Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4cjs | L0Y | Integrase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4cjs | L0Y | Integrase | / | 1.000 | |
| 4cig | X0P | Integrase | / | 0.674 | |
| 4cif | JDX | Integrase | / | 0.671 | |
| 4cgh | LOZ | Integrase | / | 0.649 | |
| 3zsr | O3N | Integrase | / | 0.645 | |
| 4cez | O3N | Integrase | / | 0.645 | |
| 4cfb | OM3 | Integrase | / | 0.613 | |
| 4cjr | FYM | Integrase | / | 0.609 | |
| 4cj5 | 4VW | Integrase | / | 0.602 | |
| 4cf2 | 3GM | Integrase | / | 0.600 | |
| 3zsv | ZSV | Integrase | / | 0.599 | |
| 4ceb | ZSV | Integrase | / | 0.599 | |
| 3zt0 | ZT0 | Integrase | / | 0.597 | |
| 4cef | D0T | Integrase | / | 0.595 | |
| 4cf0 | O5U | Integrase | / | 0.591 | |
| 4ce9 | O3N | Integrase | / | 0.590 | |
| 4ck2 | NVU | Integrase | / | 0.586 | |
| 4cfc | 7NV | Integrase | / | 0.585 | |
| 3zsy | OM3 | Integrase | / | 0.584 | |
| 4cgj | NZL | Integrase | / | 0.584 | |
| 3zsw | ZSW | Integrase | / | 0.581 | |
| 4ced | 9NS | Integrase | / | 0.578 | |
| 4ceo | G0T | Integrase | / | 0.578 | |
| 4ck1 | OM1 | Integrase | / | 0.578 | |
| 4cjf | RVN | Integrase | / | 0.576 | |
| 4cgg | K5Q | Integrase | / | 0.575 | |
| 4cer | VL4 | Integrase | / | 0.574 | |
| 4cf8 | V7H | Integrase | / | 0.574 | |
| 4cgi | NZL | Integrase | / | 0.572 | |
| 4cju | JNS | Integrase | / | 0.569 | |
| 3zsq | O4N | Integrase | / | 0.563 | |
| 4ces | NFW | Integrase | / | 0.563 | |
| 4chy | C5Q | Integrase | / | 0.562 | |
| 4cjp | 4D2 | Integrase | / | 0.562 | |
| 4cea | ZSW | Integrase | / | 0.560 | |
| 4ck3 | K1T | Integrase | / | 0.559 | |
| 4cgd | 8P3 | Integrase | / | 0.558 | |
| 3zsz | OM2 | Integrase | / | 0.557 | |
| 4cj3 | E4F | Integrase | / | 0.557 | |
| 3zcm | PX3 | Integrase | / | 0.556 | |
| 4cie | Y7N | Integrase | / | 0.554 | |
| 4cjq | VXO | Integrase | / | 0.553 | |
| 4cee | B0T | Integrase | / | 0.550 | |
| 4cj4 | S3G | Integrase | / | 0.550 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.548 | |
| 4cfa | WOP | Integrase | / | 0.545 | |
| 3zsx | N44 | Integrase | / | 0.539 | |
| 3zt2 | ZT2 | Integrase | / | 0.539 | |
| 4cjk | H39 | Integrase | / | 0.538 | |
| 3zt3 | ZT4 | Integrase | / | 0.536 | |
| 3zt1 | OM1 | Integrase | / | 0.535 | |
| 4cec | 2SS | Integrase | / | 0.531 | |
| 4cfd | S8Y | Integrase | / | 0.525 | |
| 4ceq | QCH | Integrase | / | 0.518 | |
| 4cje | Q31 | Integrase | / | 0.518 | |
| 1zys | 199 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.497 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.497 | |
| 4cf1 | IY7 | Integrase | / | 0.497 | |
| 4chq | CWU | Integrase | / | 0.489 | |
| 3bht | MFR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.486 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.485 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.484 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.481 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.481 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.479 | |
| 4cgf | UJ6 | Integrase | / | 0.479 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.477 | |
| 1th6 | OIN | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.476 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.476 | |
| 3zdu | 38R | Cyclin-dependent kinase-like 3 | 2.7.11.22 | 0.475 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.474 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.474 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.473 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.472 | |
| 3vf8 | 0JE | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.472 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1qvn | FRI | Interleukin-2 | / | 0.471 | |
| 5fa5 | MTA | Protein arginine N-methyltransferase 5 | / | 0.471 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.470 | |
| 2j62 | GSZ | O-GlcNAcase NagJ | / | 0.469 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.467 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.467 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.467 | |
| 1kqf | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.466 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.466 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.465 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.465 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.463 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.463 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 1ung | ALH | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.462 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.462 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1rx6 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.461 | |
| 3qcq | 3Q0 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.460 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 2bei | ACO | Diamine acetyltransferase 2 | 2.3.1.57 | 0.459 | |
| 3fr8 | NDP | Ketol-acid reductoisomerase, chloroplastic | 1.1.1.86 | 0.459 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.459 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.459 | |
| 3ua3 | SAH | Protein arginine N-methyltransferase 5 | / | 0.459 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 1eio | GCH | Gastrotropin | / | 0.458 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.458 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.458 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.458 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.458 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 3qcs | 3Q1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.458 | |
| 2e9p | 77A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2wip | P49 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.457 | |
| 4de5 | 0JD | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.457 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.457 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.457 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.456 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.456 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.456 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.456 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.455 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.455 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.455 | |
| 4ct1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.455 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.454 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3l1s | Z92 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.454 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.454 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.454 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.454 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.453 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.453 | |
| 2zv2 | 609 | Calcium/calmodulin-dependent protein kinase kinase 2 | 2.7.11.17 | 0.453 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.453 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.453 | |
| 4oae | CLM | Uncharacterized protein | / | 0.453 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 1m2r | MNY | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
| 1ppj | ANY | Cytochrome b | / | 0.452 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.452 | |
| 3a6q | FMN | FMN-binding protein | / | 0.452 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.452 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.452 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.452 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.452 | |
| 4d9t | 0JG | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.452 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.452 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.452 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.451 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.451 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.451 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.451 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.451 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.451 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.451 | |
| 4bdi | HAU | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.451 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.451 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.451 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.451 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4ng2 | OHN | Transcriptional activator protein LasR | / | 0.451 | |
| 5hg0 | SAM | Pantothenate synthetase | / | 0.451 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.450 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.450 | |
| 2imf | TOM | 2-hydroxychromene-2-carboxylate isomerase | 5.99.1.4 | 0.450 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.450 | |
