sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 1.000 | |
| 3zc5 | W9Z | Hepatocyte growth factor receptor | 2.7.10.1 | 0.725 | |
| 4ap7 | F47 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.653 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.638 | |
| 4aoi | 4K0 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.607 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.605 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.604 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.601 | |
| 4gg5 | 0J3 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.543 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.525 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.515 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.506 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.506 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.505 | |
| 3hzt | J60 | Calmodulin-like domain protein kinase isoform 3 | / | 0.499 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.487 | |
| 3zbx | 6XE | Hepatocyte growth factor receptor | 2.7.10.1 | 0.486 | |
| 4kb8 | 1QO | Casein kinase I isoform delta | 2.7.11.1 | 0.486 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.485 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.485 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.484 | |
| 2v00 | V15 | Endothiapepsin | 3.4.23.22 | 0.483 | |
| 2uze | C95 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.482 | |
| 3psy | RB9 | Endothiapepsin | 3.4.23.22 | 0.482 | |
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.481 | |
| 4o4e | ATP | Kinase | / | 0.481 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.479 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.477 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.477 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.477 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.476 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.476 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.474 | |
| 3cso | XNI | Genome polyprotein | 2.7.7.48 | 0.473 | |
| 2wkm | PFY | Hepatocyte growth factor receptor | 2.7.10.1 | 0.472 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.472 | |
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.472 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.472 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.471 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.471 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.471 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.470 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.470 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.468 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.468 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.468 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.467 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.467 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.466 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.466 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.466 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.466 | |
| 1c7o | PPG | Hemolysin | / | 0.465 | |
| 2c6t | DT5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 2vag | V25 | Dual specificity protein kinase CLK1 | 2.7.12.1 | 0.465 | |
| 2xiy | XIY | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.465 | |
| 4hw2 | 19H | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.465 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 3bht | MFR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 3rk7 | 08Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 4y3q | F02 | Endothiapepsin | 3.4.23.22 | 0.464 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.463 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.463 | |
| 1y91 | CT9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.463 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 3ofm | 4B0 | Casein kinase II subunit alpha' | 2.7.11.1 | 0.463 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 4iwd | 1JC | Hepatocyte growth factor receptor | 2.7.10.1 | 0.463 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.462 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.462 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.461 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.461 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.460 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.460 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.460 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.460 | |
| 3n0t | OPY | Dipeptidyl peptidase 2 | 3.4.14.2 | 0.460 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.460 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.459 | |
| 2xmy | CDK | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.459 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.459 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.459 | |
| 4nvk | 2NY | Peroxidase | / | 0.459 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.458 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.458 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.458 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3pbz | F02 | Endothiapepsin | 3.4.23.22 | 0.458 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.458 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.458 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.457 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.456 | |
| 2e15 | SAH | Diphthine synthase | / | 0.456 | |
| 2xvu | 9DN | Serum albumin | / | 0.456 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.456 | |
| 3sw4 | 18K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.456 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.456 | |
| 4y9r | FAD | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.455 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.455 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.455 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.455 | |
| 3h0b | B35 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.454 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.454 | |
| 2hvd | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.454 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.454 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.454 | |
| 3kc3 | MK2 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.454 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.454 | |
| 4l8u | 9AZ | Serum albumin | / | 0.454 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 1s0x | C3S | Nuclear receptor ROR-alpha | / | 0.453 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.453 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.453 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3pwm | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.453 | |
| 4y3j | HIC | Endothiapepsin | 3.4.23.22 | 0.453 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 1e81 | M91 | Endothiapepsin | 3.4.23.22 | 0.452 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1mwm | ADP | Plasmid segregation protein ParM | / | 0.452 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.452 | |
| 2p3b | 3TL | V-1 protease | / | 0.452 | |
| 2uzl | C94 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.452 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 3pmu | F7L | Endothiapepsin | 3.4.23.22 | 0.452 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.452 | |
| 4o4f | ATP | Kinase | / | 0.452 | |
| 4y3z | F41 | Endothiapepsin | 3.4.23.22 | 0.452 | |
| 2jjj | 0QS | Endothiapepsin | 3.4.23.22 | 0.451 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.451 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.451 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.451 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.451 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.451 | |
| 4czt | CPS | CBL-interacting serine/threonine-protein kinase 23 | 2.7.11.1 | 0.451 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.451 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.451 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.451 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.451 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.451 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.451 | |
| 5auu | LU2 | Death-associated protein kinase 1 | 2.7.11.1 | 0.451 | |
| 5c8d | 5AD | Probable transcriptional regulator | / | 0.451 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.450 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.450 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 2hut | SAH | Diphthine synthase | / | 0.450 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.450 | |
| 3axw | TID | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 3eku | CY9 | Actin-5C | / | 0.450 | |
| 3kga | LX9 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.450 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.450 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.450 | |
| 1od1 | 0QS | Endothiapepsin | 3.4.23.22 | 0.449 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.449 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1u2g | APR | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.449 | |
| 2euf | LQQ | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.449 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.449 | |
| 2vuw | 5ID | Serine/threonine-protein kinase haspin | 2.7.11.1 | 0.449 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.449 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3le6 | 2BZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4dn5 | AGS | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.449 | |
