sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1eqa | MG7 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | 2.1.1.57 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1eqa | MG7 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | 2.1.1.57 | 1.000 | |
| 1jsz | NDM | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase | 2.1.1.57 | 0.671 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.509 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.505 | |
| 4c6z | TLE | 3-oxoacyl-ACP synthase | / | 0.498 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.494 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.494 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.494 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.492 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.491 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.489 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.488 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.488 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.488 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.488 | |
| 1ja1 | FAD | NADPH--cytochrome P450 reductase | / | 0.485 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.485 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.484 | |
| 3c1o | NAP | Eugenol synthase | / | 0.483 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.483 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.483 | |
| 2nr4 | FMN | Conserved protein | / | 0.482 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.482 | |
| 2wgg | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.481 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.479 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.479 | |
| 3ihz | FK5 | Peptidylprolyl isomerase | / | 0.479 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.478 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.478 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.477 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.477 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.477 | |
| 3fpk | FAD | Ferredoxin-NADP reductase | / | 0.477 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.476 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.476 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.475 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.475 | |
| 2vkv | TDC | Tetracycline repressor protein class D | / | 0.475 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.475 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.475 | |
| 4nhy | PD2 | Prolyl 3-hydroxylase OGFOD1 | 1.14.11 | 0.475 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.474 | |
| 3hnz | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.474 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.473 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.473 | |
| 2xh9 | J01 | Uncharacterized protein | / | 0.473 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 3g11 | P9C | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.473 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.473 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.473 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.472 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.472 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.472 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.470 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.469 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.469 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.469 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.469 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.468 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.468 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.468 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.467 | |
| 1jmg | UMP | Thymidylate synthase | / | 0.467 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.467 | |
| 1zpt | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.467 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.467 | |
| 1fnc | FDA | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.466 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.466 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.465 | |
| 2wq7 | FAD | RE11660p | / | 0.465 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.465 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.464 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.464 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.464 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.464 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.464 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.463 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.463 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.463 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.463 | |
| 3egk | M18 | Prothrombin | 3.4.21.5 | 0.463 | |
| 3mhp | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.463 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.463 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.463 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4ifn | 12O | Kelch-like ECH-associated protein 1 | / | 0.463 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.462 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.462 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.462 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.462 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 3w5u | FAD | Ferredoxin | / | 0.462 | |
| 4gg1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.462 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 2a4x | BLM | Mitomycin-binding protein | / | 0.461 | |
| 2aqb | TL6 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.461 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.461 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.461 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.461 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.461 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.461 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.461 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.460 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4mpr | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.460 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1gaw | FAD | Ferredoxin | / | 0.459 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 2bn4 | FAD | NADPH--cytochrome P450 reductase | / | 0.459 | |
| 2po3 | T4K | 4-dehydrase | / | 0.459 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.459 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.459 | |
| 1gaq | FAD | Ferredoxin | / | 0.458 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.458 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.458 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 2avx | HTF | Regulatory protein SdiA | / | 0.457 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.457 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.457 | |
| 3t37 | FAD | Pyridoxine 4-oxidase | / | 0.457 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.457 | |
| 4fhp | UTP | Terminal uridylyltransferase cid1 | / | 0.457 | |
| 1amo | FAD | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.456 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.456 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.456 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.456 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.456 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.456 | |
| 1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.455 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.455 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.455 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.455 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.454 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.454 | |
| 5dhg | DGV | Nociceptin receptor | / | 0.454 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.453 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.453 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.453 | |
| 1x27 | ASP_ASP_TYR_VAL_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.453 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.453 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.453 | |
| 2tys | PLT | Tryptophan synthase beta chain | 4.2.1.20 | 0.453 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.453 | |
| 4cgi | NZL | Integrase | / | 0.453 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.453 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.453 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.452 | |
| 1eii | RTL | Retinol-binding protein 2 | / | 0.452 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.452 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.452 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.452 | |
| 2vdv | SAM | tRNA (guanine-N(7)-)-methyltransferase | / | 0.452 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.452 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 3vy2 | FMN | FMN-binding protein | / | 0.452 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.452 | |
