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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pzr ACP Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pzr ACPFibroblast growth factor receptor 2 / 0.778
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.705
2ym7 YM7Serine/threonine-protein kinase Chk1 2.7.11.1 0.676
4e6d 0NUTyrosine-protein kinase JAK2 / 0.675
4fic 0ULProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.664
4i5c C5ITyrosine-protein kinase JAK1 / 0.664
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.663
4f08 1RSTyrosine-protein kinase JAK2 / 0.661
3vs7 KS1Tyrosine-protein kinase HCK 2.7.10.2 0.660
4e5f 0N7Polymerase acidic protein / 0.660
3bht MFRCyclin-dependent kinase 2 2.7.11.22 0.658
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.656
2q0b ACPFibroblast growth factor receptor 2 / 0.654
2ym6 YM6Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.654
3w6h AZMCarbonic anhydrase 1 4.2.1.1 0.654
4oti MI1Serine/threonine-protein kinase N1 / 0.653