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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3qri919Tyrosine-protein kinase ABL12.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3qri919Tyrosine-protein kinase ABL12.7.10.21.000
2ofv242Tyrosine-protein kinase Lck2.7.10.20.567
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.562
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.559
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.558
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.558
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.547
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.546
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.545
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.540
4twnB96Ephrin type-A receptor 32.7.10.10.538
2hziJINTyrosine-protein kinase ABL12.7.10.20.536
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.534
1m52P17Tyrosine-protein kinase ABL12.7.10.20.531
1obnASVIsopenicillin N synthase1.21.3.10.523
4tyj0LIFibroblast growth factor receptor 42.7.10.10.522
2y6fM9FIsopenicillin N synthase1.21.3.10.521
4uxq0LIFibroblast growth factor receptor 42.7.10.10.519
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.518
2of2547Tyrosine-protein kinase Lck2.7.10.20.515
2vbdV10Isopenicillin N synthase1.21.3.10.513
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.510
4equG6ISerine/threonine-protein kinase 102.7.11.10.509
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.505
2vcmM11Isopenicillin N synthase1.21.3.10.505
3zkyWT4Isopenicillin N synthase1.21.3.10.505
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.504
3zoiM2WIsopenicillin N synthase1.21.3.10.504
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.503
2vbpVB1Isopenicillin N synthase1.21.3.10.503
3d7zGK5Mitogen-activated protein kinase 14/0.502
1bk0ACVIsopenicillin N synthase1.21.3.10.501
5iu86DZAdenosine receptor A2a/0.501
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.500
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.500
1blzACVIsopenicillin N synthase1.21.3.10.498
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.498
4phlPILPhosphodiesterase/0.497
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.496
3ol5SAWCamphor 5-monooxygenase1.14.15.10.495
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.495
4fnyI3KALK tyrosine kinase receptor2.7.10.10.495
2hk51BMTyrosine-protein kinase HCK2.7.10.20.494
5kf8ACOPredicted acetyltransferase/0.494
2iviACWIsopenicillin N synthase1.21.3.10.493
4bb3KKAIsopenicillin N synthase1.21.3.10.493
4qrc0LIFibroblast growth factor receptor 42.7.10.10.493
3ac2KSETyrosine-protein kinase Lck2.7.10.20.492
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.492
4hvs647Mast/stem cell growth factor receptor Kit2.7.10.10.492
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.491
1trgCB3Thymidylate synthase/0.490
1w06W05Isopenicillin N synthase1.21.3.10.490
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.490
1uzwCDHIsopenicillin N synthase1.21.3.10.489
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.488
2ydoADNAdenosine receptor A2a/0.486
3biz61EWee1-like protein kinase2.7.10.20.486
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.485
2y60M8FIsopenicillin N synthase1.21.3.10.485
3cr0809Wee1-like protein kinase2.7.10.20.485
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.484
4ambDUDPutative glycosyl transferase/0.484
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.484
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.484
1hb1OCVIsopenicillin N synthase1.21.3.10.483
1oc1ASVIsopenicillin N synthase1.21.3.10.483
1pq944BOxysterols receptor LXR-beta/0.483
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.482
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.481
3e5aVX6Aurora kinase A2.7.11.10.481
1cg6MTAS-methyl-5'-thioadenosine phosphorylase/0.480
2e0nSAHPrecorrin-2 C20-methyltransferase/0.480
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.480
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.479
1jx0DFVChalcone--flavonone isomerase 15.5.1.60.478
2bu9HFVIsopenicillin N synthase1.21.3.10.478
2jb4A14Isopenicillin N synthase1.21.3.10.478
2qu5276Vascular endothelial growth factor receptor 22.7.10.10.478
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.478
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.477
2oscMUHAngiopoietin-1 receptor2.7.10.10.477
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.477
3v94WYQPhosphodiesterase/0.477
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.476
1x8b824Wee1-like protein kinase2.7.10.20.476
