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.455
5dg3U21Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.455
5ej6TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.455
1eqhFLPProstaglandin G/H synthase 11.14.99.10.454
1rdt570Peroxisome proliferator-activated receptor gamma/0.454
1u4dDBQActivated CDC42 kinase 1/0.454
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
2eb3ANPEpidermal growth factor receptor2.7.10.10.454
2qoqANPEphrin type-A receptor 32.7.10.10.454
2vgoAD5Aurora kinase B-A2.7.11.10.454
2xclANPPhosphoribosylamine--glycine ligase/0.454
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.454
4eoi1ROCyclin-dependent kinase 22.7.11.220.454
4fuxE75Mitogen-activated protein kinase 12.7.11.240.454
4ivgANPTNF receptor-associated protein 1/0.454
4l98LRGPeroxisome proliferator-activated receptor gamma/0.454
4nu6NADPhosphonate dehydrogenase1.20.1.10.454
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.454
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1v9aSAHUncharacterized protein/0.453
2hziJINTyrosine-protein kinase ABL12.7.10.20.453
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.453
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.453
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.453
2yboSAHMethyltransferase/0.453
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.453
2yx1SFGtRNA (guanine(37)-N1)-methyltransferase Trm5b2.1.1.2280.453
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.453
3tm5SFGUncharacterized protein/0.453
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.453
3zewSTUEphrin type-B receptor 42.7.10.10.453
4be7ATPType I restriction enzyme EcoR124II R protein3.1.21.30.453
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.453
4kba1QMCasein kinase I isoform delta2.7.11.10.453
4kko1REGag-Pol polyprotein2.7.7.490.453
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.453
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1efpFADElectron transfer flavoprotein subunit alpha/0.452
1lj8NADMannitol dehydrogenase/0.452
1zyjBI5Mitogen-activated protein kinase 14/0.452
2j0m4STFocal adhesion kinase 12.7.10.20.452
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.452
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.452
2w2lNADD-mandelate dehydrogenase/0.452
3a4lANPL-seryl-tRNA(Sec) kinase2.7.1.1640.452
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
3k5uPFQAurora kinase A2.7.11.10.452
3p3zP3ZPutative cytochrome P450/0.452
3pffADPATP-citrate synthase2.3.3.80.452
3w2rW2REpidermal growth factor receptor2.7.10.10.452
4f640S8Fibroblast growth factor receptor 1/0.452
4gk3L87Ephrin type-A receptor 32.7.10.10.452
4i231C9Epidermal growth factor receptor2.7.10.10.452
4kaoKAOFocal adhesion kinase 12.7.10.20.452
4m11MXMProstaglandin G/H synthase 21.14.99.10.452
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.452
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.452
1goxFMNPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.451
1qvnFRIInterleukin-2/0.451
1tl3H20Gag-Pol polyprotein2.7.7.490.451
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.451
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.451
3ka7FADPutative oxidoreductase/0.451
3zoiM2WIsopenicillin N synthase1.21.3.10.451
4b1vATPActin, alpha skeletal muscle/0.451
4ffrATPUncharacterized protein/0.451
1esvLARActin, alpha skeletal muscle/0.450
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.450
2bx8AZQSerum albumin/0.450
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.450
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
3gbk2PQPeroxisome proliferator-activated receptor gamma/0.450
3njoP2MAbscisic acid receptor PYR1/0.450
3slkNDPPolyketide synthase extender module 2/0.450
4erwSTUCyclin-dependent kinase 22.7.11.220.450
4gt3ATPMitogen-activated protein kinase 12.7.11.240.450
4o0uADNAurora kinase A2.7.11.10.450
4u7tSAHDNA (cytosine-5)-methyltransferase 3A2.1.1.370.450
4xumIMNPeroxisome proliferator-activated receptor gamma/0.450
5c1pADPD-alanine--D-alanine ligase/0.450
1bygSTUTyrosine-protein kinase CSK/0.449
1fk9EFZGag-Pol polyprotein2.7.7.490.449
2itpAEEEpidermal growth factor receptor2.7.10.10.449
2ydfIO3Serum albumin/0.449
2zb1GK4Mitogen-activated protein kinase 14/0.449
3ds6A17Mitogen-activated protein kinase 14/0.449
3gcuR48Mitogen-activated protein kinase 14/0.449
3lu8IQXSerum albumin/0.449
3pghFLPProstaglandin G/H synthase 21.14.99.10.449