| 4fgc | PQ0 | NADPH-dependent 7-cyano-7-deazaguanine reductase | 1.7.1.13 | 0.452 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.452 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.451 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.451 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.451 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.451 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.451 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.451 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.451 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.451 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.451 | |
| 3m53 | SAH | Histone-lysine N-methyltransferase SETD7 | 2.1.1.43 | 0.451 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.451 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
| 4gm4 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 1fdr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.450 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 1ptj | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.450 | |
| 1qgy | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.450 | |
| 2eld | SAH | Diphthine synthase | / | 0.450 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.450 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.450 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.450 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.450 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.450 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 4jv3 | N32 | Beta-ketoacyl synthase | / | 0.450 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.449 | |
| 1aqv | 0HG | Glutathione S-transferase P | 2.5.1.18 | 0.449 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.449 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.449 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.449 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.449 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2zbw | FAD | Ferredoxin--NADP reductase | / | 0.449 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.449 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.449 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.449 | |
| 4nce | MGT | Polymerase basic protein 2 | / | 0.449 | |
| 5bu2 | ADP | Uncharacterized protein | / | 0.449 | |
| 1g7u | PEP | 2-dehydro-3-deoxyphosphooctonate aldolase | 2.5.1.55 | 0.448 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.448 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.448 | |
| 1tll | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.448 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.448 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.448 | |
| 2y05 | RAL | Prostaglandin reductase 1 | / | 0.448 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.448 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.448 | |
| 3wag | TYD | Glycosyltransferase | / | 0.448 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.448 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.448 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1icu | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.447 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.447 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.447 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.447 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.447 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.447 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.447 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.447 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.447 | |
| 3nzp | PLP | Arginine decarboxylase | / | 0.447 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.447 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.447 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 4dkv | 0KW | Envelope glycoprotein gp160 | / | 0.447 | |
| 4yx6 | FMN | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.447 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.447 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1fnd | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.446 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.446 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.446 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2xnc | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.446 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.446 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.446 | |
| 4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.446 | |
| 4n1g | CEI | Obelin | / | 0.446 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.446 | |
| 5cyo | GDP | Septin-9 | / | 0.446 | |
| 5d7q | AR6 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.446 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.445 | |
| 1til | ATP | Anti-sigma F factor | / | 0.445 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.445 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.445 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.445 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.445 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.445 | |
| 2g21 | L1B | Renin | 3.4.23.15 | 0.445 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.445 | |
| 2zi5 | 3L1 | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.445 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.445 | |
| 3w5h | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.445 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4ira | FAD | 4-hydroxyphenylacetate 3-monooxygenase | / | 0.445 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.445 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.445 | |
| 1bx1 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.444 | |
| 1j9z | FAD | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.444 | |
| 1nj5 | P5A | Proline--tRNA ligase | / | 0.444 | |
| 1p7t | ACO | Malate synthase G | / | 0.444 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.444 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 2pnu | ENM | Androgen receptor | / | 0.444 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.444 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.444 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.444 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.444 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.443 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.443 | |
| 1dkf | BMS | Retinoic acid receptor alpha | / | 0.443 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.443 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.443 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.443 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.443 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.443 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 2rku | R78 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.443 | |
| 2yhu | WHF | Pteridine reductase | / | 0.443 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.443 | |
| 3l9n | L9N | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3rgz | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.443 | |
| 3v2u | ATP | Protein GAL3 | / | 0.443 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.443 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.443 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4j7g | TRH | PCZA361.3 | / | 0.443 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.443 | |
| 5jad | FB2 | Platelet-activating factor acetylhydrolase | 3.1.1.47 | 0.443 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.443 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.442 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.442 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2abj | PLP | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.442 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.442 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.442 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.442 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.442 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.442 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1b5t | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.441 | |
| 1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.441 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.441 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.441 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.441 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.441 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.441 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.441 | |
| 4drk | I63 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.441 | |
| 4jbs | P52 | Endoplasmic reticulum aminopeptidase 2 | 3.4.11 | 0.441 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.441 | |
| 4pu2 | PLU | Aminopeptidase N | / | 0.441 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 1ppj | ANY | Cytochrome b | / | 0.440 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.440 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.440 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.440 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 2wp9 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.440 | |
| 2wp9 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.440 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.440 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3jqr | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.440 | |
| 4uxq | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.440 |