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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2uvyGVIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2uvyGVIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.640
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.634
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.601
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.593
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.589
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.583
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.578
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.574
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.563
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.562
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.557
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.557
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.550
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.539
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.532
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.527
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.526
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.521
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
3nf7CIWGag-Pol polyprotein/0.519
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.514
4cjwCBJIntegrase/0.512
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.503
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
2jedLG8Protein kinase C theta type2.7.11.130.499
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.499
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
4dymIYZActivin receptor type-12.7.11.300.499
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
1ppjANYCytochrome b/0.495
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
3nfaCBJGag-Pol polyprotein/0.495
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
3jynNDPQuinone oxidoreductase/0.493
1zzlTZYMitogen-activated protein kinase 14/0.492
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
3hub469Mitogen-activated protein kinase 14/0.492
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
4anmWULCasein kinase II subunit alpha2.7.11.10.491
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
3kpzZNEVitamin D3 receptor/0.489
1osvCHCBile acid receptor/0.488
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2o7pNAPRiboflavin biosynthesis protein RibD/0.486
3pm0BHFCytochrome P450 1B1/0.485
4iwc1GVEstrogen receptor/0.485
1eioGCHGastrotropin/0.484
4o701QKBromodomain-containing protein 4/0.484
5dozNDPJamJ/0.484
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.483
4iaq2GM5-hydroxytryptamine receptor 1B/0.483
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.482
2z3uCRRCytochrome P450/0.481
4fhi0S4Vitamin D3 receptor A/0.480
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.478
2pvmP29Casein kinase II subunit alpha2.7.11.10.477
2x9dITCTetracycline repressor protein class D/0.477
3qtrX36Cyclin-dependent kinase 22.7.11.220.477
4eon1ROCyclin-dependent kinase 22.7.11.220.477
4ia7BIVVitamin D3 receptor A/0.476
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.475
2yac937Serine/threonine-protein kinase PLK12.7.11.210.475
3a1l2CCCytochrome P450/0.475
3qfvNM7Serine/threonine-protein kinase MRCK beta2.7.11.10.475
3fl4FL4Mitogen-activated protein kinase 14/0.474
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.473
3p3zP3ZPutative cytochrome P450/0.473
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.472
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.472
3bgiSAHThiopurine S-methyltransferase2.1.1.670.472
3fmmXI2Mitogen-activated protein kinase 14/0.472
3tkuM77Serine/threonine-protein kinase MRCK beta2.7.11.10.472
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
1q4u4CA4-hydroxybenzoyl-CoA thioesterase3.1.2.230.471
3fknFKNMitogen-activated protein kinase 14/0.471
4r20AERCytochrome P450 family 17 polypeptide 2/0.471
4xybNDPFormate dehydrogenase/0.471
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
1xuoLA1Integrin alpha-L/0.470
3fkoFKOMitogen-activated protein kinase 14/0.470
4fhh0U3Vitamin D3 receptor A/0.470
