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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ucoIWHDNA ligase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4ucoIWHDNA ligase/1.000
5bn3ADPV-type ATP synthase alpha chain/0.521
5bn3ADPNEQ263/0.521
1yw7A41Methionine aminopeptidase 2/0.519
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.513
4to2DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.502
4qg0DUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.501
4to1DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.499
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.498
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.495
1yw9A84Methionine aminopeptidase 2/0.495
2jdcCAOProbable acetyltransferase/0.492
4pahLNRPhenylalanine-4-hydroxylase1.14.16.10.488
4boeCLRJapanin/0.487
4to4DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.487
2ga2A19Methionine aminopeptidase 2/0.486
2tohHBITyrosine 3-monooxygenase1.14.16.20.485
3pn1IVHDNA ligase/0.485
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.485
4hej14DThymidylate kinase/0.485
4fsa0V3Queuine tRNA-ribosyltransferase2.4.2.290.484
4jq1NPSAldo-keto reductase family 1 member C2/0.484
3elePLPAminotransferase/0.482
2b8jADNClass B acid phosphatase3.1.3.20.481
1lrmHBIPhenylalanine-4-hydroxylase1.14.16.10.480
1r58AO5Methionine aminopeptidase 2/0.480
3iktNADRedox-sensing transcriptional repressor Rex/0.480
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.480
3pahXDEPhenylalanine-4-hydroxylase1.14.16.10.480
3s41S41Glucokinase2.7.1.20.480
3stdMQ0Scytalone dehydratase4.2.1.940.480
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.480
4lwxMU2Ribosome inactivating protein/0.480
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.479
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.479
5stdUNNScytalone dehydratase4.2.1.940.479
1z5uCMPClass B acid phosphatase/0.478
4qa2SHHHistone deacetylase 83.5.1.980.478
5dc5B3NHistone deacetylase 83.5.1.980.478
2avxHTFRegulatory protein SdiA/0.477
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.477
3l6jZ90Alr2278 protein/0.477
4b2gV1NUncharacterized protein/0.477
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.476
2vqjTFGHistone deacetylase 43.5.1.980.475
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
3p0eBAUUridine phosphorylase 22.4.2.30.474
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.474
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
1ry0PG2Aldo-keto reductase family 1 member C3/0.473
1tg2H2BPhenylalanine-4-hydroxylase1.14.16.10.473
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.473
4rxsTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.473
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.473
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.473
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.472
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.472
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.472
5jr34MUCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.472
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.471
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.471
4emdC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.471
4xo7ASDAldo-keto reductase family 1 member C2/0.471
4xoqF42Coenzyme F420:L-glutamate ligase/0.471
7stdCRPScytalone dehydratase4.2.1.940.471
3o8gO8GHTH-type transcriptional regulator EthR/0.470
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.470
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.470
4rxpDTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.470
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
3n9jEAAGlutathione S-transferase P2.5.1.180.469
4i5xFLFAldo-keto reductase family 1 member B101.1.10.469
1dr4HBIDihydrofolate reductase1.5.1.30.468
1obnASVIsopenicillin N synthase1.21.3.10.468
4qg1DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.468
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.467
1ej3CZHAequorin-2/0.467
2vcmM11Isopenicillin N synthase1.21.3.10.467
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.467
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.467
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.467
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.466
3hfbML4Tryptophan 5-hydroxylase 11.14.16.40.466
3szfDCQSulfide-quinone reductase/0.466
4dw60MNHTH-type transcriptional regulator EthR/0.466
