sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2yog | 74X | Thymidylate kinase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2yog | 74X | Thymidylate kinase | / | 1.000 | |
| 5e9e | ANP | Myosin heavy chain kinase A | 2.7.11.7 | 0.534 | |
| 3lmh | ADP | Myosin heavy chain kinase A | 2.7.11.7 | 0.532 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.530 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.528 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.525 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.521 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.519 | |
| 2yoh | WMJ | Thymidylate kinase | / | 0.514 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.512 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.512 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.511 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.511 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.507 | |
| 4zs4 | ATP | Myosin heavy chain kinase A | 2.7.11.7 | 0.507 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.506 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.505 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.504 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.504 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.503 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.503 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.503 | |
| 4uog | YYY | Nucleoside diphosphate kinase | / | 0.503 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.502 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.502 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.501 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.501 | |
| 4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.501 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.501 | |
| 3lla | ACP | Myosin heavy chain kinase A | 2.7.11.7 | 0.500 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.499 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.498 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.498 | |
| 4j7h | TRH | PCZA361.3 | / | 0.498 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.497 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.496 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.494 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.494 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.493 | |
| 4a0s | CO8 | Octenoyl-CoA reductase/carboxylase | / | 0.493 | |
| 4zme | ADN | Myosin heavy chain kinase A | 2.7.11.7 | 0.493 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.492 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.492 | |
| 3pdt | ADP | Myosin heavy chain kinase A | 2.7.11.7 | 0.492 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.491 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.490 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.490 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.490 | |
| 1y5w | NEZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.488 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.488 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.486 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.486 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.486 | |
| 5kf2 | COA | Predicted acetyltransferase | / | 0.486 | |
| 2tpl | HPP | Tyrosine phenol-lyase | 4.1.99.2 | 0.485 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.483 | |
| 3ngu | ADP | Nucleoside diphosphate kinase | / | 0.482 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.481 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.480 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.480 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.480 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.480 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.479 | |
| 1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.478 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 4uof | DAT | Nucleoside diphosphate kinase | / | 0.478 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.477 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.476 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.476 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.476 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.475 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.474 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.474 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 4zas | TYD | CalS13 | / | 0.474 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 4ag7 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.473 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.472 | |
| 1rq1 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.472 | |
| 1s4e | ADP | Galactokinase | / | 0.472 | |
| 3gg2 | UGA | Sugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family | / | 0.472 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.472 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.472 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 5ckw | ANP | Uncharacterized protein | / | 0.472 | |
| 1bq1 | CB3 | Thymidylate synthase | / | 0.471 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.471 | |
| 1ih7 | GMP | DNA-directed DNA polymerase | / | 0.470 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.470 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.469 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.469 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 4ovi | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.469 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.468 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.468 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.468 | |
| 4ao4 | PLK | Beta-transaminase | / | 0.468 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.468 | |
| 4uoh | ADP | Nucleoside diphosphate kinase | / | 0.468 | |
| 1clq | GDP | DNA-directed DNA polymerase | / | 0.467 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.466 | |
| 2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 2wpw | ACO | Orf14 | / | 0.466 | |
| 3u3o | 3QV | Sulfotransferase 1A1 | 2.8.2.1 | 0.466 | |
| 4ttj | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.466 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.466 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.465 | |
| 1xp8 | AGS | Protein RecA | / | 0.465 | |
| 3dko | IHZ | Ephrin type-A receptor 7 | 2.7.10.1 | 0.465 | |
| 3pn1 | IVH | DNA ligase | / | 0.465 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.465 | |
| 1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.464 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.464 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.464 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.464 | |
