sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 1.000 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.775 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.745 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.644 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.595 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.574 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.569 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.553 | |
| 1ysl | COA | Hydroxymethylglutaryl-CoA synthase | 2.3.3.10 | 0.526 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.501 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.499 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.498 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.496 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.493 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.492 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.492 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.491 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.491 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.490 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.489 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.489 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.489 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.489 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.489 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.488 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.488 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.487 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.487 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.485 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.484 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.484 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.483 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.482 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.482 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.481 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.480 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.480 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.479 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.478 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.478 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.478 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.478 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.478 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.477 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.477 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.477 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.476 | |
| 1zdw | FLV | Prenyltransferase | / | 0.476 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.476 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.476 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.475 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.474 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.474 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.474 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.474 | |
| 3ndj | JHZ | Methyltransferase | / | 0.474 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.474 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.474 | |
| 4phl | PIL | Phosphodiesterase | / | 0.474 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.473 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.473 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.473 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.472 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.472 | |
| 2ym2 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.472 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.472 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.472 | |
| 4e32 | DWN | Methyltransferase | / | 0.472 | |
| 4l4x | NDP | AmphI | / | 0.472 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.472 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.471 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.471 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.471 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.471 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.471 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.471 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.471 | |
| 4lis | NAD | UDP-glucose 4-epimerase (Eurofung) | / | 0.471 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.471 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.470 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.470 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.470 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.470 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.470 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.470 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 4kcf | AKM | FAD-dependent oxidoreductase | / | 0.470 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.470 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.469 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.469 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.468 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.468 | |
| 3vqr | FAD | Putative oxidoreductase | / | 0.468 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 2e15 | SAH | Diphthine synthase | / | 0.467 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.467 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.467 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.467 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.466 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.466 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.466 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.466 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.465 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.465 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.465 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.465 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.465 | |
| 2ibw | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.465 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.465 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.465 | |
| 2eeq | SAH | Diphthine synthase | / | 0.464 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.464 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 2vj6 | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.464 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.464 | |
| 3zuy | TCH | Transporter | / | 0.464 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.464 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.464 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.463 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.463 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.463 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.463 | |
| 1o8c | NDP | Probable acrylyl-CoA reductase AcuI | 1.3.1.84 | 0.463 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.463 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.463 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.463 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.463 | |
| 1n4v | FAD | Cholesterol oxidase | 1.1.3.6 | 0.462 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.462 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.462 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.462 | |
| 2p6k | SAH | Diphthine synthase | / | 0.462 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.462 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.462 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.462 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.462 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.461 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.461 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.461 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.461 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.461 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.461 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.460 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.460 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.460 | |
| 2f3f | AXF | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.460 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.460 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.460 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.460 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.460 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.459 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.459 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.459 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.459 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.459 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.459 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.459 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.459 | |
| 4irn | FAD | AnaB | / | 0.459 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.459 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.459 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.458 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.458 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.458 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.458 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.458 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.458 | |
| 5dld | UD1 | UDP-N-Acetylglucosamine 2-epimerase | / | 0.458 | |
| 5hxw | FAD | L-amino acid deaminase | / | 0.458 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.457 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.457 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.457 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.457 | |
| 2dsh | SAH | Diphthine synthase | / | 0.457 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.457 | |
| 2pbw | DOQ | Glutamate receptor ionotropic, kainate 1 | / | 0.457 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.457 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.457 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.457 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.457 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.457 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.457 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.457 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.457 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.457 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.456 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.456 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.456 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.456 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.456 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.456 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.456 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.456 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.456 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.456 | |
| 4jdr | FAD | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.456 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.455 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.455 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.455 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.455 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.455 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.455 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.455 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.455 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.455 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.455 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.455 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.455 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.455 | |
| 3zsx | N44 | Integrase | / | 0.455 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.455 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.455 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.455 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.455 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.454 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.454 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.454 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.454 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.454 | |
| 2z9d | FMN | FMN-dependent NADH-azoreductase | / | 0.454 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.454 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.454 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3up0 | D7S | aceDAF-12 | / | 0.454 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.454 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.454 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.454 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.453 | |
| 1kia | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.453 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.453 | |
| 2owu | SAH | Diphthine synthase | / | 0.453 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 3mj4 | FAD | UDP-galactopyranose mutase | / | 0.453 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.453 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.453 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.453 | |
| 1c7o | PPG | Hemolysin | / | 0.452 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.452 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.452 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.452 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 1wwz | ACO | Uncharacterized protein | / | 0.452 | |
| 2g20 | L1A | Renin | 3.4.23.15 | 0.452 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.452 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.452 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.452 | |
| 2wf2 | ZY2 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2ylx | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.452 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.452 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.452 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.452 | |
| 3pm9 | FAD | Putative oxidoreductase | / | 0.452 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.452 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.452 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.452 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.452 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.451 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.451 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.451 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.451 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.451 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.451 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.451 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.451 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.451 | |
