sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Modes are compared using Grim.
For more information, please see the following publication:
Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5g3t | FDA | Flavin-dependent L-tryptophan oxidase VioA |
| PDB ID | HET | Uniprot Name | EC Number | Binding Mode Similarity |
Align |
|---|---|---|---|---|---|
| 5g3t | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 1.482 | |
| 5g3s | FDA | Flavin-dependent L-tryptophan oxidase VioA | / | 1.334 | |
| 2e1m | FAD | L-glutamate oxidase | / | 1.114 | |
| 2yr5 | FAD | Phenylalanine 2-monooxygenase precursor | 1.13.12.9 | 1.100 | |
| 2jae | FAD | L-amino acid oxidase | / | 1.049 | |
| 4fwf | FAD | Lysine-specific histone demethylase 1B | 1 | 1.048 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 1.047 | |
| 2jb2 | FAD | L-amino acid oxidase | / | 1.024 | |
| 3qj4 | FAD | Renalase | / | 1.023 | |
| 2jb1 | FAD | L-amino acid oxidase | / | 1.022 | |
| 2y48 | FAD | Lysine-specific histone demethylase 1A | 1 | 1.013 | |
| 3k7m | FAD | 6-hydroxy-L-nicotine oxidase | / | 1.011 | |
| 3cnt | FAD | Polyamine oxidase FMS1 | / | 1.009 | |
| 2yg4 | FAD | Putrescine oxidase | / | 1.008 | |
| 3cn8 | FAD | Polyamine oxidase FMS1 | / | 0.990 | |
| 4gut | FAD | Lysine-specific histone demethylase 1B | 1 | 0.990 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.988 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.987 | |
| 3bi2 | FAD | Polyamine oxidase FMS1 | / | 0.986 | |
| 4ech | FAD | Polyamine oxidase FMS1 | / | 0.982 | |
| 2yg6 | FAD | Putrescine oxidase | / | 0.974 | |
| 2yg3 | FAD | Putrescine oxidase | / | 0.967 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.965 | |
| 4fwj | FAD | Lysine-specific histone demethylase 1B | 1 | 0.965 | |
| 4gus | FAD | Lysine-specific histone demethylase 1B | 1 | 0.964 | |
| 4i58 | FAD | Cyclohexylamine Oxidase | / | 0.955 | |
| 3kkj | FAD | Renalase | / | 0.940 | |
| 3cnd | FAD | Polyamine oxidase FMS1 | / | 0.936 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.933 | |
| 3rha | FDA | Putrescine oxidase | / | 0.933 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.918 | |
| 2yg7 | FAD | Putrescine oxidase | / | 0.917 | |
| 5l3d | FAD | Lysine-specific histone demethylase 1A | 1 | 0.914 | |
| 2yr4 | FAD | Phenylalanine 2-monooxygenase precursor | 1.13.12.9 | 0.911 | |
| 2iw5 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.907 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.901 | |
| 4guu | FA9 | Lysine-specific histone demethylase 1B | 1 | 0.901 | |
| 3kpf | FAD | Polyamine oxidase | 1.5.3.14 | 0.899 | |
| 4cnk | FAD | L-amino acid oxidase | / | 0.898 | |
| 4gur | FAD | Lysine-specific histone demethylase 1B | 1 | 0.893 | |
| 2bab | FAD | Putative aminooxidase | / | 0.891 | |
| 1h83 | FAD | Polyamine oxidase | 1.5.3.14 | 0.886 | |
| 1yy5 | FAD | Polyamine oxidase FMS1 | / | 0.885 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.883 | |
| 2iid | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.880 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.880 | |
| 3oc4 | FAD | Oxidoreductase, pyridine nucleotide-disulfide family | / | 0.875 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.874 | |
| 2uxx | FAJ | Lysine-specific histone demethylase 1A | 1 | 0.873 | |
| 3nn6 | FB0 | 6-hydroxy-L-nicotine oxidase | / | 0.867 | |
| 1h81 | FAD | Polyamine oxidase | 1.5.3.14 | 0.863 | |
| 2vvl | FAD | Monoamine oxidase N | 1.4.3.4 | 0.863 | |
| 2bac | FAD | Putative aminooxidase | / | 0.861 | |
| 3we0 | FAD | Lysine 2-monooxygenase | / | 0.861 | |
| 1f8s | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.859 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.856 | |
| 4dsg | FAD | Uncharacterized protein | / | 0.854 | |
| 3ish | FAD | Thioredoxin reductase | 1.8.1.9 | 0.853 | |
| 2b9x | FAD | Putative aminooxidase | / | 0.849 | |
| 4hsu | FAD | Lysine-specific histone demethylase 1B | 1 | 0.842 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.840 | |
| 3zdn | FAD | Monoamine oxidase N | 1.4.3.4 | 0.840 | |
| 2bi7 | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.839 | |
| 1f8r | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.834 | |
| 3he3 | FAD | UDP-galactopyranose mutase | / | 0.832 | |
| 3k7t | FAD | 6-hydroxy-L-nicotine oxidase | / | 0.825 | |