| 3t0k | DCQ | Sulfide-quinone reductase | / | 0.464 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.464 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 4ffr | ATP | Uncharacterized protein | / | 0.464 | |
| 4fkx | CDP | Nucleoside diphosphate kinase | / | 0.464 | |
| 1iah | ADP | Transient receptor potential cation channel subfamily M member 7 | 2.7.11.1 | 0.463 | |
| 1pt8 | ACO | Formyl-CoA:oxalate CoA-transferase | / | 0.463 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.463 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.463 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4j7g | TRH | PCZA361.3 | / | 0.463 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.462 | |
| 2zcq | B65 | Dehydrosqualene synthase | / | 0.462 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.461 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.460 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.459 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4kyk | IMN | Lactoylglutathione lyase | 4.4.1.5 | 0.459 | |
| 3e23 | SAM | Uncharacterized protein | / | 0.458 | |
| 3m31 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.458 | |
| 3tpt | ADP | Serine/threonine-protein kinase toxin HipA | / | 0.458 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.458 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.457 | |
| 1s36 | CEI | Obelin | / | 0.457 | |
| 1u70 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.457 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.457 | |
| 4oma | LCS | Methionine gamma-lyase | / | 0.457 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.457 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.457 | |
| 5kf9 | COA | Predicted acetyltransferase | / | 0.457 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 1z6q | 195 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.456 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.456 | |
| 2gzl | 2AA | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.456 | |
| 2z1x | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4bl5 | GFB | GDP-L-fucose synthase | 1.1.1.271 | 0.456 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.456 | |
| 4z87 | GDP | Inosine-5'-monophosphate dehydrogenase | / | 0.456 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1ozq | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.455 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.455 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.455 | |
| 2wgs | 1AZ | Glutamine synthetase | 6.3.1.2 | 0.455 | |
| 3jwc | EKB | Dihydrofolate reductase | / | 0.455 | |
| 3p9t | TCL | Repressor | / | 0.455 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4cth | RDF | Neprilysin | / | 0.455 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.455 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.455 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.455 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1qk3 | 5GP | Hypoxanthine-guanine-xanthine phosphoribosyltransferase | 2.4.2.22 | 0.454 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.454 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2zf4 | PPY | Uncharacterized protein | / | 0.454 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.454 | |
| 4dkb | DUN | Deoxyuridine triphosphatase, putative | / | 0.454 | |
| 4e32 | DWN | Methyltransferase | / | 0.454 | |
| 4phl | PIL | Phosphodiesterase | / | 0.454 | |
| 1mjt | NAD | Nitric oxide synthase oxygenase | / | 0.453 | |
| 1n2v | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.453 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.453 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.453 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.453 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.453 | |
| 2jcs | TTP | Deoxynucleoside kinase | / | 0.453 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.453 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.453 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.453 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 2c92 | TP6 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 2kce | D16 | Thymidylate synthase | / | 0.452 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.452 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.452 | |
| 4aoa | IK2 | Beta-phenylalanine transaminase | 2.6.1 | 0.452 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.452 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.451 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.451 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.451 | |
| 1zdw | FLV | Prenyltransferase | / | 0.451 | |
| 2w5a | ADP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.451 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.451 | |
| 3dok | GWJ | Pol protein | / | 0.451 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3ptz | UDX | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.451 | |
| 3qh2 | 3NM | Thiazole tautomerase | / | 0.451 | |
| 4ag9 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.451 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.451 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.451 | |
| 5ark | UMP | Ribonuclease 4 | 3.1.27 | 0.451 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.450 | |
| 1g60 | SAM | Modification methylase MboII | 2.1.1.72 | 0.450 | |
| 1kqd | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.450 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.450 | |
| 1waj | 5GP | DNA-directed DNA polymerase | / | 0.450 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.450 | |
| 2d2g | DZZ | Phosphotriesterase | / | 0.450 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.450 | |
| 3ex8 | AIF | Riboflavin biosynthesis protein RibD | 1.1.1.193 | 0.450 | |
| 3hav | ATP | Aminoglycoside phosphotransferase | / | 0.450 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 3qp6 | HL6 | Transcriptional activator, LuxR/UhpA family of regulators | / | 0.450 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 3x0c | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.450 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4tl7 | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.450 | |
| 4tla | ADP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.450 | |
| 5ero | 210 | Fusicoccadiene synthase | 2.5.1.29 | 0.450 | |
| 1dtn | APG | Mandelate racemase | / | 0.449 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.449 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.449 | |
| 2owb | 626 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.449 | |
| 3ept | FDA | Putative FAD-monooxygenase | / | 0.449 | |
| 3gc4 | AAQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.449 | |
| 3zlm | ANP | Adenosine monophosphate-protein transferase NmFic | 2.7.7.n1 | 0.449 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.449 | |
| 4pl9 | ADP | Ethylene receptor 1 | / | 0.449 | |
| 5a2w | AGS | Mitochondrial poly(A) polymerase | / | 0.449 | |