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.476
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.476
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.476
2z3uCRRCytochrome P450/0.476
2vxkCOAGlucosamine 6-phosphate acetyltransferase, putative/0.475
3ac1KZITyrosine-protein kinase Lck2.7.10.20.475
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.475
3ds6A17Mitogen-activated protein kinase 14/0.475
3lfeZ84Mitogen-activated protein kinase 14/0.475
3q3cNADNAD-dependent L-serine dehydrogenase/0.475
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.475
4bfpSWYTankyrase-22.4.2.300.475
4u2lSFDCholesterol oxidase1.1.3.60.475
1mvsDTMDihydrofolate reductase1.5.1.30.474
2of4979Tyrosine-protein kinase Lck2.7.10.20.474
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.474
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.474
2y6o1N1Ephrin type-A receptor 42.7.10.10.474
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.474
5g53NECAdenosine receptor A2a/0.474
1bucFADAcyl-CoA dehydrogenase, short-chain specific1.3.8.10.473
3e92G6AMitogen-activated protein kinase 14/0.473
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.473
4ubvCOASteroid 3-ketoacyl-CoA thiolase/0.473
2vwx7X4Ephrin type-B receptor 42.7.10.10.472
3pg3DG7Mitogen-activated protein kinase 14/0.472
1d6w00RProthrombin3.4.21.50.471
1dr3HBIDihydrofolate reductase1.5.1.30.471
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
1qjfACSIsopenicillin N synthase1.21.3.10.471
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.471
3cth319Hepatocyte growth factor receptor2.7.10.10.471
3g0eB49Mast/stem cell growth factor receptor Kit2.7.10.10.471
3hv3R49Mitogen-activated protein kinase 14/0.471
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.471
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.471
3emlZMAAdenosine receptor A2a/0.471
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.470
2ydvNECAdenosine receptor A2a/0.470
3f82353Hepatocyte growth factor receptor2.7.10.10.470
3hx4ANPCalmodulin-domain protein kinase 1/0.470
3njoP2MAbscisic acid receptor PYR1/0.470
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.470
1pqc444Oxysterols receptor LXR-beta/0.469
4lb2DM5Serum albumin/0.469
5iubCLRAdenosine receptor A2a/0.469
2z2w770Wee1-like protein kinase2.7.10.20.468
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.468
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
3mcyZH1FimH/0.468
4c77N01Phenylacetone monooxygenase1.14.13.920.468
4twpAXITyrosine-protein kinase ABL12.7.10.20.468
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.468
2b03TUDPhospholipase A2, major isoenzyme3.1.1.40.467
3aw9NADNAD-dependent epimerase/dehydratase/0.467
3eigMTXDihydrofolate reductase1.5.1.30.467
3r5yF42Uncharacterized protein/0.467
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.467
4dvi2IWTankyrase-12.4.2.300.467
4riyADPEpidermal growth factor receptor2.7.10.10.467
5emhNAPIridoid synthase1.3.1.990.467
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.466
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.466
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.466
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4b4w9L9Bifunctional protein FolD/0.466
4q0kGA3Phytohormone-binding protein/0.466
1hb3SCVIsopenicillin N synthase1.21.3.10.465
2dhfDZFDihydrofolate reductase1.5.1.30.465
2in6839Wee1-like protein kinase2.7.10.20.465
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.465
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.465
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.465
3p6oETGCamphor 5-monooxygenase1.14.15.10.465
3rsv3RSBeta-secretase 13.4.23.460.465
4eh8IRGMitogen-activated protein kinase 14/0.465
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.464
3p6nDSOCamphor 5-monooxygenase1.14.15.10.464
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.464
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.464
4n3l2FNProthrombin3.4.21.50.464
5iu4ZMAAdenosine receptor A2a/0.464
1pd9CO4Dihydrofolate reductase1.5.1.30.463
1qiqACCIsopenicillin N synthase1.21.3.10.463
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.463
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
3gyiFADCholesterol oxidase1.1.3.60.463
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.463
3tdaPN0Cytochrome P450 2D6/0.463
4agcAXIVascular endothelial growth factor receptor 22.7.10.10.463
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.463
1bx9GLY_GGL_FOEGlutathione S-transferase F22.5.1.180.462