| 1z6l | FAD | Polyamine oxidase FMS1 | / | 0.821 | |
| 1xpq | FAD | Polyamine oxidase FMS1 | / | 0.819 | |
| 3ad9 | FAD | Subunit beta of sarcosine oxidase | / | 0.819 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.818 | |
| 3int | FDA | UDP-galactopyranose mutase | 5.4.99.9 | 0.815 | |
| 3nt6 | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.808 | |
| 2gv8 | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.807 | |
| 3lzw | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.805 | |
| 3ntd | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.805 | |
| 4xwz | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.803 | |
| 3cge | FAD | Coenzyme A disulfide reductase | / | 0.802 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.799 | |
| 4u8k | FDA | UDP-galactopyranose mutase | / | 0.799 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.798 | |
| 1sez | FAD | Protoporphyrinogen oxidase, mitochondrial | 1.3.3.4 | 0.796 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.795 | |
| 3lzx | FAD | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.795 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.792 | |
| 2ylt | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.791 | |
| 4b69 | FAD | L-ornithine N(5)-monooxygenase | / | 0.787 | |
| 2ba9 | FAD | Putative aminooxidase | / | 0.785 | |
| 3nta | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.784 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.783 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.782 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.781 | |
| 3ukk | FAD | UDP-galactopyranose mutase | / | 0.781 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.780 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.778 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.778 | |
| 1lqu | FAD | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.777 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.777 | |
| 4dsh | FDA | Uncharacterized protein | / | 0.777 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.777 | |
| 1zk7 | FAD | Mercuric reductase | 1.16.1.1 | 0.776 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.776 | |
| 3cgc | FAD | Coenzyme A disulfide reductase | / | 0.775 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.775 | |
| 3ka7 | FAD | Putative oxidoreductase | / | 0.775 | |
| 4ysh | FAD | Glycine oxidase | / | 0.774 | |
| 2c4c | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.772 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.772 | |
| 1reo | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.771 | |
| 3lov | FAD | Protoporphyrinogen oxidase | / | 0.771 | |
| 3kve | FAD | L-amino-acid oxidase | / | 0.770 | |
| 4rpg | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.769 | |
| 1nhs | FAD | NADH peroxidase | 1.11.1.1 | 0.768 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.768 | |
| 3ukl | FAD | UDP-galactopyranose mutase | / | 0.768 | |
| 4h4r | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.768 | |
| 1nhp | FAD | NADH peroxidase | 1.11.1.1 | 0.763 | |
| 2rgh | FAD | Alpha-Glycerophosphate Oxidase | / | 0.763 | |
| 4gcm | FAD | Thioredoxin reductase | 1.8.1.9 | 0.762 | |
| 4cnj | FAD | L-amino acid oxidase | / | 0.760 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.758 | |
| 4wct | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.758 | |
| 4mo2 | FAD | UDP-galactopyranose mutase | / | 0.757 | |
| 4rsl | FAD | Fructosyl peptide oxidase | / | 0.757 | |
| 1tdk | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.756 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.756 | |
| 3utf | FDA | UDP-galactopyranose mutase | / | 0.756 | |
| 4u8o | FDA | UDP-galactopyranose mutase | / | 0.755 | |
| 1tdn | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.754 | |
| 4h4p | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.754 | |
| 5j60 | FAD | Thioredoxin reductase | / | 0.753 | |
| 3uth | FDA | UDP-galactopyranose mutase | / | 0.752 | |
| 4lii | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.751 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.750 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.750 | |
| 3uka | FAD | UDP-galactopyranose mutase | / | 0.749 | |
| 4cy8 | FDA | 2-hydroxybiphenyl-3-monooxygenase | / | 0.749 | |
