sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2p98 | YE7 | Methionine aminopeptidase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2p98 | YE7 | Methionine aminopeptidase | / | 1.000 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.752 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.740 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.722 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.696 | |
| 2p99 | YE6 | Methionine aminopeptidase | / | 0.693 | |
| 3d27 | W29 | Methionine aminopeptidase | / | 0.689 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.666 | |
| 1xnz | FCD | Methionine aminopeptidase | / | 0.665 | |
| 2q93 | B21 | Methionine aminopeptidase | / | 0.664 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.659 | |
| 2gg2 | U12 | Methionine aminopeptidase | / | 0.657 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.651 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.649 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.649 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.631 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.624 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.606 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.598 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.597 | |
| 1c23 | MPH | Methionine aminopeptidase | / | 0.594 | |
| 4flj | Y08 | Methionine aminopeptidase 1 | / | 0.587 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.565 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.557 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.557 | |
| 4hxx | 1AY | Methionine aminopeptidase 1 | / | 0.555 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.546 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.543 | |
| 4iku | SHX | Methionine aminopeptidase 1 | / | 0.539 | |
| 3pkc | Y08 | Methionine aminopeptidase 2 | / | 0.530 | |
| 2nq7 | HM5 | Methionine aminopeptidase 1 | / | 0.529 | |
| 3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.528 | |
| 4ikr | PVP | Methionine aminopeptidase 1 | / | 0.523 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.520 | |
| 4fli | Y16 | Methionine aminopeptidase 1 | / | 0.519 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.515 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.512 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.511 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.509 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.501 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.499 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.499 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.499 | |
| 2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.498 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.497 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.497 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.497 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.495 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.491 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.491 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.490 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.489 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.489 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.489 | |
| 3tdv | GDP | Gentamicin resistance protein | / | 0.489 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.487 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.487 | |
| 2vd7 | PD2 | Lysine-specific demethylase 4A | 1.14.11 | 0.485 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.484 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.480 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.480 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.479 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.479 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.479 | |
| 1i9c | 5AD | Glutamate mutase epsilon subunit | / | 0.478 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.478 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.478 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.477 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.476 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.475 | |
| 4drn | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.475 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.474 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 4aws | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.473 | |
| 4dh0 | MR8 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.473 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.472 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.472 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.472 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.472 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.471 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.470 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.470 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.470 | |
| 1yum | NCN | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.469 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.469 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.469 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.469 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.469 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 4d6q | PD2 | Lysine-specific demethylase 4D | 1.14.11 | 0.469 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.468 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.466 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.466 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.466 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.466 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.466 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.465 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 1fkg | SB3 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.462 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.462 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.462 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.462 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.462 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.461 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.461 | |
| 4nv1 | 4TG | Formyl transferase | / | 0.461 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.460 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.460 | |
| 4bb2 | STR | Corticosteroid-binding globulin | / | 0.460 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.460 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.460 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.460 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.459 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1qpf | 858 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.458 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.458 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.458 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.458 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.457 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.457 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.457 | |
| 1a7x | FKA | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.456 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.456 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.456 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.456 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.455 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 1gvr | TNL | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.454 | |
| 2h3w | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.454 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.454 | |
| 3int | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.454 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.454 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.453 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.453 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.453 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3t0i | SAH | Putative methyltransferase | / | 0.453 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 1c9h | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1B | 5.2.1.8 | 0.452 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.452 | |
| 1fkj | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.451 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.451 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.451 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.451 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.451 | |
| 3o5r | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.451 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.451 | |
| 4h2w | 5GP | Amino acid--[acyl-carrier-protein] ligase 1 | 6.2.1.n2 | 0.451 | |
| 4to2 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.451 | |
| 1fkf | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.450 | |
| 1acj | THA | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2jgb | MGT | Eukaryotic translation initiation factor 4E type 2 | / | 0.449 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2xjc | 5GP | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.449 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.448 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.448 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.447 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.447 | |
| 2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.447 | |
| 2dg3 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.447 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.447 | |
| 4bf9 | FMN | tRNA-dihydrouridine(16) synthase | / | 0.447 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.447 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.446 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.446 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.446 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.446 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.446 | |
| 3egk | M18 | Prothrombin | 3.4.21.5 | 0.446 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.446 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.446 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.446 | |
| 5cho | FAD | Flavin reductase | / | 0.446 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.445 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.445 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.445 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.445 | |
| 3dz7 | O8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.445 | |
| 3juo | AJD | Phenazine biosynthesis protein A/B | / | 0.445 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.445 | |
| 4drm | 0MC | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.445 | |
| 4jic | FMN | GTN Reductase | / | 0.445 | |
| 4qfy | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.445 | |
| 1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.444 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.444 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.444 | |
| 2v9c | MRE | FMN-dependent NADH-azoreductase 1 | / | 0.444 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.444 | |
| 4q7f | 3D1 | Uncharacterized protein | / | 0.444 | |
| 5a8a | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.444 | |
| 1bl4 | AP1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.443 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.443 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.443 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.443 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.443 | |
| 4rxr | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.443 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.442 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.442 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.442 | |
| 3q7j | FBO | Tricorn protease-interacting factor F3 | 3.4.11 | 0.442 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.442 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.442 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.441 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.441 | |
| 2gou | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.441 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.441 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.441 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.441 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.441 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4ikz | AFS | Di-tripeptide ABC transporter (Permease) | / | 0.441 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.441 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.440 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.440 | |
| 2wcg | MT5 | Glucosylceramidase | 3.2.1.45 | 0.440 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.440 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.440 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.440 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.440 |