1kqgMGDFormate dehydrogenase, nitrate-inducible, major subunit1.1.5.60.462
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.462
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
3cqeP91Wee1-like protein kinase2.7.10.20.462
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3p9tTCLRepressor/0.462
3r95ACOMccE protein/0.462
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.462
4xg1LLPDiaminopimelate decarboxylase/0.462
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.462
5dbfNDPIridoid synthase1.3.1.990.462
1a8t061Metallo-beta-lactamase type 2/0.461
1jtuLYBThymidylate synthase/0.461
1kruIPTGalactoside O-acetyltransferase2.3.1.180.461
2bakAQZMitogen-activated protein kinase 14/0.461
2i0v6C3Macrophage colony-stimulating factor 1 receptor2.7.10.10.461
2io6330Wee1-like protein kinase2.7.10.20.461
2yn8STUEphrin type-B receptor 42.7.10.10.461
3bi6396Wee1-like protein kinase2.7.10.20.461
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.461
4a9yAQZMitogen-activated protein kinase 14/0.461
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
4gk2L66Ephrin type-A receptor 32.7.10.10.461
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.461
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.461
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.460
2wo7ASVIsopenicillin N synthase1.21.3.10.460
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
2dvlFADAcyl-CoA dehydrogenase/0.459
2vmyFFOSerine hydroxymethyltransferase/0.459
3eksCY9Actin-5C/0.459
3itzP66Mitogen-activated protein kinase 14/0.459
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.459
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.459
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.459
4o701QKBromodomain-containing protein 4/0.459
5kgjACOPredicted acetyltransferase/0.459
1cf3FADGlucose oxidase1.1.3.40.458
1i6xCMPcAMP-activated global transcriptional regulator CRP/0.458
1uhlMEIRetinoic acid receptor RXR-beta/0.458
1v2hGUNPurine nucleoside phosphorylase2.4.2.10.458
2abjCBCBranched-chain-amino-acid aminotransferase, cytosolic2.6.1.420.458
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.458
2ejzSAHDiphthine synthase/0.458
2vww7X2Ephrin type-B receptor 42.7.10.10.458
3c1kT15Prothrombin3.4.21.50.458
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4ag8AXIVascular endothelial growth factor receptor 22.7.10.10.458
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.458
1drfFOLDihydrofolate reductase1.5.1.30.457
1gqyACPUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.457
1l0lFMXCytochrome b/0.457
1m17AQ4Epidermal growth factor receptor2.7.10.10.457
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.457
2q0gUPUPoly(A) polymerase, putative/0.457
2vx17X8Ephrin type-B receptor 42.7.10.10.457
2xviFADPutative flavin-containing monooxygenase/0.457
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.457
3a1l2CCCytochrome P450/0.457
3fhxPXLPyridoxal kinase2.7.1.350.457
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3ox4NADAlcohol dehydrogenase 21.1.1.10.457
4jlk1NODeoxycytidine kinase2.7.1.740.457
4prxADPDNA gyrase subunit B/0.457
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.457
1fgiSU1Fibroblast growth factor receptor 1/0.456
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.456
1s7nCOAAcetyl transferase/0.456
2fzwNADAlcohol dehydrogenase class-31.1.1.10.456
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.456
2ji9ADPOxalyl-CoA decarboxylase4.1.1.80.456
2r2mI50Prothrombin3.4.21.50.456
2wdzNADGalactitol dehydrogenase/0.456
3gkiCLRNiemann-Pick C1 protein/0.456
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.456
3qm4PN0Cytochrome P450 2D6/0.456
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.456
4x7vMIVMycinamicin III 3''-O-methyltransferase2.1.1.2370.456
1kceCB3Thymidylate synthase/0.455
2e48FADD-amino-acid oxidase1.4.3.30.455
2idkC2FGlycine N-methyltransferase2.1.1.200.455
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.455
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.455
4kxn6K62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.455
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.454
1y6qTDI5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase3.2.2.90.454
2c0cNAPProstaglandin reductase 310.454
2itnANPEpidermal growth factor receptor2.7.10.10.454
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
2r0pK2CPutative FAD-monooxygenase/0.454
2vwz7X6Ephrin type-B receptor 42.7.10.10.454
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3jynNDPQuinone oxidoreductase/0.454
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.454