| 1e6e | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.748 | |
| 1tde | FAD | Thioredoxin reductase | 1.8.1.9 | 0.748 | |
| 3pvc | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.748 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.748 | |
| 1get | FAD | Glutathione reductase | 1.8.1.7 | 0.746 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.746 | |
| 3awi | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | 1.5 | 0.746 | |
| 3rp8 | FAD | FAD-dependent urate hydroxylase | / | 0.746 | |
| 1nhr | FAD | NADH peroxidase | 1.11.1.1 | 0.743 | |
| 1tdo | FAD | L-amino-acid oxidase | 1.4.3.2 | 0.743 | |
| 2fje | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.743 | |
| 3ab1 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.743 | |
| 4nzh | FAD | L-ornithine N(5)-monooxygenase | / | 0.743 | |
| 2zbw | FAD | Ferredoxin--NADP reductase | / | 0.741 | |
| 3ef6 | FAD | Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component | 1.18.1.3 | 0.741 | |
| 3m12 | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.741 | |
| 1e1l | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.740 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.740 | |
| 2wp5 | FAD | Trypanothione reductase | / | 0.739 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.738 | |
| 4tm1 | FDA | KtzI | / | 0.738 | |
| 3dk8 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.737 | |
| 3dk4 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.736 | |
| 3ukf | FDA | UDP-galactopyranose mutase | / | 0.736 | |
| 1i8t | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.735 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.735 | |
| 3cgb | FAD | Coenzyme A disulfide reductase | / | 0.735 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.735 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.734 | |
| 1joa | FAD | NADH peroxidase | 1.11.1.1 | 0.733 | |
| 1npx | FAD | NADH peroxidase | 1.11.1.1 | 0.733 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.733 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.733 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.731 | |
| 1p1h | NAD | Inositol-3-phosphate synthase | 5.5.1.4 | 0.730 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.730 | |
| 3dgz | FAD | Thioredoxin reductase 2, mitochondrial | 1.8.1.9 | 0.728 | |
| 3dh9 | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.728 | |
| 4j34 | FAD | Kynurenine 3-monooxygenase | / | 0.728 | |
| 4k5r | FAD | Oxygenase | / | 0.728 | |
| 2hqm | FAD | Glutathione reductase | 1.8.1.7 | 0.727 | |
| 3f8d | FAD | NADH oxidase/thioredoxin reductase | / | 0.727 | |
| 4u8l | FDA | UDP-galactopyranose mutase | / | 0.727 | |
| 4wx1 | FDA | UDP-galactopyranose mutase | / | 0.727 | |
| 1mo9 | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.726 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.726 | |
| 2q0l | FAD | Thioredoxin reductase | 1.8.1.9 | 0.726 | |
| 4j33 | FAD | Kynurenine 3-monooxygenase | / | 0.726 | |
| 1gv4 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.725 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.725 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.725 | |
| 4opd | FDA | Conserved Archaeal protein | / | 0.724 | |
| 1ps9 | FAD | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.723 | |
| 3ict | FAD | Coenzyme A disulfide reductase | / | 0.723 | |
| 2nvk | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.722 | |
| 3hdy | FDA | UDP-galactopyranose mutase | / | 0.722 | |
| 3hdy | FAD | UDP-galactopyranose mutase | / | 0.722 | |
| 3mj4 | FAD | UDP-galactopyranose mutase | / | 0.722 | |
| 3sm8 | FNK | FAD-dependent catabolic D-arginine dehydrogenase DauA | / | 0.722 | |
| 1ryi | FAD | Glycine oxidase | 1.4.3.19 | 0.720 | |
| 3m13 | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.720 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.719 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.718 | |
| 4opu | FDA | Conserved Archaeal protein | / | 0.718 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.717 | |
| 4opc | FDA | Conserved Archaeal protein | / | 0.717 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.717 | |
| 1zmc | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.716 | |
| 4u2s | FDA | Cholesterol oxidase | 1.1.3.6 | 0.716 | |