4o7uTHFThymidylate synthase/0.470
4othDRNSerine/threonine-protein kinase N1/0.470
2b55D31Cyclin-dependent kinase 22.7.11.220.469
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.469
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.468
4kdrSAHUbiquinone biosynthesis O-methyltransferase/0.468
1ot7CHCBile acid receptor/0.467
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.467
3w5p4OAVitamin D3 receptor/0.467
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.467
4rrfA3SThreonine--tRNA ligase6.1.1.30.467
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2ydoADNAdenosine receptor A2a/0.466
3vt3VDXVitamin D3 receptor/0.466
3w0c6DSVitamin D3 receptor/0.466
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.466
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.466
3gkjHC3Niemann-Pick C1 protein/0.465
3q44D50M1 family aminopeptidase3.4.110.465
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.465
2vcmM11Isopenicillin N synthase1.21.3.10.464
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.464
3glmCOOGlutaconyl-CoA decarboxylase alpha subunit/0.464
3stv3HOMethylketone synthase I/0.464
4u2lSFDCholesterol oxidase1.1.3.60.464
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.463
2ath3EAPeroxisome proliferator-activated receptor gamma/0.463
2bxoOPBSerum albumin/0.463
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.463
3itzP66Mitogen-activated protein kinase 14/0.463
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.463
3mtfA3FActivin receptor type-12.7.11.300.463
3r9hZ67Cyclin-dependent kinase 22.7.11.220.463
3vt8YI3Vitamin D3 receptor/0.463
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.463
4qzuRTLRetinol-binding protein 2/0.463
4y8wSTRSteroid 21-hydroxylase/0.463
1f4fTP3Thymidylate synthase/0.462
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.462
2a4nCOAAac(6')-Ii protein/0.462
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
2i9pNAD3-hydroxyisobutyrate dehydrogenase, mitochondrial1.1.1.310.462
2vbdV10Isopenicillin N synthase1.21.3.10.462
3s7a684Dihydrofolate reductase1.5.1.30.462
3vrtYS2Vitamin D3 receptor/0.462
4fx360KCyclin-dependent kinase 22.7.11.220.462
4i8vBHFCytochrome P450 1A11.14.14.10.462
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.461
3p6oETGCamphor 5-monooxygenase1.14.15.10.461
3qzgX67Cyclin-dependent kinase 22.7.11.220.461
3rak03ZCyclin-dependent kinase 22.7.11.220.461
3vt5YI2Vitamin D3 receptor/0.461
3w0jT08Vitamin D3 receptor/0.461
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.461
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.461
5uviZMAAdenosine receptor A2a/0.461
1ie9VDXVitamin D3 receptor/0.460
1tlcF89Thymidylate synthase/0.460
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.460
2bu9HFVIsopenicillin N synthase1.21.3.10.460
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.460
3cic316Beta-secretase 13.4.23.460.460
3gwfFADCyclohexanone monooxygenase/0.460
3p9kSAHCaffeic acid O-methyltransferase/0.460
3sdkP3NProteasome subunit beta type-53.4.25.10.460
3sdkP3NProteasome subunit beta type-63.4.25.10.460
3vspEK8Peroxisome proliferator-activated receptor gamma/0.460
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.460
4ez30S0Cyclin-dependent kinase 22.7.11.220.460
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.460
4iarERM5-hydroxytryptamine receptor 1B/0.460
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.460
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.460
4y6nUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.460
1ckpPVBCyclin-dependent kinase 22.7.11.220.459
1obnASVIsopenicillin N synthase1.21.3.10.459
2za0MGILactoylglutathione lyase4.4.1.50.459
3a783EVVitamin D3 receptor/0.459
3dmhSAMProbable ribosomal RNA small subunit methyltransferase/0.459
3m8qDJZGag-Pol polyprotein2.7.7.490.459
3qtzX42Cyclin-dependent kinase 22.7.11.220.459
3w0aDS5Vitamin D3 receptor/0.459
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
4g1y0VOVitamin D3 receptor A/0.459
4g2i0VQVitamin D3 receptor/0.459
1e1lFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.458
1mp0NADAlcohol dehydrogenase class-31.1.1.10.458
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.458
