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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3m13 FAD Monomeric sarcosine oxidase 1.5.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 1.585
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 1.571
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 1.534
5i39 FADL-amino acid deaminase / 0.938
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.893
4ysh FADGlycine oxidase / 0.879
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.877
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.874
4rsl FADFructosyl peptide oxidase / 0.862
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.859
3dme FADPutative conserved exported protein / 0.854
1kif FADD-amino-acid oxidase 1.4.3.3 0.851
3axb FADPutative oxidoreductase / 0.844
4opg FDAConserved Archaeal protein / 0.844
5hxw FADL-amino acid deaminase / 0.842
1ryi FADGlycine oxidase 1.4.3.19 0.839
3atq FDAConserved Archaeal protein / 0.836
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.827
3vqr FADPutative oxidoreductase / 0.826
4x9m FADUncharacterized protein MG039 homolog / 0.817
2rgh FADAlpha-Glycerophosphate Oxidase / 0.815
1ng4 FADGlycine oxidase 1.4.3.19 0.802
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.788
3gsi FADDimethylglycine oxidase 1.5.3.10 0.788
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.787
4yjd FADD-amino-acid oxidase 1.4.3.3 0.783
3ad9 FADSubunit beta of sarcosine oxidase / 0.780
4x9n FADUncharacterized protein MG039 homolog / 0.780
1c0k FADD-amino-acid oxidase 1.4.3.3 0.773
4j36 FADKynurenine 3-monooxygenase / 0.773
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.771
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.771
3cuk FADD-amino-acid oxidase 1.4.3.3 0.770
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.769
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.768
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.768
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.767
4kx6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.767
4ynt FDAGlucose oxidase, putative / 0.767
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.766
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.765
3if9 FADGlycine oxidase 1.4.3.19 0.764
2q7v FADThioredoxin reductase / 0.763
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.761
3qvr FADGlucose oxidase 1.1.3.4 0.761
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.759
3kve FADL-amino-acid oxidase / 0.758
1c0l FADD-amino-acid oxidase 1.4.3.3 0.753
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.753
1rsg FADPolyamine oxidase FMS1 / 0.751
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.750
3rp8 FADFAD-dependent urate hydroxylase / 0.749
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.746
5hsa FASAlcohol oxidase 1 1.1.3.13 0.746
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.745
1gal FADGlucose oxidase 1.1.3.4 0.744
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.744
4opi FDAConserved Archaeal protein / 0.744
4j33 FADKynurenine 3-monooxygenase / 0.741
2du8 FADD-amino-acid oxidase 1.4.3.3 0.739
4wct FADFructosyl amine:oxygen oxidoreductase / 0.739
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.738
4u8k FDAUDP-galactopyranose mutase / 0.737
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.734
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.733
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.732
4emw FADCoenzyme A disulfide reductase / 0.732
3cnd FADPolyamine oxidase FMS1 / 0.730
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.730
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.730
5buk FADFADH2-dependent halogenase / 0.730
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.729
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.729
4c3x FAD3-ketosteroid dehydrogenase / 0.727
1zk7 FADMercuric reductase 1.16.1.1 0.725
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.725
3ukk FDAUDP-galactopyranose mutase / 0.725
3uth FDAUDP-galactopyranose mutase / 0.725
2yg7 FADPutrescine oxidase / 0.724
3bi5 FADPolyamine oxidase FMS1 / 0.722
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.721
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.721
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.721
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.721
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.721
1qo8 FADFumarate reductase flavoprotein subunit / 0.720
2gr3 FADFerredoxin reductase / 0.720
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.720
1f8w FADNADH peroxidase 1.11.1.1 0.717
2uxx FAJLysine-specific histone demethylase 1A 1 0.717
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.717
1f8s FADL-amino-acid oxidase 1.4.3.2 0.716
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.716
3icr FADCoenzyme A disulfide reductase / 0.716
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.715
1tdk FADL-amino-acid oxidase 1.4.3.2 0.715
2y48 FADLysine-specific histone demethylase 1A 1 0.715
1z6l FADPolyamine oxidase FMS1 / 0.714
4yac NAIC alpha-dehydrogenase / 0.714
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.713
2eq6 FADDihydrolipoyl dehydrogenase / 0.712
2rgo FADAlpha-Glycerophosphate Oxidase / 0.712
4c3y FAD3-ketosteroid dehydrogenase / 0.711