| 3djg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.715 | |
| 3lb8 | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.715 | |
| 4xxg | FAD | Cholesterol oxidase | 1.1.3.6 | 0.715 | |
| 1k0j | FAD | p-hydroxybenzoate hydroxylase | / | 0.714 | |
| 1wam | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.714 | |
| 2gew | FAD | Cholesterol oxidase | 1.1.3.6 | 0.714 | |
| 3cnj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.714 | |
| 3gyi | FAD | Cholesterol oxidase | 1.1.3.6 | 0.714 | |
| 3q9t | FAY | Uncharacterized protein | / | 0.714 | |
| 3rnm | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.714 | |
| 4x4j | FAD | Putative oxygenase | / | 0.714 | |
| 1b4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.713 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.713 | |
| 1ger | FAD | Glutathione reductase | 1.8.1.7 | 0.713 | |
| 4opt | FDA | Conserved Archaeal protein | / | 0.713 | |
| 4tlz | FAD | KtzI | / | 0.713 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.712 | |
| 1jki | NAI | Inositol-3-phosphate synthase | 5.5.1.4 | 0.712 | |
| 2ywl | FAD | Thioredoxin reductase related protein | / | 0.712 | |
| 3ic9 | FAD | Putative dihydrolipoamide dehydrogenase | / | 0.712 | |
| 4nev | FAD | Trypanothione reductase | / | 0.712 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.712 | |
| 1b8s | FAD | Cholesterol oxidase | 1.1.3.6 | 0.711 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.711 | |
| 3cgd | FAD | Coenzyme A disulfide reductase | / | 0.711 | |
| 4x9n | FAD | Uncharacterized protein MG039 homolog | / | 0.711 | |
| 1grb | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.710 | |
| 2cdu | FAD | NADH oxidase | / | 0.710 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.709 | |
| 4gr1 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.709 | |
| 4u8m | FDA | UDP-galactopyranose mutase | / | 0.709 | |
| 4u8p | FDA | UDP-galactopyranose mutase | / | 0.709 | |
| 1grg | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.708 | |
| 1gsn | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.708 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.708 | |
| 3gyj | FAD | Cholesterol oxidase | 1.1.3.6 | 0.708 | |
| 4bk3 | FAD | Probable salicylate monooxygenase | / | 0.708 | |
| 1grh | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.707 | |
| 1k0l | FAD | p-hydroxybenzoate hydroxylase | / | 0.707 | |
| 3ukk | FDA | UDP-galactopyranose mutase | / | 0.707 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.706 | |
| 4mo2 | FDA | UDP-galactopyranose mutase | / | 0.706 | |
| 2wba | FAD | Trypanothione reductase | 1.8.1.12 | 0.705 | |
| 2zth | SAM | Catechol O-methyltransferase | 2.1.1.6 | 0.705 | |
| 4opl | FDA | Conserved Archaeal protein | / | 0.705 | |
| 5br7 | FAD | UDP-galactopyranose mutase | / | 0.705 | |
| 1bwc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.704 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.704 | |
| 2bi8 | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.704 | |
| 4rek | FAD | Cholesterol oxidase | 1.1.3.6 | 0.704 | |
| 1dnc | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.703 | |
| 2c7g | FAD | NADPH-ferredoxin reductase FprA | 1.18.1.2 | 0.703 | |
| 3atq | FDA | Conserved Archaeal protein | / | 0.703 | |
| 3ean | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.703 | |
| 4bk2 | FAD | Probable salicylate monooxygenase | / | 0.703 | |
| 4d04 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.703 | |
| 4j57 | FAD | Thioredoxin reductase 2 | 1.8.1.9 | 0.703 | |
| 1onf | FAD | Glutathione reductase | 1.8.1.7 | 0.702 | |
| 3ept | FDA | Putative FAD-monooxygenase | / | 0.702 | |
| 3v76 | FDA | Uncharacterized protein | / | 0.702 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.702 | |
| 1ges | FAD | Glutathione reductase | 1.8.1.7 | 0.701 | |
| 1geu | FAD | Glutathione reductase | 1.8.1.7 | 0.701 | |
| 1y56 | ATP | Uncharacterized protein | / | 0.701 | |
| 2gqw | FAD | Ferredoxin reductase | / | 0.701 | |
| 2xdo | FAD | TetX family tetracycline inactivation enzyme | / | 0.701 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.701 | |
| 3atr | FDA | Conserved Archaeal protein | / | 0.701 | |
| 3dk9 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.701 | |