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.458
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.458
4gueQCTRibosomal protein S6 kinase alpha-32.7.11.10.458
4j6dTESCytochrome P450 monooxygenase/0.458
4jbtASDCytochrome P450 monooxygenase/0.458
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.458
4u2sFDACholesterol oxidase1.1.3.60.458
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.457
1opbRETRetinol-binding protein 2/0.457
1zeoC01Peroxisome proliferator-activated receptor gamma/0.457
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.457
2ibzSMACytochrome b/0.457
2iqgF2IBeta-secretase 13.4.23.460.457
3hmm855TGF-beta receptor type-12.7.11.300.457
3w78CBDFMN-dependent NADH-azoreductase/0.457
3zkyWT4Isopenicillin N synthase1.21.3.10.457
4a9mP9MBromodomain-containing protein 2/0.457
4e37NDPCatalase1.11.1.60.457
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.457
4prxADPDNA gyrase subunit B/0.457
4pyoSAHCatechol O-methyltransferase2.1.1.60.457
4pytFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.457
2cnsACORibosomal-protein-alanine acetyltransferase/0.456
2owvSAHDiphthine synthase/0.456
2zb8IMNProstaglandin reductase 21.3.1.480.456
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
3ncz3NCRho-associated protein kinase 12.7.11.10.456
3oht1N1Mitogen-activated protein kinase/0.456
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
3vewADPnebramycin 5' synthase6.1.2.20.456
3vrwYS5Vitamin D3 receptor/0.456
3vt65YIVitamin D3 receptor/0.456
3w5tLHPVitamin D3 receptor/0.456
4a9hTVPBromodomain-containing protein 2/0.456
4ea2RWZDehydrosqualene synthase/0.456
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.456
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.456
1kzjCB3Thymidylate synthase/0.455
2aazCB3Thymidylate synthase2.1.1.450.455
2hamC33Vitamin D3 receptor/0.455
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.455
2w98P1ZProstaglandin reductase 21.3.1.480.455
3adaNADSubunit alpha of sarocosine oxidase/0.455
3akn11DFatty acid-binding protein, intestinal/0.455
3bg7FADPyranose 2-oxidase/0.455
3cid318Beta-secretase 13.4.23.460.455
3qtwX3ACyclin-dependent kinase 22.7.11.220.455
3slkNDPPolyketide synthase extender module 2/0.455
3tk3CPZCytochrome P450 2B41.14.14.10.455
3zsh469Mitogen-activated protein kinase 14/0.455
4iwxADPRibosomal protein S6--L-glutamate ligase/0.455
4l8u9AZSerum albumin/0.455
3sn6P0GBeta-2 adrenergic receptor/0.455
1fndA2PFerredoxin--NADP reductase, chloroplastic1.18.1.20.454
1hb1OCVIsopenicillin N synthase1.21.3.10.454
1pjkANPCasein kinase II subunit alpha2.7.11.10.454
1v1k3FPCyclin-dependent kinase 22.7.11.220.454
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.454
2hb8MVDVitamin D3 receptor/0.454
2hcdBIVVitamin D3 receptor A/0.454
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.454
2wd4TBVAscorbate peroxidase/0.454
3abaFLICytochrome P450/0.454
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.454
3gubGUBDeath-associated protein kinase 12.7.11.10.454
3s1h56ZCyclin-dependent kinase 22.7.11.220.454
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.454
3t8vBTJM1 family aminopeptidase3.4.110.454
3thrC2FGlycine N-methyltransferase2.1.1.200.454
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.454
4f6s0SQCyclin-dependent kinase 82.7.11.220.454
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.454
4q0a4OAVitamin D3 receptor A/0.454
1fvt106Cyclin-dependent kinase 22.7.11.220.453
1txiTX5Vitamin D3 receptor/0.453
1zhzERGOxysterol-binding protein homolog 4/0.453
2ftoCB3Thymidylate synthase/0.453
2pvlP55Casein kinase II subunit alpha2.7.11.10.453
2pvnP63Casein kinase II subunit alpha2.7.11.10.453
3e2sFADBifunctional protein PutA1.5.5.20.453
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
4rekFADCholesterol oxidase1.1.3.60.453
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.453
4y9xUPGGlucosyl-3-phosphoglycerate synthase2.4.1.2660.453
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.453
4z34ON7Lysophosphatidic acid receptor 1/0.453
1tduCB3Thymidylate synthase/0.452
1vceSAHDiphthine synthase/0.452
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.452
2hm9TRRDihydrofolate reductase1.5.1.30.452