| 2ydj | YDJ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.450 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 3qd0 | 3Q4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.450 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.450 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.450 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.450 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.450 | |
| 1vyw | 292 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.449 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.449 | |
| 4egn | TWO | Cytochrome P450 | / | 0.449 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.449 | |
| 4qo9 | 627 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.449 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 1fml | RTL | Retinol dehydratase | / | 0.448 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.448 | |
| 2oyf | IAC | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.448 | |
| 2pvj | P44 | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.448 | |
| 2xvu | 9DN | Serum albumin | / | 0.448 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.448 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.448 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.448 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.448 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.448 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 4ez3 | 0S0 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.448 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.448 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.448 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.448 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.447 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.447 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 4dkv | 0KW | Envelope glycoprotein gp160 | / | 0.447 | |
| 4iae | 1DX | Alr2278 protein | / | 0.447 | |
| 4j7x | SAS | Sepiapterin reductase | 1.1.1.153 | 0.447 | |
| 4olf | HFG | Proline--tRNA ligase | 6.1.1.15 | 0.447 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.446 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.446 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.446 | |
| 2vuw | 5ID | Serine/threonine-protein kinase haspin | 2.7.11.1 | 0.446 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.446 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.446 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.446 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3mfu | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.446 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3rm7 | 19Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 4fv6 | E57 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.446 | |
| 4mq2 | 2C4 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.446 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.446 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.445 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.445 | |
| 2bjh | FER | Feruloyl esterase A | 3.1.1.73 | 0.445 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2bxm | IMN | Serum albumin | / | 0.445 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 2uv0 | OHN | Transcriptional activator protein LasR | / | 0.445 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.445 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.445 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.445 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.445 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.445 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4gqb | 0XU | Protein arginine N-methyltransferase 5 | / | 0.445 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.445 | |
| 4oac | ADP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.444 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.444 | |
| 1ya3 | STR | Mineralocorticoid receptor | / | 0.444 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.444 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.444 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2dxf | GNP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.444 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 2imp | NAI | Lactaldehyde dehydrogenase | 1.2.1.22 | 0.444 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.444 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.444 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.444 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.444 | |
| 3i1y | 33N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.444 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.444 | |
| 3mfr | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.444 | |
| 3ukr | CKH | Actin-related protein 3 | / | 0.444 | |
| 3ukr | CKH | Actin-related protein 2 | / | 0.444 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.444 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.444 | |
| 4lyw | 21Q | Bromodomain-containing protein 4 | / | 0.444 | |
| 4ozn | ATP | Ammonium transporter | / | 0.444 | |
| 4z28 | BTN | Hoefavidin | / | 0.444 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.444 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.443 | |
| 1skg | VAL_ALA_PHE_ARG_SER | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.443 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.443 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3ows | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.443 | |
| 3pd3 | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.443 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.443 | |
| 4bdb | ODO | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 4mle | VO1 | Glucokinase | 2.7.1.2 | 0.443 | |
| 4ys2 | 2BA | Uncharacterized protein | / | 0.443 | |
| 5egh | PC | Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 | / | 0.443 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1nue | GDP | Nucleoside diphosphate kinase B | 2.7.4.6 | 0.442 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.442 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.442 | |
| 2ohv | NHL | Glutamate racemase | / | 0.442 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.442 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.442 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.442 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4e0h | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.442 | |
| 4i4b | 1CV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.442 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.442 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 5jr3 | 4MU | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.442 | |
| 1g7u | PEP | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.441 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.441 | |
| 2cht | TSA | Chorismate mutase AroH | 5.4.99.5 | 0.441 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.441 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.441 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.441 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.441 | |
| 2xvv | 9DN | Serum albumin | / | 0.441 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.441 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 3g2l | LEW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.441 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.441 | |
| 4bdd | Z0O | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.441 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.441 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.441 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.440 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.440 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.440 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.440 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.440 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.440 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.440 | |
| 2jfz | 003 | Glutamate racemase | / | 0.440 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3a6r | FMN | FMN-binding protein | / | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.440 | |
| 3fuf | BES | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.440 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.440 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.440 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 4apu | OR8 | Progesterone receptor | / | 0.440 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.440 | |
| 4bdf | H3R | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.440 | |
| 4n6b | COA | Uncharacterized protein | / | 0.440 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 | |
| 4pd6 | URI | Nucleoside permease | / | 0.440 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.440 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.440 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.440 | |
| 5c4f | UPG | Histo-blood group ABO system transferase | / | 0.440 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.440 | |
| 5jr3 | SAH | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.440 |