| 1gra | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.700 | |
| 1m6i | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.700 | |
| 2q28 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.700 | |
| 3cox | FAD | Cholesterol oxidase | 1.1.3.6 | 0.700 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.700 | |
| 1n4u | FAE | Cholesterol oxidase | 1.1.3.6 | 0.699 | |
| 3lad | FAD | Dihydrolipoyl dehydrogenase | / | 0.699 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.699 | |
| 4a65 | FAD | Thioredoxin reductase | / | 0.699 | |
| 4nec | SAH | Putative SAM-dependent methyltransferase | / | 0.699 | |
| 4pyn | SAH | Catechol O-methyltransferase | 2.1.1.6 | 0.699 | |
| 1cbo | FAD | Cholesterol oxidase | 1.1.3.6 | 0.698 | |
| 1d4c | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.698 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.698 | |
| 4jq9 | FAD | Dihydrolipoyl dehydrogenase | / | 0.698 | |
| 4oa5 | SAH | O-methyltransferase family protein | / | 0.698 | |
| 4u2t | FAD | Cholesterol oxidase | 1.1.3.6 | 0.698 | |
| 2c31 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.697 | |
| 4ymg | SAM | Putative SAM-dependent O-methyltranferase | / | 0.697 | |
| 1fl2 | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.696 | |
| 1tdf | FAD | Thioredoxin reductase | 1.8.1.9 | 0.696 | |
| 2qae | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.696 | |
| 2ylw | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.696 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.696 | |
| 3icr | FAD | Coenzyme A disulfide reductase | / | 0.696 | |
| 3nlc | FAD | Uncharacterized protein | / | 0.696 | |
| 1y56 | FAD | 382aa long hypothetical sarcosine oxidase | / | 0.695 | |
| 4o5q | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.695 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.694 | |
| 3k30 | ADP | Histamine dehydrogenase | / | 0.694 | |
| 1fea | FAD | Trypanothione reductase | 1.8.1.12 | 0.693 | |
| 1gte | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.693 | |
| 4bjz | FAD | Probable salicylate monooxygenase | / | 0.693 | |
| 1d7l | RFL | p-hydroxybenzoate hydroxylase | / | 0.692 | |
| 2c3c | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.692 | |
| 4ykf | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.692 | |
| 1djn | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.691 | |
| 1h2h | NAD | L-aspartate dehydrogenase | 1.4.1.21 | 0.691 | |
| 4h4t | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.691 | |
| 4pyo | SAH | Catechol O-methyltransferase | 2.1.1.6 | 0.691 | |
| 5eow | FAD | 6-hydroxynicotinate 3-monooxygenase | 1.14.13.114 | 0.691 | |
| 1mxt | FAE | Cholesterol oxidase | 1.1.3.6 | 0.690 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.690 | |
| 1w4x | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.690 | |
| 3n1s | 5GP | Purine nucleoside phosphoramidase | / | 0.690 | |
| 4icy | FAD | PgaE | / | 0.690 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.690 | |
| 4tm4 | FDA | KtzI | / | 0.690 | |
| 1c0l | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.689 | |
| 1n4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.689 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.689 | |
| 4ccq | FAD | Thioredoxin reductase | / | 0.689 | |
| 4xwr | FAD | Cholesterol oxidase | 1.1.3.6 | 0.689 | |
| 2qcu | FAD | Aerobic glycerol-3-phosphate dehydrogenase | 1.1.5.3 | 0.688 | |
| 3l8k | ADP | Dihydrolipoamide dehydrogenase (PdhD-3) | / | 0.688 | |
| 5hhf | FDA | UDP-galactopyranose mutase | / | 0.688 | |
| 5i39 | FAD | L-amino acid deaminase | / | 0.688 | |
| 1cl0 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.687 | |
| 1k4q | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.687 | |
| 2yqu | FAD | Dihydrolipoyl dehydrogenase | / | 0.687 | |
| 3duw | SAH | O-methyltransferase, putative | / | 0.687 | |
| 3gsi | FAD | Dimethylglycine oxidase | 1.5.3.10 | 0.687 | |
| 4aox | FAD | Steroid monooxygenase | / | 0.687 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.686 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.686 | |
| 3qfb | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.686 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.686 | |
| 4a5l | FAD | Thioredoxin reductase | / | 0.686 | |
| 1ebd | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.685 | |