2j9lATPH(+)/Cl(-) exchange transporter 5/0.452
3ds6A17Mitogen-activated protein kinase 14/0.452
3lu8IQXSerum albumin/0.452
3o8gO8GHTH-type transcriptional regulator EthR/0.452
3unk0BYCyclin-dependent kinase 22.7.11.220.452
3zoiM2WIsopenicillin N synthase1.21.3.10.452
4a81DXCMajor pollen allergen Bet v 1-A/0.452
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.452
5k2dZMAAdenosine receptor A2a/0.452
1bwsNDPGDP-L-fucose synthase/0.451
1cboFADCholesterol oxidase1.1.3.60.451
1g5sI17Cyclin-dependent kinase 22.7.11.220.451
1m2pHNACasein kinase II subunit alpha2.7.11.10.451
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.451
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.451
2ji9ADPOxalyl-CoA decarboxylase4.1.1.80.451
2x23TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.451
3be9P04Casein kinase II subunit alpha2.7.11.10.451
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.451
3gcq1BUMitogen-activated protein kinase 14/0.451
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.451
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.451
3t2kFADSulfide-quinone reductase/0.451
3vf2ADPnebramycin 5' synthase6.1.2.20.451
3w5q3KLVitamin D3 receptor/0.451
3zlnH0YBcl-2-like protein 1/0.451
4dsbA8SAbscisic acid receptor PYL3/0.451
4j4vSVRNucleocapsid protein/0.451
4j6cSTRCytochrome P450 monooxygenase/0.451
4nb6444Nuclear receptor ROR-gamma/0.451
4psbGA3Cytokinin-specific binding protein/0.451
4rrqA3SThreonine--tRNA ligase6.1.1.30.451
4rupH97Vitamin D3 receptor A/0.451
1ictT44Transthyretin/0.450
1ove358Mitogen-activated protein kinase 14/0.450
1powFADPyruvate oxidase1.2.3.30.450
1r6g442Thyroid hormone receptor beta/0.450
2bx8AZQSerum albumin/0.450
2yixYIXMitogen-activated protein kinase 14/0.450
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.450
3gyiFADCholesterol oxidase1.1.3.60.450
3lpfZ77Beta-glucuronidase3.2.1.310.450
3lpiZ74Beta-secretase 13.4.23.460.450
3pqbVGPPutative oxidoreductase/0.450
4bfuZVUPantothenate kinase2.7.1.330.450
4ead0NPThymidine phosphorylase2.4.2.40.450
4knzCB3Thymidylate synthase/0.450
4l9zCOAL-malyl-CoA/beta-methylmalyl-CoA lyase4.1.3.240.450
4lfiGNPCasein kinase II subunit alpha2.7.11.10.450
4zcaADPKinesin-like protein KIF11/0.450
1q4xG24Thyroid hormone receptor beta/0.449
1rk3VDXVitamin D3 receptor/0.449
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.449
2bfpH4BPteridine reductase 11.5.1.330.449
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.449
2r3yVAL_TYR_TRP_PHESerine endoprotease DegS3.4.21.1070.449
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.449
3bi5FADPolyamine oxidase FMS1/0.449
3dfcANPDeath-associated protein kinase 12.7.11.10.449
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.449
3l8p0CEAngiopoietin-1 receptor2.7.10.10.449
3ral04ZCyclin-dependent kinase 22.7.11.220.449
3up3XCAaceDAF-12/0.449
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.449
3w2eNADNADH-cytochrome b5 reductase 31.6.2.20.449
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.449
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4o71CPBBromodomain-containing protein 4/0.449
4x2qNADRetinal dehydrogenase 21.2.1.360.449
4xwrFADCholesterol oxidase1.1.3.60.449
5iqhGNPBifunctional AAC/APH2.3.10.449
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.448
1dxrMSTReaction center protein L chain/0.448
1gqyACPUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.448
1l2jETCEstrogen receptor beta/0.448
1rf9DBRCamphor 5-monooxygenase1.14.15.10.448
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.448
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.448
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.448
3cndFADPolyamine oxidase FMS1/0.448
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
3r3f4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.448
3rk708ZCyclin-dependent kinase 22.7.11.220.448
3tifADPUncharacterized ABC transporter ATP-binding protein MJ0796/0.448
3zos0LIEpithelial discoidin domain-containing receptor 12.7.10.10.448
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.448
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.448
4qi5FADCellobiose dehydrogenase/0.448
5ab7MLCNonspecific lipid-transfer protein, putative/0.448
