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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4k6i9RARetinoic acid receptor RXR-alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4k6i9RARetinoic acid receptor RXR-alpha/1.000
1mznBM6Retinoic acid receptor RXR-alpha/0.662
1mvcBM6Retinoic acid receptor RXR-alpha/0.652
1xiuREARetinoic acid receptor RXR/0.626
1fbyREARetinoic acid receptor RXR-alpha/0.622
1fm69CRRetinoic acid receptor RXR-alpha/0.621
3h0a9RARetinoic acid receptor RXR-alpha/0.614
1rdtL79Retinoic acid receptor RXR-alpha/0.596
1xlsREARetinoic acid receptor RXR-alpha/0.595
2p1u4TNRetinoic acid receptor RXR-alpha/0.595
1k749CRRetinoic acid receptor RXR-alpha/0.594
3oapREARetinoic acid receptor RXR-alpha/0.590
1uhlMEIRetinoic acid receptor RXR-beta/0.587
4m8hR4MRetinoic acid receptor RXR-alpha/0.586
2aclREARetinoic acid receptor RXR-alpha/0.585
3uvvREARetinoic acid receptor RXR-alpha/0.585
2p1t3TNRetinoic acid receptor RXR-alpha/0.581
4m8e29VRetinoic acid receptor RXR-alpha/0.579
1fm99CRRetinoic acid receptor RXR-alpha/0.575
4k4j1O8Retinoic acid receptor RXR-alpha/0.575
2p1v5TNRetinoic acid receptor RXR-alpha/0.550
3fc6REARetinoic acid receptor RXR-alpha/0.549
3falREARetinoic acid receptor RXR-alpha/0.542
3q0gBCOProbable enoyl-CoA hydratase echA84.2.1.170.523
2jb4A14Isopenicillin N synthase1.21.3.10.507
2rqfJH3Hemolymph juvenile hormone binding protein/0.507
5hs1VORLanosterol 14-alpha demethylase/0.507
3zoiM2WIsopenicillin N synthase1.21.3.10.501
1fmlRTLRetinol dehydratase/0.500
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.500
3kpzZNEVitamin D3 receptor/0.499
3zkyWT4Isopenicillin N synthase1.21.3.10.499
4jlk1NODeoxycytidine kinase2.7.1.740.499
3l6jZ90Alr2278 protein/0.497
2wo7ASVIsopenicillin N synthase1.21.3.10.494
1uzwCDHIsopenicillin N synthase1.21.3.10.492
1fmjRTLRetinol dehydratase/0.490
1bk0ACVIsopenicillin N synthase1.21.3.10.489
2vcmM11Isopenicillin N synthase1.21.3.10.489
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.487
1w06W05Isopenicillin N synthase1.21.3.10.486
2y60M8FIsopenicillin N synthase1.21.3.10.486
1drbMTXDihydrofolate reductase1.5.1.30.485
1oc1ASVIsopenicillin N synthase1.21.3.10.485
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.485
1s3yTQTDihydrofolate reductase1.5.1.30.484
4bb3KKAIsopenicillin N synthase1.21.3.10.484
4g95OAGDihydrofolate reductase1.5.1.30.484
3qm4PN0Cytochrome P450 2D6/0.483
4kne1CYDihydrofolate reductase1.5.1.30.483
1e7aPFLSerum albumin/0.482
1qiqACCIsopenicillin N synthase1.21.3.10.482
2bu9HFVIsopenicillin N synthase1.21.3.10.481
2p15EZTEstrogen receptor/0.481
4a2jAS0Progesterone receptor/0.481
4p6wMOFGlucocorticoid receptor/0.481
1nzyBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.480
3p9tTCLRepressor/0.480
4jlj1NMDeoxycytidine kinase2.7.1.740.480
1hb3SCVIsopenicillin N synthase1.21.3.10.479
3lfeZ84Mitogen-activated protein kinase 14/0.479
3p99LNPLanosterol 14-alpha-demethylase/0.479
1b2lNDCAlcohol dehydrogenase1.1.1.10.478
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.478
1s0zEB1Vitamin D3 receptor/0.478
1xddAAYIntegrin alpha-L/0.478
3q0gCOAProbable enoyl-CoA hydratase echA84.2.1.170.478
4j6cSTRCytochrome P450 monooxygenase/0.478
4jlm1NNDeoxycytidine kinase2.7.1.740.477
1obnASVIsopenicillin N synthase1.21.3.10.476
2pnuENMAndrogen receptor/0.476
2ptfFMNUncharacterized protein MTH_863/0.476
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.476
3njoPYVAbscisic acid receptor PYR1/0.476
3vt45YIVitamin D3 receptor/0.476
4apuA2KProgesterone receptor/0.476
1mvsDTMDihydrofolate reductase1.5.1.30.475