5bn4ANPV-type ATP synthase alpha chain/0.466
1yc2NADNAD-dependent protein deacylase 2/0.465
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.465
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
2r0pK2CPutative FAD-monooxygenase/0.464
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.464
3nu03TUDihydrofolate reductase1.5.1.30.464
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.464
1jf2CZHObelin/0.463
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.463
1ygkRRCPyridoxal kinase2.7.1.350.463
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
3l2kPXCEhpF/0.463
3lzzGDPUncharacterized protein/0.463
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.462
1i7lATPSynapsin-2/0.462
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.462
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.462
2poqISDTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase1.3.1.200.462
3e9sTTTReplicase polyprotein 1ab3.4.220.462
3p9tTCLRepressor/0.462
4gt8ADPSensor protein VraS2.7.13.30.462
4itxIN5Cystathionine beta-lyase MetC4.4.1.80.462
4k9yK9YFocal adhesion kinase 12.7.10.20.462
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.462
4z87GDPInosine-5'-monophosphate dehydrogenase/0.462
2yg5FADPutrescine oxidase/0.461
3znrNU9Histone deacetylase 73.5.1.980.461
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.461
4jvnYUGEstrogen sulfotransferase2.8.2.40.461
4lez1SYCyclic GMP-AMP synthase/0.461
4n1fCZHObelin/0.461
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.461
1y5wNEZQueuine tRNA-ribosyltransferase2.4.2.290.460
2bu5TF1[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.460
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.460
3gyf51PDihydrofolate reductase1.5.1.30.460
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.460
4l5b1UXDeoxycytidine kinase2.7.1.740.460
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.460
4phlPILPhosphodiesterase/0.460
1dljUGAUDP-glucose 6-dehydrogenase/0.459
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.459
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.459
2bf7HBIPteridine reductase 11.5.1.330.459
2ea4F79Methionine aminopeptidase 2/0.459
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.459
2oazI96Methionine aminopeptidase 2/0.459
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.459
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.459
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
4jlm1NNDeoxycytidine kinase2.7.1.740.459
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
1afsTES3-alpha-hydroxysteroid dehydrogenase1.1.1.500.458
1blzACVIsopenicillin N synthase1.21.3.10.458
2abaSTRPentaerythritol tetranitrate reductase/0.458
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.458
2vqqTFGHistone deacetylase 43.5.1.980.458
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3gluLYS_VAL_METNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.458
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.458
3vhmNPKAvidin/0.458
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.458
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.458
4rxqDUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.458
1qv1CZHObelin/0.457
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.457
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.457
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
4bfwZVWPantothenate kinase2.7.1.330.457
4dbw511Aldo-keto reductase family 1 member C3/0.457
4imfSI3N-acetylneuraminate lyase/0.457
4jtqFLPAldo-keto reductase family 1 member C2/0.457
1ekoI84Aldose reductase1.1.1.210.456
1h42FADFerredoxin--NADP reductase1.18.1.20.456
1n0sFLUBilin-binding protein/0.456
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.456
1y1rANUUridine phosphorylase2.4.2.30.456
2zda32UProthrombin3.4.21.50.456
3gg2UGASugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family/0.456
3gkiCLRNiemann-Pick C1 protein/0.456
3o76GTBGlutathione S-transferase P 12.5.1.180.456
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4iae1DXAlr2278 protein/0.456
4jvmXDIEstrogen sulfotransferase2.8.2.40.456
5epvACPBlue-light-activated histidine kinase2.7.13.30.456
1odjGMPPurine nucleoside phosphorylase/0.455
2a4xBLMMitomycin-binding protein/0.455
2f99AKVAklanonic acid methyl ester cyclase AcmA5.5.1.230.455
2nnqT4BFatty acid-binding protein, adipocyte/0.455
3dz7O8MS-adenosylmethionine decarboxylase proenzyme4.1.1.500.455