1d7y FADFerredoxin reductase / 0.710
1knr FADL-aspartate oxidase 1.4.3.16 0.710
4wx1 FDAUDP-galactopyranose mutase / 0.710
2gr0 FADFerredoxin reductase / 0.709
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.709
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.709
3znp FADD-amino-acid oxidase 1.4.3.3 0.709
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.708
1yy5 FADPolyamine oxidase FMS1 / 0.708
3rha FDAPutrescine oxidase / 0.708
4gde FDAUDP-galactopyranose mutase / 0.708
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.708
1d7l RFLp-hydroxybenzoate hydroxylase / 0.707
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.707
3ish FADThioredoxin reductase 1.8.1.9 0.707
3qvp FADGlucose oxidase 1.1.3.4 0.707
4jnq FDAThioredoxin reductase / 0.707
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.706
4x4j FADPutative oxygenase / 0.706
1f3p FADFerredoxin reductase / 0.704
3ics FADCoenzyme A disulfide reductase / 0.704
2iid FADL-amino-acid oxidase 1.4.3.2 0.703
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.703
1gpe FADGlucose oxidase 1.1.3.4 0.701
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.701
1h81 FADPolyamine oxidase 1.5.3.14 0.701
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.701
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.701
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.701
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.701
3ict FADCoenzyme A disulfide reductase / 0.701
4nte FADDepH / 0.701
2bab FADPutative aminooxidase / 0.700
4gut FADLysine-specific histone demethylase 1B 1 0.700
5dbj FADFADH2-dependent halogenase PltA / 0.698
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.697
2iw5 FADLysine-specific histone demethylase 1A 1 0.697
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.697
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.696
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.696
3cn8 FADPolyamine oxidase FMS1 / 0.696
3cnt FADPolyamine oxidase FMS1 / 0.696
3k30 ADPHistamine dehydrogenase / 0.696
4fwe FADLysine-specific histone demethylase 1B 1 0.696
3cgc FADCoenzyme A disulfide reductase / 0.695
3qj4 FADRenalase / 0.695
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.695
1tdo FADL-amino-acid oxidase 1.4.3.2 0.694
2bac FADPutative aminooxidase / 0.694
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.694
2oa1 FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.694
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.694
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.694
4dna FADProbable glutathione reductase / 0.693
1trb FADThioredoxin reductase 1.8.1.9 0.692
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.691
2jb2 FADL-amino acid oxidase / 0.691
4i58 FADCyclohexylamine Oxidase / 0.691
4j2w FADKynurenine 3-monooxygenase / 0.691
1ijh FADCholesterol oxidase 1.1.3.6 0.690
2cdu FADNADH oxidase / 0.690
4u8j FDAUDP-galactopyranose mutase / 0.690
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.689
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.688
1reo FADL-amino-acid oxidase 1.4.3.2 0.687
1ve9 FADD-amino-acid oxidase 1.4.3.3 0.687
2b9x FADPutative aminooxidase / 0.687
2e1m FADL-glutamate oxidase / 0.687
4xbf FADLysine-specific histone demethylase 1A 1 0.687
2b9y FADPutative aminooxidase / 0.686
3lov FADProtoporphyrinogen oxidase / 0.685
4eqs FADCoenzyme A disulfide reductase / 0.685
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.684
1nhp FADNADH peroxidase 1.11.1.1 0.684
2ar8 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.684
2qa2 FADPolyketide oxygenase CabE / 0.684
3atr FDAConserved Archaeal protein / 0.684
4uir FADOleate hydratase 4.2.1.53 0.684
1ng3 FADGlycine oxidase 1.4.3.19 0.683
1tdn FADL-amino-acid oxidase 1.4.3.2 0.683
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.683
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.683
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.683
3mbg FADFAD-linked sulfhydryl oxidase ALR 1.8.3.2 0.683
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.683
4fwf FADLysine-specific histone demethylase 1B 1 0.683
4gus FADLysine-specific histone demethylase 1B 1 0.683
4u8l FDAUDP-galactopyranose mutase / 0.683
2jae FADL-amino acid oxidase / 0.682
1nhq FADNADH peroxidase 1.11.1.1 0.681
1tdf FADThioredoxin reductase 1.8.1.9 0.681
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.681
2jb1 FADL-amino acid oxidase / 0.681
2xvf FADPutative flavin-containing monooxygenase / 0.681
2xvi FADPutative flavin-containing monooxygenase / 0.681
3bi2 FADPolyamine oxidase FMS1 / 0.681
4aox FADSteroid monooxygenase / 0.681
1tde FADThioredoxin reductase 1.8.1.9 0.680
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.680
4opd FDAConserved Archaeal protein / 0.680
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.679
3t37 FADPyridoxine 4-oxidase / 0.679
4hb9 FADUncharacterized protein / 0.679
4opc FDAConserved Archaeal protein / 0.679
3cge FADCoenzyme A disulfide reductase / 0.678
3kpf FADPolyamine oxidase 1.5.3.14 0.678
2x8g FADThioredoxin glutathione reductase / 0.677
4j34 FADKynurenine 3-monooxygenase / 0.677
1f8r FADL-amino-acid oxidase 1.4.3.2 0.676
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.676
4k5r FADOxygenase / 0.676