1pkfEPDEpothilone C/D epoxidase1.140.474
1qjfACSIsopenicillin N synthase1.21.3.10.474
2vn0TDZCytochrome P450 2C8/0.474
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.474
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.474
3vt5YI2Vitamin D3 receptor/0.474
4ead0NPThymidine phosphorylase2.4.2.40.474
1rkhVD2Vitamin D3 receptor/0.473
2iviACWIsopenicillin N synthase1.21.3.10.473
3gobHXXDdmC/0.473
3s3vTOPDihydrofolate reductase1.5.1.30.473
3tubFPUTyrosine-protein kinase SYK2.7.10.20.473
4dvi2IWTankyrase-12.4.2.300.473
4ia2BIVVitamin D3 receptor A/0.473
4ips1G4Mycocyclosin synthase1.14.21.90.473
4nb6444Nuclear receptor ROR-gamma/0.473
1osvCHCBile acid receptor/0.472
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.472
1suoCPZCytochrome P450 2B41.14.14.10.472
2imkGTXAGAP009194-PA/0.472
2zlcVDXVitamin D3 receptor/0.472
3bfa9ODOdorant binding protein ASP1/0.472
3c14FOKAdenylate cyclase type 2/0.472
3c14FOKAdenylate cyclase type 5/0.472
4iae1DXAlr2278 protein/0.472
4q72FADBifunctional protein PutA/0.472
1zg32HIIsoflavone 4'-O-methyltransferase/0.471
3cv9VDXVitamin D3 dihydroxylase/0.471
4iui1GQEstrogen receptor/0.471
1dhfFOLDihydrofolate reductase1.5.1.30.470
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.470
1x8lOXRRetinol dehydratase/0.470
1xuoLA1Integrin alpha-L/0.470
2vbpVB1Isopenicillin N synthase1.21.3.10.470
3w5q3KLVitamin D3 receptor/0.470
5stdUNNScytalone dehydratase4.2.1.940.470
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.469
1s3uTQDDihydrofolate reductase1.5.1.30.469
2bxoOPBSerum albumin/0.469
2vbdV10Isopenicillin N synthase1.21.3.10.469
3u8hBHPPhospholipase A2, membrane associated/0.469
4ia3BIVVitamin D3 receptor A/0.469
4l8u9AZSerum albumin/0.469
1hpzAAPGag-Pol polyprotein2.7.7.490.468
1nooCAHCamphor 5-monooxygenase1.14.15.10.468
2ejzSAHDiphthine synthase/0.468
3lfcZ86Mitogen-activated protein kinase 14/0.468
3oafOAGDihydrofolate reductase1.5.1.30.468
3pn1IVHDNA ligase/0.468
3w5p4OAVitamin D3 receptor/0.468
3w5tLHPVitamin D3 receptor/0.468
4lb2DM5Serum albumin/0.468
4okx198Androgen receptor/0.468
4y8vADPAcyl-CoA synthetase (NDP forming)/0.468
1dr3HBIDihydrofolate reductase1.5.1.30.467
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.467
2uxpCLMHTH-type transcriptional regulator TtgR/0.467
3vt65YIVitamin D3 receptor/0.467
3w5rLOAVitamin D3 receptor/0.467
3wv9FEGHmd co-occurring protein HcgE/0.467
4g1nNZTPyruvate kinase PKM2.7.1.400.467
4g1z0VPVitamin D3 receptor A/0.467
4iarERM5-hydroxytryptamine receptor 1B/0.467
4j24ESTEstrogen receptor beta/0.467
1upw444Oxysterols receptor LXR-beta/0.466
1yinCM3Estrogen receptor/0.466
2uxoTACHTH-type transcriptional regulator TtgR/0.466
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.466
3up0D7SaceDAF-12/0.466
4bmpFMNProtein NrdI/0.466
4dch4DCGlucokinase2.7.1.20.466
4ruoBIVVitamin D3 receptor A/0.466
3b9lAZZSerum albumin/0.465
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.465
3is9AC7Gag-Pol polyprotein2.7.7.490.465
3t2kFADSulfide-quinone reductase/0.465
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.465
3ua506XCytochrome P450 2B61.14.130.465
4ap1NAPSteroid monooxygenase/0.465
4bfpSWYTankyrase-22.4.2.300.465
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.465
1crbRTLRetinol-binding protein 1/0.464
1hb1OCVIsopenicillin N synthase1.21.3.10.464
1kzjCB3Thymidylate synthase/0.464
1nceCB3Thymidylate synthase/0.464
1rd4L08Integrin alpha-L/0.464
2be2R22Gag-Pol polyprotein2.7.7.490.464
3t8xT8XT-cell surface glycoprotein CD1b/0.464
3vtdTKDVitamin D3 receptor/0.464
4okb198Androgen receptor/0.464
