sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
3.000 Å
X-ray
2007-05-18
| Name: | Fibroblast growth factor receptor 2 |
|---|---|
| ID: | FGFR2_HUMAN |
| AC: | P21802 |
| Organism: | Homo sapiens |
| Reign: | Eukaryota |
| TaxID: | 9606 |
| EC Number: | / |
| Chain Name: | Percentage of Residues within binding site |
|---|---|
| A | 100 % |
| B-Factor: | 28.485 |
|---|---|
| Number of residues: | 16 |
| Including | |
| Standard Amino Acids: | 16 |
| Non Standard Amino Acids: | 0 |
| Water Molecules: | 0 |
| Cofactors: | |
| Metals: | |
| Ligandability | Volume (Å3) |
|---|---|
| 0.649 | 408.375 |
| % Hydrophobic | % Polar |
|---|---|
| 60.33 | 39.67 |
| According to VolSite | |
| HET Code: | ACP |
|---|---|
| Formula: | C11H14N5O12P3 |
| Molecular weight: | 501.176 g/mol |
| DrugBank ID: | DB03909 |
| Buried Surface Area: | 54.33 % |
| Polar Surface area: | 310.64 Å2 |
| Number of | |
|---|---|
| H-Bond Acceptors: | 16 |
| H-Bond Donors: | 3 |
| Rings: | 3 |
| Aromatic rings: | 2 |
| Anionic atoms: | 4 |
| Cationic atoms: | 0 |
| Rule of Five Violation: | 2 |
| Rotatable Bonds: | 8 |
| X | Y | Z |
|---|---|---|
| 29.9931 | 14.1327 | 24.7966 |
Image generated by PoseView
Represent the protein/ligand binding mode, centered on the ligand
Dashed lines represents hydrogen bonds and metal interactions
Green residue labels for amino acids with hydrophobic contacts (green lines) to the ligand
| Ligand | Protein | Interaction | |||
|---|---|---|---|---|---|
| Atom | Atom | Residue | Distance (Å) | Angle (°) | Type |
| C5 | CD1 | LEU- 487 | 3.83 | 0 | Hydrophobic |
| C5 | CG1 | VAL- 495 | 4.18 | 0 | Hydrophobic |
| N6 | O | GLU- 565 | 3.14 | 132.69 | H-Bond (Ligand Donor) |
| N1 | N | ALA- 567 | 3.2 | 153.34 | H-Bond (Protein Donor) |
| C5 | CD1 | LEU- 633 | 3.37 | 0 | Hydrophobic |