3n61H4BNitric oxide synthase, brain1.14.13.390.455
4ax9N5NProthrombin3.4.21.50.455
4b6r3DQ3-dehydroquinate dehydratase4.2.1.100.455
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.455
1l8tADPAminoglycoside 3'-phosphotransferase2.7.1.950.454
1o5gCR9Prothrombin3.4.21.50.454
1s7gNADNAD-dependent protein deacylase 2/0.454
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2d06ESTSulfotransferase 1A12.8.2.10.454
2jj1ADPATP synthase subunit alpha, mitochondrial/0.454
2jj1ADPATP synthase subunit beta, mitochondrial3.6.3.140.454
2nr4FMNConserved protein/0.454
3f6sFMNFlavodoxin/0.454
3ghwGHWDihydrofolate reductase1.5.1.30.454
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
4bfyZVYPantothenate kinase2.7.1.330.454
4d9fDCSD-cysteine desulfhydrase/0.454
4jqh1MFAlr2278 protein/0.454
4nqgCZHMitrocomin/0.454
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.454
1cjwCOTSerotonin N-acetyltransferase/0.453
1hfqMOTDihydrofolate reductase1.5.1.30.453
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
1rvvINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
1s2cFLFAldo-keto reductase family 1 member C3/0.453
2ejzSAHDiphthine synthase/0.453
2xb8XNW3-dehydroquinate dehydratase4.2.1.100.453
2xuhTZ4Acetylcholinesterase3.1.1.70.453
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.453
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.453
3mjrAC2Deoxycytidine kinase2.7.1.740.453
3v0n4GWHisto-blood group ABO system transferase/0.453
1jdzFMBPurine nucleoside phosphorylase/0.452
1qinGIPLactoylglutathione lyase4.4.1.50.452
1qipGNBLactoylglutathione lyase4.4.1.50.452
1rzuADPGlycogen synthase 12.4.1.210.452
1u65CP0Acetylcholinesterase3.1.1.70.452
2z4w749Geranylgeranyl pyrophosphate synthase/0.452
3b82NADExotoxin A2.4.2.360.452
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.452
3c3xNAPEugenol synthase 11.1.1.3180.452
3ug8IMNAldo-keto reductase family 1 member C3/0.452
4bfuZVUPantothenate kinase2.7.1.330.452
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.452
4dk70KSOxysterols receptor LXR-beta/0.452
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4jtpASCRibosome inactivating protein/0.452
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.452
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.452
1gt5BZQOdorant-binding protein/0.451
1i05LTLMajor urinary protein 6/0.451
1qvuPRLHTH-type transcriptional regulator QacR/0.451
2pg0FADAcyl-CoA dehydrogenase/0.451
3hv3R49Mitogen-activated protein kinase 14/0.451
3w5hFADNADH-cytochrome b5 reductase 31.6.2.20.451
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.451
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.451
4fa30SLAldo-keto reductase family 1 member C3/0.451
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.451
4jtrIZPAldo-keto reductase family 1 member C2/0.451
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.451
4y1bNAPAntE/0.451
4u140HKMuscarinic acetylcholine receptor M3/0.451
1je1GMPPurine nucleoside phosphorylase/0.450
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2nm2NEUDihydroneopterin aldolase/0.450
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.450
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.450
3i68J4ZDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.450
3p2oNADBifunctional protein FolD/0.450
3sl2ATPSensor histidine kinase WalK/0.450
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.450
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
4qfzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.450
1ihiIU5Aldo-keto reductase family 1 member C2/0.449
1kmvLIIDihydrofolate reductase1.5.1.30.449
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
1typNAPTrypanothione reductase1.8.1.120.449
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
1xp8AGSProtein RecA/0.449
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.449
2c97JCL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
2uuk897Prothrombin3.4.21.50.449
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.449
3q0vLL4HTH-type transcriptional regulator EthR/0.449
4bquCLRJapanin/0.449
4cbyKEEHistone deacetylase 43.5.1.980.449
4dbs0HVAldo-keto reductase family 1 member C3/0.449
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4m4821BSodium-dependent dopamine transporter/0.449
4wevSUZAldo-keto reductase family 1 member B101.1.10.449
5c1mCLRMu-type opioid receptor/0.449