| 4cbq | FAD | Thioredoxin reductase | / | 0.685 | |
| 4jnq | FDA | Thioredoxin reductase | / | 0.685 | |
| 5buk | FAD | FADH2-dependent halogenase | / | 0.685 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.685 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.684 | |
| 5hxw | FAD | L-amino acid deaminase | / | 0.684 | |
| 1cjc | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.683 | |
| 2vou | FAD | 2,6-dihydroxypyridine 3-monooxygenase | 1.14.13.10 | 0.683 | |
| 3d64 | NAD | Adenosylhomocysteinase | / | 0.683 | |
| 2whd | FAD | Thioredoxin reductase | / | 0.682 | |
| 3jsk | AHZ | Thiamine thiazole synthase | / | 0.682 | |
| 4fk1 | FAD | Putative thioredoxin reductase | / | 0.682 | |
| 4fx9 | FAD | Coenzyme A disulfide reductase | 1.8.1.14 | 0.682 | |
| 4o5u | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.682 | |
| 2o06 | MTA | Spermidine synthase | 2.5.1.16 | 0.681 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.681 | |
| 4la1 | FAD | Thioredoxin glutathione reductase | / | 0.681 | |
| 4yac | NAI | C alpha-dehydrogenase | / | 0.681 | |
| 1gre | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.680 | |
| 1ijh | FAD | Cholesterol oxidase | 1.1.3.6 | 0.680 | |
| 3sgl | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.680 | |
| 1ng3 | FAD | Glycine oxidase | 1.4.3.19 | 0.679 | |
| 1ng4 | FAD | Glycine oxidase | 1.4.3.19 | 0.679 | |
| 2eq7 | FAD | Dihydrolipoyl dehydrogenase | / | 0.679 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.679 | |
| 4krh | SAM | Phosphoethanolamine N-methyltransferase 2 | / | 0.679 | |
| 1c0k | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.677 | |
| 1djq | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.677 | |
| 1trb | FAD | Thioredoxin reductase | 1.8.1.9 | 0.677 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.677 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.677 | |
| 1fec | FAD | Trypanothione reductase | 1.8.1.12 | 0.676 | |
| 4tm0 | FAD | KtzI | / | 0.676 | |
| 5fs6 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.676 | |
| 2gmj | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.675 | |
| 2x8g | FAD | Thioredoxin glutathione reductase | / | 0.675 | |
| 3b6d | FAE | Cholesterol oxidase | 1.1.3.6 | 0.675 | |
| 4gap | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.675 | |
| 4gde | FDA | UDP-galactopyranose mutase | / | 0.675 | |
| 1nhq | FAD | NADH peroxidase | 1.11.1.1 | 0.674 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.674 | |
| 3sqp | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.674 | |
| 4ykg | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.674 | |
| 1feb | FAD | Trypanothione reductase | 1.8.1.12 | 0.673 | |
| 2eq6 | FAD | Dihydrolipoyl dehydrogenase | / | 0.673 | |
| 4r38 | RBF | Blue-light-activated histidine kinase 2 | 2.7.13.3 | 0.673 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.673 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.672 | |
| 1n1p | FAD | Cholesterol oxidase | 1.1.3.6 | 0.672 | |
| 1n4w | FAD | Cholesterol oxidase | 1.1.3.6 | 0.672 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.672 | |
| 3uj8 | SFG | Phosphoethanolamine N-methyltransferase | / | 0.672 | |
| 4eqs | FAD | Coenzyme A disulfide reductase | / | 0.672 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.671 | |
| 3urh | FAD | Dihydrolipoyl dehydrogenase | / | 0.671 | |
| 4eer | FMN | Phototropin-2 | 2.7.11.1 | 0.671 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.670 | |
| 2npx | FAD | NADH peroxidase | 1.11.1.1 | 0.670 | |
| 4xcx | SAH | Small RNA 2'-O-methyltransferase | / | 0.670 | |
| 3a6q | FMN | FMN-binding protein | / | 0.669 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.669 | |
| 4u2l | SFD | Cholesterol oxidase | 1.1.3.6 | 0.669 | |
| 3grr | SAH | Probable ribosomal RNA small subunit methyltransferase A | / | 0.668 | |
| 3rfx | NAD | Uronate dehydrogenase | / | 0.668 | |
| 4ocg | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.668 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.668 | |
| 1e1m | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.667 | |
| 2bry | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.666 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.666 | |