4rupH97Vitamin D3 receptor A/0.464
5bn4ANPV-type ATP synthase alpha chain/0.464
1drfFOLDihydrofolate reductase1.5.1.30.463
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.463
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.463
3gbk2PQPeroxisome proliferator-activated receptor gamma/0.463
4iah1DXAlr2278 protein/0.463
4o71CPBBromodomain-containing protein 4/0.463
5d7pOCZNAD-dependent protein deacetylase sirtuin-23.5.10.463
2zbaZBATrichothecene 3-O-acetyltransferase/0.462
3p0fBAUUridine phosphorylase 22.4.2.30.462
3wiyLC6Induced myeloid leukemia cell differentiation protein Mcl-1/0.462
4boeCLRJapanin/0.462
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.462
4j6dTESCytochrome P450 monooxygenase/0.462
3emlZMAAdenosine receptor A2a/0.462
1blzACVIsopenicillin N synthase1.21.3.10.461
1fm4DXCMajor pollen allergen Bet v 1-L/0.461
1toiHCIAspartate aminotransferase2.6.1.10.461
2po7CHDFerrochelatase, mitochondrial4.99.1.10.461
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.461
3irxUDRGag-Pol polyprotein2.7.7.490.461
3nksACJProtoporphyrinogen oxidase1.3.3.40.461
3vt7VDXVitamin D3 receptor/0.461
4j6bPLOCytochrome P450 monooxygenase/0.461
1fd0254Retinoic acid receptor gamma/0.460
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
1sr7MOFProgesterone receptor/0.460
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.460
2c3qGTXGlutathione S-transferase theta-12.5.1.180.460
2ed3SAHDiphthine synthase/0.460
2ewpTXFEstrogen-related receptor gamma/0.460
2wpwACOOrf14/0.460
2y6fM9FIsopenicillin N synthase1.21.3.10.460
2ydoADNAdenosine receptor A2a/0.460
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.460
3qlrQLRDihydrofolate reductase1.5.1.30.460
3t14FADSulfide-quinone reductase/0.460
3vf60H6Glucokinase2.7.1.20.460
4g210VPVitamin D3 receptor A/0.460
4o761M3Bromodomain-containing protein 4/0.460
7stdCRPScytalone dehydratase4.2.1.940.460
1dubCAAEnoyl-CoA hydratase, mitochondrial4.2.1.170.459
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.459
1jxzBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.459
1x7jGENEstrogen receptor beta/0.459
2fzhDH1Dihydrofolate reductase1.5.1.30.459
2o4rVD5Vitamin D3 receptor/0.459
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.459
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.459
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.459
3lu8IQXSerum albumin/0.459
3t3r9PLCytochrome P450 2A61.14.130.459
3tguWF3Cytochrome b/0.459
3w0jT08Vitamin D3 receptor/0.459
3w0yDS4Vitamin D3 receptor/0.459
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.459
4h9753SDihydrofolate reductase1.5.1.30.459
4ib4ERM5-hydroxytryptamine receptor 2B/0.459
1p93DEXGlucocorticoid receptor/0.458
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.458
2fziDH3Dihydrofolate reductase1.5.1.30.458
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.458
2rehFADNitroalkane oxidase1.7.3.10.458
2vzmNRBCytochrome P450 monooxygenase PikC/0.458
3c3xNAPEugenol synthase 11.1.1.3180.458
3d75NBBPheromone-binding protein ASP1/0.458
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.458
4g1d0VKVitamin D3 receptor A/0.458
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.458
1fcx184Retinoic acid receptor gamma/0.457
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.457
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
3d74NBBPheromone-binding protein ASP1/0.457
3deiRXBCaspase-33.4.22.560.457
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.457
4uymVOR14-alpha sterol demethylase Cyp51B/0.457
3qakUKAAdenosine receptor A2a/0.457