| 1daj | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2c6c | 24I | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.448 | |
| 2qjp | ANJ | Cytochrome b | / | 0.448 | |
| 3akl | ADP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.448 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.448 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.448 | |
| 5dp2 | NAP | CurF | / | 0.448 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qlt | FAD | Vanillyl-alcohol oxidase | 1.1.3.38 | 0.447 | |
| 1t3z | CAO | Formyl-CoA:oxalate CoA-transferase | / | 0.447 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.447 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1zyd | ATP | eIF-2-alpha kinase GCN2 | / | 0.447 | |
| 2bxq | IMN | Serum albumin | / | 0.447 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.447 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.447 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 2r7n | ADP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.447 | |
| 3fu9 | KIB | Laccase-1 | 1.10.3.2 | 0.447 | |
| 4f6v | ZYM | Dehydrosqualene synthase | / | 0.447 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.447 | |
| 5kf8 | ACO | Predicted acetyltransferase | / | 0.447 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 2c9e | PID | Peridinin-chlorophyll a protein, high-salt form | / | 0.446 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
| 2vqj | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.446 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2ykv | IK2 | Beta-transaminase | / | 0.446 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 3ebi | BEY | M1 family aminopeptidase | 3.4.11 | 0.446 | |
| 3glm | COO | Glutaconyl-CoA decarboxylase alpha subunit | / | 0.446 | |
| 3ogw | IMN | Lactoperoxidase | 1.11.1.7 | 0.446 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.446 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 4gqk | ADP | Actin cross-linking toxin VgrG1 | / | 0.446 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4wbd | ADP | Putative cysteine ligase BshC | / | 0.446 | |
| 1dia | L24 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.445 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 1ylu | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.445 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.445 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.445 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.445 | |
| 2vcx | D26 | Hematopoietic prostaglandin D synthase | / | 0.445 | |
| 3dau | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.445 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.445 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.445 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.445 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.445 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.445 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.444 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.444 | |
| 3aq0 | ISY | Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial | 2.5.1.85 | 0.444 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.444 | |
| 3ndj | JHZ | Methyltransferase | / | 0.444 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.444 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.444 | |
| 4lwa | Q13 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.444 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.444 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.444 | |
| 4y6u | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.444 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.443 | |
| 1pnq | NDP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.443 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.443 | |
| 1ysi | N3B | Bcl-2-like protein 1 | / | 0.443 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.443 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.443 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 2yof | 74W | Thymidylate kinase | / | 0.443 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.443 | |
| 3tdk | UPG | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.443 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.443 | |
| 4cs0 | ACO | PanD regulatory factor | / | 0.443 | |
| 4el9 | AFE | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.443 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 4tlc | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.443 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.443 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.442 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.442 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.442 | |
| 2jfz | 003 | Glutamate racemase | / | 0.442 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.442 | |
| 3kzo | AN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.442 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3qp8 | HL0 | Transcriptional activator, LuxR/UhpA family of regulators | / | 0.442 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.442 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4d04 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4fri | DWA | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 1be4 | PCG | Nucleoside diphosphate kinase A 2 | 2.7.4.6 | 0.441 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1vhn | FMN | tRNA-dihydrouridine synthase | / | 0.441 | |
| 1vi0 | DCC | Fatty acid metabolism regulator protein | / | 0.441 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.441 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.441 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2bra | FAD | [F-actin]-methionine sulfoxide oxidase MICAL1 | 1.14.13 | 0.441 | |
| 2e1z | B4P | Propionate kinase | / | 0.441 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2ji7 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.441 | |
| 3l05 | SN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.441 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.441 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.441 | |
| 4b8z | GDP | GDP-L-fucose synthase | 1.1.1.271 | 0.441 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.441 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 4ixd | 1HV | Integrin alpha-L | / | 0.441 | |
| 4nhk | PD2 | Prolyl 3,4-dihydroxylase TPA1 | 1.14.11 | 0.441 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.440 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.440 | |
| 1l0c | COT | Serotonin N-acetyltransferase | / | 0.440 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.440 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3dya | PZL | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.440 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.440 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.440 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.440 |