| 4ix5 | ANP | Uncharacterized protein | / | 0.449 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.449 | |
| 1f8g | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.448 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.448 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.448 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.448 | |
| 2iea | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.448 | |
| 2p2x | SAH | Diphthine synthase | / | 0.448 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.448 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3vuc | HHE | Renin | 3.4.23.15 | 0.448 | |
| 4bwx | AGS | PAB-dependent poly(A)-specific ribonuclease subunit pan3 | / | 0.448 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4ew3 | DXZ | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.448 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.448 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.448 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.448 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.448 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 2owu | SAH | Diphthine synthase | / | 0.447 | |
| 2p5f | SAH | Diphthine synthase | / | 0.447 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.447 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.447 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.447 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.447 | |
| 3py0 | SU9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.447 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.447 | |
| 4ih8 | B43 | Calmodulin-domain protein kinase 1 | / | 0.447 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.447 | |
| 4y4j | LNR | Endothiapepsin | 3.4.23.22 | 0.447 | |
| 1m0b | 0ZQ | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1m76 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1mez | GDP | Adenylosuccinate synthetase isozyme 1 | / | 0.446 | |
| 1r2j | FAD | FkbI | / | 0.446 | |
| 2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.446 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3s1a | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.446 | |
| 3ts1 | TYA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.446 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.446 | |
| 4ek8 | 16K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.446 | |
| 5kjc | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1gvv | 0GM | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 2dsg | SAH | Diphthine synthase | / | 0.445 | |
| 2e8h | SAH | Diphthine synthase | / | 0.445 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.445 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.445 | |
| 3ea4 | FAB | Acetolactate synthase, chloroplastic | 2.2.1.6 | 0.445 | |
| 3i81 | EBI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.445 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.445 | |
| 3pi0 | F91 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.445 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4egn | TWO | Cytochrome P450 | / | 0.445 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.445 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.445 | |
| 4oth | DRN | Serine/threonine-protein kinase N1 | / | 0.445 | |
| 4yek | THM | Thymidine phosphorylase | / | 0.445 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.445 | |
| 5cyo | GDP | Septin-9 | / | 0.445 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.445 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.445 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.445 | |
| 1cjv | DAD | Adenylate cyclase type 2 | / | 0.444 | |
| 1cjv | DAD | Adenylate cyclase type 5 | / | 0.444 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 1p2a | 5BN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.444 | |
| 1sui | FRE | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.444 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 2cjp | VPR | Epoxide hydrolase | / | 0.444 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.444 | |
| 2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.444 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.444 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 3fz1 | B98 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 3prs | RIT | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.444 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4gvj | ADP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.444 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.444 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.444 | |
| 4n1g | CEI | Obelin | / | 0.444 | |
| 4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.444 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.444 | |
| 4tle | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.444 | |
| 1aj2 | 2PH | Dihydropteroate synthase | / | 0.443 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.443 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.443 | |
| 1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.443 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.443 | |
| 1u2d | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.443 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.443 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.443 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.443 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3rk5 | 07Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3sdk | P3N | Proteasome subunit beta type-5 | 3.4.25.1 | 0.443 | |
| 3sdk | P3N | Proteasome subunit beta type-6 | 3.4.25.1 | 0.443 | |
| 3t6i | NC9 | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.443 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4dxd | 9PC | Cell division protein FtsZ | / | 0.443 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4fkw | 62K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.443 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.443 | |
| 4y38 | 0A9 | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 1ppl | 1Z7 | Penicillopepsin-1 | 3.4.23.20 | 0.442 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.442 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.442 | |
| 2el0 | SAH | Diphthine synthase | / | 0.442 | |
| 2oyf | IAC | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.442 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3stx | BKA | Methylketone synthase I | / | 0.442 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.442 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.442 | |
| 4dgm | AGI | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4l8v | NAP | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.442 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 5bmv | VLB | Tubulin alpha-1B chain | / | 0.442 | |
| 5bmv | VLB | Tubulin beta chain | / | 0.442 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.441 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.441 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.441 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.441 | |
| 2c6l | DT4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2ds1 | 1CD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.441 | |
| 2en5 | SAH | Diphthine synthase | / | 0.441 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2qe2 | 452 | Polyprotein | / | 0.441 | |
| 2vgo | AD5 | Aurora kinase B-A | 2.7.11.1 | 0.441 | |
| 2vtt | LZD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2xvv | 9DN | Serum albumin | / | 0.441 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3c4z | ADP | Rhodopsin kinase | / | 0.441 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.441 | |
| 3pd3 | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.441 | |
| 3rk9 | 09Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3rni | 21Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.441 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.441 | |
| 4req | 5AD | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.441 | |
| 4u7w | NDP | MxaA | / | 0.441 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 5hid | B1E | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.440 | |
| 1e82 | M90 | Endothiapepsin | 3.4.23.22 | 0.440 | |
| 1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1pxo | CK7 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1qf4 | RPD | Adenylosuccinate synthetase | / | 0.440 | |
| 2bt4 | CA2 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.440 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2ijg | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.440 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.440 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2vto | LZ8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.440 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.440 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.440 | |
| 3qtx | X43 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.440 | |
| 4b05 | 32D | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4bie | IE6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 4cfa | WOP | Integrase | / | 0.440 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4fg9 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.440 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 4h4t | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.440 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 4tl8 | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.440 | |
| 5bu2 | ADP | Uncharacterized protein | / | 0.440 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 |