Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.760 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.756 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.744 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.738 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.732 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.724 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.709 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.709 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.705 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.699 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.694 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.692 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.691 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.682 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.668 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.664 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.657 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.653 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.641 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.635 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.633 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.630 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.622 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.619 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.600 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.599 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.599 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.596 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.596 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.595 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.594 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.587 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.572 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.571 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.570 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.566 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.563 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.561 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.559 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.557 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.553 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.552 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.552 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.551 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.547 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.546 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.545 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.543 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.543 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.542 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.541 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.540 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.534 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.533 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.530 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.529 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.528 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.528 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.526 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.526 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.526 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.524 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.521 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.519 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.519 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.515 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.515 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.513 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.512 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.512 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.509 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.509 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.502 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.501 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.500 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.500 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.496 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.496 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.496 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.496 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.495 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.494 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.494 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.492 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.492 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.490 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.490 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.489 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.485 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.485 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.484 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.482 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.482 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.481 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.481 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.481 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.480 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.480 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.480 | |
| 2iml | FMN | Uncharacterized protein | / | 0.478 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.477 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.475 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.474 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.474 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.473 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.473 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.472 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.472 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.471 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.471 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.471 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.471 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 4nvk | 2NY | Peroxidase | / | 0.470 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.469 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.469 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.469 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.469 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.468 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.468 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.468 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.467 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.467 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.467 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.466 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.466 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.465 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.465 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.465 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.464 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.464 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.464 | |
| 4y1b | NAP | AntE | / | 0.464 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.463 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.463 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.463 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.463 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.463 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.462 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.462 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.462 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.462 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.462 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.461 | |
| 3ag6 | PAJ | Pantothenate synthetase | / | 0.461 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.461 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.461 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.461 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.461 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.460 | |
| 4iae | 1DX | Alr2278 protein | / | 0.460 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.459 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.459 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.459 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.458 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.458 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.458 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.458 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.458 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.457 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.457 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 1bl4 | AP1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.456 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.456 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.456 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.455 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.455 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.455 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.455 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.455 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.455 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.455 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.455 | |
| 5fsi | 8DG | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.455 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.454 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.454 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.454 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.453 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.453 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.453 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.453 | |
| 3tx1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.453 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.453 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.452 | |
| 1q51 | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.452 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.452 | |
| 4e2y | JHZ | Methyltransferase | / | 0.452 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.452 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.451 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.451 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.451 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.451 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.451 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.451 | |
| 3ndj | JHZ | Methyltransferase | / | 0.451 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.451 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.451 | |
| 5hg0 | SAM | Pantothenate synthetase | / | 0.451 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.450 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.450 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.450 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.450 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.450 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.450 | |
| 3mtw | M3R | Xaa-Pro dipeptidase, putative | / | 0.450 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.450 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.450 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.449 | |
| 2dg9 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.449 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.449 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.449 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.449 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 1kh3 | ANP | Argininosuccinate synthase | / | 0.448 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.448 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.448 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.448 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3wag | TYD | Glycosyltransferase | / | 0.448 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.448 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.447 | |
| 1jum | BER | HTH-type transcriptional regulator QacR | / | 0.447 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.447 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.447 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.447 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.447 | |
| 3e39 | FMN | Nitroreductase | / | 0.447 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.447 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.447 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.447 | |
| 4e32 | DWN | Methyltransferase | / | 0.447 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.447 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.447 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.447 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1n4q | LYS_CYS_VAL_ILE_LEU | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.446 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 1vf3 | GDN | Glutathione S-transferase 3 | 2.5.1.18 | 0.446 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.446 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.446 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.446 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.446 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.446 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.446 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.446 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.446 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.446 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.446 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.445 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.445 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.445 | |
| 1til | ATP | Anti-sigma F factor | / | 0.445 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.445 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.445 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.445 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.445 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.445 | |
| 3kyb | FMN | UDP-galactopyranose mutase | 5.4.99.9 | 0.445 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.445 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.445 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.445 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.445 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.445 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.445 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.445 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.444 | |
| 1s4p | GDP | Glycolipid 2-alpha-mannosyltransferase | / | 0.444 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.444 | |
| 2a84 | ATP | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.444 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.444 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3t3i | GPW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.444 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.444 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.444 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4n1g | CEI | Obelin | / | 0.444 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.443 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.443 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.443 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.443 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.443 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.443 | |
| 3pfd | FDA | Acyl-CoA dehydrogenase FadE25 | / | 0.443 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.443 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4jic | FMN | GTN Reductase | / | 0.443 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.443 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.443 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.443 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.442 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.442 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.442 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.442 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.442 | |
| 3bnk | FMN | Flavoredoxin | / | 0.442 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.442 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.442 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.441 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.441 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.441 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2ejz | SAH | Diphthine synthase | / | 0.441 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.441 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3e6e | DCS | Alanine racemase | / | 0.441 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.441 | |
| 4e31 | JHZ | Methyltransferase | / | 0.441 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.441 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.441 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.441 | |
| 1kap | GLY_SER_ASN_SER | Serralysin | 3.4.24.40 | 0.440 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.440 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.440 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.440 | |
| 2b8v | 3BN | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.440 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.440 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.440 | |
| 3amf | FMN | FMN-binding protein | / | 0.440 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.440 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.440 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.440 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.440 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 4c1e | MCO | Beta-lactamase class B VIM-2 | / | 0.440 | |
| 4e2w | JHZ | Methyltransferase | / | 0.440 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.440 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.440 | |
| 4j49 | 1J1 | Uncharacterized protein | / | 0.440 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.440 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.440 | |
| 6gsv | GPS | Glutathione S-transferase Mu 1 | 2.5.1.18 | 0.440 |