3qwbNDPProbable quinone oxidoreductase1.6.5.50.454
3rix923Luciferin 4-monooxygenase1.13.12.70.454
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.454
4b5oACOAlpha-tubulin N-acetyltransferase 1/0.454
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.454
4e2yJHZMethyltransferase/0.454
5a2yUTPMitochondrial poly(A) polymerase/0.454
5dbgNADIridoid synthase1.3.1.990.454
1cboFADCholesterol oxidase1.1.3.60.453
1i5zCMPcAMP-activated global transcriptional regulator CRP/0.453
1t0iFMNNAD(P)H-dependent FMN reductase LOT6/0.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.453
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.453
2q1wNADPutative nucleotide sugar epimerase/ dehydratase/0.453
2uuk897Prothrombin3.4.21.50.453
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
3il1B5DGlutamate receptor 2/0.453
4fhd0TTSpore photoproduct lyase/0.453
4j6cSTRCytochrome P450 monooxygenase/0.453
1s7lCOAAcetyl transferase/0.452
1srjNABStreptavidin/0.452
1yhjR6CPyridoxal kinase2.7.1.350.452
2dw4FADLysine-specific histone demethylase 1A10.452
3w78CBDFMN-dependent NADH-azoreductase/0.452
3zkuHCVIsopenicillin N synthase1.21.3.10.452
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.452
4h6zACOAlpha-tubulin N-acetyltransferase 1/0.452
4v12POGMaoC like domain protein/0.452
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
4y0kNAPAntE/0.452
5dozNDPJamJ/0.452
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.451
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.451
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.451
2pg0FADAcyl-CoA dehydrogenase/0.451
2pl0STITyrosine-protein kinase Lck2.7.10.20.451
2stdCRPScytalone dehydratase4.2.1.940.451
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.451
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.451
3w0c6DSVitamin D3 receptor/0.451
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.451
4j6bPLOCytochrome P450 monooxygenase/0.451
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.451
1swdBTNStreptavidin/0.450
1t4v14AProthrombin3.4.21.50.450
2anmCDOProthrombin3.4.21.50.450
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.450
2xw7NDPDihydrofolate reductase/0.450
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3oqfS51Renin3.4.23.150.450
3w2cN15Aurora kinase A2.7.11.10.450
4b4vL34Bifunctional protein FolD/0.450
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
4h8004TAldehyde dehydrogenase, dimeric NADP-preferring/0.450
4i09CMPcAMP-activated global transcriptional regulator CRP/0.450
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.450
4k4fK4FTankyrase-12.4.2.300.450
4kwhNAPReductase homolog/0.450
5epoTUD7-alpha-hydroxysteroid deydrogenase/0.450
1d3pBT3Prothrombin3.4.21.50.449
1jpaANPEphrin type-B receptor 22.7.10.10.449
1k27MTMS-methyl-5'-thioadenosine phosphorylase/0.449
1mg5NAIAlcohol dehydrogenase1.1.1.10.449
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.449
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.449
1swtBTNStreptavidin/0.449
1zdwFLVPrenyltransferase/0.449
2jibADPOxalyl-CoA decarboxylase4.1.1.80.449
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.449
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.449
3cobADPKinesin heavy chain-like protein/0.449
3nx4NAPPutative oxidoreductase/0.449
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.449
3sf6FDAGlutaryl-CoA dehydrogenase/0.449
3ukoNADAlcohol dehydrogenase class-3/0.449
3vryB43Tyrosine-protein kinase HCK2.7.10.20.449
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.449
4jbtASDCytochrome P450 monooxygenase/0.449
4kwi1TJReductase homolog/0.449
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.449
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.449
3sn6P0GBeta-2 adrenergic receptor/0.449
1ie9VDXVitamin D3 receptor/0.448
1nm6L86Prothrombin3.4.21.50.448
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2bbqPFGThymidylate synthase/0.448
2bvs2CEProthrombin3.4.21.50.448
2c3qGTXGlutathione S-transferase theta-12.5.1.180.448
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.448
2q7vFADThioredoxin reductase/0.448
2vx07X7Ephrin type-B receptor 42.7.10.10.448
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3hqdANPKinesin-like protein KIF11/0.448
3o6o94MHeat shock protein 83/0.448
3p6mDSOCamphor 5-monooxygenase1.14.15.10.448
4dhyS41Glucokinase2.7.1.20.448
4jlj1NMDeoxycytidine kinase2.7.1.740.448
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.448
4x24TDI5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/0.448
1b2lNDCAlcohol dehydrogenase1.1.1.10.447
1galFADGlucose oxidase1.1.3.40.447
