sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 1.000 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.663 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.642 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.630 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.616 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.600 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.599 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.599 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.599 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.597 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.597 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.597 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.594 | |
| 1u0z | RDC | Endoplasmin | / | 0.593 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.589 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.589 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.588 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.588 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.587 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.587 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.585 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.583 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.583 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.582 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.580 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.579 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.579 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.578 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.578 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.576 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.574 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.573 | |
| 2vw5 | BC6 | ATP-dependent molecular chaperone HSP82 | / | 0.570 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.567 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.566 | |
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 0.566 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.565 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 2exl | GDM | Endoplasmin | / | 0.563 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.563 | |
| 2gfd | RDA | Endoplasmin | / | 0.562 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.562 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.561 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.561 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.561 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.560 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.560 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.559 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.557 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.556 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.555 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.554 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.553 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.553 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.550 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.550 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.550 | |
| 2fyp | RDE | Endoplasmin | / | 0.548 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.547 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.546 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.546 | |
| 1qy8 | RDI | Endoplasmin | / | 0.544 | |
| 1u0y | PA7 | Endoplasmin | / | 0.544 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 2gqp | PA7 | Endoplasmin | / | 0.544 | |
| 3ied | AN2 | HSP90 | / | 0.543 | |
| 3q5l | KX2 | Heat shock protein 83-1 | / | 0.543 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.543 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.537 | |
| 2o1u | ANP | Endoplasmin | / | 0.535 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.535 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.531 | |
| 2hch | N5A | Endoplasmin | / | 0.531 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.530 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.530 | |
| 1qy5 | NEC | Endoplasmin | / | 0.529 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.525 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.524 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.524 | |
| 2hg1 | N5O | Endoplasmin | / | 0.524 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.524 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.523 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.522 | |
| 2esa | GDM | Endoplasmin | / | 0.521 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.520 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.519 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.516 | |
| 1u2o | NEC | Endoplasmin | / | 0.515 | |
| 1ysz | NEC | Endoplasmin | / | 0.515 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.514 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.513 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.512 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.510 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.510 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.510 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.509 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.509 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.508 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.508 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.505 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.504 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.503 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.502 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.501 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.501 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.500 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.500 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.497 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.496 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 3omu | IBD | Heat shock protein 83 | / | 0.488 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.487 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.487 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.486 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.485 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.483 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.481 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.479 | |
| 2o1v | ADP | Endoplasmin | / | 0.479 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.479 | |
| 2zkj | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.478 | |
| 1z59 | ADP | Type 2 DNA topoisomerase 6 subunit B | / | 0.477 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.477 | |
| 2q8i | RDC | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial | 2.7.11.2 | 0.477 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.477 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.477 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 3rlp | 3RP | Heat shock protein HSP 90-alpha | / | 0.474 | |
| 1yt0 | ADP | Endoplasmin | / | 0.472 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.472 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.472 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.472 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 1i5a | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.469 | |
| 2bu2 | ATP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.469 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.469 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.466 | |
| 1nxk | STU | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.466 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.466 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.465 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.465 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.464 | |
| 2xx5 | 13N | ATP-dependent molecular chaperone HSP82 | / | 0.464 | |
| 4j95 | ACP | Fibroblast growth factor receptor 2 | / | 0.464 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.464 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.464 | |
| 1i5b | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.463 | |
| 1i58 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.462 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.462 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.461 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.460 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.460 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.459 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.459 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.459 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.458 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.458 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.458 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.457 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.457 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.457 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.457 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.456 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.456 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.456 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.456 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.455 | |
| 3bvb | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.454 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.454 | |
| 4ict | 1ED | Mycocyclosin synthase | 1.14.21.9 | 0.454 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.454 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.454 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.454 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 3gob | HXX | DdmC | / | 0.453 | |
| 3tdl | 11D | Serum albumin | / | 0.453 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.453 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.453 | |
| 1jvs | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.452 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.452 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.452 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.452 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.452 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.452 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.452 | |
| 4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.452 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 1ida | 0PO | Gag-Pol polyprotein | 3.4.23.47 | 0.451 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.451 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.451 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.451 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.451 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.451 | |
| 3zux | TCH | Transporter | / | 0.451 | |
| 4an3 | 5Y0 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.451 | |
| 4eil | CB3 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.451 | |
| 1eio | GCH | Gastrotropin | / | 0.450 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.450 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 4bcn | T9N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.450 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.450 | |
| 5c03 | AGS | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.450 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.449 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.449 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.449 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.448 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.448 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.448 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3em6 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.448 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.447 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.447 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.447 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.447 | |
| 3eek | 53S | Uncharacterized protein | / | 0.447 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.447 | |
| 3t8o | ATP | Rhodopsin kinase | / | 0.447 | |
| 4l44 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.447 | |
| 4o3m | ADP | Bloom syndrome protein | 3.6.4.12 | 0.447 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.447 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 4f65 | 0S9 | Fibroblast growth factor receptor 1 | / | 0.446 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.445 | |
| 1ie4 | T44 | Transthyretin | / | 0.445 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.445 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.445 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2x3n | FAD | Probable FAD-dependent monooxygenase | / | 0.445 | |
| 2yi6 | 6QM | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.445 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.445 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4gu6 | 10N | Focal adhesion kinase 1 | 2.7.10.2 | 0.445 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.445 | |
| 4kba | 1QM | Casein kinase I isoform delta | 2.7.11.1 | 0.445 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.445 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.445 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.445 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.444 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.444 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1jm6 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.444 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.444 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.444 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.444 | |
| 3dsz | LIZ | Neutrophil gelatinase-associated lipocalin | / | 0.444 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.444 | |
| 3wec | AUI | Cytochrome P450 | / | 0.444 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.444 | |
| 4guv | FAD | TetX family tetracycline inactivation enzyme | / | 0.444 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.444 | |
| 4ic7 | ANP | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.444 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.443 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.443 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2b55 | D31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2c6h | PXI | Cytochrome P450 monooxygenase PikC | / | 0.443 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.443 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.443 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.443 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 3c50 | ADP | Rhodopsin kinase | / | 0.443 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.443 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.443 | |
| 3u9e | COA | Lmo1369 protein | / | 0.443 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.443 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.443 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.443 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1ke6 | LS2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.442 | |
| 1zdw | FLV | Prenyltransferase | / | 0.442 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2f3k | RO1 | Protease | / | 0.442 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.442 | |
| 3c4x | ATP | Rhodopsin kinase | / | 0.442 | |
| 3cgd | NAD | Coenzyme A disulfide reductase | / | 0.442 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.442 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4fcq | 2N6 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.442 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.441 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.441 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.441 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
| 3d7t | STU | Tyrosine-protein kinase CSK | / | 0.441 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.441 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.441 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.441 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.441 | |
| 4fg8 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.441 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 4gfg | 0XF | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.441 | |
| 4gih | 0X5 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.441 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.441 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.441 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.440 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.440 | |
| 2j0m | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.440 | |
| 2jko | BIJ | Focal adhesion kinase 1 | 2.7.10.2 | 0.440 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3jy0 | LYG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3lfn | A27 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.440 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4cdm | FAD | Deoxyribodipyrimidine photolyase | / | 0.440 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.440 | |
| 4mvf | STU | Calcium-dependent protein kinase 2 | 2.7.11.1 | 0.440 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.440 |