| 1la2 | NAD | Inositol-3-phosphate synthase | 5.5.1.4 | 0.665 | |
| 2gqf | FAD | Uncharacterized protein HI_0933 | / | 0.665 | |
| 2jib | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.665 | |
| 4up3 | FAD | Thioredoxin reductase | / | 0.665 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.664 | |
| 3grv | ADN | Probable ribosomal RNA small subunit methyltransferase A | / | 0.664 | |
| 4eqr | FAD | Coenzyme A disulfide reductase | / | 0.664 | |
| 4tlx | FDA | KtzI | / | 0.664 | |
| 5ahs | FAD | Acyl-CoA dehydrogenase | / | 0.664 | |
| 1fnd | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.663 | |
| 1lvl | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.663 | |
| 1yqz | FAD | Coenzyme A disulfide reductase | / | 0.663 | |
| 2bra | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.662 | |
| 2cvj | FAD | Thioredoxin reductase related protein | / | 0.661 | |
| 2ji6 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.661 | |
| 3zbt | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.661 | |
| 1cqx | FAD | Flavohemoprotein | / | 0.660 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.660 | |
| 3fbs | FAD | Oxidoreductase | / | 0.660 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.660 | |
| 4c43 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.660 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.660 | |
| 1h7w | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.659 | |
| 1q1w | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.659 | |
| 1sc6 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.659 | |
| 1f3p | FAD | Ferredoxin reductase | / | 0.658 | |
| 2rgj | FAD | Flavin-containing monooxygenase | / | 0.658 | |
| 3oz2 | FAD | Digeranylgeranylglycerophospholipid reductase | / | 0.658 | |
| 4emi | NAD | Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component | 1.18.1.3 | 0.658 | |
| 4jy2 | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.658 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.657 | |
| 1zy8 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.657 | |
| 2du8 | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.657 | |
| 4eo3 | FMN | Bacterioferritin comigratory protein/NADH dehydrogenase | / | 0.657 | |
| 5af7 | FAD | Acyl-CoA dehydrogenase | / | 0.657 | |
| 1zmd | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.656 | |
| 2c3d | FAD | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.656 | |
| 3alj | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.656 | |
| 3if9 | FAD | Glycine oxidase | 1.4.3.19 | 0.656 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.655 | |
| 2q0k | FAD | Thioredoxin reductase | 1.8.1.9 | 0.655 | |
| 3ics | FAD | Coenzyme A disulfide reductase | / | 0.655 | |
| 3uov | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.655 | |
| 4b1b | FAD | Thioredoxin reductase | 1.8.1.9 | 0.655 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.655 | |
| 1gal | FAD | Glucose oxidase | 1.1.3.4 | 0.654 | |
| 1gxf | FAD | Trypanothione reductase | 1.8.1.12 | 0.654 | |
| 2f5z | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.654 | |
| 3qgz | ADN | Histidine triad nucleotide-binding protein 1 | 3 | 0.654 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.654 | |
| 2pr5 | FMN | Blue-light photoreceptor | / | 0.653 | |
| 4gqb | 0XU | Protein arginine N-methyltransferase 5 | / | 0.653 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.652 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.652 | |
| 2rab | FAD | Glutathione amide reductase | / | 0.652 | |
| 3d72 | FAD | Vivid PAS protein VVD | / | 0.652 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.652 | |
| 3uox | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.652 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.652 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.651 | |
| 2fsv | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.651 | |
| 2r0c | FAD | Putative FAD-monooxygenase | / | 0.651 | |
| 3grs | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.651 | |
| 3qvx | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.651 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.651 | |
| 5cku | FAD | L-ornithine N(5)-monooxygenase | / | 0.651 | |
| 1pkv | RBF | Riboflavin synthase | 2.5.1.9 | 0.650 | |
| 1usc | FMN | Monooxygenase | / | 0.650 |