1kqwRTLCellular retinol-binding protein type II/0.447
1o97FADElectron transfer flavoprotein subunit alpha/0.447
1ra3NAPDihydrofolate reductase1.5.1.30.447
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.447
1uyrD1LAcetyl-CoA carboxylase/0.447
2qo9ANPEphrin type-A receptor 32.7.10.10.447
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
2wyaHMGHydroxymethylglutaryl-CoA synthase, mitochondrial2.3.3.100.447
3adaNADSubunit alpha of sarocosine oxidase/0.447
3fln3FNMitogen-activated protein kinase 14/0.447
3qwc98PProthrombin3.4.21.50.447
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.447
4a87NARMajor pollen allergen Bet v 1-A/0.447
4gs4ACOAlpha-tubulin N-acetyltransferase 1/0.447
4i02CMPcAMP-activated global transcriptional regulator CRP/0.447
4iaq2GM5-hydroxytryptamine receptor 1B/0.447
4ma628EAra h 8 allergen/0.447
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4pl9ADPEthylene receptor 1/0.447
4rekFADCholesterol oxidase1.1.3.60.447
4u2sFDACholesterol oxidase1.1.3.60.447
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.447
1mvcBM6Retinoic acid receptor RXR-alpha/0.446
2f2sCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.446
2jh0701Prothrombin3.4.21.50.446
2qoqANPEphrin type-A receptor 32.7.10.10.446
2yk2YJXHeat shock protein HSP 90-alpha/0.446
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.446
3mzhCMPCRP-like cAMP-activated global transcriptional regulator/0.446
3q44D50M1 family aminopeptidase3.4.110.446
3ska053Genome polyprotein2.7.7.480.446
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4ddrMMVDihydrofolate reductase1.5.1.30.446
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.446
4g210VPVitamin D3 receptor A/0.446
4o761M3Bromodomain-containing protein 4/0.446
4uyf73BBromodomain-containing protein 2/0.446
1g6nCMPcAMP-activated global transcriptional regulator CRP/0.445
1ijhFADCholesterol oxidase1.1.3.60.445
1khrVIRStreptogramin A acetyltransferase2.3.10.445
1qorNDPQuinone oxidoreductase 1/0.445
1s3uTQDDihydrofolate reductase1.5.1.30.445
1yc2NADNAD-dependent protein deacylase 2/0.445
1z7yAA5Cysteine synthase 12.5.1.470.445
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2bdyUNBProthrombin3.4.21.50.445
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
2bjsACVIsopenicillin N synthase1.21.3.10.445
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.445
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.445
3b7dCNIGlutamate receptor 2/0.445
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.445
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3slkNDPPolyketide synthase extender module 2/0.445
3stxBKAMethylketone synthase I/0.445
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.445
4af3VX6Aurora kinase B2.7.11.10.445
4an4DUDPutative glycosyl transferase/0.445
4bj9UHBTankyrase-22.4.2.300.445
4d03NAPPhenylacetone monooxygenase1.14.13.920.445
4qzuRTLRetinol-binding protein 2/0.445
4rh10TTSpore photoproduct lyase/0.445
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.445
4xxgFADCholesterol oxidase1.1.3.60.445
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.445
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.445
7catNDPCatalase1.11.1.60.445
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.444
1g63FMNEpidermin decarboxylase4.1.10.444
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.444
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.444
1txtCAAHMG-CoA synthase/0.444
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.444
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.444
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
2tctCTCTetracycline repressor protein class D/0.444
2w3mFOLDihydrofolate reductase1.5.1.30.444
2xlrFADPutative flavin-containing monooxygenase/0.444
3a783EVVitamin D3 receptor/0.444
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3ekuCY9Actin-5C/0.444
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3ixp834Ecdysone receptor/0.444
3vjoANPEpidermal growth factor receptor2.7.10.10.444
3w0iO11Vitamin D3 receptor/0.444
4cdmFO1Deoxyribodipyrimidine photolyase/0.444
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.444
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.444
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
5kf2ACOPredicted acetyltransferase/0.444
1f5fDHTSex hormone-binding globulin/0.443
1mewXMPInosine-5'-monophosphate dehydrogenase/0.443
1n4uFAECholesterol oxidase1.1.3.60.443
1wn3HXCPhenylacetic acid degradation protein PaaI/0.443
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.443