1m9m6NINitric oxide synthase, endothelial1.14.13.390.456
1p7tACOMalate synthase G/0.456
1vrwNAIEnoyl-ACP reductase/0.456
1z95198Androgen receptor/0.456
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.456
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.456
2zlaVDBVitamin D3 receptor/0.456
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.456
3dd125DGlycogen phosphorylase, liver form2.4.1.10.456
3dejRXCCaspase-33.4.22.560.456
3ol5SAWCamphor 5-monooxygenase1.14.15.10.456
4b2gV1NUncharacterized protein/0.456
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
4iw8KN3Estrogen receptor/0.456
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.456
1zdwFLVPrenyltransferase/0.455
2cy2ACOProbable acetyltransferase/0.455
2dqsTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.455
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.455
3qly55VUncharacterized protein/0.455
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.455
3zeiAWHO-acetylserine sulfhydrylase/0.455
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.455
4jbtASDCytochrome P450 monooxygenase/0.455
4l0qNADAlcohol dehydrogenase class-3/0.455
4li71XPTankyrase-12.4.2.300.455
4mt92D6Tankyrase-12.4.2.300.455
4n1gCEIObelin/0.455
4zj8SUVOrexin receptor type 1/0.455
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.454
1ek2CDUBifunctional epoxide hydrolase 2/0.454
1pd9CO4Dihydrofolate reductase1.5.1.30.454
1u3s797Estrogen receptor beta/0.454
1wpgADPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.454
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.454
2nr4FMNConserved protein/0.454
2o7pNAPRiboflavin biosynthesis protein RibD/0.454
2uxhQUEHTH-type transcriptional regulator TtgR/0.454
3adaNADSubunit alpha of sarocosine oxidase/0.454
3d77NBBPheromone-binding protein ASP1/0.454
3eigMTXDihydrofolate reductase1.5.1.30.454
3gcnTYR_GLN_PHESerine endoprotease DegS3.4.21.1070.454
3qls55VDihydrofolate reductase1.5.1.30.454
4b8uIBK3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase4.2.1.590.454
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.454
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.454
4klaCHDFerrochelatase, mitochondrial4.99.1.10.454
4lsjLSJGlucocorticoid receptor/0.454
4ojb198Androgen receptor/0.454
4q73FADBifunctional protein PutA/0.454
4zowCLMMultidrug transporter MdfA/0.454
5c1mCLRMu-type opioid receptor/0.454
1diuBDMDihydrofolate reductase1.5.1.30.453
1eioGCHGastrotropin/0.453
1ot7CHCBile acid receptor/0.453
1q5dEPBEpothilone C/D epoxidase1.140.453
2d29FADAcyl-CoA dehydrogenase/0.453
2jedLG8Protein kinase C theta type2.7.11.130.453
3cgeNDPCoenzyme A disulfide reductase/0.453
3g70A5TRenin3.4.23.150.453
3h1vTK1Glucokinase2.7.1.20.453
3ibdCPZCytochrome P450 2B61.14.130.453
4bfwZVWPantothenate kinase2.7.1.330.453
4enhFVXCholesterol 24-hydroxylase/0.453
1hk1T44Serum albumin/0.452
1kceCB3Thymidylate synthase/0.452
1phgMYTCamphor 5-monooxygenase1.14.15.10.452
1pq944BOxysterols receptor LXR-beta/0.452
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.452
1trgCB3Thymidylate synthase/0.452
1zgaHMKIsoflavone 4'-O-methyltransferase/0.452
2puiADPMethylthioribose kinase2.7.1.1000.452
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.452
2xvv9DNSerum albumin/0.452
3ad9NADSubunit alpha of sarocosine oxidase/0.452
3cgdNADCoenzyme A disulfide reductase/0.452
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3kduNKSPeroxisome proliferator-activated receptor alpha/0.452
3l0lHC3Nuclear receptor ROR-gamma/0.452
3l71AZOCytochrome b/0.452
3stdMQ0Scytalone dehydratase4.2.1.940.452
3w0gW07Vitamin D3 receptor/0.452