1b4vFADCholesterol oxidase1.1.3.60.447
1blzACVIsopenicillin N synthase1.21.3.10.447
1e92HBIPteridine reductase 11.5.1.330.447
1ijhFADCholesterol oxidase1.1.3.60.447
1ke9LS5Cyclin-dependent kinase 22.7.11.220.447
1y4lSVRBasic phospholipase A2 homolog 2/0.447
1yqj6NPMitogen-activated protein kinase 14/0.447
1z6tADPApoptotic protease-activating factor 1/0.447
1zq9SAMProbable dimethyladenosine transferase/0.447
2dw4FADLysine-specific histone demethylase 1A10.447
2hb7O1CVitamin D3 receptor/0.447
2hnzPC0Gag-Pol polyprotein2.7.7.490.447
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.447
2q9fC3SCholesterol 24-hydroxylase/0.447
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.447
2y6fM9FIsopenicillin N synthase1.21.3.10.447
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.447
3bx5304Mitogen-activated protein kinase 14/0.447
3il4ACO3-oxoacyl-[acyl-carrier-protein] synthase 3/0.447
3nynSGVG protein-coupled receptor kinase 62.7.11.160.447
3p6nDSOCamphor 5-monooxygenase1.14.15.10.447
3qn8NI7Gag-Pol polyprotein3.4.23.160.447
3ukoNADAlcohol dehydrogenase class-3/0.447
3uxhUXHRibosyldihydronicotinamide dehydrogenase [quinone]/0.447
3wixLC3Induced myeloid leukemia cell differentiation protein Mcl-1/0.447
4ceqQCHIntegrase/0.447
4dm6TTBRetinoic acid receptor beta/0.447
4elb34RDihydrofolate reductase/0.447
4g6hNAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.447
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.447
4n4t2GVTankyrase-12.4.2.300.447
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.446
1wuuANPGalactokinase2.7.1.60.446
2gfsPQBMitogen-activated protein kinase 14/0.446
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.446
3fc6REARetinoic acid receptor RXR-alpha/0.446
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3gbuATPUncharacterized sugar kinase PH14592.7.10.446
3id8MRKGlucokinase2.7.1.20.446
3iupNDPPossible NADH oxidoreductase/0.446
3pm9FADPutative oxidoreductase/0.446
3qwkX62Cyclin-dependent kinase 22.7.11.220.446
3r374CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.446
3rgfBAXCyclin-dependent kinase 82.7.11.220.446
3rni21ZCyclin-dependent kinase 22.7.11.220.446
3w0gW07Vitamin D3 receptor/0.446
3wleNAD(R)-specific carbonyl reductase/0.446
4an2EUIDual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.446
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.446
4g1z0VPVitamin D3 receptor A/0.446
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.446
4i3wNADAldehyde dehydrogenase (NAD+)/0.446
4id71G0Activated CDC42 kinase 1/0.446
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.446
4nc3ERM5-hydroxytryptamine receptor 2B/0.446
4xrgNADHomospermidine synthase2.5.1.440.446
4y8vADPAcyl-CoA synthetase (NDP forming)/0.446
5bp9SAHPutative methyltransferase protein/0.446
3reyXACAdenosine receptor A2a/0.446
1diuBDMDihydrofolate reductase1.5.1.30.445
1egcCO8Medium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.445
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.445
1iyzNDPProbable quinone oxidoreductase/0.445
1ly4COQDihydrofolate reductase1.5.1.30.445
1w06W05Isopenicillin N synthase1.21.3.10.445
2djiFADPyruvate oxidase/0.445
2idkC2FGlycine N-methyltransferase2.1.1.200.445
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
2p83MR0Beta-secretase 13.4.23.460.445
2pvhP19Casein kinase II subunit alpha2.7.11.10.445
2wlgSOPPolysialic acid O-acetyltransferase/0.445
2y6dTQJMatrilysin3.4.24.230.445
2ylxFADPhenylacetone monooxygenase1.14.13.920.445
3gc8B45Mitogen-activated protein kinase 112.7.11.240.445
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.445
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.445
3qbwADPAnhydro-N-acetylmuramic acid kinase/0.445
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.445
3vtbTKAVitamin D3 receptor/0.445
4agcAXIVascular endothelial growth factor receptor 22.7.10.10.445
4dkv0KWEnvelope glycoprotein gp160/0.445
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.445
4g1d0VKVitamin D3 receptor A/0.445
4lxhC1EAlpha/beta hydrolase fold/0.445
4r21STRCytochrome P450 family 17 polypeptide 2/0.445
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.445
6upjNIUGag-Pol polyprotein/0.445