5e9eANPMyosin heavy chain kinase A2.7.11.70.449
1drfFOLDihydrofolate reductase1.5.1.30.448
1ezfIN0Squalene synthase2.5.1.210.448
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.448
1sl9CZHObelin/0.448
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
2vqoTFGHistone deacetylase 43.5.1.980.448
3bmqAX5Pteridine reductase/0.448
3d2dRENReticuline oxidase1.21.3.30.448
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3ntz3TZDihydrofolate reductase1.5.1.30.448
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.448
4jq4IMNAldo-keto reductase family 1 member C2/0.448
4zwpM44Xaa-Pro dipeptidase3.4.13.90.448
5bv3M7Gm7GpppX diphosphatase3.6.1.590.448
6stdMS2Scytalone dehydratase4.2.1.940.448
1kmsLIHDihydrofolate reductase1.5.1.30.447
1nbmADPATP synthase subunit beta, mitochondrial3.6.3.140.447
1pqc444Oxysterols receptor LXR-beta/0.447
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1rftPXMPyridoxal kinase2.7.1.350.447
1yhjR6CPyridoxal kinase2.7.1.350.447
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.447
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.447
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.447
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.447
3lfeZ84Mitogen-activated protein kinase 14/0.447
3ocw3AMLipoprotein E/0.447
3ptzUDXUDP-glucose 6-dehydrogenase1.1.1.220.447
3r8hZOMAldo-keto reductase family 1 member C3/0.447
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.447
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.447
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4hmn16JAldo-keto reductase family 1 member C3/0.447
4kc1WS1Histo-blood group ABO system transferase/0.447
4qfyDCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.447
4to0DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.447
1ah3TOLAldose reductase1.1.1.210.446
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.446
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.446
1k8zIAGTryptophan synthase alpha chain/0.446
1kuyCOTSerotonin N-acetyltransferase/0.446
1stdBFSScytalone dehydratase4.2.1.940.446
1swnBTNStreptavidin/0.446
1swpBTNStreptavidin/0.446
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
2ea2F77Methionine aminopeptidase 2/0.446
2gywOBIAcetylcholinesterase3.1.1.70.446
2v57PRLTetR family transcriptional regulator/0.446
2yg3FADPutrescine oxidase/0.446
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.446
3dsrADPV-type ATP synthase beta chain/0.446
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3qwc98PProthrombin3.4.21.50.446
4e37NDPCatalase1.11.1.60.446
4hh4SAHCcbJ/0.446
4iilRBFMembrane lipoprotein TpN38(b)/0.446
4imuH4BNitric oxide synthase, brain1.14.13.390.446
4ise1FWGlucokinase2.7.1.20.446
4klrCHDFerrochelatase, mitochondrial4.99.1.10.446
4rbs0RVMetallo-beta-lactamase type 2/0.446
4tnyDGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.446
1cl2PPGCystathionine beta-lyase MetC4.4.1.80.445
1dp2LPBThiosulfate sulfurtransferase/0.445
1ppjANYCytochrome b/0.445
2bd0BIOSepiapterin reductase/0.445
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.445
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
2tplHPPTyrosine phenol-lyase4.1.99.20.445
2zymACXPeriplasmic binding protein/0.445
3axbFADPutative oxidoreductase/0.445
3fznD7KBenzoylformate decarboxylase4.1.1.70.445
3ghvGHCDihydrofolate reductase1.5.1.30.445
3ix4TX1Transcriptional activator protein LasR/0.445
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
3qpg3QPAspartate aminotransferase2.6.1.10.445
3s7a684Dihydrofolate reductase1.5.1.30.445
4ag9COAGlucosamine 6-phosphate N-acetyltransferase/0.445
4bubADPUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase/0.445
4dyp0MSNucleoprotein/0.445
4psbGA3Cytokinin-specific binding protein/0.445
4stdBFSScytalone dehydratase4.2.1.940.445
4ttjFMCPurine nucleoside phosphorylase DeoD-type/0.445
1h22E10Acetylcholinesterase3.1.1.70.444
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.444
1lkeDOGBilin-binding protein/0.444
1nm6L86Prothrombin3.4.21.50.444
1p33MTXPteridine reductase 11.5.1.330.444
1t48BB3Tyrosine-protein phosphatase non-receptor type 13.1.3.480.444
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1w6jR71Lanosterol synthase5.4.99.70.444
1w7kADPDihydrofolate synthase/folylpolyglutamate synthase6.3.2.120.444
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2g6pHM2Methionine aminopeptidase 1/0.444