5l3d FADLysine-specific histone demethylase 1A 1 0.676
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.675
2oal FADFlavin-dependent tryptophan halogenase RebH 1.14.19.9 0.675
2yg3 FADPutrescine oxidase / 0.675
3cty FADProbable thioredoxin reductase / 0.675
4c5o FADPutative monooxygenase / 0.675
4opu FDAConserved Archaeal protein / 0.675
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.674
1nhr FADNADH peroxidase 1.11.1.1 0.674
2igo FADPyranose 2-oxidase / 0.674
2x8h FADThioredoxin glutathione reductase / 0.674
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.674
1npx FADNADH peroxidase 1.11.1.1 0.673
2yg5 FADPutrescine oxidase / 0.673
4ntd FADThioredoxin reductase / 0.673
1knp FADL-aspartate oxidase 1.4.3.16 0.672
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.672
2r9z FADGlutathione amide reductase / 0.672
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.672
2vq7 FADPutative flavin-containing monooxygenase / 0.671
3ept FDAPutative FAD-monooxygenase / 0.671
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.671
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.671
4a99 FADTetX family tetracycline inactivation enzyme / 0.671
4bk2 FADProbable salicylate monooxygenase / 0.671
4u8i FDAUDP-galactopyranose mutase / 0.671
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.671
2yg4 FADPutrescine oxidase / 0.670
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.670
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.670
4opt FDAConserved Archaeal protein / 0.670
2dw4 FADLysine-specific histone demethylase 1A 1 0.669
4k2x FADPolyketide oxygenase/hydroxylase / 0.669
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.668
4j49 NAIUncharacterized protein / 0.668
2yg6 FADPutrescine oxidase / 0.667
3fmw FADOxygenase / 0.667
4mo2 FADUDP-galactopyranose mutase / 0.667
1ger FADGlutathione reductase 1.8.1.7 0.666
1joa FADNADH peroxidase 1.11.1.1 0.666
1xpq FADPolyamine oxidase FMS1 / 0.666
2npx FADNADH peroxidase 1.11.1.1 0.666
2xdo FADTetX family tetracycline inactivation enzyme / 0.666
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.666
3f8d FADNADH oxidase/thioredoxin reductase / 0.665
3hji FADVivid PAS protein VVD / 0.665
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.665
3sfd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.665
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.665
4guv FADTetX family tetracycline inactivation enzyme / 0.665
3utg FDAUDP-galactopyranose mutase / 0.664
5j60 FADThioredoxin reductase / 0.664
2abb FMNPentaerythritol tetranitrate reductase / 0.663
2x3n FADProbable FAD-dependent monooxygenase / 0.663
2pd7 FADVivid PAS protein VVD / 0.662
3cox FADCholesterol oxidase 1.1.3.6 0.662
3fbs FADOxidoreductase / 0.662
3ukk FADUDP-galactopyranose mutase / 0.662
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.662
4mih FADPyranose 2-oxidase 1.1.3.10 0.662
4tm3 FADKtzI / 0.662
1geu FADGlutathione reductase 1.8.1.7 0.661
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.661
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.661
3p8i FMNPentaerythritol tetranitrate reductase / 0.661
3utf FDAUDP-galactopyranose mutase / 0.661
1k0l FADp-hydroxybenzoate hydroxylase / 0.660
3ukl FADUDP-galactopyranose mutase / 0.660
4b68 FADL-ornithine N(5)-monooxygenase / 0.660
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.660
4u8n FDAUDP-galactopyranose mutase / 0.660
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.659
4u8p FDAUDP-galactopyranose mutase / 0.659
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
2eq7 NADDihydrolipoyl dehydrogenase / 0.657
2yqu FADDihydrolipoyl dehydrogenase / 0.657
3jqr FADFerredoxin--NADP reductase, apicoplast / 0.657
3ukf FDAUDP-galactopyranose mutase / 0.657
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.656
2wba FADTrypanothione reductase 1.8.1.12 0.656
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.656
1b4v FADCholesterol oxidase 1.1.3.6 0.655
1get FADGlutathione reductase 1.8.1.7 0.655
1gxf FADTrypanothione reductase 1.8.1.12 0.655
3cgb FADCoenzyme A disulfide reductase / 0.655
4ccq FADThioredoxin reductase / 0.655
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.655
4j57 FADThioredoxin reductase 2 1.8.1.9 0.655
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.655
1mxt FAECholesterol oxidase 1.1.3.6 0.654
2hq9 FADMll6688 protein / 0.654
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.654
2yvf FADFerredoxin reductase / 0.654
3cgd FADCoenzyme A disulfide reductase / 0.654
3e4v FMNUncharacterized protein / 0.654
3hdy FADUDP-galactopyranose mutase / 0.654
4eqw FADCoenzyme A disulfide reductase / 0.654
1ojt FADDihydrolipoyl dehydrogenase / 0.653
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.653
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.653
2e48 FADD-amino-acid oxidase 1.4.3.3 0.652
2o06 MTASpermidine synthase 2.5.1.16 0.652
3awi FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC 1.5 0.652
3g8a SAHRibosomal RNA small subunit methyltransferase G / 0.652
3qvt NAIMyo-inositol-1-phosphate synthase (Ino1) / 0.652
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.651
3k4c FADPyranose 2-oxidase / 0.651
1n9l FMNPutative blue light receptor / 0.650
1vhn FMNtRNA-dihydrouridine synthase / 0.650
4icy FADPgaE / 0.650