1dkfBMSRetinoic acid receptor alpha/0.444
1h1pCMGCyclin-dependent kinase 22.7.11.220.444
1jutLYDThymidylate synthase/0.444
1lp4ANPCasein kinase II subunit alpha2.7.11.10.444
1lwlDSOCamphor 5-monooxygenase1.14.15.10.444
1n4uFAECholesterol oxidase1.1.3.60.444
1p0hCOAMycothiol acetyltransferase2.3.1.1890.444
1poxFADPyruvate oxidase1.2.3.30.444
1w83L11Mitogen-activated protein kinase 14/0.444
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.444
2ckeIQUDeath-associated protein kinase 2/0.444
2fzhDH1Dihydrofolate reductase1.5.1.30.444
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.444
2w1hL0FCyclin-dependent kinase 22.7.11.220.444
2zl9VDAVitamin D3 receptor/0.444
3acw651Dehydrosqualene synthase/0.444
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.444
3gcnTYR_GLN_PHESerine endoprotease DegS3.4.21.1070.444
3lu6IMXSerum albumin/0.444
3nieANPMitogen-activated protein kinase/0.444
3nu5478Gag-Pol polyprotein3.4.23.160.444
3oiaA31Camphor 5-monooxygenase1.14.15.10.444
3oqkS52Renin3.4.23.150.444
3rjc06ZCyclin-dependent kinase 22.7.11.220.444
3sheI85MAP kinase-activated protein kinase 32.7.11.10.444
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.444
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.444
4ib4ERM5-hydroxytryptamine receptor 2B/0.444
4impNDPPolyketide synthase extender modules 3-4/0.444
4nieNBHNuclear receptor ROR-gamma/0.444
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.444
1bsvNDPGDP-L-fucose synthase/0.443
1di8DTQCyclin-dependent kinase 22.7.11.220.443
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.443
1s60COAAminoglycoside N(6')-acetyltransferase type 1/0.443
1s9dAFBCytohesin-2/0.443
1s9dAFBADP-ribosylation factor 1/0.443
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.443
1sqvUHDCytochrome b/0.443
2hl1A3SThreonine--tRNA ligase6.1.1.30.443
2iviACWIsopenicillin N synthase1.21.3.10.443
2j4z626Aurora kinase A2.7.11.10.443
2xikJ60Serine/threonine-protein kinase 252.7.11.10.443
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.443
3bhrTHGThymidylate synthase/0.443
3cd2MTXDihydrofolate reductase1.5.1.30.443
3cib314Beta-secretase 13.4.23.460.443
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.443
3gkiCLRNiemann-Pick C1 protein/0.443
3k9vCPS1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial/0.443
3lpkZ76Beta-secretase 13.4.23.460.443
3p2eSAH16S rRNA (adenine(1408)-N(1))-methyltransferase2.1.1.1800.443
3qm4PN0Cytochrome P450 2D6/0.443
3s0o50ZCyclin-dependent kinase 22.7.11.220.443
3stxBKAMethylketone synthase I/0.443
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.443
4ez8DHFThymidylate synthase2.1.1.450.443
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4hjoAQ4Epidermal growth factor receptor2.7.10.10.443
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.443
4ii5ADPCyclin-dependent kinase 22.7.11.220.443
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.443
4uhrNGIAdenosine receptor A2a/0.443
1disBDMDihydrofolate reductase1.5.1.30.442
1eh4IC1Casein kinase I homolog 12.7.11.10.442
1fmlRTLRetinol dehydratase/0.442
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.442
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.442
1lhvNOGSex hormone-binding globulin/0.442
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.442
1xlsREARetinoic acid receptor RXR-alpha/0.442
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.442
2ca0PXICytochrome P450 monooxygenase PikC/0.442
2dshSAHDiphthine synthase/0.442
2g37FADProline dehydrogenase/0.442
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.442
2iw94SPCyclin-dependent kinase 22.7.11.220.442
2oaxSNLMineralocorticoid receptor/0.442
2p1u4TNRetinoic acid receptor RXR-alpha/0.442
2qjpANJCytochrome b/0.442
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.442
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.442
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
2ydfIO3Serum albumin/0.442
3aw9NADNAD-dependent epimerase/dehydratase/0.442
3axwTIDCasein kinase II subunit alpha2.7.11.10.442
3em6017Gag-Pol polyprotein3.4.23.160.442
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.442
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