4a81DXCMajor pollen allergen Bet v 1-A/0.452
4hyf1AKTankyrase-22.4.2.300.452
4uyf73BBromodomain-containing protein 2/0.452
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.451
1khrCOAStreptogramin A acetyltransferase2.3.10.451
1kk4ACOStreptogramin A acetyltransferase2.3.10.451
1knuYPAPeroxisome proliferator-activated receptor gamma/0.451
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1s19MC9Vitamin D3 receptor/0.451
1txiTX5Vitamin D3 receptor/0.451
1x2hLPALipoate-protein ligase A6.3.1.200.451
1xj7DHTAndrogen receptor/0.451
2hc4VDXVitamin D3 receptor A/0.451
2hcdBIVVitamin D3 receptor A/0.451
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.451
3ds6A17Mitogen-activated protein kinase 14/0.451
3gcq1BUMitogen-activated protein kinase 14/0.451
3n0hTOPDihydrofolate reductase1.5.1.30.451
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.451
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.451
4g3jVNTLanosterol 14-alpha-demethylase/0.451
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.451
4n4v2GYTankyrase-12.4.2.300.451
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.451
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.451
3pwhZMAAdenosine receptor A2a/0.451
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.450
2ewaSB2Mitogen-activated protein kinase 14/0.450
2pmdGNPTranslation initiation factor 2 subunit gamma/0.450
2znq401Peroxisome proliferator-activated receptor delta/0.450
3cseN22Uncharacterized protein/0.450
3d78NBBPheromone-binding protein ASP1/0.450
3gdsVAL_TYR_TYR_PHESerine endoprotease DegS3.4.21.1070.450
3lpiZ74Beta-secretase 13.4.23.460.450
3mdmFJZCholesterol 24-hydroxylase/0.450
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.450
4aosNAPSteroid monooxygenase/0.450
4jqh1MFAlr2278 protein/0.450
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.450
5kf8ACOPredicted acetyltransferase/0.450
1aoeGW3Dihydrofolate reductase1.5.1.30.449
1cjkFOKAdenylate cyclase type 2/0.449
1cjkFOKAdenylate cyclase type 5/0.449
1dhiMTXDihydrofolate reductase1.5.1.30.449
1dhjMTXDihydrofolate reductase1.5.1.30.449
1jtuLYBThymidylate synthase/0.449
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.449
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.449
2wpxACOOrf14/0.449
3cz09ODPheromone-binding protein ASP1/0.449
3h1jSMACytochrome b/0.449
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3n5xXFKNitric oxide synthase, brain1.14.13.390.449
3nhpHGZRibosyldihydronicotinamide dehydrogenase [quinone]/0.449
3qpg3QPAspartate aminotransferase2.6.1.10.449
3uteFADUDP-galactopyranose mutase/0.449
4b1fKRHGlutamate racemase/0.449
4ivy1GTEstrogen receptor/0.449
4r21STRCytochrome P450 family 17 polypeptide 2/0.449
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1dnaCB3Thymidylate synthase/0.448
1nyxDRFPeroxisome proliferator-activated receptor gamma/0.448
1og5SWFCytochrome P450 2C9/0.448
1zeoC01Peroxisome proliferator-activated receptor gamma/0.448
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2fhjMFNFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.448
2hbhXE4Vitamin D3 receptor A/0.448
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.448
2xviFADPutative flavin-containing monooxygenase/0.448
2zl9VDAVitamin D3 receptor/0.448
3g5hYTTMycocyclosin synthase1.14.21.90.448
3s1dZIRCytokinin dehydrogenase 11.5.99.120.448
3sp9IL2Peroxisome proliferator-activated receptor delta/0.448
3tmz06XCytochrome P450 2B41.14.14.10.448
3vtbTKAVitamin D3 receptor/0.448
4a83DXCMajor pollen allergen Bet v 1-A/0.448
4dscA8SAbscisic acid receptor PYL3/0.448
