sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4eh9 | IRG | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 4dli | IRG | Mitogen-activated protein kinase 14 | / | 0.588 | |
| 3hl7 | I46 | Mitogen-activated protein kinase 14 | / | 0.543 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.535 | |
| 4eh6 | IRG | Mitogen-activated protein kinase 14 | / | 0.533 | |
| 4eh3 | IRG | Mitogen-activated protein kinase 14 | / | 0.524 | |
| 4eh4 | IRG | Mitogen-activated protein kinase 14 | / | 0.516 | |
| 3hll | I46 | Mitogen-activated protein kinase 14 | / | 0.512 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.508 | |
| 3roc | 29B | Mitogen-activated protein kinase 14 | / | 0.507 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.507 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.501 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.499 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.497 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.497 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.491 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.489 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.489 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.488 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.487 | |
| 2b0m | 201 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.486 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.486 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.486 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.486 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.484 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.484 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.482 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.482 | |
| 2yis | I46 | Mitogen-activated protein kinase 14 | / | 0.482 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.482 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.481 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.480 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.478 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.478 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.478 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.477 | |
| 1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.476 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.475 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.474 | |
| 1r2j | FAD | FkbI | / | 0.472 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.472 | |
| 3kgc | LY7 | Glutamate receptor 2 | / | 0.472 | |
| 4kfp | 1R7 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.472 | |
| 3w4y | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.471 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.471 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.471 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.471 | |
| 4iwv | 1J9 | Glucokinase | 2.7.1.2 | 0.470 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.469 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.469 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.468 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.468 | |
| 3w0p | ADP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.468 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.468 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.467 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.467 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 1osv | CHC | Bile acid receptor | / | 0.466 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.466 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.466 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.466 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.466 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.466 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.466 | |
| 1fml | RTL | Retinol dehydratase | / | 0.465 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.465 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.465 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.465 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.465 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.464 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.464 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.464 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.464 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4o28 | 1QS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.464 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.464 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.463 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.463 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.463 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.463 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.462 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.462 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.462 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.461 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.461 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.461 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.461 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.461 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.461 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.461 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 3ce3 | 1FN | Hepatocyte growth factor receptor | 2.7.10.1 | 0.460 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.460 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.460 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.460 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.460 | |
| 1err | RAL | Estrogen receptor | / | 0.459 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.459 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.459 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.459 | |
| 2z4z | SC0 | Geranylgeranyl pyrophosphate synthase | / | 0.459 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 4fhi | 0S4 | Vitamin D3 receptor A | / | 0.459 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.459 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.459 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.458 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.458 | |
| 1q4u | 4CA | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.458 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.458 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.458 | |
| 2vr1 | ATF | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.458 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.458 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.458 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.458 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.458 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.457 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.457 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.457 | |
| 4lva | 20M | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.457 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.456 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.456 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.456 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.456 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4ixc | 1JD | Glucokinase | 2.7.1.2 | 0.456 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.456 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.456 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.455 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.455 | |
| 1i8t | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.455 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.455 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.455 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.455 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.455 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 2w6n | OA2 | Biotin carboxylase | 6.3.4.14 | 0.454 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.454 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3zuy | TCH | Transporter | / | 0.454 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.454 | |
| 4nr4 | 2LK | CREB-binding protein | / | 0.454 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.454 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.454 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.453 | |
| 1y4l | SVR | Basic phospholipase A2 homolog 2 | / | 0.453 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.453 | |
| 2itz | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.453 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3nbv | ANP | Ketohexokinase | / | 0.453 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.453 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.453 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.453 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.453 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.452 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.452 | |
| 1gii | 1PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 2w03 | ADN | AcsD | / | 0.452 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.452 | |
| 3owu | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.452 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.452 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.452 | |
| 1d3g | BRE | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.451 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.451 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.451 | |
| 3eej | 53R | Uncharacterized protein | / | 0.451 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3id8 | MRK | Glucokinase | 2.7.1.2 | 0.451 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.451 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.451 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.451 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 4fhp | UTP | Terminal uridylyltransferase cid1 | / | 0.451 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.451 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.450 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.450 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.450 | |
| 2am2 | 2LG | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.450 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.450 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.450 | |