3il1B5DGlutamate receptor 2/0.442
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.442
3r3d4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.442
3rf7NADIron-containing alcohol dehydrogenase/0.442
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.442
3vtcTK3Vitamin D3 receptor/0.442
3wmxNADNAD dependent epimerase/dehydratase/0.442
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.442
4fwjFADLysine-specific histone demethylase 1B10.442
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4gyiADPUncharacterized protein/0.442
4ho8THMGlucose-1-phosphate thymidylyltransferase/0.442
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.442
4ruoBIVVitamin D3 receptor A/0.442
1an5CB3Thymidylate synthase/0.441
1aypINBPhospholipase A2, membrane associated/0.441
1kuyCOTSerotonin N-acetyltransferase/0.441
1mxtFAECholesterol oxidase1.1.3.60.441
1qiqACCIsopenicillin N synthase1.21.3.10.441
1r8qAFBCytohesin-2/0.441
1r8qAFBADP-ribosylation factor 1/0.441
1rrmAPRLactaldehyde reductase1.1.1.770.441
1s0zEB1Vitamin D3 receptor/0.441
1wmaAB3Carbonyl reductase [NADPH] 11.1.1.1840.441
1zsnTN2Enoyl-ACP reductase/0.441
2bu7TF3[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.441
2fxdDR7Pol polyprotein/0.441
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.441
2vbpVB1Isopenicillin N synthase1.21.3.10.441
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.441
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.441
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.441
3dl9V2HVitamin D 25-hydroxylase/0.441
3hk1B64Fatty acid-binding protein, adipocyte/0.441
3hv3R49Mitogen-activated protein kinase 14/0.441
3l0lHC3Nuclear receptor ROR-gamma/0.441
3mnrSD1Heat shock protein HSP 90-alpha/0.441
3p3c3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.441
3rmf20ZCyclin-dependent kinase 22.7.11.220.441
3zh8C58Protein kinase C iota type2.7.11.130.441
4at0FADPossible succinate dehydrogenase/0.441
4b1fKRHGlutamate racemase/0.441
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4eb4D16Thymidylate synthase2.1.1.450.441
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.441
4iwyADPRibosomal protein S6--L-glutamate ligase/0.441
4xbfFADLysine-specific histone demethylase 1A10.441
4y6gF6FTryptophan synthase alpha chain/0.441
5c7hNDPPutative oxidoreductase/0.441
5caeCOASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial6.2.1.40.441
5e8xSTUTGF-beta receptor type-12.7.11.300.441
5g53NECAdenosine receptor A2a/0.441
1bk0ACVIsopenicillin N synthase1.21.3.10.440
1cc2FADCholesterol oxidase1.1.3.60.440
1iiuRTLRetinol-binding protein 4/0.440
1jujLYAThymidylate synthase2.1.1.450.440
1o6rR19Squalene--hopene cyclase4.2.1.1290.440
1ysx4EBSerum albumin/0.440
2aylFLPProstaglandin G/H synthase 11.14.99.10.440
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
2jb4A14Isopenicillin N synthase1.21.3.10.440
2nq8ZIDEnoyl-ACP reductase/0.440
2vczVC3Hematopoietic prostaglandin D synthase/0.440
3bqdDAYGlucocorticoid receptor/0.440
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.440
3fzsB96Protein-tyrosine kinase 2-beta2.7.10.20.440
3gwnFADProbable FAD-linked sulfhydryl oxidase R5961.8.3.20.440
3h4vDVPPteridine reductase 11.5.1.330.440
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440
3juhANPCasein kinase II subunit alpha2.7.11.10.440
3lltANPProtein serine/threonine kinase-1/0.440
3oibFDAPutative acyl-CoA dehydrogenase/0.440
3r9dX6BCyclin-dependent kinase 22.7.11.220.440
3r9oZ71Cyclin-dependent kinase 22.7.11.220.440
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3rk507ZCyclin-dependent kinase 22.7.11.220.440
3up0D7SaceDAF-12/0.440
3zbnCOA3-ketoacyl-CoA thiolase-like protein/0.440
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4fnyI3KALK tyrosine kinase receptor2.7.10.10.440
4g210VPVitamin D3 receptor A/0.440
4h4m494Gag-Pol polyprotein2.7.7.490.440
4ict1EDMycocyclosin synthase1.14.21.90.440
4inb1F6Gag protein/0.440
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.440
4jlk1NODeoxycytidine kinase2.7.1.740.440
4prvADPDNA gyrase subunit B/0.440
4qa0SHHHistone deacetylase 83.5.1.980.440
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4xwtU5PRibonuclease J/0.440
5dp2NAPCurF/0.440