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.444
2p1t3TNRetinoic acid receptor RXR-alpha/0.444
2pdlTOLAldose reductase1.1.1.210.444
2rd2QSIGlutamine--tRNA ligase6.1.1.180.444
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.444
2zhq27UProthrombin3.4.21.50.444
3n76CA23-dehydroquinate dehydratase4.2.1.100.444
3vhhVHHAvidin/0.444
3x025GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.444
3zoiM2WIsopenicillin N synthase1.21.3.10.444
4b67NAPL-ornithine N(5)-monooxygenase/0.444
4jln18VDeoxycytidine kinase2.7.1.740.444
4mryCEIObelin/0.444
4n9qFMNFMN-dependent NADH-azoreductase 1/0.444
5bu2ADPUncharacterized protein/0.444
5d4vYGPUncharacterized protein MJ0489/0.444
7catNDPCatalase1.11.1.60.444
1ddtAPUDiphtheria toxin/0.443
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.443
1ja0FMNNADPH--cytochrome P450 reductase/0.443
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
1w19T2P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
1ypeUIPProthrombin3.4.21.50.443
2c3p1TPPyruvate synthase/0.443
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3juqAKDPhenazine biosynthesis protein A/B/0.443
3qeoLLTDeoxycytidine kinase2.7.1.740.443
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.443
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.443
4dhyS41Glucokinase2.7.1.20.443
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.443
4s1iPLPPyridoxal kinase, putative/0.443
4wctFADFructosyl amine:oxygen oxidoreductase/0.443
1hfpMOTDihydrofolate reductase1.5.1.30.442
1ngsTPPTransketolase 12.2.1.10.442
1rs6H4BNitric oxide synthase, brain1.14.13.390.442
1thnADPAnti-sigma F factor/0.442
1ve74NPAcylamino-acid-releasing enzyme3.4.19.10.442
1vi0DCCFatty acid metabolism regulator protein/0.442
1xngDNDNH(3)-dependent NAD(+) synthetase6.3.1.50.442
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2hwuURIUridine phosphorylase2.4.2.30.442
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2owb626Serine/threonine-protein kinase PLK12.7.11.210.442
2qw8NAPEugenol synthase 11.1.1.3180.442
2vbpVB1Isopenicillin N synthase1.21.3.10.442
2vqbNAPPutative flavin-containing monooxygenase/0.442
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.442
3cv6HXSAldo-keto reductase family 1 member C21/0.442
3dr7GPDGDP-perosamine synthase/0.442
3ix8TX3Transcriptional activator protein LasR/0.442
3nxrD2DDihydrofolate reductase1.5.1.30.442
3t0kDCQSulfide-quinone reductase/0.442
3vf60H6Glucokinase2.7.1.20.442
4b65NDPL-ornithine N(5)-monooxygenase/0.442
4dlcUMPDeoxyuridine triphosphatase, putative/0.442
4dz5NAPAldo-keto reductase family 1 member C3/0.442
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4m6l21VDihydrofolate reductase1.5.1.30.442
1pkfEPDEpothilone C/D epoxidase1.140.441
1s36CEIObelin/0.441
1tllFMNNitric oxide synthase, brain1.14.13.390.441
1w4lGL8Acetylcholinesterase3.1.1.70.441
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
2fzbTOLAldose reductase1.1.1.210.441
2vt4P32Beta-1 adrenergic receptor/0.441
2zhf49UProthrombin3.4.21.50.441
2zreAGSProtein RecA/0.441
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.441
3uyk0CXProbable NDP-rhamnosyltransferase/0.441
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.441
4fam0SZAldo-keto reductase family 1 member C3/0.441
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.441
4rtbSAMPutative thiazole biosynthesis protein ThiH/0.441
5cmx0G6Prothrombin3.4.21.50.441
1h61PDNPentaerythritol tetranitrate reductase/0.440
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
1lelBH7Avidin/0.440
1nbhSAMGlycine N-methyltransferase2.1.1.200.440
1pfyMSPMethionine--tRNA ligase6.1.1.100.440
1uhjCZBAequorin-2/0.440
1upw444Oxysterols receptor LXR-beta/0.440
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
1ygjRMCPyridoxal kinase2.7.1.350.440
2cf8ESHProthrombin3.4.21.50.440
2gqnBLPCystathionine beta-lyase MetC4.4.1.80.440
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.440
2oatPFMOrnithine aminotransferase, mitochondrial2.6.1.130.440
2ohjFMNType A flavoprotein FprA10.440
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
2zevB71Geranylgeranyl pyrophosphate synthase/0.440
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.440
3c1oNAPEugenol synthase/0.440
3fowIMHPurine nucleoside phosphorylase/0.440
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4hqvQEIQueuine tRNA-ribosyltransferase2.4.2.290.440
4kyhZSTLactoylglutathione lyase4.4.1.50.440