| 2wpx | ACO | Orf14 | / | 0.450 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3l08 | ZIG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.450 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.450 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 4o0s | ADN | Aurora kinase A | 2.7.11.1 | 0.450 | |
| 4xzn | NAP | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.450 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.449 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1eio | GCH | Gastrotropin | / | 0.449 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.449 | |
| 1nde | MON | Estrogen receptor beta | / | 0.449 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.449 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.449 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.449 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.449 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.449 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.449 | |
| 4e37 | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.449 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.449 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.449 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.448 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.448 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.448 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.448 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.448 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.448 | |
| 3mqg | ACO | Lipopolysaccharides biosynthesis acetyltransferase | / | 0.448 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.448 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.448 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.448 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.448 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 4rqv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2zv2 | 609 | Calcium/calmodulin-dependent protein kinase kinase 2 | 2.7.11.17 | 0.447 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.447 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.447 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.447 | |
| 3k3j | I46 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3p3e | 3P3 | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.447 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.447 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4fhh | 0U3 | Vitamin D3 receptor A | / | 0.447 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.447 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.447 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.447 | |
| 5a3c | NAD | SIR2 family protein | / | 0.447 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.447 | |
| 5hyn | SAH | Histone-lysine N-methyltransferase EZH2 | 2.1.1.43 | 0.447 | |
| 1ahi | CHO | 7-alpha-hydroxysteroid dehydrogenase | 1.1.1.159 | 0.446 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.446 | |
| 1ol5 | ADP | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.446 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.446 | |
| 3eek | 53S | Uncharacterized protein | / | 0.446 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.446 | |
| 3qfc | FAD | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 3rnn | RNN | Glutamate receptor 2 | / | 0.446 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.446 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4b1f | KRH | Glutamate racemase | / | 0.446 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.446 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.445 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.445 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.445 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.445 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.445 | |
| 3cy2 | MB9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.445 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.445 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.445 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.445 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.445 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 4ma6 | 28E | Ara h 8 allergen | / | 0.445 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.445 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.445 | |
| 4v12 | POG | MaoC like domain protein | / | 0.445 | |
| 1dub | CAA | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.444 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.444 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.444 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.444 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.444 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.444 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.444 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.444 | |
| 2xvu | 9DN | Serum albumin | / | 0.444 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.444 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.444 | |
| 3qly | 55V | Uncharacterized protein | / | 0.444 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.444 | |
| 4wsq | KSA | AP2-associated protein kinase 1 | 2.7.11.1 | 0.444 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1gij | 2PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1khr | VIR | Streptogramin A acetyltransferase | 2.3.1 | 0.443 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.443 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1pxx | DIF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.443 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.443 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.443 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.443 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.443 | |
| 2v4l | ABJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.443 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.443 | |
| 3gob | HXX | DdmC | / | 0.443 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.443 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.443 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.443 | |
| 4m6p | 20R | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.443 | |
| 4prv | ADP | DNA gyrase subunit B | / | 0.443 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.443 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 1a80 | NDP | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.442 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.442 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 1j4j | ACO | Acetyltransferase | 2.3.1 | 0.442 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.442 | |
| 1zz2 | B11 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2e9d | B76 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 2l84 | J28 | CREB-binding protein | / | 0.442 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 2qdx | FAD | Ferredoxin--NADP+ reductase | / | 0.442 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.442 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.442 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.442 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.442 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.442 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.442 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.442 | |
| 4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.442 | |
| 4oae | CLM | Uncharacterized protein | / | 0.442 | |
| 4oty | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.442 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.441 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.441 | |
| 1ppj | ANY | Cytochrome b | / | 0.441 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.441 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.441 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.441 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.441 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 3cgd | NAD | Coenzyme A disulfide reductase | / | 0.441 | |
| 3f90 | FMN | Flavodoxin | / | 0.441 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.441 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.441 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3r37 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.441 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.441 | |
| 3v2u | ATP | Protein GAL3 | / | 0.441 | |
| 3wxy | COA | Uncharacterized protein | / | 0.441 | |
| 3zsr | O3N | Integrase | / | 0.441 | |
| 3zux | TCH | Transporter | / | 0.441 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4cez | O3N | Integrase | / | 0.441 | |
| 4dij | BLF | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.441 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.441 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.441 | |
| 4l7s | G7K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.441 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.441 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.441 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.441 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 1okz | UCN | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.440 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 2fna | ADP | Uncharacterized protein | / | 0.440 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.440 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.440 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.440 | |
| 2jg7 | NAD | Antiquitin | / | 0.440 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.440 | |
| 2y3s | TIR | TamL | / | 0.440 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.440 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.440 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.440 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.440 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.440 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 4a4w | YFB | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4f9y | GG5 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.440 | |
| 4hnf | 16W | Casein kinase I isoform delta | 2.7.11.1 | 0.440 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 4kfo | 1QS | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.440 | |
| 4oav | ACP | 2-5A-dependent ribonuclease | 3.1.26 | 0.440 | |
| 4zse | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 |