| 3klb | FMN | Uncharacterized protein | / | 0.451 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.451 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.451 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.451 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.451 | |
| 5jyd | NAD | Short chain dehydrogenase | / | 0.451 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.450 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.450 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.450 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 1mv8 | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.450 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.450 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.450 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.450 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.450 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.450 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.450 | |
| 3kmx | G00 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.450 | |
| 3v2u | ATP | Protein GAL3 | / | 0.450 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.450 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.450 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 4u2l | SFD | Cholesterol oxidase | 1.1.3.6 | 0.450 | |
| 1k0j | FAD | p-hydroxybenzoate hydroxylase | / | 0.449 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.449 | |
| 2cdu | FAD | NADH oxidase | / | 0.449 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.449 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.449 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.449 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.449 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 2z6r | SAH | Diphthine synthase | / | 0.449 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.449 | |
| 3ih0 | ANP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.449 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.449 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.449 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.449 | |
| 5e7o | MGD | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.449 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.449 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.448 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.448 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.448 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.448 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.448 | |
| 1ye6 | NAD | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.448 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.448 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.448 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.448 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.448 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.448 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.448 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.448 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.448 | |
| 3eks | CY9 | Actin-5C | / | 0.448 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.448 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.448 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.448 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.448 | |
| 3sgl | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.448 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.448 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.448 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.448 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.448 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.448 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.448 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.448 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.448 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.448 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.448 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.448 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.448 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.447 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.447 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.447 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.447 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.447 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.447 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.447 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.447 | |
| 4blr | UTP | NTPase P4 | / | 0.447 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.447 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.447 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.446 | |
| 1osv | CHC | Bile acid receptor | / | 0.446 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.446 | |
| 2ejz | SAH | Diphthine synthase | / | 0.446 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.446 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.446 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.446 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.446 | |
| 2ylw | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.446 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.446 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.446 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.446 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.446 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.446 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.446 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.446 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.446 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.446 | |
| 5ej7 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.446 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.446 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.445 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.445 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.445 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.445 | |
| 2e77 | FMN | Lactate oxidase | / | 0.445 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.445 | |
| 2ohv | NHL | Glutamate racemase | / | 0.445 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.445 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 3tfy | MET_LEU_GLY_PRO | N-alpha-acetyltransferase 50 | 2.3.1 | 0.445 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.445 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 4ca8 | 3ES | Angiotensin-converting enzyme | 3.4.15.1 | 0.445 | |
| 4d04 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.445 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.445 | |
| 4ttj | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.445 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.445 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.445 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 1ppj | ANY | Cytochrome b | / | 0.444 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.444 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.444 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.444 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.444 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 2dxw | SAH | Diphthine synthase | / | 0.444 | |
| 2egl | SAH | Diphthine synthase | / | 0.444 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2p2x | SAH | Diphthine synthase | / | 0.444 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.444 | |
| 2vce | U2F | UDP-glycosyltransferase 72B1 | / | 0.444 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2xvh | FAD | Putative flavin-containing monooxygenase | / | 0.444 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.444 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.444 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.444 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.444 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.444 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.444 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.444 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4p5a | FAD | Flavin-dependent thymidylate synthase | / | 0.444 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.444 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.444 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.444 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.443 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.443 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.443 | |
| 1vf3 | GDN | Glutathione S-transferase 3 | 2.5.1.18 | 0.443 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.443 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.443 | |
| 2dxv | SAH | Diphthine synthase | / | 0.443 | |
| 2fiw | ACO | GCN5-related N-acetyltransferase:Aminotransferase, class-II | / | 0.443 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.443 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.443 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.443 | |
| 3cis | ATP | Universal stress protein Rv2623 | / | 0.443 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.443 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.443 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.443 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.443 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.443 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.443 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.443 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4ng5 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 4tlx | FDA | KtzI | / | 0.443 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.443 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.443 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.442 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.442 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.442 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.442 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.442 | |
| 2dv5 | SAH | Diphthine synthase | / | 0.442 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.442 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.442 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 2g94 | ZPQ | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 2qo6 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.442 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.442 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.442 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.442 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.442 | |
| 4i8q | NAD | Putative betaine aldehyde dehyrogenase | / | 0.442 | |
| 4jxr | ACO | Acetyltransferase | / | 0.442 | |
| 4n6b | COA | Uncharacterized protein | / | 0.442 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.442 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.442 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.441 | |
| 1h6d | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.441 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.441 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.441 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.441 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.441 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.441 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.441 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.441 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 2hay | FMN | Putative NAD(P)H-flavin oxidoreductase | / | 0.441 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.441 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.441 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.441 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 2oah | QIN | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2p6l | SAH | Diphthine synthase | / | 0.441 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2x92 | X92 | Angiotensin-converting enzyme | 3.4.15.1 | 0.441 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.441 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3b04 | OOP | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.441 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.441 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.441 | |
| 3r1k | COA | N-acetyltransferase Eis | / | 0.441 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.441 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.441 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.441 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.441 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4e2b | FMN | Dehydrogenase | / | 0.441 | |
| 4e4q | RRH | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.441 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.441 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4jwp | ACO | GCN5-related N-acetyltransferase | / | 0.441 | |
| 4k9p | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
| 4lj6 | ACP | Chaperone protein ClpB | / | 0.441 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.441 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.441 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.441 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.441 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.440 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.440 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.440 | |
| 1m4i | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.440 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.440 | |
| 1tj2 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.440 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.440 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.440 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2e8s | SAH | Diphthine synthase | / | 0.440 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.440 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 2p5n | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.440 | |
| 2zu8 | GDD | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.440 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.440 | |
| 3csj | CBL | Glutathione S-transferase P | 2.5.1.18 | 0.440 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
| 3mkh | FAD | Nitroalkane oxidase | / | 0.440 | |
| 3mzh | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.440 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.440 | |
| 3vx4 | ATP | Putative ABC transporter, ATP-binding protein ComA | / | 0.440 | |
| 3w8w | FAD | Putative FAD-dependent oxygenase EncM | / | 0.440 | |
| 4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.440 | |
| 4fkz | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.440 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.440 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.440 | |
| 4ol0 | GTP | GTP-binding nuclear protein Ran | / | 0.440 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.440 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.440 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.440 |