4ej1FOLDihydrofolate reductase1.5.1.30.448
4g7gVFVLanosterol 14-alpha-demethylase/0.448
4tuvCPZCytochrome P450 1191.140.448
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.448
1ep4S11Gag-Pol polyprotein2.7.7.490.447
1iyzNDPProbable quinone oxidoreductase/0.447
1rf9DBRCamphor 5-monooxygenase1.14.15.10.447
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.447
2hasC3OVitamin D3 receptor/0.447
2hk9NAPShikimate dehydrogenase (NADP(+))/0.447
2iogIOGEstrogen receptor/0.447
2ph5NADHomospermidine synthase/0.447
3a1l2CCCytochrome P450/0.447
3cd2MTXDihydrofolate reductase1.5.1.30.447
3d76NBBPheromone-binding protein ASP1/0.447
3lalKRVGag-Pol polyprotein2.7.7.490.447
3mqe416Prostaglandin G/H synthase 21.14.99.10.447
3nhrRZWRibosyldihydronicotinamide dehydrogenase [quinone]/0.447
3oqfS51Renin3.4.23.150.447
3p6nDSOCamphor 5-monooxygenase1.14.15.10.447
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
4gueQCTRibosomal protein S6 kinase alpha-32.7.11.10.447
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4hni16WCasein kinase I isoform epsilon2.7.11.10.447
4inb1F6Gag protein/0.447
4ktkKTKCytochrome P450/0.447
4r20AERCytochrome P450 family 17 polypeptide 2/0.447
5bp9SAHPutative methyltransferase protein/0.447
3uzcT4EAdenosine receptor A2a/0.447
1cjuFOKAdenylate cyclase type 2/0.446
1cjuFOKAdenylate cyclase type 5/0.446
1dajMOTDihydrofolate reductase1.5.1.30.446
1fwmCB3Thymidylate synthase/0.446
1ia3TQ5Dihydrofolate reductase1.5.1.30.446
1ly4COQDihydrofolate reductase1.5.1.30.446
1ot7IU5Bile acid receptor/0.446
1s0xC3SNuclear receptor ROR-alpha/0.446
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1yc2NADNAD-dependent protein deacylase 2/0.446
1zaf789Estrogen receptor beta/0.446
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2stdCRPScytalone dehydratase4.2.1.940.446
2tscCB3Thymidylate synthase/0.446
3aosJH2Hemolymph juvenile hormone binding protein/0.446
3bgxMEFThymidylate synthase/0.446
3dolGWIPol protein/0.446
3dyaPZLGag-Pol polyprotein2.7.7.490.446
3lakKR1Gag-Pol polyprotein2.7.7.490.446
3mg3ECHOrange carotenoid-binding protein/0.446
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.446
4bfvZVVPantothenate kinase2.7.1.330.446
4bubADPUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase/0.446
4e6a0O9Mitogen-activated protein kinase 14/0.446
4i9i1DYTankyrase-12.4.2.300.446
5k2bZMAAdenosine receptor A2a/0.446
1jomFFODihydrofolate reductase1.5.1.30.445
1mj3HXCEnoyl-CoA hydratase, mitochondrial4.2.1.170.445
1re7FOLDihydrofolate reductase1.5.1.30.445
1s9qOHTEstrogen-related receptor gamma/0.445
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.445
1tvrTB9Gag-Pol polyprotein2.7.7.490.445
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
1vj3TABDihydrofolate reductase1.5.1.30.445
1xpcAITEstrogen receptor/0.445
2ev9NAPShikimate dehydrogenase (NADP(+))/0.445
2fszOHTEstrogen receptor beta/0.445
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.445
3p6oETGCamphor 5-monooxygenase1.14.15.10.445
3uwlFOZThymidylate synthase/0.445
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
4equG6ISerine/threonine-protein kinase 102.7.11.10.445
4gg70J8Hepatocyte growth factor receptor2.7.10.10.445
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.445
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.445
4q0a4OAVitamin D3 receptor A/0.445
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.445
5fsxADPUncharacterized protein/0.445
1e79ADPATP synthase subunit alpha, mitochondrial/0.444
1e79ADPATP synthase subunit beta, mitochondrial3.6.3.140.444
1ie8KH1Vitamin D3 receptor/0.444