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2ol4JPNEnoyl-ACP reductase/0.443
2ozuACOHistone acetyltransferase KAT6A/0.443
2qocANPEphrin type-A receptor 32.7.10.10.443
2x9dITCTetracycline repressor protein class D/0.443
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.443
3flyFLYMitogen-activated protein kinase 14/0.443
3htjETEbrA repressor/0.443
3pqbVGPPutative oxidoreductase/0.443
3up0D7SaceDAF-12/0.443
4at0FADPossible succinate dehydrogenase/0.443
4ceqQCHIntegrase/0.443
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.443
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.443
5aluHD2Bifunctional epoxide hydrolase 23.1.3.760.443
5uviZMAAdenosine receptor A2a/0.443
5iua6DXAdenosine receptor A2a/0.443
1cqp803Integrin alpha-L/0.442
1ie8KH1Vitamin D3 receptor/0.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1mp0NADAlcohol dehydrogenase class-31.1.1.10.442
1re9DSOCamphor 5-monooxygenase1.14.15.10.442
1uyePU9Heat shock protein HSP 90-alpha/0.442
2c42TPPPyruvate synthase/0.442
2clfF6FTryptophan synthase alpha chain/0.442
2cn0F25Prothrombin3.4.21.50.442
2eerNADNAD-dependent alcohol dehydrogenase1.1.1.10.442
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.442
2p1t3TNRetinoic acid receptor RXR-alpha/0.442
2ph5NADHomospermidine synthase/0.442
2rabNADGlutathione amide reductase/0.442
2rr1W8RGenome polyprotein/0.442
2w6cBM4Acetylcholinesterase3.1.1.70.442
3c35KAIGlutamate receptor ionotropic, kainate 1/0.442
3falREARetinoic acid receptor RXR-alpha/0.442
3kpzZNEVitamin D3 receptor/0.442
3maaFKPAdenylate cyclase type 2/0.442
3maaFKPAdenylate cyclase type 5/0.442
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
3pm9FADPutative oxidoreductase/0.442
3thrC2FGlycine N-methyltransferase2.1.1.200.442
3vw8DF6Hepatocyte growth factor receptor2.7.10.10.442
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.442
4bfvZVVPantothenate kinase2.7.1.330.442
4gsuDWZL,D-transpeptidase 22.3.20.442
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.442
4jq8KJ8Epidermal growth factor receptor2.7.10.10.442
4mka2AYGenome polyprotein2.7.7.480.442
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.442
4rvgTYDD-mycarose 3-C-methyltransferase/0.442
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.442
5d0rB1TAdenylate cyclase type 10/0.442
5dp2NAPCurF/0.442
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.442
1f0xFADD-lactate dehydrogenase1.1.1.280.441
1jwtBLIProthrombin3.4.21.50.441
1me6IVSPlasmepsin-23.4.23.390.441
1pu9COAHAT A1/0.441
1ut6A8NAcetylcholinesterase3.1.1.70.441
2givACOHistone acetyltransferase KAT8/0.441
2iko7IGRenin3.4.23.150.441
2ykeYKEHeat shock protein HSP 90-alpha/0.441
3b9oFMNAlkane monoxygenase/0.441
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.441
3l0lHC3Nuclear receptor ROR-gamma/0.441
3px3T3QdTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase2.1.1.2350.441
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3vs3VSETyrosine-protein kinase HCK2.7.10.20.441
3vt9YI4Vitamin D3 receptor/0.441
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
4kfjFOLDihydrofolate reductase1.5.1.30.441
4pd6URINucleoside permease/0.441
5k2aZMAAdenosine receptor A2a/0.441
1crbRTLRetinol-binding protein 1/0.440
1fm69CRRetinoic acid receptor RXR-alpha/0.440
1gc5ADPADP-dependent glucokinase2.7.1.1470.440
1kkq471Peroxisome proliferator-activated receptor alpha/0.440
1mxtFAECholesterol oxidase1.1.3.60.440
1puaCOAHAT A1/0.440
1qsnCOAHAT A1/0.440
1re0AFBADP-ribosylation factor 1/0.440
1re0AFBARF guanine-nucleotide exchange factor 1/0.440
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.440
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
1zosMTM5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/0.440
1zprCB3Thymidylate synthase/0.440
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.440
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.440
2ym2NAPPhenylacetone monooxygenase1.14.13.920.440
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
3deiRXBCaspase-33.4.22.560.440
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
3s41S41Glucokinase2.7.1.20.440
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3zsh469Mitogen-activated protein kinase 14/0.440
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.440
4jv41ORcAMP-dependent protein kinase type I-alpha regulatory subunit/0.440
4xqcNADHomospermidine synthase2.5.1.440.440
4xx0COASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial6.2.1.40.440
5c3jFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.440
5cb5APRO-acetyl-ADP-ribose deacetylase/0.440
3qakUKAAdenosine receptor A2a/0.440