3vspEK8Peroxisome proliferator-activated receptor gamma/0.449
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.449
1bcpATPPertussis toxin subunit 4/0.448
1bcpATPPertussis toxin subunit 5/0.448
1ewyFADFerredoxin--NADP reductase1.18.1.20.448
1qmzATPCyclin-dependent kinase 22.7.11.220.448
2aibERGBeta-elicitin cinnamomin/0.448
2p33J07Mitogen-activated protein kinase 102.7.11.240.448
2w4jADPDeath-associated protein kinase 12.7.11.10.448
2zzaFOLDihydrofolate reductase/0.448
3ac1KZITyrosine-protein kinase Lck2.7.10.20.448
3cntFADPolyamine oxidase FMS1/0.448
3igoANPCalmodulin-domain protein kinase 1, putative/0.448
3tqhNDPQuinone oxidoreductase/0.448
4c58824Cyclin-G-associated kinase2.7.11.10.448
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.448
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4otiMI1Serine/threonine-protein kinase N1/0.448
4z34ON7Lysophosphatidic acid receptor 1/0.448
1i44ACPInsulin receptor2.7.10.10.447
1rc0KT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.447
1rrmAPRLactaldehyde reductase1.1.1.770.447
2b9yFADPutative aminooxidase/0.447
2g5cNADPrephenate dehydrogenase/0.447
2vwx7X4Ephrin type-B receptor 42.7.10.10.447
3cyz9ODPheromone-binding protein ASP1/0.447
3fskRO6Mitogen-activated protein kinase 14/0.447
3hv4L51Mitogen-activated protein kinase 14/0.447
3ix9MTXDihydrofolate reductase1.5.1.30.447
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.447
3nux3NVCyclin-dependent kinase 62.7.11.220.447
3pjtC2EDiguanylate cyclase/phosphodiesterase/0.447
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.447
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.447
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.447
4lxhC1EAlpha/beta hydrolase fold/0.447
4nks2M2Fibroblast growth factor receptor 1/0.447
5awmANPStress-activated protein kinase JNK2.7.11.240.447
5djuFMNNPH1-2/0.447
1e94ANPATP-dependent protease ATPase subunit HslU/0.446
1hrvSDZGenome polyprotein/0.446
1njfAGSDNA polymerase III subunit tau2.7.7.70.446
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.446
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.446
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3lltANPProtein serine/threonine kinase-1/0.446
3lovFADProtoporphyrinogen oxidase/0.446
3megT27Gag-Pol polyprotein2.7.7.490.446
4e5nNADPhosphonate dehydrogenase1.20.1.10.446
4fk8FADFerredoxin--NADP reductase/0.446
4fxfATPPyruvate kinase PKM2.7.1.400.446
4gncASORegucalcin3.1.1.170.446
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4ic7ANPMitogen-activated protein kinase 72.7.11.240.446
4k8aK8AFocal adhesion kinase 12.7.10.20.446
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
1ai9NDPDihydrofolate reductase1.5.1.30.445
1hk4T44Serum albumin/0.445
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.445
1rbqKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.445
1sn5T3Transthyretin/0.445
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.445
2y60M8FIsopenicillin N synthase1.21.3.10.445
3anmNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.445
3cgfJNFMitogen-activated protein kinase 102.7.11.240.445
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.445
3qa2XNAKetohexokinase/0.445
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.445
4mv8ACPBiotin carboxylase6.3.4.140.445
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.445
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
5dnrATPAurora kinase A2.7.11.10.445
5eg3ACPFibroblast growth factor receptor 2/0.445
1b15NAEAlcohol dehydrogenase1.1.1.10.444
1bk0ACVIsopenicillin N synthase1.21.3.10.444
1fbmRTLCartilage oligomeric matrix protein/0.444
1uzwCDHIsopenicillin N synthase1.21.3.10.444
2ewpTXFEstrogen-related receptor gamma/0.444
2nnlNAPDihydroflavonol 4-reductase1.1.1.2190.444
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.444
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.444
3hng8STVascular endothelial growth factor receptor 12.7.10.10.444
3meeT27Gag-Pol polyprotein2.7.7.490.444
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.444
3op5REBSerine/threonine-protein kinase VRK12.7.11.10.444
3uvqFS8Mitogen-activated protein kinase 14/0.444
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.444
4o8fBRLPeroxisome proliferator-activated receptor gamma/0.444
1hb1OCVIsopenicillin N synthase1.21.3.10.443
1qjfACSIsopenicillin N synthase1.21.3.10.443