1ie9VDXVitamin D3 receptor/0.444
1l2jETCEstrogen receptor beta/0.444
1mr9ACOStreptogramin A acetyltransferase2.3.10.444
1nhz486Glucocorticoid receptor/0.444
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.444
1sqpMYXCytochrome b/0.444
1wsvTHHAminomethyltransferase, mitochondrial/0.444
1xqcAEJEstrogen receptor/0.444
2j4z626Aurora kinase A2.7.11.10.444
2owb626Serine/threonine-protein kinase PLK12.7.11.210.444
2pogWSTEstrogen receptor/0.444
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.444
2zevB71Geranylgeranyl pyrophosphate synthase/0.444
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3cic316Beta-secretase 13.4.23.460.444
3d90NOGProgesterone receptor/0.444
3e5aVX6Aurora kinase A2.7.11.10.444
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3gwfNAPCyclohexanone monooxygenase/0.444
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.444
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.444
3koo24DBifunctional epoxide hydrolase 23.3.2.100.444
3new3NEMitogen-activated protein kinase 14/0.444
3r7cFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.444
3tk3CPZCytochrome P450 2B41.14.14.10.444
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.444
4c717RD3-oxoacyl-ACP synthase/0.444
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.444
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.444
4i2q1BTGag-Pol polyprotein2.7.7.490.444
4iyg1HUStrictosidine synthase4.3.3.20.444
4zhiADPKinesin-like protein KIF11/0.444
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.444
5k2cZMAAdenosine receptor A2a/0.444
3reyXACAdenosine receptor A2a/0.444
1cjtFOKAdenylate cyclase type 2/0.443
1cjtFOKAdenylate cyclase type 5/0.443
1kziTHGThymidylate synthase/0.443
1m79MQ1Dihydrofolate reductase1.5.1.30.443
1ndeMONEstrogen receptor beta/0.443
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.443
1rdt570Peroxisome proliferator-activated receptor gamma/0.443
1s36CEIObelin/0.443
1sqbAZOCytochrome b/0.443
2bbqPFGThymidylate synthase/0.443
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
2ovmAS0Progesterone receptor/0.443
2piwDHTAndrogen receptor/0.443
2qboCAMCamphor 5-monooxygenase1.14.15.10.443
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.443
2x7hPFNProstaglandin reductase 310.443
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.443
3l70JZVCytochrome b/0.443
3p3zP3ZPutative cytochrome P450/0.443
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3qlhT27Gag-Pol polyprotein2.7.7.490.443
3td8D2RDihydrofolate reductase1.5.1.30.443
3tdaPN0Cytochrome P450 2D6/0.443
3w0aDS5Vitamin D3 receptor/0.443
4at0FADPossible succinate dehydrogenase/0.443
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4do30LAFatty-acid amide hydrolase 13.5.1.990.443
4fhh0U3Vitamin D3 receptor A/0.443
4iq71G9Mycocyclosin synthase1.14.21.90.443
4jnc1LFBifunctional epoxide hydrolase 23.1.3.760.443
4qa0SHHHistone deacetylase 83.5.1.980.443
4xymCOAAcyl-CoA synthetase (NDP forming)/0.443
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.443
5kf9ACOPredicted acetyltransferase/0.443
4uhrNGIAdenosine receptor A2a/0.443
1hniAAAGag-Pol polyprotein2.7.7.490.442
1ia4TQ6Dihydrofolate reductase1.5.1.30.442
1jolFFODihydrofolate reductase1.5.1.30.442
1pp9SMACytochrome b/0.442
2j7yE3OEstrogen receptor beta/0.442
2opsHBQGag-Pol polyprotein2.7.7.490.442
2w4qCBWProstaglandin reductase 21.3.1.480.442
3dgaRJ1Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3mjrAC2Deoxycytidine kinase2.7.1.740.442
3p6pA6BCamphor 5-monooxygenase1.14.15.10.442
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4bfxZVXPantothenate kinase2.7.1.330.442