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.443
2bxe1FLSerum albumin/0.443
2cduFADNADH oxidase/0.443
2gejGDDPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.443
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.443
2itxANPEpidermal growth factor receptor2.7.10.10.443
2pz5ACPFibroblast growth factor receptor 2/0.443
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.443
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.443
3av7KYAUncharacterized protein/0.443
3buzLARActin, alpha skeletal muscle/0.443
3dfcANPDeath-associated protein kinase 12.7.11.10.443
3kvxFMYMitogen-activated protein kinase 102.7.11.240.443
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.443
3ujlA8SAbscisic acid receptor PYL2/0.443
3vqxBLKPyrrolysine--tRNA ligase/0.443
4eym0RXMitogen-activated protein kinase 132.7.11.240.443
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.443
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4qmlANPSerine/threonine-protein kinase 242.7.11.10.443
1dawANPCasein kinase II subunit alpha2.7.11.10.442
1dkfBMSRetinoic acid receptor alpha/0.442
1gd1NADGlyceraldehyde-3-phosphate dehydrogenase/0.442
1uyuCAMCamphor 5-monooxygenase1.14.15.10.442
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.442
2e2b406Tyrosine-protein kinase ABL12.7.10.20.442
2o2u738Mitogen-activated protein kinase 102.7.11.240.442
2qimZEAClass 10 plant pathogenesis-related protein/0.442
2vbdV10Isopenicillin N synthase1.21.3.10.442
3cgoJNOMitogen-activated protein kinase 102.7.11.240.442
3dauMTXDihydrofolate reductase1.5.1.30.442
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.442
3gcsBAXMitogen-activated protein kinase 14/0.442
3nwyGTPUridylate kinase/0.442
4aa5NQBMitogen-activated protein kinase 14/0.442
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.442
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.442
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.442
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.442
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.442
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.442
4mxeACON-acetyltransferase ESCO12.3.10.442
4nr42LKCREB-binding protein/0.442
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.442
4xhgADPUncharacterized protein/0.442
1fm4DXCMajor pollen allergen Bet v 1-L/0.441
1knuYPAPeroxisome proliferator-activated receptor gamma/0.441
1rfqLARActin, alpha skeletal muscle/0.441
2c475IDCasein kinase I isoform gamma-2/0.441
2c9cATPPsp operon transcriptional activator/0.441
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.441
2itwITQEpidermal growth factor receptor2.7.10.10.441
3acjKSSTyrosine-protein kinase Lck2.7.10.20.441
3c3dFO12-phospho-L-lactate transferase/0.441
3d7kD7KBenzaldehyde lyase/0.441
3h1jSMACytochrome b/0.441
3jzdNADMaleylacetate reductase/0.441
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.441
3v013V0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.441
3w32W32Epidermal growth factor receptor2.7.10.10.441
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4e5kNADPhosphonate dehydrogenase1.20.1.10.441
4lrjANPUncharacterized protein/0.441
4nxvGDPMitochondrial dynamics protein MID51/0.441
4oauADP2-5A-dependent ribonuclease3.1.260.441
4tvbNADHomospermidine synthase2.5.1.440.441
4ysjADPCalmodulin-like domain protein kinase/0.441
1bl6SB6Mitogen-activated protein kinase 14/0.440
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.440
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.440
2aylFLPProstaglandin G/H synthase 11.14.99.10.440
2djiFADPyruvate oxidase/0.440
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.440
2jb4A14Isopenicillin N synthase1.21.3.10.440
2qo7ANPEphrin type-A receptor 32.7.10.10.440
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.440
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.440
3fpbCZASarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
3ncz3NCRho-associated protein kinase 12.7.11.10.440
3opdHIEHeat shock protein 83/0.440
3pcrGTPADP-ribosylation factor 6/0.440
3u2xASOGlycogenin-12.4.1.1860.440
3zkyWT4Isopenicillin N synthase1.21.3.10.440
4b99R4LMitogen-activated protein kinase 72.7.11.240.440
4c3pACPAurora kinase A2.7.11.10.440
4do30LAFatty-acid amide hydrolase 13.5.1.990.440
4fd2ADPChaperone protein ClpB/0.440
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4r2mANPUniversal stress protein F/0.440
5dosATPAurora kinase A2.7.11.10.440