4djaFAD(6-4) photolyase/0.442
4eiyZMAAdenosine receptor A2a/0.442
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.442
4ok1198Androgen receptor/0.442
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.442
5bmvVLBTubulin alpha-1B chain/0.442
5bmvVLBTubulin beta chain/0.442
5bn3ADPV-type ATP synthase alpha chain/0.442
5bn3ADPNEQ263/0.442
1e1qADPATP synthase subunit beta, mitochondrial3.6.3.140.441
1fm9570Peroxisome proliferator-activated receptor gamma/0.441
1k6tXN1Gag-Pol polyprotein3.4.23.160.441
1m9k7NINitric oxide synthase, endothelial1.14.13.390.441
1mvtDTMDihydrofolate reductase1.5.1.30.441
1n8wCOAMalate synthase G/0.441
1rk3VDXVitamin D3 receptor/0.441
1rx7FOLDihydrofolate reductase1.5.1.30.441
1s9pDESEstrogen-related receptor gamma/0.441
1t85CAMCamphor 5-monooxygenase1.14.15.10.441
1uydPU8Heat shock protein HSP 90-alpha/0.441
1yw9A84Methionine aminopeptidase 2/0.441
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.441
2ban357Gag-Pol polyprotein2.7.7.490.441
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2g44T3OEstrogen receptor/0.441
2mm3CHOGastrotropin/0.441
2wesFADTryptophan 5-halogenase/0.441
2znpK55Peroxisome proliferator-activated receptor delta/0.441
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3d7kD7KBenzaldehyde lyase/0.441
3h3r14HCollagen type IV alpha-3-binding protein/0.441
3ijdC2FMethylenetetrahydrofolate reductase/0.441
3nx4NAPPutative oxidoreductase/0.441
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.441
3rpnGTXGlutathione S-transferase kappa 12.5.1.180.441
3vrwYS5Vitamin D3 receptor/0.441
3zqtTESAndrogen receptor/0.441
4cd2FOLDihydrofolate reductase1.5.1.30.441
4dbs0HVAldo-keto reductase family 1 member C3/0.441
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4i1nFOLDihydrofolate reductase1.5.1.30.441
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.441
4jjiNADAlcohol dehydrogenase class-3/0.441
4ktl1CQCytochrome P450/0.441
4o1mNADEnoyl-acyl carrier reductase/0.441
1cq8PY6Aspartate aminotransferase2.6.1.10.440
1dd6MCIMetallo-beta-lactamase type 2/0.440
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.440
1jtqLY3Thymidylate synthase/0.440
1lwlDSOCamphor 5-monooxygenase1.14.15.10.440
1olmVTQSEC14-like protein 2/0.440
1pq6965Oxysterols receptor LXR-beta/0.440
1u0wSTLChalcone synthase 22.3.1.740.440
1xp6AIUEstrogen receptor/0.440
1yvfPH7Polyprotein/0.440
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.440
2drcMTXDihydrofolate reductase1.5.1.30.440
2g0gSP0Peroxisome proliferator-activated receptor gamma/0.440
2ij7TPFMycocyclosin synthase1.14.21.90.440
2nv7555Estrogen receptor beta/0.440
2pirDHTAndrogen receptor/0.440
2rlcCHDCholoylglycine hydrolase3.5.1.240.440
2w0bCMWLanosterol 14-alpha demethylase1.14.13.700.440
3a3yOBNSodium/potassium-transporting ATPase subunit alpha/0.440
3ezpB3NHistone deacetylase 83.5.1.980.440
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.440
3hv3R49Mitogen-activated protein kinase 14/0.440
3i1fGCPTranslation initiation factor 2 subunit gamma/0.440
3ipq965Oxysterols receptor LXR-alpha/0.440
3l8sBFFMitogen-activated protein kinase 14/0.440
3m7rVDXVitamin D3 receptor/0.440
3vt8YI3Vitamin D3 receptor/0.440
4fhi0S4Vitamin D3 receptor A/0.440
4jx1CAHCamphor 5-monooxygenase1.14.15.10.440
4n4t2GVTankyrase-12.4.2.300.440
4nc3ERM5-hydroxytryptamine receptor 2B/0.440
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.440
6cp4CAMCamphor 5-monooxygenase1.14.15.10.440
6stdMS2Scytalone dehydratase4.2.1.940.440
4z34ON7Lysophosphatidic acid receptor 1/0.440